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The map label for this gene is IlvB [H]

Identifier: 20806563

GI number: 20806563

Start: 24838

End: 26496

Strand: Direct

Name: IlvB [H]

Synonym: TTE0021

Alternate gene names: 20806563

Gene position: 24838-26496 (Clockwise)

Preceding gene: 20806562

Following gene: 20806565

Centisome position: 0.92

GC content: 40.93

Gene sequence:

>1659_bases
ATGAAGCTAAAAGGGGCTCAAGTTGTGATAGAAGTTTTAAAGGAGATGGGGGTTGATAATGTATTTGGAATCCCTGGAGG
AGCAGTTATTCCGATTTACGATGCTTTGTATGACTCTGACATAAGGCATATTTTAGCAACACACGAACAAATGGCTGCTC
ATATGGCAGATGGATATGCTAGGGCTACCGGAAAAGTTGGGGTGTGCATTGCAACTTCAGGGCCAGGAGCTACTAATTTA
GTTACAGGGATTGCCAATGCTTATATGGATTCTGTTCCGGTTGTCGCTATAACCGGCCAGGTTCCAACTTACCTGATAGG
AAAGGACGCATTTCAGGAGGTAGACATTACAGGCATCACAATGCCTATTACAAAGCACAATTTTGTGGTAAAATCTCCTG
AAAAGCTGGCAGATACTTTAAGGGAAGCATTTGCAATTGCAAAGAGCGGAAGGCCAGGGCCGGTTTTGGTGGACATTCCA
AAGGATATACAAAATGCAGAAATAGAGTATGAAAGAAAGGGAGAGATAGAATACAAAAATGGAATAAAAGAAATTATTTC
TGAAGAGAGCTTGTCAAAGGCGGTGGAGTTGATTTTAGAAAGCAAGAAGCCTGTTATCTTTGCAGGCGGGGGAGTGATAT
GGGGAGAAGCCTGTGGGGAACTTTTGGAATTTGCTGAAAAGACGAATATCCCTGTTGCAACTTCACTGATGGGGTTAGGA
TGCTTCCCCGGAGACCATCCTCTATCTTTGGGACTTATAGGTATGCATGGAAGCAGATTTGCAAATTTAGCTGTATATCA
CTCAGACCTTGTGATAGCTGTAGGAACGAGATTTAGCGATAGAGTGGCAGGAAAGGCCGGAGGGCTTGCACCAAAGGCCA
AATTTATACACATTGACATCGATGCAGCAGAAATAGGCAAAAATGTAGAAGTGGATGTGGGGATAGTTGGGAAGATAAAG
AAGGTATTAAAGCTTCTTGCAGATAGAGTTCCATCTATGGAAAGAAGAGAATGGTTAGAGGAAGTAGAAGAATTAAGAGT
GAAACATGGGCTTAGATATAAAAAAGACGACATGTTAAGGCCCCAATGGATAGTAGAAAAAATTCAAGAGCTCTCAAATG
ATGATCTCATTATAGCTACAGAAGTAGGGCAAAATCAAATGTGGGCAGCACAGTTTTACAAATTTAAAAAGCCTAGAACT
TTTGTCACTTCAGGGGGATTAGGGGCAATGGGTTTTGGCCTTCCCGCATCAATAGGTGCGCAGGTGGGAAGGCCAGATAA
AAGGGTTGTGAATATTGCAGGAGATGGAAGCTTGAGAATGAATATACACGCCTTAGAGACTGCTGCTTTCTACAATATCC
CGGTTATTATAGTACTACTTAATAATCAGGCTTTAGGAATGGTAAGGCAGTGGCAGTATCTTTTTAACGAAAAGAGATTT
TCTCAGACAGATTTAAATCCACACCTTAACTTTGCCAAAATTGCCAGTGATTTTGGAGTGGAAGGAATAAGAGTTACAAC
AAAAGAGGATTTTGAAAAAGCTTTTAAAAAAGCCTATAGCGAAAAAAAACCTTTTATGATAGAATGTATTATAGACAAAG
ACGAAATGGTGCTTCCATTTATTCCCGCAGGTGGGACTGTGGAAGATACTATTGCATAA

Upstream 100 bases:

>100_bases
GGAAGAGGCCAGAACCCAAGATAAAGAAGGGTTATATGGCGAGGTATACAAGAGAGGTGACTTCGGGGAGTAAAGGAGCG
GTATTTAGGGAGGGAGGAGT

Downstream 100 bases:

>100_bases
AAAGAAAGGGTTTGTGACCCTTTCTTTTTATTTCCAAGGCGGGATAATTTCTGCTTTTTGAAGAGCTTTAAATACTACTA
CAAATACAGGCCCTATTACA

Product: acetolactate synthase large subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 552; Mature: 552

Protein sequence:

>552_residues
MKLKGAQVVIEVLKEMGVDNVFGIPGGAVIPIYDALYDSDIRHILATHEQMAAHMADGYARATGKVGVCIATSGPGATNL
VTGIANAYMDSVPVVAITGQVPTYLIGKDAFQEVDITGITMPITKHNFVVKSPEKLADTLREAFAIAKSGRPGPVLVDIP
KDIQNAEIEYERKGEIEYKNGIKEIISEESLSKAVELILESKKPVIFAGGGVIWGEACGELLEFAEKTNIPVATSLMGLG
CFPGDHPLSLGLIGMHGSRFANLAVYHSDLVIAVGTRFSDRVAGKAGGLAPKAKFIHIDIDAAEIGKNVEVDVGIVGKIK
KVLKLLADRVPSMERREWLEEVEELRVKHGLRYKKDDMLRPQWIVEKIQELSNDDLIIATEVGQNQMWAAQFYKFKKPRT
FVTSGGLGAMGFGLPASIGAQVGRPDKRVVNIAGDGSLRMNIHALETAAFYNIPVIIVLLNNQALGMVRQWQYLFNEKRF
SQTDLNPHLNFAKIASDFGVEGIRVTTKEDFEKAFKKAYSEKKPFMIECIIDKDEMVLPFIPAGGTVEDTIA

Sequences:

>Translated_552_residues
MKLKGAQVVIEVLKEMGVDNVFGIPGGAVIPIYDALYDSDIRHILATHEQMAAHMADGYARATGKVGVCIATSGPGATNL
VTGIANAYMDSVPVVAITGQVPTYLIGKDAFQEVDITGITMPITKHNFVVKSPEKLADTLREAFAIAKSGRPGPVLVDIP
KDIQNAEIEYERKGEIEYKNGIKEIISEESLSKAVELILESKKPVIFAGGGVIWGEACGELLEFAEKTNIPVATSLMGLG
CFPGDHPLSLGLIGMHGSRFANLAVYHSDLVIAVGTRFSDRVAGKAGGLAPKAKFIHIDIDAAEIGKNVEVDVGIVGKIK
KVLKLLADRVPSMERREWLEEVEELRVKHGLRYKKDDMLRPQWIVEKIQELSNDDLIIATEVGQNQMWAAQFYKFKKPRT
FVTSGGLGAMGFGLPASIGAQVGRPDKRVVNIAGDGSLRMNIHALETAAFYNIPVIIVLLNNQALGMVRQWQYLFNEKRF
SQTDLNPHLNFAKIASDFGVEGIRVTTKEDFEKAFKKAYSEKKPFMIECIIDKDEMVLPFIPAGGTVEDTIA
>Mature_552_residues
MKLKGAQVVIEVLKEMGVDNVFGIPGGAVIPIYDALYDSDIRHILATHEQMAAHMADGYARATGKVGVCIATSGPGATNL
VTGIANAYMDSVPVVAITGQVPTYLIGKDAFQEVDITGITMPITKHNFVVKSPEKLADTLREAFAIAKSGRPGPVLVDIP
KDIQNAEIEYERKGEIEYKNGIKEIISEESLSKAVELILESKKPVIFAGGGVIWGEACGELLEFAEKTNIPVATSLMGLG
CFPGDHPLSLGLIGMHGSRFANLAVYHSDLVIAVGTRFSDRVAGKAGGLAPKAKFIHIDIDAAEIGKNVEVDVGIVGKIK
KVLKLLADRVPSMERREWLEEVEELRVKHGLRYKKDDMLRPQWIVEKIQELSNDDLIIATEVGQNQMWAAQFYKFKKPRT
FVTSGGLGAMGFGLPASIGAQVGRPDKRVVNIAGDGSLRMNIHALETAAFYNIPVIIVLLNNQALGMVRQWQYLFNEKRF
SQTDLNPHLNFAKIASDFGVEGIRVTTKEDFEKAFKKAYSEKKPFMIECIIDKDEMVLPFIPAGGTVEDTIA

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=555, Percent_Identity=25.9459459459459, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI21361361, Length=507, Percent_Identity=26.0355029585799, Blast_Score=149, Evalue=8e-36,
Organism=Escherichia coli, GI87081685, Length=562, Percent_Identity=42.1708185053381, Blast_Score=475, Evalue=1e-135,
Organism=Escherichia coli, GI1790104, Length=546, Percent_Identity=44.8717948717949, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI1786717, Length=557, Percent_Identity=36.0861759425494, Blast_Score=356, Evalue=3e-99,
Organism=Escherichia coli, GI1787096, Length=555, Percent_Identity=28.6486486486486, Blast_Score=215, Evalue=7e-57,
Organism=Escherichia coli, GI1788716, Length=563, Percent_Identity=27.5310834813499, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17531299, Length=565, Percent_Identity=27.0796460176991, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17531301, Length=565, Percent_Identity=27.0796460176991, Blast_Score=158, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17542570, Length=520, Percent_Identity=25.7692307692308, Blast_Score=146, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323755, Length=576, Percent_Identity=42.5347222222222, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6320816, Length=565, Percent_Identity=23.716814159292, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6321524, Length=480, Percent_Identity=22.9166666666667, Blast_Score=98, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6323163, Length=561, Percent_Identity=22.9946524064171, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320123, Length=512, Percent_Identity=22.65625, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323073, Length=479, Percent_Identity=22.5469728601253, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19922626, Length=540, Percent_Identity=25.5555555555556, Blast_Score=160, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 60249; Mature: 60249

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLKGAQVVIEVLKEMGVDNVFGIPGGAVIPIYDALYDSDIRHILATHEQMAAHMADGYA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
RATGKVGVCIATSGPGATNLVTGIANAYMDSVPVVAITGQVPTYLIGKDAFQEVDITGIT
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCHHHHHCCEEEEE
MPITKHNFVVKSPEKLADTLREAFAIAKSGRPGPVLVDIPKDIQNAEIEYERKGEIEYKN
EEEECCCEEEECHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEECCCCCCCHHH
GIKEIISEESLSKAVELILESKKPVIFAGGGVIWGEACGELLEFAEKTNIPVATSLMGLG
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEHHHHHHHHHHHHHCCCCCHHHHHHCC
CFPGDHPLSLGLIGMHGSRFANLAVYHSDLVIAVGTRFSDRVAGKAGGLAPKAKFIHIDI
CCCCCCCCEEEEEECCCCCCEEEEEEECCEEEEECCCCCHHHCCCCCCCCCCCEEEEEEE
DAAEIGKNVEVDVGIVGKIKKVLKLLADRVPSMERREWLEEVEELRVKHGLRYKKDDMLR
EHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PQWIVEKIQELSNDDLIIATEVGQNQMWAAQFYKFKKPRTFVTSGGLGAMGFGLPASIGA
HHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHCC
QVGRPDKRVVNIAGDGSLRMNIHALETAAFYNIPVIIVLLNNQALGMVRQWQYLFNEKRF
CCCCCCCEEEEEECCCEEEEEEEEEEHHEEECCCEEEEEECCCHHHHHHHHHHHHHHCCC
SQTDLNPHLNFAKIASDFGVEGIRVTTKEDFEKAFKKAYSEKKPFMIECIIDKDEMVLPF
CCCCCCCCCCHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEE
IPAGGTVEDTIA
ECCCCCCHHCCC
>Mature Secondary Structure
MKLKGAQVVIEVLKEMGVDNVFGIPGGAVIPIYDALYDSDIRHILATHEQMAAHMADGYA
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
RATGKVGVCIATSGPGATNLVTGIANAYMDSVPVVAITGQVPTYLIGKDAFQEVDITGIT
CCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCHHHHHCCEEEEE
MPITKHNFVVKSPEKLADTLREAFAIAKSGRPGPVLVDIPKDIQNAEIEYERKGEIEYKN
EEEECCCEEEECHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCEEECCCCCCCHHH
GIKEIISEESLSKAVELILESKKPVIFAGGGVIWGEACGELLEFAEKTNIPVATSLMGLG
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEHHHHHHHHHHHHHCCCCCHHHHHHCC
CFPGDHPLSLGLIGMHGSRFANLAVYHSDLVIAVGTRFSDRVAGKAGGLAPKAKFIHIDI
CCCCCCCCEEEEEECCCCCCEEEEEEECCEEEEECCCCCHHHCCCCCCCCCCCEEEEEEE
DAAEIGKNVEVDVGIVGKIKKVLKLLADRVPSMERREWLEEVEELRVKHGLRYKKDDMLR
EHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PQWIVEKIQELSNDDLIIATEVGQNQMWAAQFYKFKKPRTFVTSGGLGAMGFGLPASIGA
HHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHCC
QVGRPDKRVVNIAGDGSLRMNIHALETAAFYNIPVIIVLLNNQALGMVRQWQYLFNEKRF
CCCCCCCEEEEEECCCEEEEEEEEEEHHEEECCCEEEEEECCCHHHHHHHHHHHHHHCCC
SQTDLNPHLNFAKIASDFGVEGIRVTTKEDFEKAFKKAYSEKKPFMIECIIDKDEMVLPF
CCCCCCCCCCHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEE
IPAGGTVEDTIA
ECCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]