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The map label for this gene is dnaA [H]

Identifier: 20806543

GI number: 20806543

Start: 365

End: 1696

Strand: Direct

Name: dnaA [H]

Synonym: TTE0001

Alternate gene names: 20806543

Gene position: 365-1696 (Clockwise)

Preceding gene: NA

Following gene: 20806544

Centisome position: 0.01

GC content: 36.34

Gene sequence:

>1332_bases
ATGTATGGTGATTACCGTCAAATTTGGGAGAGGATAGTAGAAGTTATAAAAAGTGAGCTAACCCCCACCAGCTACAATAC
TTGGCTTGTTCACATAAAGCCTTTAGCCTTTGCAGAAGACACCTTGTTTTTGAGCACTCCTAACACATTTACAAAAAATA
TAATAAATGGAAGATATATTAATATAATTTACGATGCAGCTTCCAAAGTCACAAATAGGTTTATAGAAATAAAGATACTT
TCAGAAGACGAAGAAGAATACAGAGAGATAAAAGAGTCAATTGAAAGAGAAAATTCGTCCGAATCAACTCTTTTGTCTAC
TCTAAATCCAAAGTACACCTTCGACACATTTGTCGTAGGAAATAGCAATAAACTAGCCCATGCCGCATGCCTTGCAGTAG
CTCAATCTCCAGCAAAAGCGTACAACCCTCTTTTCATTTATGGAGGAGTTGGACTTGGAAAAACTCACTTAATGCACGCT
ATAGGACACTTCATCAACAAGAACCACGCAGGTTACAAAATAATGTACGTAACGTCCGAAACGTTTACAAATGAGCTGGT
AAACTCCATCAAGGACGATAAAAACGAAGAATTCCGCAATAAGTATAGAAATATTGATGTCCTACTAATAGATGATATTC
AATTCATAGCAAATAAAGAACGAACTCAAGAGGAATTTTTCCATACATTTAATACCCTGTACGAAGCAAATAAGCAGATA
GTTATATCAAGCGATAGACCCCCAAAAGAGATTCCGACTTTAGAAGAAAGGTTAAGGTCGAGGTTTGAATGGGGCCTTAT
AGCTGACATTCAGCCACCAGATTATGAAACTAGAGTGGCAATACTTAAGAAAAAAGCTCAATCAGAAAACCTCAATATCC
CGGATGAAGTGCTAGCTTATGTTGCAGAAAAAATACAGTCAAACATAAGAGAATTGGAAGGAGCTTTAATAAGGATAGTT
GCCTTTGCAACTCTTACAAAGTCAAACATAGACCTAGAGCTCACCAAGCATGCGTTAAAAGACATTGTGTCTAACAAAAC
AAGAGAAATAACAGTAAAGCTCATTCAAGAAGAAGTGTGCAAATATTACAACATAAAGTTAGAAGATTTTAGGTCAAGAA
AGAGGACAAAAAATATCGCATATCCTAGGCAAATAGCTATGTACCTGGCAAGAGAACTCACAGACCTCTCTCTTCCAAAA
ATAGGAGAAGAATTTGGAAAAGACCACACCACGGTCATACACGCCTATGAAAAAATTTCAAATGAAATAAAGCAGGATGA
ATCCCTTGCAAGGCAGATTGAAGAACTTAAAAAAAGGATAAAAGGTTATTAA

Upstream 100 bases:

>100_bases
TAAAAATTACTTATCCACAAAATAGTTGTGTCGATAATATAGTATGCCACCCTTTTTAATTAAATTATCCACATTATTCT
TTAGCCTAGGAGGTCATACA

Downstream 100 bases:

>100_bases
CATATAAACAGGGATAACCTTGTTTATATGTTTTAAAATTCGCCTTCTGTGAATAATGTCGATAATTTTTAAAGTTTGTC
CTCATTTTATCCACATTATT

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 443

Protein sequence:

>443_residues
MYGDYRQIWERIVEVIKSELTPTSYNTWLVHIKPLAFAEDTLFLSTPNTFTKNIINGRYINIIYDAASKVTNRFIEIKIL
SEDEEEYREIKESIERENSSESTLLSTLNPKYTFDTFVVGNSNKLAHAACLAVAQSPAKAYNPLFIYGGVGLGKTHLMHA
IGHFINKNHAGYKIMYVTSETFTNELVNSIKDDKNEEFRNKYRNIDVLLIDDIQFIANKERTQEEFFHTFNTLYEANKQI
VISSDRPPKEIPTLEERLRSRFEWGLIADIQPPDYETRVAILKKKAQSENLNIPDEVLAYVAEKIQSNIRELEGALIRIV
AFATLTKSNIDLELTKHALKDIVSNKTREITVKLIQEEVCKYYNIKLEDFRSRKRTKNIAYPRQIAMYLARELTDLSLPK
IGEEFGKDHTTVIHAYEKISNEIKQDESLARQIEELKKRIKGY

Sequences:

>Translated_443_residues
MYGDYRQIWERIVEVIKSELTPTSYNTWLVHIKPLAFAEDTLFLSTPNTFTKNIINGRYINIIYDAASKVTNRFIEIKIL
SEDEEEYREIKESIERENSSESTLLSTLNPKYTFDTFVVGNSNKLAHAACLAVAQSPAKAYNPLFIYGGVGLGKTHLMHA
IGHFINKNHAGYKIMYVTSETFTNELVNSIKDDKNEEFRNKYRNIDVLLIDDIQFIANKERTQEEFFHTFNTLYEANKQI
VISSDRPPKEIPTLEERLRSRFEWGLIADIQPPDYETRVAILKKKAQSENLNIPDEVLAYVAEKIQSNIRELEGALIRIV
AFATLTKSNIDLELTKHALKDIVSNKTREITVKLIQEEVCKYYNIKLEDFRSRKRTKNIAYPRQIAMYLARELTDLSLPK
IGEEFGKDHTTVIHAYEKISNEIKQDESLARQIEELKKRIKGY
>Mature_443_residues
MYGDYRQIWERIVEVIKSELTPTSYNTWLVHIKPLAFAEDTLFLSTPNTFTKNIINGRYINIIYDAASKVTNRFIEIKIL
SEDEEEYREIKESIERENSSESTLLSTLNPKYTFDTFVVGNSNKLAHAACLAVAQSPAKAYNPLFIYGGVGLGKTHLMHA
IGHFINKNHAGYKIMYVTSETFTNELVNSIKDDKNEEFRNKYRNIDVLLIDDIQFIANKERTQEEFFHTFNTLYEANKQI
VISSDRPPKEIPTLEERLRSRFEWGLIADIQPPDYETRVAILKKKAQSENLNIPDEVLAYVAEKIQSNIRELEGALIRIV
AFATLTKSNIDLELTKHALKDIVSNKTREITVKLIQEEVCKYYNIKLEDFRSRKRTKNIAYPRQIAMYLARELTDLSLPK
IGEEFGKDHTTVIHAYEKISNEIKQDESLARQIEELKKRIKGY

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=458, Percent_Identity=42.1397379912664, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI226510964, Length=204, Percent_Identity=24.5098039215686, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 51364; Mature: 51364

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYGDYRQIWERIVEVIKSELTPTSYNTWLVHIKPLAFAEDTLFLSTPNTFTKNIINGRYI
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEECCEEEEECCCHHHHHCCCCEEE
NIIYDAASKVTNRFIEIKILSEDEEEYREIKESIERENSSESTLLSTLNPKYTFDTFVVG
EEEEHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEEEC
NSNKLAHAACLAVAQSPAKAYNPLFIYGGVGLGKTHLMHAIGHFINKNHAGYKIMYVTSE
CCCCHHHHHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECH
TFTNELVNSIKDDKNEEFRNKYRNIDVLLIDDIQFIANKERTQEEFFHTFNTLYEANKQI
HHHHHHHHHHCCCCCHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHHHHHHHHCCCEE
VISSDRPPKEIPTLEERLRSRFEWGLIADIQPPDYETRVAILKKKAQSENLNIPDEVLAY
EEECCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
VAEKIQSNIRELEGALIRIVAFATLTKSNIDLELTKHALKDIVSNKTREITVKLIQEEVC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KYYNIKLEDFRSRKRTKNIAYPRQIAMYLARELTDLSLPKIGEEFGKDHTTVIHAYEKIS
HHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHH
NEIKQDESLARQIEELKKRIKGY
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYGDYRQIWERIVEVIKSELTPTSYNTWLVHIKPLAFAEDTLFLSTPNTFTKNIINGRYI
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEECCEEEEECCCHHHHHCCCCEEE
NIIYDAASKVTNRFIEIKILSEDEEEYREIKESIERENSSESTLLSTLNPKYTFDTFVVG
EEEEHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEEEC
NSNKLAHAACLAVAQSPAKAYNPLFIYGGVGLGKTHLMHAIGHFINKNHAGYKIMYVTSE
CCCCHHHHHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEEECH
TFTNELVNSIKDDKNEEFRNKYRNIDVLLIDDIQFIANKERTQEEFFHTFNTLYEANKQI
HHHHHHHHHHCCCCCHHHHHHHCCCEEEEECCHHHHHCCHHHHHHHHHHHHHHHHCCCEE
VISSDRPPKEIPTLEERLRSRFEWGLIADIQPPDYETRVAILKKKAQSENLNIPDEVLAY
EEECCCCCCCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHH
VAEKIQSNIRELEGALIRIVAFATLTKSNIDLELTKHALKDIVSNKTREITVKLIQEEVC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
KYYNIKLEDFRSRKRTKNIAYPRQIAMYLARELTDLSLPKIGEEFGKDHTTVIHAYEKIS
HHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHH
NEIKQDESLARQIEELKKRIKGY
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA