Click here to switch to the map view.

The map label for this gene is SerS

Identifier: 20094896

GI number: 20094896

Start: 1486724

End: 1488307

Strand: Direct

Name: SerS

Synonym: MK1460

Alternate gene names: 20094896

Gene position: 1486724-1488307 (Clockwise)

Preceding gene: 20094895

Following gene: 20094897

Centisome position: 87.71

GC content: 62.12

Gene sequence:

>1584_bases
GTGGAGCTGAAGTTCTCGGCTGAAGTCGAGCTCACTCTCTCGCGTGAAGTCGACCCCGCCGAGATCGAGCCTACGGTTGA
GGAGTTCGTCAAAGAGGCTAACGAGGATCTCCTCCAGCGAGGTGTCCCCACGGGGAAGGAGGGGGCCAAGATCGAGAGTT
ATCGGGTACTCGAGGACACCATCGAGATGGAGATTACCGGAACGAGGTACCTGCGTCCCCACGAGGCCGCTATGAGGGTC
CGTAAGCGGCTCGCCGAACGTCTCGGGAGGAAGCACCGGGTCGGCGTCCGCGACCTGAAGATCCCGCGGTACGAGGTTGT
GCTCCGGTTCGACCGTGAGGTCACGCGTGACGACGTCGGGTACGTACCCGTAGCCGACGACGTGGTGGTGGAGGACGGGA
CCGTACGGCTGACGTTCCAAGACGTCGACGAGGAGATGCTCCGCCGGCACGTCATCGATCGGGTGATACGGCTCGTAGCT
TGGGCCGTCGAGGAGAGGTCGGAGCTAGTGGAGCGCGTCACCAAGGTCGAACCCGGTACCGTGGTGGACGAGAGCGGTCC
GCGAGAGATCCGGTTCGATGGGGACGTCACCGAAGAGGCGCGTCGACGGGGTTGGGTGAAGGAGTTCCCCGGCCGCGGAC
AGTGGATTTACACCCCTCCGATGGCCGCCCTGTTCGAAGTCCTCCGTGACTTCCTTCTGGAGCGTGTGACGCGTAAGTTG
GGCTTCGAGCCCGCCCTGTTCCCGAAGCTAATTCCGTTGGAGACTATGTTCCGGATGCGTTACCTCCACGGTCTACCCGA
CGGTATGTACTACGTGTGTCCCCCGAAGCGCGACCCGGAGCTGTTCGATGATTTCAAGCGAGAGCTCTACGTGTGGGGAG
AACTCAACGAGAGGACCCTCGGATCGTTGAAGGAGAAGCTCCGCGATCCCGGGTACGTTCTGGCACCGGCCCAGTGTGAG
CCGTTCTACGAGCTGCTGCGGGACGAGGTGGTGGACCCCGAGCGACTCCCGATCAAGCTCTACGACTGCAGTGGCTGGAC
GTACCGGTGGGAGGGTGGTGCCGCGAAGGGTCTGGAACGCGTGAACGAGTTCCAGCGGATCGAGCACGTGTGGATCGCCG
AGCCGGAGGAGGCGGAGAGGATCCGAGAGGAGTTACTGGAAGCTACCAAGCGGGTCGCGGAAGAGCTGGAGCTCGAGTGG
AAGGTAGTCGTATCGGACGATCCCTTCTACCTAGAGGGTCGGCTGCTGGAGGATCGGGACATCGAGCTCCCGGACGTACC
GTCGTACGAGTTCGAAGTCTACTTACCGTTCAAGGGAGAACGGTCGTCGGAAGAAGCCTGGATCTCGGTGGGCTCGTTCA
ACGTGCACGGCGAACACTTCGTCGATGGCTTCAACGTGAAGGAGAAGTCGGGAAGGACCCTGTTCACGGGCTGTGCGGGT
CTGGGTGTCACCCGATGGGTGGTTGGGTTACTGGCTCAACACGGGTTCGAACCCGAGGAGTGGCCGGAGCCTATCCTCGA
GAGAATCGACGAGAAGTTCGGTGGGCTACCCGAGGTACCGAAGACGCTAACCTGGCCGGAGTAG

Upstream 100 bases:

>100_bases
GGGGAAGTTCAACACGGCGGGACTCGGACGCTTCGTCCTCGGAGAGGCCGGATGAACTAAAACCGGACCACCGAGACCGA
CCGGGAAGGGGGCAGCTTGA

Downstream 100 bases:

>100_bases
TCCGATCCCGATCCTTTTTTCAACGGCGCCTTCCGGCGGGCCGGGGGGCTTGCGAGCTTGGTCAGGGACAAGTGGAAGGA
TAAGGTATGGTACACGATCC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MELKFSAEVELTLSREVDPAEIEPTVEEFVKEANEDLLQRGVPTGKEGAKIESYRVLEDTIEMEITGTRYLRPHEAAMRV
RKRLAERLGRKHRVGVRDLKIPRYEVVLRFDREVTRDDVGYVPVADDVVVEDGTVRLTFQDVDEEMLRRHVIDRVIRLVA
WAVEERSELVERVTKVEPGTVVDESGPREIRFDGDVTEEARRRGWVKEFPGRGQWIYTPPMAALFEVLRDFLLERVTRKL
GFEPALFPKLIPLETMFRMRYLHGLPDGMYYVCPPKRDPELFDDFKRELYVWGELNERTLGSLKEKLRDPGYVLAPAQCE
PFYELLRDEVVDPERLPIKLYDCSGWTYRWEGGAAKGLERVNEFQRIEHVWIAEPEEAERIREELLEATKRVAEELELEW
KVVVSDDPFYLEGRLLEDRDIELPDVPSYEFEVYLPFKGERSSEEAWISVGSFNVHGEHFVDGFNVKEKSGRTLFTGCAG
LGVTRWVVGLLAQHGFEPEEWPEPILERIDEKFGGLPEVPKTLTWPE

Sequences:

>Translated_527_residues
MELKFSAEVELTLSREVDPAEIEPTVEEFVKEANEDLLQRGVPTGKEGAKIESYRVLEDTIEMEITGTRYLRPHEAAMRV
RKRLAERLGRKHRVGVRDLKIPRYEVVLRFDREVTRDDVGYVPVADDVVVEDGTVRLTFQDVDEEMLRRHVIDRVIRLVA
WAVEERSELVERVTKVEPGTVVDESGPREIRFDGDVTEEARRRGWVKEFPGRGQWIYTPPMAALFEVLRDFLLERVTRKL
GFEPALFPKLIPLETMFRMRYLHGLPDGMYYVCPPKRDPELFDDFKRELYVWGELNERTLGSLKEKLRDPGYVLAPAQCE
PFYELLRDEVVDPERLPIKLYDCSGWTYRWEGGAAKGLERVNEFQRIEHVWIAEPEEAERIREELLEATKRVAEELELEW
KVVVSDDPFYLEGRLLEDRDIELPDVPSYEFEVYLPFKGERSSEEAWISVGSFNVHGEHFVDGFNVKEKSGRTLFTGCAG
LGVTRWVVGLLAQHGFEPEEWPEPILERIDEKFGGLPEVPKTLTWPE
>Mature_527_residues
MELKFSAEVELTLSREVDPAEIEPTVEEFVKEANEDLLQRGVPTGKEGAKIESYRVLEDTIEMEITGTRYLRPHEAAMRV
RKRLAERLGRKHRVGVRDLKIPRYEVVLRFDREVTRDDVGYVPVADDVVVEDGTVRLTFQDVDEEMLRRHVIDRVIRLVA
WAVEERSELVERVTKVEPGTVVDESGPREIRFDGDVTEEARRRGWVKEFPGRGQWIYTPPMAALFEVLRDFLLERVTRKL
GFEPALFPKLIPLETMFRMRYLHGLPDGMYYVCPPKRDPELFDDFKRELYVWGELNERTLGSLKEKLRDPGYVLAPAQCE
PFYELLRDEVVDPERLPIKLYDCSGWTYRWEGGAAKGLERVNEFQRIEHVWIAEPEEAERIREELLEATKRVAEELELEW
KVVVSDDPFYLEGRLLEDRDIELPDVPSYEFEVYLPFKGERSSEEAWISVGSFNVHGEHFVDGFNVKEKSGRTLFTGCAG
LGVTRWVVGLLAQHGFEPEEWPEPILERIDEKFGGLPEVPKTLTWPE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-2 seryl-tRNA synthetase subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS2_METKA (Q8TVD2)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614743.1
- ProteinModelPortal:   Q8TVD2
- GeneID:   1478055
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1460
- NMPDR:   fig|190192.1.peg.1456
- HOGENOM:   HBG542255
- OMA:   PAQCEPF
- ProtClustDB:   PRK00960
- BioCyc:   MKAN190192:MK1460-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_01278
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR004503
- PANTHER:   PTHR11778
- TIGRFAMs:   TIGR00415

Pfam domain/function: PF00587 tRNA-synt_2b

EC number: =6.1.1.11

Molecular weight: Translated: 61368; Mature: 61368

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 317-317 BINDING 349-349 BINDING 485-485

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKFSAEVELTLSREVDPAEIEPTVEEFVKEANEDLLQRGVPTGKEGAKIESYRVLEDT
CCCEECCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
IEMEITGTRYLRPHEAAMRVRKRLAERLGRKHRVGVRDLKIPRYEVVLRFDREVTRDDVG
EEEEECCCCCCCHHHHHHHHHHHHHHHHCHHHCCCCHHCCCCCEEEEEEECCHHCCCCCC
YVPVADDVVVEDGTVRLTFQDVDEEMLRRHVIDRVIRLVAWAVEERSELVERVTKVEPGT
CEECCCCEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VVDESGPREIRFDGDVTEEARRRGWVKEFPGRGQWIYTPPMAALFEVLRDFLLERVTRKL
EECCCCCCEEEECCCCHHHHHHCCCHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
GFEPALFPKLIPLETMFRMRYLHGLPDGMYYVCPPKRDPELFDDFKRELYVWGELNERTL
CCCCCCCCHHCCHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHEEEECCCCHHHH
GSLKEKLRDPGYVLAPAQCEPFYELLRDEVVDPERLPIKLYDCSGWTYRWEGGAAKGLER
HHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHH
VNEFQRIEHVWIAEPEEAERIREELLEATKRVAEELELEWKVVVSDDPFYLEGRLLEDRD
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECEEECCCC
IELPDVPSYEFEVYLPFKGERSSEEAWISVGSFNVHGEHFVDGFNVKEKSGRTLFTGCAG
CCCCCCCCCCEEEEEECCCCCCCCCCEEEECCEECCCHHHCCCCCCCCCCCCEEEECHHH
LGVTRWVVGLLAQHGFEPEEWPEPILERIDEKFGGLPEVPKTLTWPE
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MELKFSAEVELTLSREVDPAEIEPTVEEFVKEANEDLLQRGVPTGKEGAKIESYRVLEDT
CCCEECCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
IEMEITGTRYLRPHEAAMRVRKRLAERLGRKHRVGVRDLKIPRYEVVLRFDREVTRDDVG
EEEEECCCCCCCHHHHHHHHHHHHHHHHCHHHCCCCHHCCCCCEEEEEEECCHHCCCCCC
YVPVADDVVVEDGTVRLTFQDVDEEMLRRHVIDRVIRLVAWAVEERSELVERVTKVEPGT
CEECCCCEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VVDESGPREIRFDGDVTEEARRRGWVKEFPGRGQWIYTPPMAALFEVLRDFLLERVTRKL
EECCCCCCEEEECCCCHHHHHHCCCHHCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHH
GFEPALFPKLIPLETMFRMRYLHGLPDGMYYVCPPKRDPELFDDFKRELYVWGELNERTL
CCCCCCCCHHCCHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHEEEECCCCHHHH
GSLKEKLRDPGYVLAPAQCEPFYELLRDEVVDPERLPIKLYDCSGWTYRWEGGAAKGLER
HHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHH
VNEFQRIEHVWIAEPEEAERIREELLEATKRVAEELELEWKVVVSDDPFYLEGRLLEDRD
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEECEEECCCC
IELPDVPSYEFEVYLPFKGERSSEEAWISVGSFNVHGEHFVDGFNVKEKSGRTLFTGCAG
CCCCCCCCCCEEEEEECCCCCCCCCCEEEECCEECCCHHHCCCCCCCCCCCCEEEECHHH
LGVTRWVVGLLAQHGFEPEEWPEPILERIDEKFGGLPEVPKTLTWPE
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014