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The map label for this gene is GyrA [H]

Identifier: 20806553

GI number: 20806553

Start: 11704

End: 14127

Strand: Direct

Name: GyrA [H]

Synonym: TTE0011

Alternate gene names: 20806553

Gene position: 11704-14127 (Clockwise)

Preceding gene: 20806552

Following gene: 20806556

Centisome position: 0.44

GC content: 38.08

Gene sequence:

>2424_bases
ATGAACGAAGAAATGGACAAGGTCATTCCTGTTGATATAGAAGATGAGATGAGAAATTCCTATATTGATTATGCGATGAG
CGTGATTGTAGGAAGAGCCCTTCCTGACGTGAGGGATGGTTTAAAACCTGTTCATAGAAGAATTCTTTATGCCATGAATG
AGATGGGTTTGACACCAGACAAGCCCTATAAAAAGAGCGTAGCAGTAGTTGGTGAAGTTTTGGGGAAATACCATCCTCAC
GGAGATGCTGCTGTATATGATACGCTTGTCAGGCTTGCACAGGACTTTTCCATGAGAGAGGTTTTGATAGACGGGCATGG
AAATTTTGGCAGCATAGATGGAGACCCTCCTGCCGCAATGAGGTATACAGAAGCTAGGCTTTCCCGTATCGCTCTTGAAA
TGCTTACAGATATAAACAAGGAGACTGTAGATTTCGTTCCAAACTTTGATGAAACTTTGAAAGAGCCCGTGGTTTTGCCT
TCTCGCTTTCCAAACTTACTGGTAAACGGATCTCAAGGAATTGCAGTAGGAATGGCTACAAATATACCTCCTCACAATTT
AGCAGAAGTTATAGATGGCATTGTTGCCTATATAGACAACCCTTACATCACAGTGGATGAACTGATGAAGTACATTAAAG
GACCAGATTTCCCAACAGGAGGTATAATCCTAGGTAGGGACGGAATAAAGGAGACGTATGAGACAGGTAGAGGCAAAATT
ATCGTCAGAGCAAAGGCGGAAATTGAAGAGCACAAAGGCAAAACGAGAATTGTAATCACAGAAATTCCTTACATGGTTTT
AAAGGCTAAATTGATTGAAAAAATTGCTGAATTGGTGCACAACAAGCAAATAGAGGGAATTGCTGACTTAAGAGATGAAT
CTGACAGGAATGGAATGAAAATTGTAATAGAGCTAAAAAGGGATGTCAACCCAAAAGTTATACTTAACAAATTGTACATG
CATACTCAGATGCAGCAGACCTTTGGAGCTATAATGTTAGCTCTGGTAGATGGAGAGCCAAAAATACTCAATCTCAAGCA
GATTATTGAAAAGTACGTAGACCATCAGGCTGATGTAGTGACAAGAAGAACTAAATTTGACTTGAAAAAAGCGGAAGAAA
GAGCGCATATTTTGGAAGGTTTAAAAATAGCTCTCGACTACATAGATGAAGTGATAAACATAATAAGAAGTTCTAAAACA
GAAGCTATTGCTAAAGAAAATTTGATGAAGAGGTTTGGACTAAGCGATAAACAAGCACAAGCAATAGTTGACATGAGATT
AGGAAGGCTGACAGGGCTTGAGAGGCAAAAAGTAGAAGATGAGTTAAAAGAACTCATAGAGAAGATAAAAGAGTTGAAAG
AGATTTTAGCAGATGAAAGGAAAGTGTTGGAGATAATAAAGAAAGAGCTTTTAGAAATAAAAAATAAATACGCATCTCCA
AGAAAGACAGTTATTGTAGCAAAGGAAGAGGAATTAGATTTTGAAGATTTGGTTCAGCTGGAAGATGTAGTAGTTACTAT
GACCCACTACGGGTATATAAAGAGGATGCCTCTTGACACCTATAAGTCTCAAAAGAGAGGCGGTAAAGGAATTTTAGGAA
TATCTACCAGAGAAGATGATTTTGTGGAAGATATATTCATAACCACTACCCACGATAGGCTGTTGTTTTTCACGAATAAA
GGGAAAGTATATAGTTTGAGGACTATAGATATTCCTGAAAGTGGGAGACAAGCCAAAGGAACTGCTATAGTAAACTTGAT
ACAGATTTCTCAAGGTGAAAAGGTCACGGCAGTTATTCCTCTTAAGAAGTCAGACGACATAAAGTATGTCCTTATGTGTA
CCAAAAAGGGCATAATAAAGAAAACTTCCATTGAAGAATTTAAATCTATTAAGAGAAATGGAATAATTGCCATAACTCTG
GATGAAAATGATGAGCTCATAAATGTAAAGTTGACAAATGGAGAAAGAGAGGTAATAATAGGTACTGCCAAAGGATATGC
GATAAGGTTCAACGAAAAAGATGTAAGGCCAATGGGAAGGGTTGCAAGAGGAGTGATGGCTATATCGCTAAGAGAAGACG
ATGAAGTCGTGGAAATGGATTTGGTACATCCTGACGGAGAAGTTTTGACTGTTACAGAAAAGGGATTTGGCAAGAGAACT
GATTTAGAAGAATATAGAATCCAAGGAAGAGCAGGTAAGGGAATAATTGCAATGAAACTTAGCAAAAAAACAGGAAAACT
CGTCTCCATAAGGTGTGTCCAACCGGAAGATGAGTTTATGATAATCTCTGCTAACGGAATTTTGATAAGAATGAAAGTAA
AAGATATATCAAAAATGCACAGAGACACTCAAGGAGTCACCCTTATGAAATTAGAAGACGGAGATAGAGTGGTCTCTACG
GCAAGAATTGAAAGTGAGGAATAA

Upstream 100 bases:

>100_bases
TTTACTATACTGATGGGAGACAAAGTAGAGCCCAGAAGAGAATTTATAGAAAAATATGCTAAGACAGTAAGGAATTTGGA
TATATGAAGAGGTGAAATGG

Downstream 100 bases:

>100_bases
AACTAAGCCCTCAAGTTTTGGGGGCTTAGTTTTTAAATGCTCTTTCATATTGTTTTGGCCAGTCTTCCTTTGAAGTGTAT
GTATGCAAAACCCAATAGGG

Product: DNA gyrase (topoisomerase II) A subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 807; Mature: 807

Protein sequence:

>807_residues
MNEEMDKVIPVDIEDEMRNSYIDYAMSVIVGRALPDVRDGLKPVHRRILYAMNEMGLTPDKPYKKSVAVVGEVLGKYHPH
GDAAVYDTLVRLAQDFSMREVLIDGHGNFGSIDGDPPAAMRYTEARLSRIALEMLTDINKETVDFVPNFDETLKEPVVLP
SRFPNLLVNGSQGIAVGMATNIPPHNLAEVIDGIVAYIDNPYITVDELMKYIKGPDFPTGGIILGRDGIKETYETGRGKI
IVRAKAEIEEHKGKTRIVITEIPYMVLKAKLIEKIAELVHNKQIEGIADLRDESDRNGMKIVIELKRDVNPKVILNKLYM
HTQMQQTFGAIMLALVDGEPKILNLKQIIEKYVDHQADVVTRRTKFDLKKAEERAHILEGLKIALDYIDEVINIIRSSKT
EAIAKENLMKRFGLSDKQAQAIVDMRLGRLTGLERQKVEDELKELIEKIKELKEILADERKVLEIIKKELLEIKNKYASP
RKTVIVAKEEELDFEDLVQLEDVVVTMTHYGYIKRMPLDTYKSQKRGGKGILGISTREDDFVEDIFITTTHDRLLFFTNK
GKVYSLRTIDIPESGRQAKGTAIVNLIQISQGEKVTAVIPLKKSDDIKYVLMCTKKGIIKKTSIEEFKSIKRNGIIAITL
DENDELINVKLTNGEREVIIGTAKGYAIRFNEKDVRPMGRVARGVMAISLREDDEVVEMDLVHPDGEVLTVTEKGFGKRT
DLEEYRIQGRAGKGIIAMKLSKKTGKLVSIRCVQPEDEFMIISANGILIRMKVKDISKMHRDTQGVTLMKLEDGDRVVST
ARIESEE

Sequences:

>Translated_807_residues
MNEEMDKVIPVDIEDEMRNSYIDYAMSVIVGRALPDVRDGLKPVHRRILYAMNEMGLTPDKPYKKSVAVVGEVLGKYHPH
GDAAVYDTLVRLAQDFSMREVLIDGHGNFGSIDGDPPAAMRYTEARLSRIALEMLTDINKETVDFVPNFDETLKEPVVLP
SRFPNLLVNGSQGIAVGMATNIPPHNLAEVIDGIVAYIDNPYITVDELMKYIKGPDFPTGGIILGRDGIKETYETGRGKI
IVRAKAEIEEHKGKTRIVITEIPYMVLKAKLIEKIAELVHNKQIEGIADLRDESDRNGMKIVIELKRDVNPKVILNKLYM
HTQMQQTFGAIMLALVDGEPKILNLKQIIEKYVDHQADVVTRRTKFDLKKAEERAHILEGLKIALDYIDEVINIIRSSKT
EAIAKENLMKRFGLSDKQAQAIVDMRLGRLTGLERQKVEDELKELIEKIKELKEILADERKVLEIIKKELLEIKNKYASP
RKTVIVAKEEELDFEDLVQLEDVVVTMTHYGYIKRMPLDTYKSQKRGGKGILGISTREDDFVEDIFITTTHDRLLFFTNK
GKVYSLRTIDIPESGRQAKGTAIVNLIQISQGEKVTAVIPLKKSDDIKYVLMCTKKGIIKKTSIEEFKSIKRNGIIAITL
DENDELINVKLTNGEREVIIGTAKGYAIRFNEKDVRPMGRVARGVMAISLREDDEVVEMDLVHPDGEVLTVTEKGFGKRT
DLEEYRIQGRAGKGIIAMKLSKKTGKLVSIRCVQPEDEFMIISANGILIRMKVKDISKMHRDTQGVTLMKLEDGDRVVST
ARIESEE
>Mature_807_residues
MNEEMDKVIPVDIEDEMRNSYIDYAMSVIVGRALPDVRDGLKPVHRRILYAMNEMGLTPDKPYKKSVAVVGEVLGKYHPH
GDAAVYDTLVRLAQDFSMREVLIDGHGNFGSIDGDPPAAMRYTEARLSRIALEMLTDINKETVDFVPNFDETLKEPVVLP
SRFPNLLVNGSQGIAVGMATNIPPHNLAEVIDGIVAYIDNPYITVDELMKYIKGPDFPTGGIILGRDGIKETYETGRGKI
IVRAKAEIEEHKGKTRIVITEIPYMVLKAKLIEKIAELVHNKQIEGIADLRDESDRNGMKIVIELKRDVNPKVILNKLYM
HTQMQQTFGAIMLALVDGEPKILNLKQIIEKYVDHQADVVTRRTKFDLKKAEERAHILEGLKIALDYIDEVINIIRSSKT
EAIAKENLMKRFGLSDKQAQAIVDMRLGRLTGLERQKVEDELKELIEKIKELKEILADERKVLEIIKKELLEIKNKYASP
RKTVIVAKEEELDFEDLVQLEDVVVTMTHYGYIKRMPLDTYKSQKRGGKGILGISTREDDFVEDIFITTTHDRLLFFTNK
GKVYSLRTIDIPESGRQAKGTAIVNLIQISQGEKVTAVIPLKKSDDIKYVLMCTKKGIIKKTSIEEFKSIKRNGIIAITL
DENDELINVKLTNGEREVIIGTAKGYAIRFNEKDVRPMGRVARGVMAISLREDDEVVEMDLVHPDGEVLTVTEKGFGKRT
DLEEYRIQGRAGKGIIAMKLSKKTGKLVSIRCVQPEDEFMIISANGILIRMKVKDISKMHRDTQGVTLMKLEDGDRVVST
ARIESEE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=175, Percent_Identity=29.7142857142857, Blast_Score=70, Evalue=8e-12,
Organism=Homo sapiens, GI19913408, Length=175, Percent_Identity=29.1428571428571, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1788562, Length=839, Percent_Identity=50.0595947556615, Blast_Score=830, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=634, Percent_Identity=38.9589905362776, Blast_Score=421, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17535065, Length=170, Percent_Identity=32.3529411764706, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=386, Percent_Identity=23.3160621761658, Blast_Score=67, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=280, Percent_Identity=27.5, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91164; Mature: 91164

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEEMDKVIPVDIEDEMRNSYIDYAMSVIVGRALPDVRDGLKPVHRRILYAMNEMGLTPD
CCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KPYKKSVAVVGEVLGKYHPHGDAAVYDTLVRLAQDFSMREVLIDGHGNFGSIDGDPPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHH
RYTEARLSRIALEMLTDINKETVDFVPNFDETLKEPVVLPSRFPNLLVNGSQGIAVGMAT
HHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLAEVIDGIVAYIDNPYITVDELMKYIKGPDFPTGGIILGRDGIKETYETGRGKI
CCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCEE
IVRAKAEIEEHKGKTRIVITEIPYMVLKAKLIEKIAELVHNKQIEGIADLRDESDRNGMK
EEEEEHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCE
IVIELKRDVNPKVILNKLYMHTQMQQTFGAIMLALVDGEPKILNLKQIIEKYVDHQADVV
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEECHHHHHHHHHCCHHHHH
TRRTKFDLKKAEERAHILEGLKIALDYIDEVINIIRSSKTEAIAKENLMKRFGLSDKQAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHH
AIVDMRLGRLTGLERQKVEDELKELIEKIKELKEILADERKVLEIIKKELLEIKNKYASP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RKTVIVAKEEELDFEDLVQLEDVVVTMTHYGYIKRMPLDTYKSQKRGGKGILGISTREDD
CEEEEEEECCCCCHHHHHHHHHHHEEEECCCEEEECCCHHHHHHCCCCCEEEEECCCCCC
FVEDIFITTTHDRLLFFTNKGKVYSLRTIDIPESGRQAKGTAIVNLIQISQGEKVTAVIP
CHHEEEEEEECCEEEEEECCCCEEEEEEECCCCCCCCCCCCEEEEEEEECCCCEEEEEEE
LKKSDDIKYVLMCTKKGIIKKTSIEEFKSIKRNGIIAITLDENDELINVKLTNGEREVII
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCEEEEE
GTAKGYAIRFNEKDVRPMGRVARGVMAISLREDDEVVEMDLVHPDGEVLTVTEKGFGKRT
EECCCEEEEECCCCCCHHHHHHHCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCCCC
DLEEYRIQGRAGKGIIAMKLSKKTGKLVSIRCVQPEDEFMIISANGILIRMKVKDISKMH
CHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEEECCEEEEEEHHHHHHHH
RDTQGVTLMKLEDGDRVVSTARIESEE
CCCCCEEEEEECCCCEEEEEEECCCCC
>Mature Secondary Structure
MNEEMDKVIPVDIEDEMRNSYIDYAMSVIVGRALPDVRDGLKPVHRRILYAMNEMGLTPD
CCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCC
KPYKKSVAVVGEVLGKYHPHGDAAVYDTLVRLAQDFSMREVLIDGHGNFGSIDGDPPAAM
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHH
RYTEARLSRIALEMLTDINKETVDFVPNFDETLKEPVVLPSRFPNLLVNGSQGIAVGMAT
HHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCEECCCCCCCEEEECCCCEEEEEEC
NIPPHNLAEVIDGIVAYIDNPYITVDELMKYIKGPDFPTGGIILGRDGIKETYETGRGKI
CCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCCCCCEEECCCCCHHHHHCCCCEE
IVRAKAEIEEHKGKTRIVITEIPYMVLKAKLIEKIAELVHNKQIEGIADLRDESDRNGMK
EEEEEHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCE
IVIELKRDVNPKVILNKLYMHTQMQQTFGAIMLALVDGEPKILNLKQIIEKYVDHQADVV
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCEECHHHHHHHHHCCHHHHH
TRRTKFDLKKAEERAHILEGLKIALDYIDEVINIIRSSKTEAIAKENLMKRFGLSDKQAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHH
AIVDMRLGRLTGLERQKVEDELKELIEKIKELKEILADERKVLEIIKKELLEIKNKYASP
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
RKTVIVAKEEELDFEDLVQLEDVVVTMTHYGYIKRMPLDTYKSQKRGGKGILGISTREDD
CEEEEEEECCCCCHHHHHHHHHHHEEEECCCEEEECCCHHHHHHCCCCCEEEEECCCCCC
FVEDIFITTTHDRLLFFTNKGKVYSLRTIDIPESGRQAKGTAIVNLIQISQGEKVTAVIP
CHHEEEEEEECCEEEEEECCCCEEEEEEECCCCCCCCCCCCEEEEEEEECCCCEEEEEEE
LKKSDDIKYVLMCTKKGIIKKTSIEEFKSIKRNGIIAITLDENDELINVKLTNGEREVII
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCEEEEE
GTAKGYAIRFNEKDVRPMGRVARGVMAISLREDDEVVEMDLVHPDGEVLTVTEKGFGKRT
EECCCEEEEECCCCCCHHHHHHHCEEEEEECCCCCEEEEEEECCCCCEEEEECCCCCCCC
DLEEYRIQGRAGKGIIAMKLSKKTGKLVSIRCVQPEDEFMIISANGILIRMKVKDISKMH
CHHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEEECCEEEEEEHHHHHHHH
RDTQGVTLMKLEDGDRVVSTARIESEE
CCCCCEEEEEECCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]