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The map label for this gene is InfA

Identifier: 20093953

GI number: 20093953

Start: 478853

End: 479188

Strand: Reverse

Name: InfA

Synonym: MK0515

Alternate gene names: 20093953

Gene position: 479188-478853 (Counterclockwise)

Preceding gene: 20093954

Following gene: 20093952

Centisome position: 28.27

GC content: 53.57

Gene sequence:

>336_bases
ATGGGTAAGCGCATCGACGACGAGACCCTGAAGAAGATCAGACTTCCAAAGGAAGGCGAAATATTCGGAGTTGTGGAGAA
AATGTTGGGTAACGACCGCGTGCAGGTGAGGTGTGTCGACGGAAAGACTAGAGTAGCGAGGATACCCGGAAAGATGCGTA
AGCGTGTCTGGATCAGGGAAGGAGACGTTGTCCTCGTGAAACCCTGGGAATTCCAACCTGAACGCGCCGACGTTACGTGG
AGGTATACTAGGGTACAGGTCGACTGGCTGAAGCGCAAGGGTAAATTGGACGAACGTGTGACCAAGCTCCTTGAGGAGAT
CATACCGGGCGCCTGA

Upstream 100 bases:

>100_bases
GTGAAGGCGCTGTCCGGTATCGACGCGCTACTGGCGTGTGTCCGCGTTTCCGAGGAAGTACTTAAGCTCGTGAGACCGGC
AAAAGACGGGGGTGACGCCG

Downstream 100 bases:

>100_bases
CTTTGTCTGAAGATAAATACTTCTCCGCGATCGAGGAACTGGAGCCGAAACCAGGAAAGGTCAAAAGACTGGAGAAAACC
CTGGAAGATCTGAAGGTAGA

Product: translation initiation factor IF-1A

Products: NA

Alternate protein names: aIF-1A

Number of amino acids: Translated: 111; Mature: 110

Protein sequence:

>111_residues
MGKRIDDETLKKIRLPKEGEIFGVVEKMLGNDRVQVRCVDGKTRVARIPGKMRKRVWIREGDVVLVKPWEFQPERADVTW
RYTRVQVDWLKRKGKLDERVTKLLEEIIPGA

Sequences:

>Translated_111_residues
MGKRIDDETLKKIRLPKEGEIFGVVEKMLGNDRVQVRCVDGKTRVARIPGKMRKRVWIREGDVVLVKPWEFQPERADVTW
RYTRVQVDWLKRKGKLDERVTKLLEEIIPGA
>Mature_110_residues
GKRIDDETLKKIRLPKEGEIFGVVEKMLGNDRVQVRCVDGKTRVARIPGKMRKRVWIREGDVVLVKPWEFQPERADVTWR
YTRVQVDWLKRKGKLDERVTKLLEEIIPGA

Specific function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits

COG id: COG0361

COG function: function code J; Translation initiation factor 1 (IF-1)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1-like domain

Homologues:

Organism=Homo sapiens, GI4503499, Length=99, Percent_Identity=35.3535353535354, Blast_Score=70, Evalue=3e-13,
Organism=Homo sapiens, GI33356163, Length=99, Percent_Identity=35.3535353535354, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17540984, Length=99, Percent_Identity=44.4444444444444, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323916, Length=84, Percent_Identity=41.6666666666667, Blast_Score=79, Evalue=2e-16,
Organism=Drosophila melanogaster, GI45553405, Length=79, Percent_Identity=43.0379746835443, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647907, Length=79, Percent_Identity=43.0379746835443, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF1A_METKA (Q8TXZ3)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613800.1
- ProteinModelPortal:   Q8TXZ3
- SMR:   Q8TXZ3
- GeneID:   1476616
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0515
- NMPDR:   fig|190192.1.peg.513
- HOGENOM:   HBG521228
- OMA:   DITWRYE
- ProtClustDB:   PRK04012
- BioCyc:   MKAN190192:MK0515-MONOMER
- HAMAP:   MF_00216
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR006196
- InterPro:   IPR001253
- InterPro:   IPR018104
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR21668
- ProDom:   PD005579
- SMART:   SM00652
- TIGRFAMs:   TIGR00523

Pfam domain/function: PF01176 eIF-1a; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 13084; Mature: 12952

Theoretical pI: Translated: 10.73; Mature: 10.73

Prosite motif: PS01262 IF1A; PS50832 S1_IF1_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKRIDDETLKKIRLPKEGEIFGVVEKMLGNDRVQVRCVDGKTRVARIPGKMRKRVWIRE
CCCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEECCHHHHHEEEEEC
GDVVLVKPWEFQPERADVTWRYTRVQVDWLKRKGKLDERVTKLLEEIIPGA
CCEEEEECCCCCCCCCCEEEEEEEEEEHHHHCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GKRIDDETLKKIRLPKEGEIFGVVEKMLGNDRVQVRCVDGKTRVARIPGKMRKRVWIRE
CCCCCHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEECCHHHHHEEEEEC
GDVVLVKPWEFQPERADVTWRYTRVQVDWLKRKGKLDERVTKLLEEIIPGA
CCEEEEECCCCCCCCCCEEEEEEEEEEHHHHCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014