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The map label for this gene is NrdD [C]

Identifier: 20094337

GI number: 20094337

Start: 854758

End: 856533

Strand: Reverse

Name: NrdD [C]

Synonym: MK0901

Alternate gene names: 20094337

Gene position: 856533-854758 (Counterclockwise)

Preceding gene: 20094338

Following gene: 161485663

Centisome position: 50.53

GC content: 61.94

Gene sequence:

>1776_bases
TTGACCGGGATCCCCGAGGAGGTTCTTGAGGAACCCCTCCGGGTCGCCCGCAACGCCAACATGCTACCGACTCCGGAGGT
CATCTCAAAGATCTTCCAAGACCGATGGCAAAAACGCCACTTCCTTAAGCACGTGCTGGACGGTAAGACGGCACGGGCGC
ACCTAGAGGGGTACATCCACATCCACGACCTCGACTACGCGTTGACCAGGTCGAACTGCTGCCAGCACGACTGCCGGTGG
GTGCTGAAGTACGGGCTGTACGCTCGGAACCCGATCGGTCGGCTGACCTGCGTGAGCAAGCCCGCCAAGCACGCGGAGGT
GGCCGTGTTACACATCCTGAAGTGGCTGATGACCTCGCAGAACTTCTTCGCGGGCGGCCAAGGTCAGGACTTCGTTAACT
TCCTAGTAGCCCCTTATATAGCCGAGGAGGGACTGTCTTACGAGGAGATACGGCAGCTCGCCCAGATCATGATGTTCGAG
GCCACTCAGGACCTAGTGGCTCGAGGAGGGCAGCCCGCCTTCACGAACGTGAACCTCGAGCTCACGTGTCCGGACTTCCT
AGAGGACGAGCCCGCCGTCGGTCCTGGCGGGGAGATCGTGGGTACCTACGGCGACTTCGAGGAAGAAGCCATCATGTTCG
CTCGAGCCCTCCTGGACGTGCAGCTGGAGGGTGACGCCGCGGGGGCTCCGCTCAAGTTCCCGCAGATAATCGTGAAAGTC
CGACCCGGCTATGACAAGGAGACTCTGGAGCTCGCCTTCGAAGTCGCGGCCGAGAACGGGGCCGTGTACTTCGCCAACAT
GCTTAATCGGGACTGGCGCAAGCTCGTGGGCGACAACGTGAACTACATGGGATGTAGGACGTGCCTCGCCACCAACTGGA
CCGGAGACTGGGAAATCGACACCATCCGCACCGGCAACTTCGAGTACGTCACGCTGAACTTACCTCTCCTCGCCCACGAA
TCACGTGATGAGGACGAATTCCTGGAGAAGATTCGTGAGTACTGCGAGGTGGCCAGGGAGGCTCTCCTGGCGCGGTGGAG
ATGCGTCAAGAAGTGCCTGGAGGCGGGACTGTACGACGGGTGTCAGCGTTGGAAGCCGGACGGGGAGTACTACTTCCGGT
ACGAGCACACGACGTGGAGCCTCGGGTTCGTCGGGCTGGCCGAGGCGATCGAGGTCCTCACGGGATACGGCTTCTGGGAG
GATCCCTCGGCGATGCGTCTGGCCGAGCGGGTGCTGGAGGAACTGAACGACGTGCGAGAAGAGTTCCACGAGCGGGATGG
ACGCAGGTGGTCGGTCGTGCAGTCACCGGCCGAATCGGCCGCCGAACGCCTTGCCAGGAAGTACCTGGAGAAGTACCCGG
ACGCGAAGGTACGCGGTACGGAGCACCGTCCCTACCTCACGAACTCGTGCCATGTGCCGTACGACGAGGACGTGAACGTC
GTCGAGCGGGCCGAGATCGAGGCGAAGTTCCACCCCATGACCTTGGGAGGCCACATCACCCACTTCTGGCTCGGGGAGCG
GACGGACCCGAGAAGCCTCATGAAGCTGACCGTGCGCGTGCTCCGTCGGAACACGATAGGGTTCCTCGCGATCACCAGGG
ATTACAGCGTGTGCGACCGGTGCCAGCGTACCTACGAGGGAGTGGTCGAGCAGTGTCCGGAGTGCGGCCGCAGGTGCACA
ATATGGTCGAGGGTGACCGGGTACCTGGCGCCAGTGGATTCGTTCGTGGACGGTAAAAAGCAAGAGCATAAGGAGCGCCT
GCGTCACGAGCTTTGA

Upstream 100 bases:

>100_bases
GCCCGTGTGCTCAATACCCCCCGTCTACGTCGCGCCTACGTCCGCTTGTGGGCGAAGGGAGCTTACAGGAGGGTCCCAGC
CCCCGTTACGGGGGGAGGGG

Downstream 100 bases:

>100_bases
CCGCCCCTCCCCTCGCGACCCATACGTCGATATTTGTGCGACTGAAGATTTCGGACACTTGGAAGCCTTCCGCGGCTCGG
CGAATTTTGTGCGACTAGAG

Product: oxygen-sensitive ribonucleoside-triphosphate reductase

Products: ribonucleoside triphosphate; thioredoxin

Alternate protein names: NA

Number of amino acids: Translated: 591; Mature: 590

Protein sequence:

>591_residues
MTGIPEEVLEEPLRVARNANMLPTPEVISKIFQDRWQKRHFLKHVLDGKTARAHLEGYIHIHDLDYALTRSNCCQHDCRW
VLKYGLYARNPIGRLTCVSKPAKHAEVAVLHILKWLMTSQNFFAGGQGQDFVNFLVAPYIAEEGLSYEEIRQLAQIMMFE
ATQDLVARGGQPAFTNVNLELTCPDFLEDEPAVGPGGEIVGTYGDFEEEAIMFARALLDVQLEGDAAGAPLKFPQIIVKV
RPGYDKETLELAFEVAAENGAVYFANMLNRDWRKLVGDNVNYMGCRTCLATNWTGDWEIDTIRTGNFEYVTLNLPLLAHE
SRDEDEFLEKIREYCEVAREALLARWRCVKKCLEAGLYDGCQRWKPDGEYYFRYEHTTWSLGFVGLAEAIEVLTGYGFWE
DPSAMRLAERVLEELNDVREEFHERDGRRWSVVQSPAESAAERLARKYLEKYPDAKVRGTEHRPYLTNSCHVPYDEDVNV
VERAEIEAKFHPMTLGGHITHFWLGERTDPRSLMKLTVRVLRRNTIGFLAITRDYSVCDRCQRTYEGVVEQCPECGRRCT
IWSRVTGYLAPVDSFVDGKKQEHKERLRHEL

Sequences:

>Translated_591_residues
MTGIPEEVLEEPLRVARNANMLPTPEVISKIFQDRWQKRHFLKHVLDGKTARAHLEGYIHIHDLDYALTRSNCCQHDCRW
VLKYGLYARNPIGRLTCVSKPAKHAEVAVLHILKWLMTSQNFFAGGQGQDFVNFLVAPYIAEEGLSYEEIRQLAQIMMFE
ATQDLVARGGQPAFTNVNLELTCPDFLEDEPAVGPGGEIVGTYGDFEEEAIMFARALLDVQLEGDAAGAPLKFPQIIVKV
RPGYDKETLELAFEVAAENGAVYFANMLNRDWRKLVGDNVNYMGCRTCLATNWTGDWEIDTIRTGNFEYVTLNLPLLAHE
SRDEDEFLEKIREYCEVAREALLARWRCVKKCLEAGLYDGCQRWKPDGEYYFRYEHTTWSLGFVGLAEAIEVLTGYGFWE
DPSAMRLAERVLEELNDVREEFHERDGRRWSVVQSPAESAAERLARKYLEKYPDAKVRGTEHRPYLTNSCHVPYDEDVNV
VERAEIEAKFHPMTLGGHITHFWLGERTDPRSLMKLTVRVLRRNTIGFLAITRDYSVCDRCQRTYEGVVEQCPECGRRCT
IWSRVTGYLAPVDSFVDGKKQEHKERLRHEL
>Mature_590_residues
TGIPEEVLEEPLRVARNANMLPTPEVISKIFQDRWQKRHFLKHVLDGKTARAHLEGYIHIHDLDYALTRSNCCQHDCRWV
LKYGLYARNPIGRLTCVSKPAKHAEVAVLHILKWLMTSQNFFAGGQGQDFVNFLVAPYIAEEGLSYEEIRQLAQIMMFEA
TQDLVARGGQPAFTNVNLELTCPDFLEDEPAVGPGGEIVGTYGDFEEEAIMFARALLDVQLEGDAAGAPLKFPQIIVKVR
PGYDKETLELAFEVAAENGAVYFANMLNRDWRKLVGDNVNYMGCRTCLATNWTGDWEIDTIRTGNFEYVTLNLPLLAHES
RDEDEFLEKIREYCEVAREALLARWRCVKKCLEAGLYDGCQRWKPDGEYYFRYEHTTWSLGFVGLAEAIEVLTGYGFWED
PSAMRLAERVLEELNDVREEFHERDGRRWSVVQSPAESAAERLARKYLEKYPDAKVRGTEHRPYLTNSCHVPYDEDVNVV
ERAEIEAKFHPMTLGGHITHFWLGERTDPRSLMKLTVRVLRRNTIGFLAITRDYSVCDRCQRTYEGVVEQCPECGRRCTI
WSRVTGYLAPVDSFVDGKKQEHKERLRHEL

Specific function: Unknown

COG id: COG1328

COG function: function code F; Oxygen-sensitive ribonucleoside-triphosphate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 DOD-type homing endonuclease domains [H]

Homologues:

Organism=Escherichia coli, GI1790686, Length=618, Percent_Identity=24.9190938511327, Blast_Score=117, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR003586
- InterPro:   IPR003587
- InterPro:   IPR007869
- InterPro:   IPR006142
- InterPro:   IPR004042
- InterPro:   IPR006141
- InterPro:   IPR012833 [H]

Pfam domain/function: PF03477 ATP-cone; PF05204 Hom_end [H]

EC number: 1.17.4.2

Molecular weight: Translated: 67967; Mature: 67836

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGIPEEVLEEPLRVARNANMLPTPEVISKIFQDRWQKRHFLKHVLDGKTARAHLEGYIH
CCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEE
IHDLDYALTRSNCCQHDCRWVLKYGLYARNPIGRLTCVSKPAKHAEVAVLHILKWLMTSQ
EEECCHHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCC
NFFAGGQGQDFVNFLVAPYIAEEGLSYEEIRQLAQIMMFEATQDLVARGGQPAFTNVNLE
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
LTCPDFLEDEPAVGPGGEIVGTYGDFEEEAIMFARALLDVQLEGDAAGAPLKFPQIIVKV
EECCHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEEE
RPGYDKETLELAFEVAAENGAVYFANMLNRDWRKLVGDNVNYMGCRTCLATNWTGDWEID
CCCCCHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHCCCCCEEHHHHHHCCCCCCCEEEE
TIRTGNFEYVTLNLPLLAHESRDEDEFLEKIREYCEVAREALLARWRCVKKCLEAGLYDG
EEECCCEEEEEEECEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
CQRWKPDGEYYFRYEHTTWSLGFVGLAEAIEVLTGYGFWEDPSAMRLAERVLEELNDVRE
HHHCCCCCCEEEEEECCEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
EFHERDGRRWSVVQSPAESAAERLARKYLEKYPDAKVRGTEHRPYLTNSCHVPYDEDVNV
HHHHCCCCEEEHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
VERAEIEAKFHPMTLGGHITHFWLGERTDPRSLMKLTVRVLRRNTIGFLAITRDYSVCDR
HHHHHHHHEECCEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHH
CQRTYEGVVEQCPECGRRCTIWSRVTGYLAPVDSFVDGKKQEHKERLRHEL
HHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TGIPEEVLEEPLRVARNANMLPTPEVISKIFQDRWQKRHFLKHVLDGKTARAHLEGYIH
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEEEEE
IHDLDYALTRSNCCQHDCRWVLKYGLYARNPIGRLTCVSKPAKHAEVAVLHILKWLMTSQ
EEECCHHHHHHHHHHHHHHHHHHHCCHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHCCC
NFFAGGQGQDFVNFLVAPYIAEEGLSYEEIRQLAQIMMFEATQDLVARGGQPAFTNVNLE
CCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEE
LTCPDFLEDEPAVGPGGEIVGTYGDFEEEAIMFARALLDVQLEGDAAGAPLKFPQIIVKV
EECCHHCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHEEECCCCCCCCCCCCEEEEEE
RPGYDKETLELAFEVAAENGAVYFANMLNRDWRKLVGDNVNYMGCRTCLATNWTGDWEID
CCCCCHHHHHHHHHHHHCCCCEEEHHHHCHHHHHHHCCCCCEEHHHHHHCCCCCCCEEEE
TIRTGNFEYVTLNLPLLAHESRDEDEFLEKIREYCEVAREALLARWRCVKKCLEAGLYDG
EEECCCEEEEEEECEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
CQRWKPDGEYYFRYEHTTWSLGFVGLAEAIEVLTGYGFWEDPSAMRLAERVLEELNDVRE
HHHCCCCCCEEEEEECCEEECHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
EFHERDGRRWSVVQSPAESAAERLARKYLEKYPDAKVRGTEHRPYLTNSCHVPYDEDVNV
HHHHCCCCEEEHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
VERAEIEAKFHPMTLGGHITHFWLGERTDPRSLMKLTVRVLRRNTIGFLAITRDYSVCDR
HHHHHHHHEECCEEECCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHH
CQRTYEGVVEQCPECGRRCTIWSRVTGYLAPVDSFVDGKKQEHKERLRHEL
HHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2'-deoxyribonucleoside triphosphate; thioredoxin disulfide; H2O

Specific reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]