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The map label for this gene is mptA

Identifier: 20093923

GI number: 20093923

Start: 444618

End: 445595

Strand: Reverse

Name: mptA

Synonym: MK0485

Alternate gene names: 20093923

Gene position: 445595-444618 (Counterclockwise)

Preceding gene: 20093927

Following gene: 20093922

Centisome position: 26.29

GC content: 54.81

Gene sequence:

>978_bases
TTGCGGTCTTGCTTCCCCGATGTTCAGAGTGCCGACCCTCAGATCCCGGCTCACCTCACCCGGGTCGGGATCAGCGGGAT
AAAGAAGCTCGTAAAAATACCGCGTCGCGGGAAGCGCTCCATCGTACTCGTGTCCACGTTCAACCTGTTCGTGGATCTCC
CCGCTCACCAGAAAGGGATCCATATGTCACGCAGTCACGAGGTGTTACAGGAAGTCCTCGAGGAGCTTGAGATGTCGGTT
GAGGGGAGTGACACCGTCATTGAAGACCTCTGCTCGCGGATATCCCGAAGACTCCTGGAACGTCATGATTACGCGACGCG
ATCGGAGGTTTACATGACCGGCGAACTAATACTATCCCGGCGGACTCCGGTGACGAAGCTCCCGACTCAAGAACCTTACA
AAATCATCGGTCGTGCGGTGTCCAAGAGGACCGATAACGGCATCGAGACTAGGAAGATGGTCGGAGCCGAGGTAGTCGGA
CTGACAGCGTGTCCGTGCGCCCTCGAAATGATGCGCGAGCACGGTAAAGAACGCGTGAAGCACAGGTTAATGGAAGAACT
CGACTTGGAAGAGGAAGAGGCGGAAGATCTCGCCAAGAAGATAGTGCGTGAGGATGTGCATCCTATGACCCATAATCAGC
GAGGAGTGGGGACTATACTCATCGAAGTGTCCGACGTGCATAGGGTGAGCATCAACGATATCATTGAAATAATAGAGGAG
TCCATGAGCGCCCCGACCTACGAGCTACTGAAAAGACCCGATGAGCTTAAGGTCACGTGCTCTGCGTGTGAGAACCCGAA
ATTCGTCGAGGATTGCGTCCGCGAGATGATCAGGCGAATTGTCGAACGGTTCGACTACCTTCCCGACGACGCTGTAGTGA
TAGTCCGCCAGGTGAACAAGGAGTCCATCCACAAACACGACGCGTTCGCGGAACGTGTGACTACCATGGGAGAGCTAAGG
AAGGAACTGGGGAGTTGA

Upstream 100 bases:

>100_bases
TAATTGGCAAGCCTGGCACCCCCGACGTGATACGTTCCTCCGGTCCGAATAGTGAACTACCGTATAAAGAGCGCCGTACC
TCCTTAGGGGAGGGTACCCT

Downstream 100 bases:

>100_bases
TCGTGCCCGGCACCCCGATCCACATTCATCGACTCGCCAAGAAGATCATGATGGAACTGGACGCTTTCGAGGGCTCGCGG
CCGCTATTGGATGACGTAGA

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MRSCFPDVQSADPQIPAHLTRVGISGIKKLVKIPRRGKRSIVLVSTFNLFVDLPAHQKGIHMSRSHEVLQEVLEELEMSV
EGSDTVIEDLCSRISRRLLERHDYATRSEVYMTGELILSRRTPVTKLPTQEPYKIIGRAVSKRTDNGIETRKMVGAEVVG
LTACPCALEMMREHGKERVKHRLMEELDLEEEEAEDLAKKIVREDVHPMTHNQRGVGTILIEVSDVHRVSINDIIEIIEE
SMSAPTYELLKRPDELKVTCSACENPKFVEDCVREMIRRIVERFDYLPDDAVVIVRQVNKESIHKHDAFAERVTTMGELR
KELGS

Sequences:

>Translated_325_residues
MRSCFPDVQSADPQIPAHLTRVGISGIKKLVKIPRRGKRSIVLVSTFNLFVDLPAHQKGIHMSRSHEVLQEVLEELEMSV
EGSDTVIEDLCSRISRRLLERHDYATRSEVYMTGELILSRRTPVTKLPTQEPYKIIGRAVSKRTDNGIETRKMVGAEVVG
LTACPCALEMMREHGKERVKHRLMEELDLEEEEAEDLAKKIVREDVHPMTHNQRGVGTILIEVSDVHRVSINDIIEIIEE
SMSAPTYELLKRPDELKVTCSACENPKFVEDCVREMIRRIVERFDYLPDDAVVIVRQVNKESIHKHDAFAERVTTMGELR
KELGS
>Mature_325_residues
MRSCFPDVQSADPQIPAHLTRVGISGIKKLVKIPRRGKRSIVLVSTFNLFVDLPAHQKGIHMSRSHEVLQEVLEELEMSV
EGSDTVIEDLCSRISRRLLERHDYATRSEVYMTGELILSRRTPVTKLPTQEPYKIIGRAVSKRTDNGIETRKMVGAEVVG
LTACPCALEMMREHGKERVKHRLMEELDLEEEEAEDLAKKIVREDVHPMTHNQRGVGTILIEVSDVHRVSINDIIEIIEE
SMSAPTYELLKRPDELKVTCSACENPKFVEDCVREMIRRIVERFDYLPDDAVVIVRQVNKESIHKHDAFAERVTTMGELR
KELGS

Specific function: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MPTA_METKA (Q8TY21)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613770.1
- ProteinModelPortal:   Q8TY21
- SMR:   Q8TY21
- GeneID:   1477788
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0485
- NMPDR:   fig|190192.1.peg.483
- HOGENOM:   HBG626871
- OMA:   ACPCAQN
- ProtClustDB:   PRK13675
- BioCyc:   MKAN190192:MK0485-MONOMER
- HAMAP:   MF_01527_A
- InterPro:   IPR003801
- InterPro:   IPR022840
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10
- TIGRFAMs:   TIGR00294

Pfam domain/function: PF02649 DUF198

EC number: NA

Molecular weight: Translated: 37112; Mature: 37112

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSCFPDVQSADPQIPAHLTRVGISGIKKLVKIPRRGKRSIVLVSTFNLFVDLPAHQKGI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHHEECCCCCCCC
HMSRSHEVLQEVLEELEMSVEGSDTVIEDLCSRISRRLLERHDYATRSEVYMTGELILSR
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHEEHHHHHHCC
RTPVTKLPTQEPYKIIGRAVSKRTDNGIETRKMVGAEVVGLTACPCALEMMREHGKERVK
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLMEELDLEEEEAEDLAKKIVREDVHPMTHNQRGVGTILIEVSDVHRVSINDIIEIIEE
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHH
SMSAPTYELLKRPDELKVTCSACENPKFVEDCVREMIRRIVERFDYLPDDAVVIVRQVNK
HHCCCHHHHHCCCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCH
ESIHKHDAFAERVTTMGELRKELGS
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRSCFPDVQSADPQIPAHLTRVGISGIKKLVKIPRRGKRSIVLVSTFNLFVDLPAHQKGI
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEHHEECCCCCCCC
HMSRSHEVLQEVLEELEMSVEGSDTVIEDLCSRISRRLLERHDYATRSEVYMTGELILSR
CCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHEEHHHHHHCC
RTPVTKLPTQEPYKIIGRAVSKRTDNGIETRKMVGAEVVGLTACPCALEMMREHGKERVK
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HRLMEELDLEEEEAEDLAKKIVREDVHPMTHNQRGVGTILIEVSDVHRVSINDIIEIIEE
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHH
SMSAPTYELLKRPDELKVTCSACENPKFVEDCVREMIRRIVERFDYLPDDAVVIVRQVNK
HHCCCHHHHHCCCCHHEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCH
ESIHKHDAFAERVTTMGELRKELGS
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014