Click here to switch to the map view.

The map label for this gene is HMG1 [H]

Identifier: 20093793

GI number: 20093793

Start: 343442

End: 344674

Strand: Reverse

Name: HMG1 [H]

Synonym: MK0355

Alternate gene names: 20093793

Gene position: 344674-343442 (Counterclockwise)

Preceding gene: 20093794

Following gene: 20093791

Centisome position: 20.34

GC content: 59.12

Gene sequence:

>1233_bases
GTGGACGAGAAGAAGATTGAGGAGCTCGTGAGCAAGGTAGTAAAAGGCGAGATCAAGTTCCACGAGGTGGAGAAGTACAC
CGACGGTGACAGTGAGGTGGCCACGGAAGTTCGACGTCGTGCGCTGGAGCGGTTGACCGGTGCGAAGCTCGAGCATCTCG
GCAAGTACACCATCGACGCGAACCGTGCGATGGACAAGAACATCGAGAACATGATCGGAGCCGTCCAGGTGCCGGTCGGT
ATCGCCGGCCCGCTGTTAGTGCACGGGGAGTACGCCGAGGGGGAATACTACGTACCGCTCGCGACGACGGAGGGAGCGTT
GGTGGCCTCCGTCAACCGTGGCTGTTCGACTATTACCGATTCAGGCGGTGCCCACGTGAGGATCGTGAGAGACGGAATGA
CGCGTGCTCCTGTGTTCAAACTGCCGTCCGCTCGTAAAGCGTTGGAGTTCTGTGAGTGGGTACGTAAGCACTTCGACGAT
ATCAAAGAGGTGGCCGAGAGTACCACACGTCACGGTGAGCTACTCGATATTCAGGAGTTCGTGGTCGGTAGGCACGTGTT
CCTCCGGTTCGAGTTCGACACGAAGGACGCAATGGGTATGAACATGGTCACTATCGCCACTGAGGAAGCCGTGAACTGGA
TCGAGGAGAAGTATCCGGACGCGAAGTGCGTTTCGGCGAGCGGGAACGTTTGTGTGGACAAGAAACCCTCGTGGCTCAAC
AACGTGCTGGGTCGAGGTCGGACGGTGGTGGCCGAGGTCGAAGTCCCGCGCGATATAGTCGAGGAGAAGCTGAAGACTAC
CCCGGAAGCCATGGCCGAGGTCAATTACAGGAAGAACCTGGTAGGCTCCGCGGCCGCCGGTAACATCGGGTTCAACGCGC
ATCACGCGAACATTGTGGCCGCTATTTTCATCGCTACAGGCCAGGACGAGGCGCATGCTGTCGATGGATCCACTGGGTAC
ACCACGATGGAGGTTACGGAGGACGGCGACCTGTACGCTAGTGTGACGATTCCCAGCTTGAACGTAGGGACGGTTGGAGG
GGGTACCGGGGTGGAGACACAGCGCGAGTGTCTGGAAATCCTCGGCGTGGCTGGTGGAGGGAACCCACCCGGTGTCAACG
CTAAAGAGTTCGCCGAAGTGGTCGCCGCCGCGGTCTTGGCAGGTGAGCTGTCACTCGTAGCTGCACTGGCGGCGGGACAT
TTGGGTAAAGCGCACAGGCTCTTAGGTCGCTAA

Upstream 100 bases:

>100_bases
GACTATCGTAGCGGAGCTCGCGAGAACCGGTGTCGAACCTAAGTACGCTTCGAGCTGCTTTTAGGTTCCCTCTTCGAGTG
TCCGTCGGGGGCTGTCCTTC

Downstream 100 bases:

>100_bases
GCTTCGAAAATCGGGAGTGGGAACTCCTCCTTCCCTTCCCCTCCCTCTACGAGCTCACGCATGAGTTCGTGGACGCGCTC
CCGGATCTCTTGGTACTCTT

Product: hydroxymethylglutaryl-CoA reductase

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MDEKKIEELVSKVVKGEIKFHEVEKYTDGDSEVATEVRRRALERLTGAKLEHLGKYTIDANRAMDKNIENMIGAVQVPVG
IAGPLLVHGEYAEGEYYVPLATTEGALVASVNRGCSTITDSGGAHVRIVRDGMTRAPVFKLPSARKALEFCEWVRKHFDD
IKEVAESTTRHGELLDIQEFVVGRHVFLRFEFDTKDAMGMNMVTIATEEAVNWIEEKYPDAKCVSASGNVCVDKKPSWLN
NVLGRGRTVVAEVEVPRDIVEEKLKTTPEAMAEVNYRKNLVGSAAAGNIGFNAHHANIVAAIFIATGQDEAHAVDGSTGY
TTMEVTEDGDLYASVTIPSLNVGTVGGGTGVETQRECLEILGVAGGGNPPGVNAKEFAEVVAAAVLAGELSLVAALAAGH
LGKAHRLLGR

Sequences:

>Translated_410_residues
MDEKKIEELVSKVVKGEIKFHEVEKYTDGDSEVATEVRRRALERLTGAKLEHLGKYTIDANRAMDKNIENMIGAVQVPVG
IAGPLLVHGEYAEGEYYVPLATTEGALVASVNRGCSTITDSGGAHVRIVRDGMTRAPVFKLPSARKALEFCEWVRKHFDD
IKEVAESTTRHGELLDIQEFVVGRHVFLRFEFDTKDAMGMNMVTIATEEAVNWIEEKYPDAKCVSASGNVCVDKKPSWLN
NVLGRGRTVVAEVEVPRDIVEEKLKTTPEAMAEVNYRKNLVGSAAAGNIGFNAHHANIVAAIFIATGQDEAHAVDGSTGY
TTMEVTEDGDLYASVTIPSLNVGTVGGGTGVETQRECLEILGVAGGGNPPGVNAKEFAEVVAAAVLAGELSLVAALAAGH
LGKAHRLLGR
>Mature_410_residues
MDEKKIEELVSKVVKGEIKFHEVEKYTDGDSEVATEVRRRALERLTGAKLEHLGKYTIDANRAMDKNIENMIGAVQVPVG
IAGPLLVHGEYAEGEYYVPLATTEGALVASVNRGCSTITDSGGAHVRIVRDGMTRAPVFKLPSARKALEFCEWVRKHFDD
IKEVAESTTRHGELLDIQEFVVGRHVFLRFEFDTKDAMGMNMVTIATEEAVNWIEEKYPDAKCVSASGNVCVDKKPSWLN
NVLGRGRTVVAEVEVPRDIVEEKLKTTPEAMAEVNYRKNLVGSAAAGNIGFNAHHANIVAAIFIATGQDEAHAVDGSTGY
TTMEVTEDGDLYASVTIPSLNVGTVGGGTGVETQRECLEILGVAGGGNPPGVNAKEFAEVVAAAVLAGELSLVAALAAGH
LGKAHRLLGR

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=411, Percent_Identity=44.7688564476886, Blast_Score=333, Evalue=2e-91,
Organism=Homo sapiens, GI196049380, Length=295, Percent_Identity=48.8135593220339, Blast_Score=275, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI25144592, Length=407, Percent_Identity=45.2088452088452, Blast_Score=318, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6323565, Length=412, Percent_Identity=44.1747572815534, Blast_Score=317, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6323483, Length=407, Percent_Identity=43.980343980344, Blast_Score=313, Evalue=3e-86,
Organism=Drosophila melanogaster, GI281362379, Length=412, Percent_Identity=44.1747572815534, Blast_Score=281, Evalue=6e-76,
Organism=Drosophila melanogaster, GI45553469, Length=412, Percent_Identity=44.1747572815534, Blast_Score=281, Evalue=6e-76,
Organism=Drosophila melanogaster, GI24649399, Length=412, Percent_Identity=44.1747572815534, Blast_Score=281, Evalue=6e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 44038; Mature: 44038

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS00318 HMG_COA_REDUCTASE_2 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEKKIEELVSKVVKGEIKFHEVEKYTDGDSEVATEVRRRALERLTGAKLEHLGKYTIDA
CCHHHHHHHHHHHHHCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCEEEEC
NRAMDKNIENMIGAVQVPVGIAGPLLVHGEYAEGEYYVPLATTEGALVASVNRGCSTITD
CHHHHHHHHHHHHHEECCCCCCCCEEEECEECCCCEEEEEECCCCCEEEECCCCCCCCCC
SGGAHVRIVRDGMTRAPVFKLPSARKALEFCEWVRKHFDDIKEVAESTTRHGELLDIQEF
CCCCEEEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
VVGRHVFLRFEFDTKDAMGMNMVTIATEEAVNWIEEKYPDAKCVSASGNVCVDKKPSWLN
HCCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEECCCCEEECCCCHHHH
NVLGRGRTVVAEVEVPRDIVEEKLKTTPEAMAEVNYRKNLVGSAAAGNIGFNAHHANIVA
HHHCCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCEEE
AIFIATGQDEAHAVDGSTGYTTMEVTEDGDLYASVTIPSLNVGTVGGGTGVETQRECLEI
EEEEECCCCCCEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
LGVAGGGNPPGVNAKEFAEVVAAAVLAGELSLVAALAAGHLGKAHRLLGR
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
>Mature Secondary Structure
MDEKKIEELVSKVVKGEIKFHEVEKYTDGDSEVATEVRRRALERLTGAKLEHLGKYTIDA
CCHHHHHHHHHHHHHCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCEEEEC
NRAMDKNIENMIGAVQVPVGIAGPLLVHGEYAEGEYYVPLATTEGALVASVNRGCSTITD
CHHHHHHHHHHHHHEECCCCCCCCEEEECEECCCCEEEEEECCCCCEEEECCCCCCCCCC
SGGAHVRIVRDGMTRAPVFKLPSARKALEFCEWVRKHFDDIKEVAESTTRHGELLDIQEF
CCCCEEEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHH
VVGRHVFLRFEFDTKDAMGMNMVTIATEEAVNWIEEKYPDAKCVSASGNVCVDKKPSWLN
HCCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHHHCCCCEEEECCCCEEECCCCHHHH
NVLGRGRTVVAEVEVPRDIVEEKLKTTPEAMAEVNYRKNLVGSAAAGNIGFNAHHANIVA
HHHCCCCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCEEE
AIFIATGQDEAHAVDGSTGYTTMEVTEDGDLYASVTIPSLNVGTVGGGTGVETQRECLEI
EEEEECCCCCCEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
LGVAGGGNPPGVNAKEFAEVVAAAVLAGELSLVAALAAGHLGKAHRLLGR
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]