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The map label for this gene is FumA [C]

Identifier: 20806608

GI number: 20806608

Start: 82441

End: 82992

Strand: Direct

Name: FumA [C]

Synonym: TTE0076

Alternate gene names: 20806608

Gene position: 82441-82992 (Clockwise)

Preceding gene: 20806607

Following gene: 20806609

Centisome position: 3.07

GC content: 37.14

Gene sequence:

>552_bases
ATGTACAGAAAATTAAATACACCTTTACTAGATGAAGTAACAGTACAATTGAAAGCAGGGGATTTGATTTTGCTCTCAGG
AGAGATTTATACTGCAAGAGATGAAGCTCATAAAAGGATGGTTGAAGCACTGGATAGAGGGGAAATGCTACCTTTTGAAA
TTAAAAATTCTATCATTTACTACGTTGGACCTTGTCCTCCTAGACCAGGACAAGTTGTTGGAAGTTGTGGGCCTACTACA
AGTGGAAGAATGGACAAATATGCTCCGAGATTGATTGAATTAGGATTAAAAGGGATGATTGGGAAGGGTGCTAGGTCAGA
AGAAGTTGTAGAATTCATGAAAAAACATAAGGCAGTTTATTTTACTGCTGTAGGAGGAGCTGGTGCTTTACTTGCCCAAA
GAGTCAAAAAAGTGGAAGTAGTAGCTTATGAAGATTTAGGGCCAGAGGCTATTTATAAGTTTACTGTAGAAGATTTTCCT
CTGATTGTGACTATAGACTGCTATGGAAACAATCTTTATGAAATTGAAAGAGAAAAATACAGGAAAAGGTGA

Upstream 100 bases:

>100_bases
TATCCTACCCACATTGCTTCTTTGCCTGTTGCAGTAAATTTGGGATGCCATGCTACGAGACACGCTACTTTTGTATTATA
ATTATGTTTGGAGGGAAAAC

Downstream 100 bases:

>100_bases
TAAAAATGGCACTTTTACCTTTAAAAGAACTATATCTTGCTTGTTTACACTGCACAAAGTGCGATTTGCACAAGACCAAA
ACTAATATGGTATTTGGTGA

Product: tartrate dehydratase subunit beta

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MYRKLNTPLLDEVTVQLKAGDLILLSGEIYTARDEAHKRMVEALDRGEMLPFEIKNSIIYYVGPCPPRPGQVVGSCGPTT
SGRMDKYAPRLIELGLKGMIGKGARSEEVVEFMKKHKAVYFTAVGGAGALLAQRVKKVEVVAYEDLGPEAIYKFTVEDFP
LIVTIDCYGNNLYEIEREKYRKR

Sequences:

>Translated_183_residues
MYRKLNTPLLDEVTVQLKAGDLILLSGEIYTARDEAHKRMVEALDRGEMLPFEIKNSIIYYVGPCPPRPGQVVGSCGPTT
SGRMDKYAPRLIELGLKGMIGKGARSEEVVEFMKKHKAVYFTAVGGAGALLAQRVKKVEVVAYEDLGPEAIYKFTVEDFP
LIVTIDCYGNNLYEIEREKYRKR
>Mature_183_residues
MYRKLNTPLLDEVTVQLKAGDLILLSGEIYTARDEAHKRMVEALDRGEMLPFEIKNSIIYYVGPCPPRPGQVVGSCGPTT
SGRMDKYAPRLIELGLKGMIGKGARSEEVVEFMKKHKAVYFTAVGGAGALLAQRVKKVEVVAYEDLGPEAIYKFTVEDFP
LIVTIDCYGNNLYEIEREKYRKR

Specific function: It Functions As An Aerobic Enzyme In The Citric Acid Cycle. It Accounts For About 80% Of The Fumarase Activity When The Bacteria Grows Aerobically. [C]

COG id: COG1838

COG function: function code C; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1787897, Length=175, Percent_Identity=42.2857142857143, Blast_Score=129, Evalue=8e-32,
Organism=Escherichia coli, GI1790564, Length=175, Percent_Identity=41.7142857142857, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789443, Length=188, Percent_Identity=34.5744680851064, Blast_Score=101, Evalue=2e-23,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004647 [H]

Pfam domain/function: PF05683 Fumerase_C [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 20537; Mature: 20537

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYRKLNTPLLDEVTVQLKAGDLILLSGEIYTARDEAHKRMVEALDRGEMLPFEIKNSIIY
CCCCCCCCCCCCEEEEEECCCEEEECCCEEECHHHHHHHHHHHHHCCCCCCEEECCCEEE
YVGPCPPRPGQVVGSCGPTTSGRMDKYAPRLIELGLKGMIGKGARSEEVVEFMKKHKAVY
EEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEE
FTAVGGAGALLAQRVKKVEVVAYEDLGPEAIYKFTVEDFPLIVTIDCYGNNLYEIEREKY
EEEECCHHHHHHHHHHHEEEEEECCCCCCCEEEEEECCCCEEEEEEECCCCEEEECHHHH
RKR
CCC
>Mature Secondary Structure
MYRKLNTPLLDEVTVQLKAGDLILLSGEIYTARDEAHKRMVEALDRGEMLPFEIKNSIIY
CCCCCCCCCCCCEEEEEECCCEEEECCCEEECHHHHHHHHHHHHHCCCCCCEEECCCEEE
YVGPCPPRPGQVVGSCGPTTSGRMDKYAPRLIELGLKGMIGKGARSEEVVEFMKKHKAVY
EEECCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEE
FTAVGGAGALLAQRVKKVEVVAYEDLGPEAIYKFTVEDFPLIVTIDCYGNNLYEIEREKY
EEEECCHHHHHHHHHHHEEEEEECCCCCCCEEEEEECCCCEEEEEEECCCCEEEECHHHH
RKR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]