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The map label for this gene is rph [C]

Identifier: 20093818

GI number: 20093818

Start: 365802

End: 366605

Strand: Reverse

Name: rph [C]

Synonym: MK0380

Alternate gene names: 20093818

Gene position: 366605-365802 (Counterclockwise)

Preceding gene: 20093819

Following gene: 20093817

Centisome position: 21.63

GC content: 57.59

Gene sequence:

>804_bases
GTGGACCTGGACCTGCTAGCCCGTATTAAACGTCATGAGGTACTCGCCGCTATCAGGGCCGGAGAGAGGATCGACGGGCG
TGATTTCGAAGAGTTTCGTCCCATCGAGGTACGTGCCGGGGTCATCTCCAAAGCGAACGGGTCGGCCTTGGTCCGTCTCG
GGAACACCCAGCTGGTCGTCGGTGTGAAGCTGGAGGTGGGTCGCCCTTACCCCGATTCACCTAACGAAGGAGCCCTGGCG
GTCAACGCGGAACTCGTTCCGCTCGCCGACCCATCCTTCGAACCTGGTCCTCCGGATGAAAACGCGATCGAGCTCTCTCG
TGTCGTAGACAGGGGGATCCGCGAGTCCGAGATGATAGATCTTGAGGAGCTCTGCATAGAGGAAGGTGAGCACTGCTGGG
TCACCTTCGTAGACATCCACGTACTGGACCACGACGGGAACTTGTTCGACGCCTCCATGATCGGCTCGGTTTCCGCACTC
TCCATCACCGAGGTGCCAAAAGCCGAAGTCGTGGACGATGAGGTTGAAGTTATGGAGGAAGATACCGAACCGCTCGCTAT
CAACGACTTTCCCATCTCCGTTACTATCGCTAAAGTCGGTGAGTACCTGCTCGTCGACCCCTGTCTTGAGGAGGAGGTCA
TCATGGACACCAGGCTGACAGTAACCGTCACCGAAAGTGGAGAAGTCTGCGCGGTTCAGAAGGGAGAGCTTGGGGATTTT
CCCGAGCATCTACTGGAGGACGCTATCGACCTAGCCACGAAGAAGGCGGAAGAAGTCCGACGCACCGTCAAGGCTCAACT
GTAA

Upstream 100 bases:

>100_bases
GGGGAGTTCAAACAGGCGGTGAAGCTGGCCAAGAAAGGGTGCAAGATAGTGTACAAAGAGCAGCGCAGGGCGTTAAAGGA
GAAATACGGGGGAGACTGAC

Downstream 100 bases:

>100_bases
CCCACTCCCCAAACCTTATAGGGGTCAAAGGGCCTGCGCGCGGGGGGTGCAGGACGGTGGGTCGTACGAAGAAGGTCGGT
CCAGCGGGACGCTTCGGACC

Product: exosome complex RNA-binding protein Rrp42

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MDLDLLARIKRHEVLAAIRAGERIDGRDFEEFRPIEVRAGVISKANGSALVRLGNTQLVVGVKLEVGRPYPDSPNEGALA
VNAELVPLADPSFEPGPPDENAIELSRVVDRGIRESEMIDLEELCIEEGEHCWVTFVDIHVLDHDGNLFDASMIGSVSAL
SITEVPKAEVVDDEVEVMEEDTEPLAINDFPISVTIAKVGEYLLVDPCLEEEVIMDTRLTVTVTESGEVCAVQKGELGDF
PEHLLEDAIDLATKKAEEVRRTVKAQL

Sequences:

>Translated_267_residues
MDLDLLARIKRHEVLAAIRAGERIDGRDFEEFRPIEVRAGVISKANGSALVRLGNTQLVVGVKLEVGRPYPDSPNEGALA
VNAELVPLADPSFEPGPPDENAIELSRVVDRGIRESEMIDLEELCIEEGEHCWVTFVDIHVLDHDGNLFDASMIGSVSAL
SITEVPKAEVVDDEVEVMEEDTEPLAINDFPISVTIAKVGEYLLVDPCLEEEVIMDTRLTVTVTESGEVCAVQKGELGDF
PEHLLEDAIDLATKKAEEVRRTVKAQL
>Mature_267_residues
MDLDLLARIKRHEVLAAIRAGERIDGRDFEEFRPIEVRAGVISKANGSALVRLGNTQLVVGVKLEVGRPYPDSPNEGALA
VNAELVPLADPSFEPGPPDENAIELSRVVDRGIRESEMIDLEELCIEEGEHCWVTFVDIHVLDHDGNLFDASMIGSVSAL
SITEVPKAEVVDDEVEVMEEDTEPLAINDFPISVTIAKVGEYLLVDPCLEEEVIMDTRLTVTVTESGEVCAVQKGELGDF
PEHLLEDAIDLATKKAEEVRRTVKAQL

Specific function: Probably involved in the 3'->5' degradation of a variety of RNA species (Potential)

COG id: COG2123

COG function: function code J; RNase PH-related exoribonuclease

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase PH family

Homologues:

Organism=Homo sapiens, GI31415882, Length=242, Percent_Identity=35.5371900826446, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI189083688, Length=232, Percent_Identity=37.5, Blast_Score=147, Evalue=9e-36,
Organism=Homo sapiens, GI77812670, Length=233, Percent_Identity=37.3390557939914, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI77812672, Length=233, Percent_Identity=37.3390557939914, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25144570, Length=252, Percent_Identity=29.7619047619048, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI32566065, Length=231, Percent_Identity=29.8701298701299, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320486, Length=246, Percent_Identity=32.9268292682927, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24642649, Length=234, Percent_Identity=31.6239316239316, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI28573444, Length=215, Percent_Identity=32.5581395348837, Blast_Score=120, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECX2_METKA (Q8TYC2)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613665.1
- ProteinModelPortal:   Q8TYC2
- SMR:   Q8TYC2
- GeneID:   1477683
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0380
- NMPDR:   fig|190192.1.peg.378
- HOGENOM:   HBG737187
- OMA:   VEYNEET
- ProtClustDB:   PRK04282
- BioCyc:   MKAN190192:MK0380-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00622
- InterPro:   IPR001247
- InterPro:   IPR015847
- InterPro:   IPR020869
- InterPro:   IPR020568

Pfam domain/function: PF01138 RNase_PH; PF03725 RNase_PH_C; SSF55666 3_ExoRNase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.1.13.-

Molecular weight: Translated: 29277; Mature: 29277

Theoretical pI: Translated: 4.03; Mature: 4.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLDLLARIKRHEVLAAIRAGERIDGRDFEEFRPIEVRAGVISKANGSALVRLGNTQLVV
CCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEEECEEECCCCCEEEEECCEEEEE
GVKLEVGRPYPDSPNEGALAVNAELVPLADPSFEPGPPDENAIELSRVVDRGIRESEMID
EEEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHCCC
LEELCIEEGEHCWVTFVDIHVLDHDGNLFDASMIGSVSALSITEVPKAEVVDDEVEVMEE
HHHHHHHCCCEEEEEEEEEEEEECCCCEEEHHHHCCEEEEEECCCCCCHHCCHHHHHHHC
DTEPLAINDFPISVTIAKVGEYLLVDPCLEEEVIMDTRLTVTVTESGEVCAVQKGELGDF
CCCCEEEECCCEEEEHHHCCCEEEECCCCCCCEEECCEEEEEEECCCCEEEEECCCCCCC
PEHLLEDAIDLATKKAEEVRRTVKAQL
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDLDLLARIKRHEVLAAIRAGERIDGRDFEEFRPIEVRAGVISKANGSALVRLGNTQLVV
CCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEEECEEECCCCCEEEEECCEEEEE
GVKLEVGRPYPDSPNEGALAVNAELVPLADPSFEPGPPDENAIELSRVVDRGIRESEMID
EEEEEECCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCHHHCCC
LEELCIEEGEHCWVTFVDIHVLDHDGNLFDASMIGSVSALSITEVPKAEVVDDEVEVMEE
HHHHHHHCCCEEEEEEEEEEEEECCCCEEEHHHHCCEEEEEECCCCCCHHCCHHHHHHHC
DTEPLAINDFPISVTIAKVGEYLLVDPCLEEEVIMDTRLTVTVTESGEVCAVQKGELGDF
CCCCEEEECCCEEEEHHHCCCEEEECCCCCCCEEECCEEEEEEECCCCEEEEECCCCCCC
PEHLLEDAIDLATKKAEEVRRTVKAQL
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014