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The map label for this gene is Fba [H]

Identifier: 20806666

GI number: 20806666

Start: 136351

End: 137202

Strand: Direct

Name: Fba [H]

Synonym: TTE0137

Alternate gene names: 20806666

Gene position: 136351-137202 (Clockwise)

Preceding gene: 20806665

Following gene: 20806667

Centisome position: 5.07

GC content: 42.61

Gene sequence:

>852_bases
ATGTTAGTTACAGGGATTGAAATACTTGAGAAGGCTCACAAAGAAGGGTATGCGGTCGGAGCTTTTAACACCAGCAACCT
GGAAATTACGCAGGCTATTGTAGAGGCTGCAGAAGAGACCAGGTCTCCTGTGATAATTCAGGTGAGTGAAGGGGGCCTTA
AGTACGCTGGCATTGAGGCGATTTCAGCTATTGTAAGGACACTGGCTGAAAAAGCTACAGTTCCCATTGCTCTTCACTTG
GATCACGGTACAGATTTTAACACCATAATGAAGTGCTTAAGGAATGGCTGGACTTCTGTTATGATTGATGCTTCTAAATT
TCCTTTAGAGGAAAACATACAAAGGACCAGGAAAATTGTTGAGATTGCCCACAGCATGGGAGTTTCAGTCGAGGCAGAAA
TAGGTAAAATTGGCGGAACGGAAGACCACATTACAGTTGATGAAAGGGAAGCTTCAATGACTGACCCTGAAGAAGCTCTG
CGCTTTGCCAAGGAGACAGGAGTTGATTATTTGGCAATAGCAATTGGCACGGCCCATGGGCCATACAAAGGAGAGCCTAA
ACTTGATTTTGAGAGGTTAAAGAGAATAAAAGAGCTTTTAAACATGCCTTTAGTTTTGCATGGAGCTTCAGGGGTACCTG
AGGAAGCGATAAAAAAAGCTGTAAGTCTTGGGATTAACAAGATAAACATAGATACGGATGTAAGACAGGCTTTTACAGCG
AGGTTAAGAAGGCTCCTTGAAGAAGATAAAGAAGTCTATGACCCGAGAAAGATTTTAGGCCCCTGCAAAGAGGCGATGAA
AGAGGTCATAAAGCAGAAAATGATTTTATTTGGCTCATCTTTAAAGGCATAA

Upstream 100 bases:

>100_bases
CCTTTTGACATACTTGAGCTAAAAAAATTAGTTTATGAAAATCTAAAACAGGAAATGGCGGTATAAATACAAATTTTATA
GACTGAAGGAGTTGTTGAAG

Downstream 100 bases:

>100_bases
AGCGGGTTTTACCCGCTTTAAATTTTATGTATAAATTTTTGCAAAATGGCAAAAATATCAATGAACTTGTTAAAAAAGGC
ACTTGACATGTTGATAAAAT

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MLVTGIEILEKAHKEGYAVGAFNTSNLEITQAIVEAAEETRSPVIIQVSEGGLKYAGIEAISAIVRTLAEKATVPIALHL
DHGTDFNTIMKCLRNGWTSVMIDASKFPLEENIQRTRKIVEIAHSMGVSVEAEIGKIGGTEDHITVDEREASMTDPEEAL
RFAKETGVDYLAIAIGTAHGPYKGEPKLDFERLKRIKELLNMPLVLHGASGVPEEAIKKAVSLGINKINIDTDVRQAFTA
RLRRLLEEDKEVYDPRKILGPCKEAMKEVIKQKMILFGSSLKA

Sequences:

>Translated_283_residues
MLVTGIEILEKAHKEGYAVGAFNTSNLEITQAIVEAAEETRSPVIIQVSEGGLKYAGIEAISAIVRTLAEKATVPIALHL
DHGTDFNTIMKCLRNGWTSVMIDASKFPLEENIQRTRKIVEIAHSMGVSVEAEIGKIGGTEDHITVDEREASMTDPEEAL
RFAKETGVDYLAIAIGTAHGPYKGEPKLDFERLKRIKELLNMPLVLHGASGVPEEAIKKAVSLGINKINIDTDVRQAFTA
RLRRLLEEDKEVYDPRKILGPCKEAMKEVIKQKMILFGSSLKA
>Mature_283_residues
MLVTGIEILEKAHKEGYAVGAFNTSNLEITQAIVEAAEETRSPVIIQVSEGGLKYAGIEAISAIVRTLAEKATVPIALHL
DHGTDFNTIMKCLRNGWTSVMIDASKFPLEENIQRTRKIVEIAHSMGVSVEAEIGKIGGTEDHITVDEREASMTDPEEAL
RFAKETGVDYLAIAIGTAHGPYKGEPKLDFERLKRIKELLNMPLVLHGASGVPEEAIKKAVSLGINKINIDTDVRQAFTA
RLRRLLEEDKEVYDPRKILGPCKEAMKEVIKQKMILFGSSLKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI87082041, Length=271, Percent_Identity=45.3874538745387, Blast_Score=256, Evalue=9e-70,
Organism=Escherichia coli, GI1789526, Length=273, Percent_Identity=43.5897435897436, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1788072, Length=275, Percent_Identity=40.7272727272727, Blast_Score=199, Evalue=1e-52,
Organism=Escherichia coli, GI1789293, Length=323, Percent_Identity=27.8637770897833, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322790, Length=285, Percent_Identity=27.3684210526316, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 31116; Mature: 31116

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVTGIEILEKAHKEGYAVGAFNTSNLEITQAIVEAAEETRSPVIIQVSEGGLKYAGIEA
CCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
ISAIVRTLAEKATVPIALHLDHGTDFNTIMKCLRNGWTSVMIDASKFPLEENIQRTRKIV
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
EIAHSMGVSVEAEIGKIGGTEDHITVDEREASMTDPEEALRFAKETGVDYLAIAIGTAHG
HHHHHHCCEEEEHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCC
PYKGEPKLDFERLKRIKELLNMPLVLHGASGVPEEAIKKAVSLGINKINIDTDVRQAFTA
CCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCEEECCHHHHHHHHH
RLRRLLEEDKEVYDPRKILGPCKEAMKEVIKQKMILFGSSLKA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLVTGIEILEKAHKEGYAVGAFNTSNLEITQAIVEAAEETRSPVIIQVSEGGLKYAGIEA
CCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHH
ISAIVRTLAEKATVPIALHLDHGTDFNTIMKCLRNGWTSVMIDASKFPLEENIQRTRKIV
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHH
EIAHSMGVSVEAEIGKIGGTEDHITVDEREASMTDPEEALRFAKETGVDYLAIAIGTAHG
HHHHHHCCEEEEHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCC
PYKGEPKLDFERLKRIKELLNMPLVLHGASGVPEEAIKKAVSLGINKINIDTDVRQAFTA
CCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHCCCEEECCHHHHHHHHH
RLRRLLEEDKEVYDPRKILGPCKEAMKEVIKQKMILFGSSLKA
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA