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The map label for this gene is pth

Identifier: 20095033

GI number: 20095033

Start: 1606866

End: 1607216

Strand: Reverse

Name: pth

Synonym: MK1597

Alternate gene names: 20095033

Gene position: 1607216-1606866 (Counterclockwise)

Preceding gene: 20095036

Following gene: 20095032

Centisome position: 94.82

GC content: 58.69

Gene sequence:

>351_bases
TTGTACAAACAGGTGATCGTGGTTAGAGGAGACCTGAAACTCAGTCGTGGGAAGCTCGCGGCCCAGGTGGCGCACGCATC
ACTGGGAGCCTTTCTACGCGCCAAAGAGTCCGGGGCGCCGGTGGAGGAGTGGTTAAGAGAAGGTCAGAAGAAGGTAGTGC
TCAAGTGTAAGGACAAGGAGGAACTCCTGGAGCTCCACGAGCTGGCTAAGAGGAGGGGCTTACCGTCGTTTTTGGTCCGA
GACGCGGGGCTCACGGAGTTAGAGCCCGGAACGGTAACTTGTCTCGGAATCGGACCCGAGCGCGAGGAGGAGATCGACCG
AGTTACGGGCGACTTGCCGTTACTGAGGTGA

Upstream 100 bases:

>100_bases
TGAAATAAATAAAGTTTCGCCGGTGTCTTACGGGCCCCAATGAAGAGGAGCTGACGGGCCGAGTCTGTGACGAGACTCCT
CTCAGCCGAGGGGGTTCACC

Downstream 100 bases:

>100_bases
CGGAGGGTTGATCGCGGTTCTGTTAGTCCTGCTAGCGCTCCCGACGTCCGGATGTTGTGAGGCGGTGTGGACGGTGTACG
ATTGGGGTTCCAAGGGTAAC

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 116; Mature: 116

Protein sequence:

>116_residues
MYKQVIVVRGDLKLSRGKLAAQVAHASLGAFLRAKESGAPVEEWLREGQKKVVLKCKDKEELLELHELAKRRGLPSFLVR
DAGLTELEPGTVTCLGIGPEREEEIDRVTGDLPLLR

Sequences:

>Translated_116_residues
MYKQVIVVRGDLKLSRGKLAAQVAHASLGAFLRAKESGAPVEEWLREGQKKVVLKCKDKEELLELHELAKRRGLPSFLVR
DAGLTELEPGTVTCLGIGPEREEEIDRVTGDLPLLR
>Mature_116_residues
MYKQVIVVRGDLKLSRGKLAAQVAHASLGAFLRAKESGAPVEEWLREGQKKVVLKCKDKEELLELHELAKRRGLPSFLVR
DAGLTELEPGTVTCLGIGPEREEEIDRVTGDLPLLR

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG1990

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH2 family

Homologues:

Organism=Homo sapiens, GI7706351, Length=114, Percent_Identity=44.7368421052632, Blast_Score=95, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17558188, Length=117, Percent_Identity=41.8803418803419, Blast_Score=86, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319414, Length=119, Percent_Identity=38.655462184874, Blast_Score=92, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646438, Length=117, Percent_Identity=42.7350427350427, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281376919, Length=115, Percent_Identity=40, Blast_Score=89, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24644665, Length=115, Percent_Identity=40, Blast_Score=89, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_METKA (Q8TV04)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614880.1
- ProteinModelPortal:   Q8TV04
- SMR:   Q8TV04
- GeneID:   1478192
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1597
- NMPDR:   fig|190192.1.peg.1593
- HOGENOM:   HBG526257
- OMA:   IQRRNPE
- ProtClustDB:   PRK04322
- BioCyc:   MKAN190192:MK1597-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00628
- InterPro:   IPR002833
- TIGRFAMs:   TIGR00283

Pfam domain/function: PF01981 PTH2

EC number: =3.1.1.29

Molecular weight: Translated: 12871; Mature: 12871

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKQVIVVRGDLKLSRGKLAAQVAHASLGAFLRAKESGAPVEEWLREGQKKVVLKCKDKE
CCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCHH
ELLELHELAKRRGLPSFLVRDAGLTELEPGTVTCLGIGPEREEEIDRVTGDLPLLR
HHHHHHHHHHHCCCCHHHHHCCCCCEECCCEEEEEECCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MYKQVIVVRGDLKLSRGKLAAQVAHASLGAFLRAKESGAPVEEWLREGQKKVVLKCKDKE
CCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEECCHH
ELLELHELAKRRGLPSFLVRDAGLTELEPGTVTCLGIGPEREEEIDRVTGDLPLLR
HHHHHHHHHHHCCCCHHHHHCCCCCEECCCEEEEEECCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014