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The map label for this gene is rho [H]

Identifier: 20806667

GI number: 20806667

Start: 137437

End: 138903

Strand: Direct

Name: rho [H]

Synonym: TTE0138

Alternate gene names: 20806667

Gene position: 137437-138903 (Clockwise)

Preceding gene: 20806666

Following gene: 20806668

Centisome position: 5.11

GC content: 40.49

Gene sequence:

>1467_bases
TTGGAGTTTGATATTAATAATCTGGAAAATTTAGGTTTAATGGAATTGAGGGAAATTGCGAAAGAGCTGGGCATCAAGAG
TATTACGAAATACAGAAAGCAGCAGTTGAGAGAAAAAATTATTGAAAAAGTAAAAGAAAAAGAGGAAGAAAAGCTTAAGC
AAGAAGAAAAAATTCCAGAGGAGAATAAAGAGAATAAAGAAGAAAATAAAGAAGAGGGCGAAGAGGAAAAGGTTCAATCT
GTGGCTCTTAGCAATAACGGCCTCCAATCTCAGCAGGCTTTCTTAAAAGAGAACTTACCTATGGTGAAGGACCTTTCTGA
CCCTTTGAAAGAGCTTATACAGACGCAGGGAGACGTAGTAGCAGAAGGGATTTTGGATATTCTGCCTGATGGGTTTGGAT
TTTTAAGAGTAGAAAATTTTACACAGGGGCCAAAGGACATATATATTTCTCAGTCTCAGATAAGAAGATTTGGACTTAAA
GTGGGAGACAAGGTCAGAGGAATCACTCGAATTCCGAGAGAAGGAGAAAAGTATTCTGCTATTTTGTACGTTGAGGCTAT
AAATGATGAAGACCCAGAAAAGGCCAAAAAGAGAATTCCTTTTGATGAACTTACCCCTATTTTCCCTAATCAAAAGTTAA
GGCTTGAGACATCCCCTCGTGAGTTTTCTATGAGGCTGGTGGACCTAATAGCGCCTATAGGCAAAGGTCAGAGGGGAATG
ATTGTCGCTCCTCCTAAAGCCGGTAAGACGACTTTGTTAAAGCAGATCGCCAATAGCATTTCTCAAAACCATCCCGAAGT
AGTTTTAATAGTCCTTTTGATCGATGAGAGGCCTGAAGAAGTAACTGATATGAAGAGGTCTATAAAAGGGGAAGTAGTGT
ATTCTACTTTTGACGAACTGCCAGAGCACCACATCAAAGTTGCAGAGATGGTCTTAGAGCATGCCAAAAGATTGGTAGAA
TACAAAAGAGATGTGGTTATTTTATTGGACAGCATTACAAGATTAGCAAGGGCATACAATTTGGTGACACCACCTTCAGG
AAGGACTCTATCAGGTGGAATTGACCCTGCTGCTTTGCATCCGCCGAAGAGATTTTTTGGGGCAGCAAGGAACATTGAAG
AAGGCGGAAGCCTCACGATTTTGGCGACTGCCTTAGTTGAGACGGGAAGCCGTATGGATGAAGTGATATTTGAAGAGTTT
AAAGGGACGGGCAATATGGAGCTGCACTTAGATAGAAAGCTTCAGGAAAGAAGGATATTCCCTGCCATTGACATATATAA
ATCCGGTACGAGGAAAGAAGAGCTGCTGCTCACGCAGGAGGAGCTGGAAGCCATGTGGATTTTGAGAAAAGCCATGTCAA
ATCTTCCTCCTCAAGAAGTTACAGAAATGATAATTGAGAAATTGATAAGGACGAAGTCAAATGCTGAGTTTGTAAATATG
ATAAGGTCCCAATTTTATAAATCTTGA

Upstream 100 bases:

>100_bases
TTCTCAGCTTTTGTTTTTCTTCGTGCGGTTTGTCCGTTCTCATTTATCCCCAGTTTAGAATGGAAATTTTTTAAAAATCT
ATATTTTGGGAGGTGCGCTT

Downstream 100 bases:

>100_bases
TATTGTCCACAACTTGTGTTATAATTTCACCGTATGAGTTTGGGCTTGAGTGAGGTGAGATAGCGATGAAACCAGGTATA
CATCCCACCTATTATCACGA

Product: transcription termination factor Rho

Products: NA

Alternate protein names: ATP-dependent helicase Rho [H]

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MEFDINNLENLGLMELREIAKELGIKSITKYRKQQLREKIIEKVKEKEEEKLKQEEKIPEENKENKEENKEEGEEEKVQS
VALSNNGLQSQQAFLKENLPMVKDLSDPLKELIQTQGDVVAEGILDILPDGFGFLRVENFTQGPKDIYISQSQIRRFGLK
VGDKVRGITRIPREGEKYSAILYVEAINDEDPEKAKKRIPFDELTPIFPNQKLRLETSPREFSMRLVDLIAPIGKGQRGM
IVAPPKAGKTTLLKQIANSISQNHPEVVLIVLLIDERPEEVTDMKRSIKGEVVYSTFDELPEHHIKVAEMVLEHAKRLVE
YKRDVVILLDSITRLARAYNLVTPPSGRTLSGGIDPAALHPPKRFFGAARNIEEGGSLTILATALVETGSRMDEVIFEEF
KGTGNMELHLDRKLQERRIFPAIDIYKSGTRKEELLLTQEELEAMWILRKAMSNLPPQEVTEMIIEKLIRTKSNAEFVNM
IRSQFYKS

Sequences:

>Translated_488_residues
MEFDINNLENLGLMELREIAKELGIKSITKYRKQQLREKIIEKVKEKEEEKLKQEEKIPEENKENKEENKEEGEEEKVQS
VALSNNGLQSQQAFLKENLPMVKDLSDPLKELIQTQGDVVAEGILDILPDGFGFLRVENFTQGPKDIYISQSQIRRFGLK
VGDKVRGITRIPREGEKYSAILYVEAINDEDPEKAKKRIPFDELTPIFPNQKLRLETSPREFSMRLVDLIAPIGKGQRGM
IVAPPKAGKTTLLKQIANSISQNHPEVVLIVLLIDERPEEVTDMKRSIKGEVVYSTFDELPEHHIKVAEMVLEHAKRLVE
YKRDVVILLDSITRLARAYNLVTPPSGRTLSGGIDPAALHPPKRFFGAARNIEEGGSLTILATALVETGSRMDEVIFEEF
KGTGNMELHLDRKLQERRIFPAIDIYKSGTRKEELLLTQEELEAMWILRKAMSNLPPQEVTEMIIEKLIRTKSNAEFVNM
IRSQFYKS
>Mature_488_residues
MEFDINNLENLGLMELREIAKELGIKSITKYRKQQLREKIIEKVKEKEEEKLKQEEKIPEENKENKEENKEEGEEEKVQS
VALSNNGLQSQQAFLKENLPMVKDLSDPLKELIQTQGDVVAEGILDILPDGFGFLRVENFTQGPKDIYISQSQIRRFGLK
VGDKVRGITRIPREGEKYSAILYVEAINDEDPEKAKKRIPFDELTPIFPNQKLRLETSPREFSMRLVDLIAPIGKGQRGM
IVAPPKAGKTTLLKQIANSISQNHPEVVLIVLLIDERPEEVTDMKRSIKGEVVYSTFDELPEHHIKVAEMVLEHAKRLVE
YKRDVVILLDSITRLARAYNLVTPPSGRTLSGGIDPAALHPPKRFFGAARNIEEGGSLTILATALVETGSRMDEVIFEEF
KGTGNMELHLDRKLQERRIFPAIDIYKSGTRKEELLLTQEELEAMWILRKAMSNLPPQEVTEMIIEKLIRTKSNAEFVNM
IRSQFYKS

Specific function: Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template [H]

COG id: COG1158

COG function: function code K; Transcription termination factor

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Rho family [H]

Homologues:

Organism=Escherichia coli, GI1790217, Length=379, Percent_Identity=60.6860158311346, Blast_Score=476, Evalue=1e-135,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000194
- InterPro:   IPR003593
- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR011112
- InterPro:   IPR011113
- InterPro:   IPR004665 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF07498 Rho_N; PF07497 Rho_RNA_bind [H]

EC number: NA

Molecular weight: Translated: 55767; Mature: 55767

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFDINNLENLGLMELREIAKELGIKSITKYRKQQLREKIIEKVKEKEEEKLKQEEKIPE
CCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ENKENKEENKEEGEEEKVQSVALSNNGLQSQQAFLKENLPMVKDLSDPLKELIQTQGDVV
CCCCCHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHH
AEGILDILPDGFGFLRVENFTQGPKDIYISQSQIRRFGLKVGDKVRGITRIPREGEKYSA
HHHHHHHCCCCCCEEEECCCCCCCHHEEECHHHHHHHHHHHCHHHHHHHCCCCCCCCEEE
ILYVEAINDEDPEKAKKRIPFDELTPIFPNQKLRLETSPREFSMRLVDLIAPIGKGQRGM
EEEEEECCCCCHHHHHHCCCHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCE
IVAPPKAGKTTLLKQIANSISQNHPEVVLIVLLIDERPEEVTDMKRSIKGEVVYSTFDEL
EECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHH
PEHHIKVAEMVLEHAKRLVEYKRDVVILLDSITRLARAYNLVTPPSGRTLSGGIDPAALH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PPKRFFGAARNIEEGGSLTILATALVETGSRMDEVIFEEFKGTGNMELHLDRKLQERRIF
CCHHHHHHHCCCCCCCCEEHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECHHHHHCCCC
PAIDIYKSGTRKEELLLTQEELEAMWILRKAMSNLPPQEVTEMIIEKLIRTKSNAEFVNM
CHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHH
IRSQFYKS
HHHHHCCC
>Mature Secondary Structure
MEFDINNLENLGLMELREIAKELGIKSITKYRKQQLREKIIEKVKEKEEEKLKQEEKIPE
CCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ENKENKEENKEEGEEEKVQSVALSNNGLQSQQAFLKENLPMVKDLSDPLKELIQTQGDVV
CCCCCHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHH
AEGILDILPDGFGFLRVENFTQGPKDIYISQSQIRRFGLKVGDKVRGITRIPREGEKYSA
HHHHHHHCCCCCCEEEECCCCCCCHHEEECHHHHHHHHHHHCHHHHHHHCCCCCCCCEEE
ILYVEAINDEDPEKAKKRIPFDELTPIFPNQKLRLETSPREFSMRLVDLIAPIGKGQRGM
EEEEEECCCCCHHHHHHCCCHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCE
IVAPPKAGKTTLLKQIANSISQNHPEVVLIVLLIDERPEEVTDMKRSIKGEVVYSTFDEL
EECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHHHHHHHH
PEHHIKVAEMVLEHAKRLVEYKRDVVILLDSITRLARAYNLVTPPSGRTLSGGIDPAALH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PPKRFFGAARNIEEGGSLTILATALVETGSRMDEVIFEEFKGTGNMELHLDRKLQERRIF
CCHHHHHHHCCCCCCCCEEHHHHHHHHCCCHHHHHHHHHHCCCCCEEEEECHHHHHCCCC
PAIDIYKSGTRKEELLLTQEELEAMWILRKAMSNLPPQEVTEMIIEKLIRTKSNAEFVNM
CHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHH
IRSQFYKS
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8423140; 9353933; 9384377 [H]