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The map label for this gene is FolP

Identifier: 20094919

GI number: 20094919

Start: 1504035

End: 1505579

Strand: Reverse

Name: FolP

Synonym: MK1483

Alternate gene names: NA

Gene position: 1505579-1504035 (Counterclockwise)

Preceding gene: 20094920

Following gene: 20094902

Centisome position: 88.83

GC content: 61.81

Gene sequence:

>1545_bases
GTGAGGGTACTACTCCTGACAGGTAGGCTGGCCGCCGATGACGTCAGGAAGGCGGCGGAGGATTTCGAGTGGGCCGAGGT
CAAGGTACTGCCCATCGACGTGGCCGCGCTGATGACCACGCGCTTCGTCATCGAGCAGCTGCGCGGAGAGGACCTCACGC
GGTACGACTACATCCTGCTACCGGGTTGGTTCCGTGGCGACGTCAGGAAGCTGGACGAAGCCTTGGACGCGGACTTCAGG
CTGAGCTCCCGGGAAGCCCGTGACCTTCCCCTGGTCCTCCGCAAGATGGAGGAAGGATTCGTCCCCTCCAAGGACGTGCC
GGCCTGCGTGCTGCTCCGTGACGAGATCCTACGGGAGCTGGGACGGAAGGTTCGGGATGTCGAGCGGGATATTCCCGAAC
GGAGTTGGATCGATGTGGGGCCCGTAAGGATCGCACGAGGGTGTAGACCGCGAGTTCTGTCCGAGGTGTTCGCTGATGAC
CTTTCCCCGGAGGAGGCAGCGTCTGAAGCGGAGAGAAGGGCGGAGCTGGGTGCCGAAATAGTCGACCTGGGATTCCACGA
GCGGTCTCCCGAGGACGTCCGCCAGATCGTGGAGACGGTTCGGGATCGCGTGGGAGATCGCGTCGCGGTGAGCATCGACT
CGGGTGACCCGGGCATTCTCGAGGCGGGTGTCGAGGCGGGCGCGGACATCCTTCTCAACGCGTTCCCGGATTTAAAAGAG
CCCGTGGACCTGGCGGATGAGTACGACGTGCCGGTGGTTTTAGTCCCCGAGAACAAGAAACCCGAGATCGCCGTCCGACA
GCTCCGAGAGCTGGTCGATCTGTGCGAACGTCGCGACGTCGACTACGTCCTGGACCCAGTGATGGATCCACCGGGAGGTA
TCGTGGAATCGATAGTGCGATATCGCGCCGTGGCCGAGGAGTTCCCTGAGGCGCCACTCTTCTTCGGTGCGGGAAACGTG
CTCGAGCTCATAGATGCCGATTCTCCCGGAACTTCGGCCCTCTGCGCGCAGCTCGCGGTCGAACTGGAGTGCTCTATAAT
CTTCACTCCGGAGGCCAGCGGGAAGACCAAGATGAGCACGCTCGAGCTCGCGGTGGCGTCCAGGATGTGTTACGTGGCCC
ACAAATTCGGCGGTTTCCCCAAGGACGTCGGGTTGGACCTCGTCGTGTTCAAAGACAAACGTGTCGATAGTGTCAGCGCG
TCGGGTCTCGACGCCGAGCGCTTCGCCTCGAAGCCACAACGAGACGTGCGCGGAGACTTCGTGATCCTGACGGACCATGA
CCGTGGCGTCCTGATCTTAGAGCATAGATGCGGCGATGACGAACCGTTACGCTTAGAATCCGACGACGGCTTGGAACTGG
GGGCGGCGGCGGTGTCCCTGGGACTGCTGTCCGACCTCCGTCACGCCCTGTACTTAGGGTACGAGCTGGCACGTGCGGAA
GAGCGGCTGAAGTCTTACGGTCAATACATCCAGGATGACGGGATAGAGCGCTACGATCGCCTGTTACACGATTTAAAGAT
CCTGGAGGAGGTCGAGGAACGTTGA

Upstream 100 bases:

>100_bases
TCCGTCGACGCGGAAAACGTGAGGAAACTGGAGCGGATCGAAGGTATCGAGGTCTTACGACACCCCGAGGAGATCCCGGA
GCGACTCGGGGAACTCGCGG

Downstream 100 bases:

>100_bases
GGGTCGTGGCGACGCCGTACTACGCCAGATTACTGGAGCGTCTGAGCCTCGACGTCGACGTGGTCGATCCCAATCCCGAG
GTCCTTCGAAGGACCAAGGC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MRVLLLTGRLAADDVRKAAEDFEWAEVKVLPIDVAALMTTRFVIEQLRGEDLTRYDYILLPGWFRGDVRKLDEALDADFR
LSSREARDLPLVLRKMEEGFVPSKDVPACVLLRDEILRELGRKVRDVERDIPERSWIDVGPVRIARGCRPRVLSEVFADD
LSPEEAASEAERRAELGAEIVDLGFHERSPEDVRQIVETVRDRVGDRVAVSIDSGDPGILEAGVEAGADILLNAFPDLKE
PVDLADEYDVPVVLVPENKKPEIAVRQLRELVDLCERRDVDYVLDPVMDPPGGIVESIVRYRAVAEEFPEAPLFFGAGNV
LELIDADSPGTSALCAQLAVELECSIIFTPEASGKTKMSTLELAVASRMCYVAHKFGGFPKDVGLDLVVFKDKRVDSVSA
SGLDAERFASKPQRDVRGDFVILTDHDRGVLILEHRCGDDEPLRLESDDGLELGAAAVSLGLLSDLRHALYLGYELARAE
ERLKSYGQYIQDDGIERYDRLLHDLKILEEVEER

Sequences:

>Translated_514_residues
MRVLLLTGRLAADDVRKAAEDFEWAEVKVLPIDVAALMTTRFVIEQLRGEDLTRYDYILLPGWFRGDVRKLDEALDADFR
LSSREARDLPLVLRKMEEGFVPSKDVPACVLLRDEILRELGRKVRDVERDIPERSWIDVGPVRIARGCRPRVLSEVFADD
LSPEEAASEAERRAELGAEIVDLGFHERSPEDVRQIVETVRDRVGDRVAVSIDSGDPGILEAGVEAGADILLNAFPDLKE
PVDLADEYDVPVVLVPENKKPEIAVRQLRELVDLCERRDVDYVLDPVMDPPGGIVESIVRYRAVAEEFPEAPLFFGAGNV
LELIDADSPGTSALCAQLAVELECSIIFTPEASGKTKMSTLELAVASRMCYVAHKFGGFPKDVGLDLVVFKDKRVDSVSA
SGLDAERFASKPQRDVRGDFVILTDHDRGVLILEHRCGDDEPLRLESDDGLELGAAAVSLGLLSDLRHALYLGYELARAE
ERLKSYGQYIQDDGIERYDRLLHDLKILEEVEER
>Mature_514_residues
MRVLLLTGRLAADDVRKAAEDFEWAEVKVLPIDVAALMTTRFVIEQLRGEDLTRYDYILLPGWFRGDVRKLDEALDADFR
LSSREARDLPLVLRKMEEGFVPSKDVPACVLLRDEILRELGRKVRDVERDIPERSWIDVGPVRIARGCRPRVLSEVFADD
LSPEEAASEAERRAELGAEIVDLGFHERSPEDVRQIVETVRDRVGDRVAVSIDSGDPGILEAGVEAGADILLNAFPDLKE
PVDLADEYDVPVVLVPENKKPEIAVRQLRELVDLCERRDVDYVLDPVMDPPGGIVESIVRYRAVAEEFPEAPLFFGAGNV
LELIDADSPGTSALCAQLAVELECSIIFTPEASGKTKMSTLELAVASRMCYVAHKFGGFPKDVGLDLVVFKDKRVDSVSA
SGLDAERFASKPQRDVRGDFVILTDHDRGVLILEHRCGDDEPLRLESDDGLELGAAAVSLGLLSDLRHALYLGYELARAE
ERLKSYGQYIQDDGIERYDRLLHDLKILEEVEER

Specific function: Unknown. Does not possess dihydropteroate synthase (DHPS) activity since it does not catalyze the condensation of 6- hydroxymethyl-7,8-dihydropterin pyrophosphate (DHPP) and 4- aminobenzoate to form 7,8-dihydropteroate [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005236
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: NA

Molecular weight: Translated: 57386; Mature: 57386

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLLLTGRLAADDVRKAAEDFEWAEVKVLPIDVAALMTTRFVIEQLRGEDLTRYDYILL
CEEEEEECCCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEE
PGWFRGDVRKLDEALDADFRLSSREARDLPLVLRKMEEGFVPSKDVPACVLLRDEILREL
CCCCCHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
GRKVRDVERDIPERSWIDVGPVRIARGCRPRVLSEVFADDLSPEEAASEAERRAELGAEI
HHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHH
VDLGFHERSPEDVRQIVETVRDRVGDRVAVSIDSGDPGILEAGVEAGADILLNAFPDLKE
HHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCHHHHHCCCCCCC
PVDLADEYDVPVVLVPENKKPEIAVRQLRELVDLCERRDVDYVLDPVMDPPGGIVESIVR
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHH
YRAVAEEFPEAPLFFGAGNVLELIDADSPGTSALCAQLAVELECSIIFTPEASGKTKMST
HHHHHHHCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHEEEEEEEECCCCCCCCHHHH
LELAVASRMCYVAHKFGGFPKDVGLDLVVFKDKRVDSVSASGLDAERFASKPQRDVRGDF
HHHHHHHHHHHHHHHHCCCCHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCHHCCCCE
VILTDHDRGVLILEHRCGDDEPLRLESDDGLELGAAAVSLGLLSDLRHALYLGYELARAE
EEEEECCCCEEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLKSYGQYIQDDGIERYDRLLHDLKILEEVEER
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVLLLTGRLAADDVRKAAEDFEWAEVKVLPIDVAALMTTRFVIEQLRGEDLTRYDYILL
CEEEEEECCCCHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEEE
PGWFRGDVRKLDEALDADFRLSSREARDLPLVLRKMEEGFVPSKDVPACVLLRDEILREL
CCCCCHHHHHHHHHHCCCCEECCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
GRKVRDVERDIPERSWIDVGPVRIARGCRPRVLSEVFADDLSPEEAASEAERRAELGAEI
HHHHHHHHHCCCCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHH
VDLGFHERSPEDVRQIVETVRDRVGDRVAVSIDSGDPGILEAGVEAGADILLNAFPDLKE
HHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCHHHHHCCCCCCC
PVDLADEYDVPVVLVPENKKPEIAVRQLRELVDLCERRDVDYVLDPVMDPPGGIVESIVR
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHHHH
YRAVAEEFPEAPLFFGAGNVLELIDADSPGTSALCAQLAVELECSIIFTPEASGKTKMST
HHHHHHHCCCCCEEECCCCEEEEECCCCCCHHHHHHHHHHEEEEEEEECCCCCCCCHHHH
LELAVASRMCYVAHKFGGFPKDVGLDLVVFKDKRVDSVSASGLDAERFASKPQRDVRGDF
HHHHHHHHHHHHHHHHCCCCHHCCCEEEEEECCCCCCCCCCCCCHHHHHCCCCHHCCCCE
VILTDHDRGVLILEHRCGDDEPLRLESDDGLELGAAAVSLGLLSDLRHALYLGYELARAE
EEEEECCCCEEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ERLKSYGQYIQDDGIERYDRLLHDLKILEEVEER
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]