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The map label for this gene is ydiS [C]

Identifier: 20094879

GI number: 20094879

Start: 1475944

End: 1477071

Strand: Direct

Name: ydiS [C]

Synonym: MK1443

Alternate gene names: 20094879

Gene position: 1475944-1477071 (Clockwise)

Preceding gene: 20094878

Following gene: 20094882

Centisome position: 87.08

GC content: 61.52

Gene sequence:

>1128_bases
ATGGAGTTCGATGTGGTGGTGGTCGGTGCGGGTCCGGCGGGTTCGGTGGCGGCGTGGGCCGCGGCGGAGGCCGGTTGTGA
TGTCCTGATACTCGAGCGTAAGGCCGAGATCGGCGTCCCCAAACAGTGCGCCGAAGGCATCAGCGCACGAGCTCTCGAGG
AGGTCGGAATCAGACCTGACGACGGTTGGATAGCCGCGGAAATAGAGCGTGGTATCCTCTCGCTACCGAGTGGTTCCAAG
TTCGAGGTTGAGGTCGAAGGGTACGTGTTGGAGCGTCGTGTGTTTGATAAGTGGTTGGTTGTTCGGGCGGTGGAGGCTGG
TGCGGAGGTCGAGTTGTTGGCGCATGCTCGACGGGCGTTGTTAGATGAGGGTCGGGTGGTCGGGGTCGAGTACGAGGGCG
AGGATGGAGTGCACGAGGTCCGAGCCCGCATCGTCATCGCCGCAGACGGAATCGAATCACGCATAGGAAGAACCGCCGGA
CTGGTTCCTCAACTCGAGCCTGATCATATATGCACCTGCGCACAGTACGAGGTCGTCGGCGACCGGTACGATCCGAAGGC
GTTCATGATCCACTTCGATCCCGAGCGGATACCCGGCGGGTACGCATGGGTCTTCCCGAAAGGGGAGAACCGGGCGAACG
TAGGGGTGGGAATCCGAGGGTCCGAATCCAGTCCAGGTCTGGCCTTAAAAACGCTCGACGAGCTCGTCGAGGGTCCCTTA
TCCGAGCTCGTAGCGGGGACGCCAGTGGAGGTGAACGTGGGTGGTGTGCCGGTGTGCGGGCCCGTCGAGCGGACGTACGG
TGACGGGATCCTCCTCGTGGGTGATGCGGCCCGCCAGGTCAACCCGTTAACCGGTGGCGGGTTGAACACCGCGCTTATCT
GCGGTCGGATCGCGGGCGAGGTGGCGGTCGAGGCGATCGAAGAGGACGACACGTCCGCCTCCTTCCTGAAACGGTACCAA
GACCGGTGGGAAGAAGAATTCAGGGACACGTTCGAATGTGCGCGTGAGGTGGCGGAAATGCTCCCAGAGCTTGACTTGAA
GGAAGTCGTCGAGTTCCTATCGTCGGTGGAAAACTTGGAGGAAATGCTGAGGACATCTGGTATCTTGGAGGACGTGTGGT
GGGGTTAG

Upstream 100 bases:

>100_bases
TTCGGGACGTGGAATTCCCTGAGCGATGAGGACAGGCCCAATAGCCGAAACCCGATGACGAGCTCCCGGTCCCATCCGAG
CCCTCGCGGGTGAAACGCTT

Downstream 100 bases:

>100_bases
AGTTCTCCGCGCTGCTCGGCCATGAACTCCCGATGCTTCTCCGTCCAGCGAACCTTCTTCGGATCCCTTCCGAGCTTCAG
CATGTTACGCTCGCACTTGC

Product: dehydrogenase (flavoprotein)

Products: NA

Alternate protein names: DGGGPL reductase 1; 2,3-di-O-geranylgeranylglyceryl phosphate reductase 1; Geranylgeranyl reductase 1; GGR 1

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MEFDVVVVGAGPAGSVAAWAAAEAGCDVLILERKAEIGVPKQCAEGISARALEEVGIRPDDGWIAAEIERGILSLPSGSK
FEVEVEGYVLERRVFDKWLVVRAVEAGAEVELLAHARRALLDEGRVVGVEYEGEDGVHEVRARIVIAADGIESRIGRTAG
LVPQLEPDHICTCAQYEVVGDRYDPKAFMIHFDPERIPGGYAWVFPKGENRANVGVGIRGSESSPGLALKTLDELVEGPL
SELVAGTPVEVNVGGVPVCGPVERTYGDGILLVGDAARQVNPLTGGGLNTALICGRIAGEVAVEAIEEDDTSASFLKRYQ
DRWEEEFRDTFECAREVAEMLPELDLKEVVEFLSSVENLEEMLRTSGILEDVWWG

Sequences:

>Translated_375_residues
MEFDVVVVGAGPAGSVAAWAAAEAGCDVLILERKAEIGVPKQCAEGISARALEEVGIRPDDGWIAAEIERGILSLPSGSK
FEVEVEGYVLERRVFDKWLVVRAVEAGAEVELLAHARRALLDEGRVVGVEYEGEDGVHEVRARIVIAADGIESRIGRTAG
LVPQLEPDHICTCAQYEVVGDRYDPKAFMIHFDPERIPGGYAWVFPKGENRANVGVGIRGSESSPGLALKTLDELVEGPL
SELVAGTPVEVNVGGVPVCGPVERTYGDGILLVGDAARQVNPLTGGGLNTALICGRIAGEVAVEAIEEDDTSASFLKRYQ
DRWEEEFRDTFECAREVAEMLPELDLKEVVEFLSSVENLEEMLRTSGILEDVWWG
>Mature_375_residues
MEFDVVVVGAGPAGSVAAWAAAEAGCDVLILERKAEIGVPKQCAEGISARALEEVGIRPDDGWIAAEIERGILSLPSGSK
FEVEVEGYVLERRVFDKWLVVRAVEAGAEVELLAHARRALLDEGRVVGVEYEGEDGVHEVRARIVIAADGIESRIGRTAG
LVPQLEPDHICTCAQYEVVGDRYDPKAFMIHFDPERIPGGYAWVFPKGENRANVGVGIRGSESSPGLALKTLDELVEGPL
SELVAGTPVEVNVGGVPVCGPVERTYGDGILLVGDAARQVNPLTGGGLNTALICGRIAGEVAVEAIEEDDTSASFLKRYQ
DRWEEEFRDTFECAREVAEMLPELDLKEVVEFLSSVENLEEMLRTSGILEDVWWG

Specific function: Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily

Homologues:

Organism=Escherichia coli, GI1787991, Length=369, Percent_Identity=30.0813008130081, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786227, Length=356, Percent_Identity=26.9662921348315, Blast_Score=84, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GGR1_METKA (Q8TVE9)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614726.1
- ProteinModelPortal:   Q8TVE9
- GeneID:   1478038
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1443
- NMPDR:   fig|190192.1.peg.1439
- HOGENOM:   HBG626912
- OMA:   YRFDARV
- ProtClustDB:   CLSK283431
- BioCyc:   MKAN190192:MK1443-MONOMER
- HAMAP:   MF_01287
- InterPro:   IPR003953
- InterPro:   IPR011777
- InterPro:   IPR002938
- InterPro:   IPR003042
- PRINTS:   PR00420
- TIGRFAMs:   TIGR02032

Pfam domain/function: PF00890 FAD_binding_2; PF01494 FAD_binding_3

EC number: 1.5.5.- [C]

Molecular weight: Translated: 40496; Mature: 40496

Theoretical pI: Translated: 4.15; Mature: 4.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFDVVVVGAGPAGSVAAWAAAEAGCDVLILERKAEIGVPKQCAEGISARALEEVGIRPD
CCEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCHHHHHHHHCCCCCC
DGWIAAEIERGILSLPSGSKFEVEVEGYVLERRVFDKWLVVRAVEAGAEVELLAHARRAL
CCEEEEEECCCEEECCCCCEEEEEECCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LDEGRVVGVEYEGEDGVHEVRARIVIAADGIESRIGRTAGLVPQLEPDHICTCAQYEVVG
HCCCCEEEEEECCCCCHHHHHEEEEEEECCHHHHHCCHHCCCCCCCCCCEEEEEEEEEEC
DRYDPKAFMIHFDPERIPGGYAWVFPKGENRANVGVGIRGSESSPGLALKTLDELVEGPL
CCCCCCEEEEEECHHHCCCCEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCH
SELVAGTPVEVNVGGVPVCGPVERTYGDGILLVGDAARQVNPLTGGGLNTALICGRIAGE
HHHHCCCCEEEECCCCCCCCCCHHHCCCCEEEEECCHHHCCCCCCCCCHHHHHHHHHHHH
VAVEAIEEDDTSASFLKRYQDRWEEEFRDTFECAREVAEMLPELDLKEVVEFLSSVENLE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EMLRTSGILEDVWWG
HHHHHCCCHHHHCCC
>Mature Secondary Structure
MEFDVVVVGAGPAGSVAAWAAAEAGCDVLILERKAEIGVPKQCAEGISARALEEVGIRPD
CCEEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCHHHHHHHHCCCCCC
DGWIAAEIERGILSLPSGSKFEVEVEGYVLERRVFDKWLVVRAVEAGAEVELLAHARRAL
CCEEEEEECCCEEECCCCCEEEEEECCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LDEGRVVGVEYEGEDGVHEVRARIVIAADGIESRIGRTAGLVPQLEPDHICTCAQYEVVG
HCCCCEEEEEECCCCCHHHHHEEEEEEECCHHHHHCCHHCCCCCCCCCCEEEEEEEEEEC
DRYDPKAFMIHFDPERIPGGYAWVFPKGENRANVGVGIRGSESSPGLALKTLDELVEGPL
CCCCCCEEEEEECHHHCCCCEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCH
SELVAGTPVEVNVGGVPVCGPVERTYGDGILLVGDAARQVNPLTGGGLNTALICGRIAGE
HHHHCCCCEEEECCCCCCCCCCHHHCCCCEEEEECCHHHCCCCCCCCCHHHHHHHHHHHH
VAVEAIEEDDTSASFLKRYQDRWEEEFRDTFECAREVAEMLPELDLKEVVEFLSSVENLE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
EMLRTSGILEDVWWG
HHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014