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The map label for this gene is GuaB [H]

Identifier: 20095036

GI number: 20095036

Start: 1608909

End: 1610417

Strand: Reverse

Name: GuaB [H]

Synonym: MK1600

Alternate gene names: 20095036

Gene position: 1610417-1608909 (Counterclockwise)

Preceding gene: 20095037

Following gene: 20095033

Centisome position: 95.01

GC content: 61.23

Gene sequence:

>1509_bases
TTGGTCGGGCGGTACACTCGAAAGCTGGAGGATGCCGAGCTGGCACTCACGTTCGACGACGTCCTCCTACTCCCCGAACG
ATCCTCGGTAGAACCCGCCGATGTGGACGTATCCACACGAGTCACCGTCAACTACCGGATCAACATACCGATCCTGAGTG
CTGCCATGGATACTGTCACCGAAGCCGAGATGGCTATCGCGATGGCCCGACACGGCGGCCTCGGTGTAATCCACAGAAAC
ATGACCGTGGAGGAGCAGGTGAAGGAGGTCAGGCGCGTCAAGGAGGCCAGGGATGTAGTGCAACGTGATGTCGTGACGAT
TTCACCGGACGAGAGTGTGAAGCGAGCCGTAGAGCTGATGGAGAAGCATGACGTCGGAGGTCTGCCTGTCGTCGACGAAG
AGGGTAAGGTCGTCGGCATCATCACGCGGCGCGACGTGGGCCTGCTTTCCGAGGAAGAGATCGGAGAGTTGGACGTGAAG
AGCGTGATGACGGAAGAGCCGGTCGTCATTGAGGAGGGTGAAGACCTCGAGGAAAGAGCTCTACGGGTGATGAGGGAGGA
GAAGATCGAACGCGTGCCCGTAGTAGACGACGAAGGTCGCCTCTTAGGGATCGTGACCGCCAAGGACGTAACGGAGCTCC
GTGAGGAGACGGAAGCGGCCACCGACGAGGAGAGACGATACCTCGCGGCCGCAGCCGTGGGTCCGAAGGATCCCGACCGA
GCGATCGCCCTGGACGAGGCCGGCGCGGACATCCTCGTAGTCGACTGCGCCCACGCGCATACGGAGACGGTCATCAACTT
CGTGAAGGAGATCAAGCGTGAGGTCGACGCGGACATCATCGCCGGCAACATCGCCACGGCCGAAGCTGCGGAGGACCTCA
TCGCCGCGGGTGCCGACGCTCTGAAGGTCGGTATCGGTCCGGGTTCCATATGCACTACGAGGATCGTCGCCGGTGTCGGC
GTACCTCAGATCACCGCCGTAGCCTGGGTGGCCGATGTCGCGGAGGAACATGACATCCCCGTCATCGCGGACGGTGGTAT
CAGGTACTCCGGAGACATCGCCAAGGCGATCGCCGCGGGCGCCGATGCCGTGATGCTGGGTAACCTGTTGGCAGGCACGG
ACGAGGCTCCAGGCCGGGTGATCCGGTTACGCGGACGTCTGTACAAGCAGTACCGTGGTATGGGAAGCCTGGGAGCCATG
ATGAAGGGTGAATCGGCCGACCGCTACTTCAAGCAACCCGAACAGGGAGGCCGCCACGTCGCCCAAACGAAGTTCGTACC
GGAGGGAGTCGAGGGAGTCGTTCCGTACAAAGGTCCGGTGAGCGAGGTCCTCTACACCCTCGTGGGTGGACTCAGATCCA
GCATGGGATACGTCGGCGCCAAGAACATTGAGGAAATGAAGAAGAAGGCGAGGTTCGTACGGATCACTCGAGCCGGGTAC
GAGGAGAGTCACCCACACGACATCGCCATCACGGACGAGGCACCGAATTACCCGATATCGAATCAGTAG

Upstream 100 bases:

>100_bases
GTCTGAAACGGAGGAGACGGAGGAGTCCGAGTAACCGCCCTCGCACAACCTTTAACTCCCCCCGCCTCCGTTCCCCGCAA
AAGGCGCGGGGAACGGGGGC

Downstream 100 bases:

>100_bases
GCGTCGCCGACGTCCCCTCATAGTTTTTCAGGTTTATCAGCCTGATCCCGTTCACCTTCTTCAGGTACTCGTACTGGAGT
CTCTTGTAGTGCGAGAGCTC

Product: IMP dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MVGRYTRKLEDAELALTFDDVLLLPERSSVEPADVDVSTRVTVNYRINIPILSAAMDTVTEAEMAIAMARHGGLGVIHRN
MTVEEQVKEVRRVKEARDVVQRDVVTISPDESVKRAVELMEKHDVGGLPVVDEEGKVVGIITRRDVGLLSEEEIGELDVK
SVMTEEPVVIEEGEDLEERALRVMREEKIERVPVVDDEGRLLGIVTAKDVTELREETEAATDEERRYLAAAAVGPKDPDR
AIALDEAGADILVVDCAHAHTETVINFVKEIKREVDADIIAGNIATAEAAEDLIAAGADALKVGIGPGSICTTRIVAGVG
VPQITAVAWVADVAEEHDIPVIADGGIRYSGDIAKAIAAGADAVMLGNLLAGTDEAPGRVIRLRGRLYKQYRGMGSLGAM
MKGESADRYFKQPEQGGRHVAQTKFVPEGVEGVVPYKGPVSEVLYTLVGGLRSSMGYVGAKNIEEMKKKARFVRITRAGY
EESHPHDIAITDEAPNYPISNQ

Sequences:

>Translated_502_residues
MVGRYTRKLEDAELALTFDDVLLLPERSSVEPADVDVSTRVTVNYRINIPILSAAMDTVTEAEMAIAMARHGGLGVIHRN
MTVEEQVKEVRRVKEARDVVQRDVVTISPDESVKRAVELMEKHDVGGLPVVDEEGKVVGIITRRDVGLLSEEEIGELDVK
SVMTEEPVVIEEGEDLEERALRVMREEKIERVPVVDDEGRLLGIVTAKDVTELREETEAATDEERRYLAAAAVGPKDPDR
AIALDEAGADILVVDCAHAHTETVINFVKEIKREVDADIIAGNIATAEAAEDLIAAGADALKVGIGPGSICTTRIVAGVG
VPQITAVAWVADVAEEHDIPVIADGGIRYSGDIAKAIAAGADAVMLGNLLAGTDEAPGRVIRLRGRLYKQYRGMGSLGAM
MKGESADRYFKQPEQGGRHVAQTKFVPEGVEGVVPYKGPVSEVLYTLVGGLRSSMGYVGAKNIEEMKKKARFVRITRAGY
EESHPHDIAITDEAPNYPISNQ
>Mature_502_residues
MVGRYTRKLEDAELALTFDDVLLLPERSSVEPADVDVSTRVTVNYRINIPILSAAMDTVTEAEMAIAMARHGGLGVIHRN
MTVEEQVKEVRRVKEARDVVQRDVVTISPDESVKRAVELMEKHDVGGLPVVDEEGKVVGIITRRDVGLLSEEEIGELDVK
SVMTEEPVVIEEGEDLEERALRVMREEKIERVPVVDDEGRLLGIVTAKDVTELREETEAATDEERRYLAAAAVGPKDPDR
AIALDEAGADILVVDCAHAHTETVINFVKEIKREVDADIIAGNIATAEAAEDLIAAGADALKVGIGPGSICTTRIVAGVG
VPQITAVAWVADVAEEHDIPVIADGGIRYSGDIAKAIAAGADAVMLGNLLAGTDEAPGRVIRLRGRLYKQYRGMGSLGAM
MKGESADRYFKQPEQGGRHVAQTKFVPEGVEGVVPYKGPVSEVLYTLVGGLRSSMGYVGAKNIEEMKKKARFVRITRAGY
EESHPHDIAITDEAPNYPISNQ

Specific function: IMP is the rate limiting enzyme in the de novo synthesis of guanine nucleotides and therefore is involved in the regulation of cell growth [H]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=474, Percent_Identity=38.3966244725738, Blast_Score=291, Evalue=1e-78,
Organism=Homo sapiens, GI217035146, Length=474, Percent_Identity=37.3417721518987, Blast_Score=279, Evalue=5e-75,
Organism=Homo sapiens, GI156616279, Length=474, Percent_Identity=37.3417721518987, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI34328928, Length=474, Percent_Identity=37.3417721518987, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI34328930, Length=474, Percent_Identity=37.3417721518987, Blast_Score=278, Evalue=8e-75,
Organism=Homo sapiens, GI217035152, Length=458, Percent_Identity=37.7729257641921, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI217035148, Length=474, Percent_Identity=36.7088607594937, Blast_Score=265, Evalue=9e-71,
Organism=Homo sapiens, GI217035150, Length=461, Percent_Identity=35.3579175704989, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI50541956, Length=252, Percent_Identity=40.4761904761905, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI50541954, Length=252, Percent_Identity=40.4761904761905, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI50541952, Length=252, Percent_Identity=40.4761904761905, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI50541948, Length=252, Percent_Identity=40.4761904761905, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI156104880, Length=251, Percent_Identity=39.4422310756972, Blast_Score=169, Evalue=7e-42,
Organism=Escherichia coli, GI1788855, Length=496, Percent_Identity=50.6048387096774, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1786293, Length=227, Percent_Identity=39.2070484581498, Blast_Score=158, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=482, Percent_Identity=33.195020746888, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71994389, Length=423, Percent_Identity=35.2245862884161, Blast_Score=231, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI17560440, Length=248, Percent_Identity=38.3064516129032, Blast_Score=171, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6322012, Length=505, Percent_Identity=35.2475247524752, Blast_Score=290, Evalue=4e-79,
Organism=Saccharomyces cerevisiae, GI6323464, Length=491, Percent_Identity=36.8635437881874, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6323585, Length=469, Percent_Identity=36.0341151385927, Blast_Score=284, Evalue=3e-77,
Organism=Saccharomyces cerevisiae, GI6319352, Length=355, Percent_Identity=36.3380281690141, Blast_Score=216, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6319353, Length=130, Percent_Identity=35.3846153846154, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24641071, Length=488, Percent_Identity=37.2950819672131, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24641073, Length=488, Percent_Identity=37.2950819672131, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI28571163, Length=448, Percent_Identity=37.9464285714286, Blast_Score=259, Evalue=4e-69,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 54340; Mature: 54340

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGRYTRKLEDAELALTFDDVLLLPERSSVEPADVDVSTRVTVNYRINIPILSAAMDTVT
CCCCHHHCCCCCEEEEEECCEEEECCCCCCCCCCCCEEEEEEEEEEECCEEHHHHHHHHH
EAEMAIAMARHGGLGVIHRNMTVEEQVKEVRRVKEARDVVQRDVVTISPDESVKRAVELM
HHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHH
EKHDVGGLPVVDEEGKVVGIITRRDVGLLSEEEIGELDVKSVMTEEPVVIEEGEDLEERA
HHCCCCCCCEECCCCCEEEEEEECCCCCCCCHHCCCHHHHHHHCCCCEEEECCCCHHHHH
LRVMREEKIERVPVVDDEGRLLGIVTAKDVTELREETEAATDEERRYLAAAAVGPKDPDR
HHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCC
AIALDEAGADILVVDCAHAHTETVINFVKEIKREVDADIIAGNIATAEAAEDLIAAGADA
EEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCC
LKVGIGPGSICTTRIVAGVGVPQITAVAWVADVAEEHDIPVIADGGIRYSGDIAKAIAAG
EEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCC
ADAVMLGNLLAGTDEAPGRVIRLRGRLYKQYRGMGSLGAMMKGESADRYFKQPEQGGRHV
CCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCHHHCCCCC
AQTKFVPEGVEGVVPYKGPVSEVLYTLVGGLRSSMGYVGAKNIEEMKKKARFVRITRAGY
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEEECCC
EESHPHDIAITDEAPNYPISNQ
CCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MVGRYTRKLEDAELALTFDDVLLLPERSSVEPADVDVSTRVTVNYRINIPILSAAMDTVT
CCCCHHHCCCCCEEEEEECCEEEECCCCCCCCCCCCEEEEEEEEEEECCEEHHHHHHHHH
EAEMAIAMARHGGLGVIHRNMTVEEQVKEVRRVKEARDVVQRDVVTISPDESVKRAVELM
HHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHH
EKHDVGGLPVVDEEGKVVGIITRRDVGLLSEEEIGELDVKSVMTEEPVVIEEGEDLEERA
HHCCCCCCCEECCCCCEEEEEEECCCCCCCCHHCCCHHHHHHHCCCCEEEECCCCHHHHH
LRVMREEKIERVPVVDDEGRLLGIVTAKDVTELREETEAATDEERRYLAAAAVGPKDPDR
HHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHEEEEEECCCCCCCC
AIALDEAGADILVVDCAHAHTETVINFVKEIKREVDADIIAGNIATAEAAEDLIAAGADA
EEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHCCCCC
LKVGIGPGSICTTRIVAGVGVPQITAVAWVADVAEEHDIPVIADGGIRYSGDIAKAIAAG
EEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCC
ADAVMLGNLLAGTDEAPGRVIRLRGRLYKQYRGMGSLGAMMKGESADRYFKQPEQGGRHV
CCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCHHHCCCCC
AQTKFVPEGVEGVVPYKGPVSEVLYTLVGGLRSSMGYVGAKNIEEMKKKARFVRITRAGY
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHEEEEEECCC
EESHPHDIAITDEAPNYPISNQ
CCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]