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The map label for this gene is gyrB [H]

Identifier: 20806552

GI number: 20806552

Start: 9726

End: 11690

Strand: Direct

Name: gyrB [H]

Synonym: TTE0010

Alternate gene names: 20806552

Gene position: 9726-11690 (Clockwise)

Preceding gene: 20806548

Following gene: 20806553

Centisome position: 0.36

GC content: 39.44

Gene sequence:

>1965_bases
TTGAGCAATTTAAAAAAGAATGATAAAATAAAACTGTTGGATAAATTTTTGGAGGGCAGGACTATGGCAAAGGATGAAAC
TTACACTGCAAGTCAAATACAAATATTAGAAGGTTTGGAAGCTGTCAGAAAAAGGCCGGGGATGTATATAGGTTCTACTG
GCAGCAGGGGATTACATCATCTGGTTTATGAAGTTGTTGACAACAGTATAGATGAAGCGCTGGCAGGCTACTGCAAAAAT
ATAGTGGTAACTATTCACAAAGATAATTCAATTACAGTGGAAGACGATGGAAGAGGTATTCCAACAGATATACACCCAAA
GGTTGGCAAGCCCGCAGTTGAAGTAGCCCTTACTATGCTTCACGCTGGAGGAAAATTTAATAACGATGCCTACAAGGTCT
CTGGAGGGCTCCACGGCGTTGGTGTTTCTGTAGTTAATGCTTTGTCAGAGAGGTTAGAGGTAATAGTAAAGCAGAGGGGA
AAGGTTTTTAGGCAGGTGTATGAAAGAGGAGTGCCAAAGACTCCTCTTGAAGTGATAGGGGAAACTGAAGAGACAGGGAC
TATTATTACTTTTAAACCTGATAAGGAAATTTTTGAAGAAATTGTATTTGATTATGATATTTTAGCCCAGAGATTGAGAG
AATTGGCTTTTTTAAACAAGGGCATAAATATAAAGCTTATAGATGAGAGAGATGGAAAGGAAGAAGTCTTCAATTACGAA
GGGGGCCTTATAGCTTTTGTAAAGTATTTGAACAGAAATAAAGAAGTCCTCCACGAAGAGCCGATATACATGGAAGCAAA
GAACACCGATTATGAAGTAGAAGTGTGCATGCAGTATAATGATAGTTACAATGAGAACATATACAGCTTTGCCAATAATA
TTGACACAAAAGAAGGAGGAACACACTTAATAGGCTTTAAATCAGCTTTAACCAAAGTGATAAACGATTATGCTAAAAAG
TATGGGATGATAAAGGACGGAGAAAAAAATCTGCAGGGAGAGGATGTAAGAGAGGGCCTTACTGCTATAGTCAGCGTGAA
GCTTAAAAATCCGCAGTTTGAAGGGCAGACAAAGACGAGGCTCGGAAATCCTGAGATGAGGTCTATTGTCGAAGGAGTAG
TTACAGAAAAACTCTCTGCTTACCTTGAGGAAAATCCTTCTGTTGCCAGAATAATTGTTGAAAAGGCTCTGCAGGCTGCA
AGAGCAAGAGAAGCAGCAAGAAAGGCGAGAGAACTGACAAGAAGGAAATCAGCTCTTGAAAATACAGCCCTGCCAGGAAA
ACTGGCGGACTGCTCAGAGAAAGACCCTTCAAAATGCGAGCTTTTCATAGTAGAAGGAGACTCGGCAGGAGGTTCTGCTA
AGGCAGGCAGAAACAGTAGATTCCAGGCAATACTCCCTTTAAGAGGTAAGATTTTAAATGTGGAAAAAGCTCGACTTGAT
AAAATTTTCTCTAACGAAGAAATTCGCTCTATAATAACTGCTCTTGGAACTGGAATTGGAGAGGATTTTGATATAAGCAA
GTTAAGGTATCACAAAGTGATTATAATGACAGATGCCGATGTGGACGGAAGCCACATAAGAACGCTTCTTCTCACATTTT
TCTTCAGATTTATGAAGCCACTTATTGAAAATGGACATATATACATTGCTCAACCGCCCTTGTATAAAATTACAAAGGGT
AAGAAGGTCTACTACGCTTATTCGGACAGGGAATTGGATAAAATTTTGAGTGAGATTGGGAGAGAAAACATTGTAGTGCA
AAGGTACAAAGGTTTAGGTGAAATGAATGCAGACCAGCTCTGGGAAACTACAATGGACCCAGAAAAAAGGACAATGCTTA
AAGTCACCCTTGAGGACGCCATTGCTGCCGATGAAATTTTTACTATACTGATGGGAGACAAAGTAGAGCCCAGAAGAGAA
TTTATAGAAAAATATGCTAAGACAGTAAGGAATTTGGATATATGA

Upstream 100 bases:

>100_bases
CACCTCAATTTAAGTATATTATAATATAGGCAGATTTGTTAAGTATATTATAGTATAGGGAATAATAAAAATAAACATTT
CCCGGGAAATTTTCTTTCAA

Downstream 100 bases:

>100_bases
AGAGGTGAAATGGATGAACGAAGAAATGGACAAGGTCATTCCTGTTGATATAGAAGATGAGATGAGAAATTCCTATATTG
ATTATGCGATGAGCGTGATT

Product: DNA gyrase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 654; Mature: 653

Protein sequence:

>654_residues
MSNLKKNDKIKLLDKFLEGRTMAKDETYTASQIQILEGLEAVRKRPGMYIGSTGSRGLHHLVYEVVDNSIDEALAGYCKN
IVVTIHKDNSITVEDDGRGIPTDIHPKVGKPAVEVALTMLHAGGKFNNDAYKVSGGLHGVGVSVVNALSERLEVIVKQRG
KVFRQVYERGVPKTPLEVIGETEETGTIITFKPDKEIFEEIVFDYDILAQRLRELAFLNKGINIKLIDERDGKEEVFNYE
GGLIAFVKYLNRNKEVLHEEPIYMEAKNTDYEVEVCMQYNDSYNENIYSFANNIDTKEGGTHLIGFKSALTKVINDYAKK
YGMIKDGEKNLQGEDVREGLTAIVSVKLKNPQFEGQTKTRLGNPEMRSIVEGVVTEKLSAYLEENPSVARIIVEKALQAA
RAREAARKARELTRRKSALENTALPGKLADCSEKDPSKCELFIVEGDSAGGSAKAGRNSRFQAILPLRGKILNVEKARLD
KIFSNEEIRSIITALGTGIGEDFDISKLRYHKVIIMTDADVDGSHIRTLLLTFFFRFMKPLIENGHIYIAQPPLYKITKG
KKVYYAYSDRELDKILSEIGRENIVVQRYKGLGEMNADQLWETTMDPEKRTMLKVTLEDAIAADEIFTILMGDKVEPRRE
FIEKYAKTVRNLDI

Sequences:

>Translated_654_residues
MSNLKKNDKIKLLDKFLEGRTMAKDETYTASQIQILEGLEAVRKRPGMYIGSTGSRGLHHLVYEVVDNSIDEALAGYCKN
IVVTIHKDNSITVEDDGRGIPTDIHPKVGKPAVEVALTMLHAGGKFNNDAYKVSGGLHGVGVSVVNALSERLEVIVKQRG
KVFRQVYERGVPKTPLEVIGETEETGTIITFKPDKEIFEEIVFDYDILAQRLRELAFLNKGINIKLIDERDGKEEVFNYE
GGLIAFVKYLNRNKEVLHEEPIYMEAKNTDYEVEVCMQYNDSYNENIYSFANNIDTKEGGTHLIGFKSALTKVINDYAKK
YGMIKDGEKNLQGEDVREGLTAIVSVKLKNPQFEGQTKTRLGNPEMRSIVEGVVTEKLSAYLEENPSVARIIVEKALQAA
RAREAARKARELTRRKSALENTALPGKLADCSEKDPSKCELFIVEGDSAGGSAKAGRNSRFQAILPLRGKILNVEKARLD
KIFSNEEIRSIITALGTGIGEDFDISKLRYHKVIIMTDADVDGSHIRTLLLTFFFRFMKPLIENGHIYIAQPPLYKITKG
KKVYYAYSDRELDKILSEIGRENIVVQRYKGLGEMNADQLWETTMDPEKRTMLKVTLEDAIAADEIFTILMGDKVEPRRE
FIEKYAKTVRNLDI
>Mature_653_residues
SNLKKNDKIKLLDKFLEGRTMAKDETYTASQIQILEGLEAVRKRPGMYIGSTGSRGLHHLVYEVVDNSIDEALAGYCKNI
VVTIHKDNSITVEDDGRGIPTDIHPKVGKPAVEVALTMLHAGGKFNNDAYKVSGGLHGVGVSVVNALSERLEVIVKQRGK
VFRQVYERGVPKTPLEVIGETEETGTIITFKPDKEIFEEIVFDYDILAQRLRELAFLNKGINIKLIDERDGKEEVFNYEG
GLIAFVKYLNRNKEVLHEEPIYMEAKNTDYEVEVCMQYNDSYNENIYSFANNIDTKEGGTHLIGFKSALTKVINDYAKKY
GMIKDGEKNLQGEDVREGLTAIVSVKLKNPQFEGQTKTRLGNPEMRSIVEGVVTEKLSAYLEENPSVARIIVEKALQAAR
AREAARKARELTRRKSALENTALPGKLADCSEKDPSKCELFIVEGDSAGGSAKAGRNSRFQAILPLRGKILNVEKARLDK
IFSNEEIRSIITALGTGIGEDFDISKLRYHKVIIMTDADVDGSHIRTLLLTFFFRFMKPLIENGHIYIAQPPLYKITKGK
KVYYAYSDRELDKILSEIGRENIVVQRYKGLGEMNADQLWETTMDPEKRTMLKVTLEDAIAADEIFTILMGDKVEPRREF
IEKYAKTVRNLDI

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=670, Percent_Identity=27.0149253731343, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI19913406, Length=663, Percent_Identity=26.0935143288084, Blast_Score=152, Evalue=8e-37,
Organism=Escherichia coli, GI48994957, Length=551, Percent_Identity=59.8911070780399, Blast_Score=672, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=629, Percent_Identity=41.1764705882353, Blast_Score=472, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17535065, Length=618, Percent_Identity=26.537216828479, Blast_Score=158, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI212645845, Length=597, Percent_Identity=27.3031825795645, Blast_Score=151, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI212645657, Length=178, Percent_Identity=30.8988764044944, Blast_Score=84, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324241, Length=692, Percent_Identity=26.7341040462428, Blast_Score=143, Evalue=8e-35,
Organism=Drosophila melanogaster, GI17136538, Length=613, Percent_Identity=26.4274061990212, Blast_Score=156, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 73653; Mature: 73522

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLKKNDKIKLLDKFLEGRTMAKDETYTASQIQILEGLEAVRKRPGMYIGSTGSRGLHH
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHH
LVYEVVDNSIDEALAGYCKNIVVTIHKDNSITVEDDGRGIPTDIHPKVGKPAVEVALTML
HHHHHHHCHHHHHHHHHHCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
HAGGKFNNDAYKVSGGLHGVGVSVVNALSERLEVIVKQRGKVFRQVYERGVPKTPLEVIG
HCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHC
ETEETGTIITFKPDKEIFEEIVFDYDILAQRLRELAFLNKGINIKLIDERDGKEEVFNYE
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCC
GGLIAFVKYLNRNKEVLHEEPIYMEAKNTDYEVEVCMQYNDSYNENIYSFANNIDTKEGG
CCHHHHHHHHCCCHHHHCCCCCEEEECCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCC
THLIGFKSALTKVINDYAKKYGMIKDGEKNLQGEDVREGLTAIVSVKLKNPQFEGQTKTR
CEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEEEEEEECCCCCCCCHHHC
LGNPEMRSIVEGVVTEKLSAYLEENPSVARIIVEKALQAARAREAARKARELTRRKSALE
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTALPGKLADCSEKDPSKCELFIVEGDSAGGSAKAGRNSRFQAILPLRGKILNVEKARLD
HCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHH
KIFSNEEIRSIITALGTGIGEDFDISKLRYHKVIIMTDADVDGSHIRTLLLTFFFRFMKP
HHHCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
LIENGHIYIAQPPLYKITKGKKVYYAYSDRELDKILSEIGRENIVVQRYKGLGEMNADQL
HHHCCCEEEECCCCEEECCCCEEEEEECCHHHHHHHHHHCCCCEEHHHHHCCCCCCHHHH
WETTMDPEKRTMLKVTLEDAIAADEIFTILMGDKVEPRREFIEKYAKTVRNLDI
HHHCCCCCHHHEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNLKKNDKIKLLDKFLEGRTMAKDETYTASQIQILEGLEAVRKRPGMYIGSTGSRGLHH
CCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHH
LVYEVVDNSIDEALAGYCKNIVVTIHKDNSITVEDDGRGIPTDIHPKVGKPAVEVALTML
HHHHHHHCHHHHHHHHHHCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
HAGGKFNNDAYKVSGGLHGVGVSVVNALSERLEVIVKQRGKVFRQVYERGVPKTPLEVIG
HCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHC
ETEETGTIITFKPDKEIFEEIVFDYDILAQRLRELAFLNKGINIKLIDERDGKEEVFNYE
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCC
GGLIAFVKYLNRNKEVLHEEPIYMEAKNTDYEVEVCMQYNDSYNENIYSFANNIDTKEGG
CCHHHHHHHHCCCHHHHCCCCCEEEECCCCCEEEEEEEECCCCCCHHHHHHHCCCCCCCC
THLIGFKSALTKVINDYAKKYGMIKDGEKNLQGEDVREGLTAIVSVKLKNPQFEGQTKTR
CEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHEEEEEEECCCCCCCCHHHC
LGNPEMRSIVEGVVTEKLSAYLEENPSVARIIVEKALQAARAREAARKARELTRRKSALE
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NTALPGKLADCSEKDPSKCELFIVEGDSAGGSAKAGRNSRFQAILPLRGKILNVEKARLD
HCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEECHHHHHHH
KIFSNEEIRSIITALGTGIGEDFDISKLRYHKVIIMTDADVDGSHIRTLLLTFFFRFMKP
HHHCCHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
LIENGHIYIAQPPLYKITKGKKVYYAYSDRELDKILSEIGRENIVVQRYKGLGEMNADQL
HHHCCCEEEECCCCEEECCCCEEEEEECCHHHHHHHHHHCCCCEEHHHHHCCCCCCHHHH
WETTMDPEKRTMLKVTLEDAIAADEIFTILMGDKVEPRREFIEKYAKTVRNLDI
HHHCCCCCHHHEEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]