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The map label for this gene is TrpE [H]

Identifier: 20093875

GI number: 20093875

Start: 407723

End: 409129

Strand: Reverse

Name: TrpE [H]

Synonym: MK0437

Alternate gene names: 20093875

Gene position: 409129-407723 (Counterclockwise)

Preceding gene: 20093876

Following gene: 20093874

Centisome position: 24.14

GC content: 60.7

Gene sequence:

>1407_bases
GTGCGCTTGACTGTAAGGGAGCTAGATATAGACAGGTCTCCCGACGAGGTCTACGCGGCCTTGAGGACGCTGTCCTCACA
CACGTTCCTATTCGAGTCGGCCGAGATCGGTGCCAGCGGCCGGTACTCCTTCGTAGGCTTCTCACCGGCGCTTAGGATAG
AGTGCGTCGACGGTCGAGTCCGCGTGGACGTCGGTGACCCGGAGTACGCCGATTTAGTGGTTGAAGGTCGAAAGGAAACG
GATGAGGACCACTTCCAGCTCATGCGCCGCGTGTTCTCCCGAATCCCGAAGGTCGAGGGGTCCGGCTTCGTCGGCGGTCT
CGTGGGCTACATATCGTACGACGTCGTCGAAGACTGGCTGGACGTCAAATCGACCACCGTCGCCGACCCGGAGTGGCCGT
CCTTCGAGCTGTGCCTCTACGACTCGGTGGTGCGCTTCGACCACTACGAGGACAGAGTCGAGCTGATCTCCGTCCATCCC
GACGACTACGAGGTCGAGTGGACGGCGGAGGCGATCGAGGAGTGTGTCCGAGAGGTGAGCGGACAGACGGCCCCTAAGGT
GCACCGGACGGGGGAGCTGAAGCGGGACCTGGAGAAAGAGGAGTTCGAGGGGATCGTCGAGCGGGCGAAGGAGTACATAA
TCTCGGGGGACATCTTCCAGGTTGTACTCTCGAGGCGGGTGGAGGTGCGAGCGGTCGCGGATCCGCTCGAGGTGTACCGA
AGGCTCCGCGACATCAACCCGTCCCCGTACATGTACTGCTTGGAGTTCGGCGAGCGGAGGATCATCGGGTCCAGTCCCGA
GACGCTCGTCCGGCTGGAAGGTGATCGCATCATCACGAAACCCATAGCCGGCACCAGGCCCCGTGGTAGTACCCCAGAAG
AGGACGAAGAGCTGGCCCGTGAGATGCTCGAAGATGAGAAAGAGCTCGCGGAGCACGCGATGCTCGTGGATCTCGCCAGA
AACGACGTGGGTAAGGTCTCGAGACCCGGAACGGTCGAAGTCACGCGGCTCATGGAGATCGAGAAGTACAGTCACGTGCA
GCACATCGTGTCCGAGGTGGTGGGTGAGAGAAAGGAGGGAGTTACCCCCTGGGACGTACTCCGGGCGACGTTCCCGGCCG
GAACCGTCTCCGGGGCCCCGAAGGTGAGGGCTATGGAAATCATCGACGAGCTGGAGGTGTACAAGCGAGGCCCGTACGCC
GGAGGCGTCGGATACGTCAGCTGGACAGGGGATATGGACTTCGCGATATCGATCCGTACCATTTTCTCGACGGGCCGTCG
ATGGTTCACGCAGGCGGGTGCCGGTATCGTGTACGACTCGGTGCCCGAAAACGAGTGGTTCGAAACTGAAAATAAAATGA
AAGCGATGGTGGGAGCTATCCTTGAGGAGACTAGTTCTGATAAATAA

Upstream 100 bases:

>100_bases
GTTGGGTAATCCGTAACACGGCCGCCTGTATCGCAGGCCTGACCGTCGCCGCGTACTTAGAAGTTCATATAACACCGATA
GTGGCAGGGTGTGTGATGAA

Downstream 100 bases:

>100_bases
CAAGGATAGTTTCGTGTATAATCTCTACCATTTGTTCGCCTCATATGATCTCGATTTGAAAGTTGTCTCCAACAAGGTTC
CGCTCTCCAGGCTCGAGCGG

Product: anthranilate/para-aminobenzoate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I 2 [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MRLTVRELDIDRSPDEVYAALRTLSSHTFLFESAEIGASGRYSFVGFSPALRIECVDGRVRVDVGDPEYADLVVEGRKET
DEDHFQLMRRVFSRIPKVEGSGFVGGLVGYISYDVVEDWLDVKSTTVADPEWPSFELCLYDSVVRFDHYEDRVELISVHP
DDYEVEWTAEAIEECVREVSGQTAPKVHRTGELKRDLEKEEFEGIVERAKEYIISGDIFQVVLSRRVEVRAVADPLEVYR
RLRDINPSPYMYCLEFGERRIIGSSPETLVRLEGDRIITKPIAGTRPRGSTPEEDEELAREMLEDEKELAEHAMLVDLAR
NDVGKVSRPGTVEVTRLMEIEKYSHVQHIVSEVVGERKEGVTPWDVLRATFPAGTVSGAPKVRAMEIIDELEVYKRGPYA
GGVGYVSWTGDMDFAISIRTIFSTGRRWFTQAGAGIVYDSVPENEWFETENKMKAMVGAILEETSSDK

Sequences:

>Translated_468_residues
MRLTVRELDIDRSPDEVYAALRTLSSHTFLFESAEIGASGRYSFVGFSPALRIECVDGRVRVDVGDPEYADLVVEGRKET
DEDHFQLMRRVFSRIPKVEGSGFVGGLVGYISYDVVEDWLDVKSTTVADPEWPSFELCLYDSVVRFDHYEDRVELISVHP
DDYEVEWTAEAIEECVREVSGQTAPKVHRTGELKRDLEKEEFEGIVERAKEYIISGDIFQVVLSRRVEVRAVADPLEVYR
RLRDINPSPYMYCLEFGERRIIGSSPETLVRLEGDRIITKPIAGTRPRGSTPEEDEELAREMLEDEKELAEHAMLVDLAR
NDVGKVSRPGTVEVTRLMEIEKYSHVQHIVSEVVGERKEGVTPWDVLRATFPAGTVSGAPKVRAMEIIDELEVYKRGPYA
GGVGYVSWTGDMDFAISIRTIFSTGRRWFTQAGAGIVYDSVPENEWFETENKMKAMVGAILEETSSDK
>Mature_468_residues
MRLTVRELDIDRSPDEVYAALRTLSSHTFLFESAEIGASGRYSFVGFSPALRIECVDGRVRVDVGDPEYADLVVEGRKET
DEDHFQLMRRVFSRIPKVEGSGFVGGLVGYISYDVVEDWLDVKSTTVADPEWPSFELCLYDSVVRFDHYEDRVELISVHP
DDYEVEWTAEAIEECVREVSGQTAPKVHRTGELKRDLEKEEFEGIVERAKEYIISGDIFQVVLSRRVEVRAVADPLEVYR
RLRDINPSPYMYCLEFGERRIIGSSPETLVRLEGDRIITKPIAGTRPRGSTPEEDEELAREMLEDEKELAEHAMLVDLAR
NDVGKVSRPGTVEVTRLMEIEKYSHVQHIVSEVVGERKEGVTPWDVLRATFPAGTVSGAPKVRAMEIIDELEVYKRGPYA
GGVGYVSWTGDMDFAISIRTIFSTGRRWFTQAGAGIVYDSVPENEWFETENKMKAMVGAILEETSSDK

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=395, Percent_Identity=37.4683544303797, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1788114, Length=392, Percent_Identity=32.6530612244898, Blast_Score=220, Evalue=1e-58,
Organism=Escherichia coli, GI87082077, Length=283, Percent_Identity=26.1484098939929, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1786809, Length=264, Percent_Identity=28.4090909090909, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320935, Length=478, Percent_Identity=38.2845188284519, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6324361, Length=400, Percent_Identity=24, Blast_Score=113, Evalue=5e-26,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR010116
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 53030; Mature: 53030

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLTVRELDIDRSPDEVYAALRTLSSHTFLFESAEIGASGRYSFVGFSPALRIECVDGRV
CCEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCEEEEEECCEE
RVDVGDPEYADLVVEGRKETDEDHFQLMRRVFSRIPKVEGSGFVGGLVGYISYDVVEDWL
EEECCCCCHHHHEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
DVKSTTVADPEWPSFELCLYDSVVRFDHYEDRVELISVHPDDYEVEWTAEAIEECVREVS
HCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHC
GQTAPKVHRTGELKRDLEKEEFEGIVERAKEYIISGDIFQVVLSRRVEVRAVADPLEVYR
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHH
RLRDINPSPYMYCLEFGERRIIGSSPETLVRLEGDRIITKPIAGTRPRGSTPEEDEELAR
HHHCCCCCCEEEEEECCCCEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCCHHHHHHH
EMLEDEKELAEHAMLVDLARNDVGKVSRPGTVEVTRLMEIEKYSHVQHIVSEVVGERKEG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
VTPWDVLRATFPAGTVSGAPKVRAMEIIDELEVYKRGPYAGGVGYVSWTGDMDFAISIRT
CCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEHHH
IFSTGRRWFTQAGAGIVYDSVPENEWFETENKMKAMVGAILEETSSDK
HHHCCHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRLTVRELDIDRSPDEVYAALRTLSSHTFLFESAEIGASGRYSFVGFSPALRIECVDGRV
CCEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCEEEEEECCEE
RVDVGDPEYADLVVEGRKETDEDHFQLMRRVFSRIPKVEGSGFVGGLVGYISYDVVEDWL
EEECCCCCHHHHEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
DVKSTTVADPEWPSFELCLYDSVVRFDHYEDRVELISVHPDDYEVEWTAEAIEECVREVS
HCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCEEEEEECCCCCEEEEHHHHHHHHHHHHC
GQTAPKVHRTGELKRDLEKEEFEGIVERAKEYIISGDIFQVVLSRRVEVRAVADPLEVYR
CCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHH
RLRDINPSPYMYCLEFGERRIIGSSPETLVRLEGDRIITKPIAGTRPRGSTPEEDEELAR
HHHCCCCCCEEEEEECCCCEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCCHHHHHHH
EMLEDEKELAEHAMLVDLARNDVGKVSRPGTVEVTRLMEIEKYSHVQHIVSEVVGERKEG
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
VTPWDVLRATFPAGTVSGAPKVRAMEIIDELEVYKRGPYAGGVGYVSWTGDMDFAISIRT
CCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEHHH
IFSTGRRWFTQAGAGIVYDSVPENEWFETENKMKAMVGAILEETSSDK
HHHCCHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA