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The map label for this gene is HdrA_1 [H]

Identifier: 20093689

GI number: 20093689

Start: 238965

End: 240974

Strand: Reverse

Name: HdrA_1 [H]

Synonym: MK0249

Alternate gene names: 20093689

Gene position: 240974-238965 (Counterclockwise)

Preceding gene: 20093690

Following gene: 20093688

Centisome position: 14.22

GC content: 62.64

Gene sequence:

>2010_bases
GTGGGCGACAAGGACGACGTCAGGATAGGCGTGTTCGTGTGCCACTGCGGTGTGAACATCAAGGCGTCCGTCGACGTCGA
AGAGGTCGTTGAGTACGCCAAGAAACTGCCCGGCGTCGTGTACGCGACGGATTACCCGTTCTTCTGCGCCGATCCGGGTC
AGGAGATCATCCAGGAAGCCATCAAGGAACACGACCTCGACCGAGTAGTCGTGGCAGCTTGTACGCCGAAGATCCACGAG
AACACGTTCAGGAACTGCGTCAAGGAGGCCGGATTGTCGCCATACTACATGGAGATGGTAAACATCCGAGAGCACTGCTC
GTTCGTGCACATGCAGGAGCCGGAGAAGGCCACGGAGAAGGCCAAGGACCTAATTCGGGCGGCAGTGGAGCGTGCTAAGC
GGCTCGAGGACGTGCCGACGAAGGAGGTGGAGGTCGAGAACAGCGTTCTCATCATCGGTGGTGGTATCGCCGGGATCCAG
GCGGCCCTGGACCTCGCGGATCAGGGCTTCAAGGTGTACCTGGTGGAGAAGGAGCCGACGATCGGAGGCAACATGGCACG
GCTGGCGAAGACGTTCCCGACCGACGACTGCGCCATGTGAATCCTGGCTCCGAAGATGGTGCAGGTGGGTAACCACCCGA
ACATCGAGATGATCACTTACGCCGAGGTCAAGGACGTGGACGGCTACATCGGTAACTTCGAGGTAACGATCGAGAAGAAG
CCGCGGTACGTGGACGAGGACGCGTGCACGGGCTGCGGAGTCTGCGCCGAGGTCTGTCCGATCGAGGTGCCCAACGAGTT
CGATCTGGGAATCGGCACCAGGAAGGCGATCTACGTGCCGTTCCCGCAGGCGATGCCGTTGGTGTACACGATCGACATGG
AGCACTGCATCCAGTGCGGCCTGTGCGAGGAGGCGTGCCCACAGGACCCGCCGGCGATAGACTTCGACCAGGAGCCGGAG
GAAATCAGGCTGAAGGTCGGCACGATCATCGTGGCGACCGGTTACGAGGAGTTCGACGCGAGCAAGCTCGAGGAGTACGG
CTACGGTAAGTACGACAACGTGATCACCACGCTGGAGCTGGAGCGGATGATCAACCCCGCCGGTCCGACGGAGGGTCACG
TGATCCGACCGAGCGACGGCAAGGAGCCGCACAGGATCGTGTTCATCCACTGTGTCGGATCGCGGTGCCCGGGCAAGGAG
GAGAAGGGTGAGGCGTACTGCAGCAGGATCTGCTGTATGTTCATCCTCAAGAACGCGCAGCTGATCAAGCAGCACGAGCC
GGACGCGGAGGTCTACTGCTGCTACATGGACGTGCGGGCGTTCGGTAAGGGTTACGAGGAGTACTACGAGCGTGCCCAGA
AGCAGTTCGGTGTGCGCTTCATCCGAGGTAGACCGGCCGAGATCGTCGAAGACCCGGAGACCAAGAACCTCATCGTGCGC
GTCGAGGACACGCTCACCGGCGAGCCGATGGAGATCGAGGCGGACCTCGTGGTGCTGGGCTGCGGTCTAGTGGCGCCGGA
GGAGACGTACTCCAAGCTCGCCGACATCCTGGGCATCGACAGGTCGCCGGACGGGTTCTTCAAGGAGCTACACCCGAAGC
TAGAGCCGGTCAGCACGAAGGTCCGCGGCGTCCAGATCGCCGGTGTAGCTCAGGGTCCGAAGGACATCCCGGACACTGTG
GCCCAGGCGAAGGGTGCCGCCAGCGAGGCCAGCATCCCGATGTCCCAGGGTAAGGTCGAGATCGAGCTGATCACCGCGAC
CGTGGACGAGGACGTCTGCGGCGGCTGCGGAGCGTGCGCGCAGGTGTGTCCGTTCGACGCCATCGAAATGGTGGAGAAGG
ACGGTAAGAGGGTCGCCGAGGTGCAGGACGTGGCCTGCCAGGGCTGCGGACAGTGCGCCGCCGCGTGCCCGAGCGGTGCA
ATGCAGCTACGCTACTACCGGGACGAGCAGCTGATGCCACAGATCGAGGCGCTGCTGGCGGAAGCACTCGAGGAGGAAGA
GGAGGAGTAA

Upstream 100 bases:

>100_bases
CCCTCCAATCTCCCCGATTTCCGCCTCCAATATCCCAACGCTTATAACTCGGACATCGTGTGACCGGGCGTGGCCACAAC
GGCATAGGGGGTGAGAACCA

Downstream 100 bases:

>100_bases
CGGAAGGCCTCAAGATCACGAGTCCCCGATGACCCCGCCCCCGAAGGGCGAAAGCCCAGGGGGTGGGGGATGGGGCCCAC
GCCCGGCGCGAATCGTTATG

Product: heterodisulfide reductase, subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 669; Mature: 668

Protein sequence:

>669_residues
MGDKDDVRIGVFVCHCGVNIKASVDVEEVVEYAKKLPGVVYATDYPFFCADPGQEIIQEAIKEHDLDRVVVAACTPKIHE
NTFRNCVKEAGLSPYYMEMVNIREHCSFVHMQEPEKATEKAKDLIRAAVERAKRLEDVPTKEVEVENSVLIIGGGIAGIQ
AALDLADQGFKVYLVEKEPTIGGNMARLAKTFPTDDCAMUILAPKMVQVGNHPNIEMITYAEVKDVDGYIGNFEVTIEKK
PRYVDEDACTGCGVCAEVCPIEVPNEFDLGIGTRKAIYVPFPQAMPLVYTIDMEHCIQCGLCEEACPQDPPAIDFDQEPE
EIRLKVGTIIVATGYEEFDASKLEEYGYGKYDNVITTLELERMINPAGPTEGHVIRPSDGKEPHRIVFIHCVGSRCPGKE
EKGEAYCSRICCMFILKNAQLIKQHEPDAEVYCCYMDVRAFGKGYEEYYERAQKQFGVRFIRGRPAEIVEDPETKNLIVR
VEDTLTGEPMEIEADLVVLGCGLVAPEETYSKLADILGIDRSPDGFFKELHPKLEPVSTKVRGVQIAGVAQGPKDIPDTV
AQAKGAASEASIPMSQGKVEIELITATVDEDVCGGCGACAQVCPFDAIEMVEKDGKRVAEVQDVACQGCGQCAAACPSGA
MQLRYYRDEQLMPQIEALLAEALEEEEEE

Sequences:

>Translated_669_residues
MGDKDDVRIGVFVCHCGVNIKASVDVEEVVEYAKKLPGVVYATDYPFFCADPGQEIIQEAIKEHDLDRVVVAACTPKIHE
NTFRNCVKEAGLSPYYMEMVNIREHCSFVHMQEPEKATEKAKDLIRAAVERAKRLEDVPTKEVEVENSVLIIGGGIAGIQ
AALDLADQGFKVYLVEKEPTIGGNMARLAKTFPTDDCAM*ILAPKMVQVGNHPNIEMITYAEVKDVDGYIGNFEVTIEKK
PRYVDEDACTGCGVCAEVCPIEVPNEFDLGIGTRKAIYVPFPQAMPLVYTIDMEHCIQCGLCEEACPQDPPAIDFDQEPE
EIRLKVGTIIVATGYEEFDASKLEEYGYGKYDNVITTLELERMINPAGPTEGHVIRPSDGKEPHRIVFIHCVGSRCPGKE
EKGEAYCSRICCMFILKNAQLIKQHEPDAEVYCCYMDVRAFGKGYEEYYERAQKQFGVRFIRGRPAEIVEDPETKNLIVR
VEDTLTGEPMEIEADLVVLGCGLVAPEETYSKLADILGIDRSPDGFFKELHPKLEPVSTKVRGVQIAGVAQGPKDIPDTV
AQAKGAASEASIPMSQGKVEIELITATVDEDVCGGCGACAQVCPFDAIEMVEKDGKRVAEVQDVACQGCGQCAAACPSGA
MQLRYYRDEQLMPQIEALLAEALEEEEEE
>Mature_668_residues
GDKDDVRIGVFVCHCGVNIKASVDVEEVVEYAKKLPGVVYATDYPFFCADPGQEIIQEAIKEHDLDRVVVAACTPKIHEN
TFRNCVKEAGLSPYYMEMVNIREHCSFVHMQEPEKATEKAKDLIRAAVERAKRLEDVPTKEVEVENSVLIIGGGIAGIQA
ALDLADQGFKVYLVEKEPTIGGNMARLAKTFPTDDCAM*ILAPKMVQVGNHPNIEMITYAEVKDVDGYIGNFEVTIEKKP
RYVDEDACTGCGVCAEVCPIEVPNEFDLGIGTRKAIYVPFPQAMPLVYTIDMEHCIQCGLCEEACPQDPPAIDFDQEPEE
IRLKVGTIIVATGYEEFDASKLEEYGYGKYDNVITTLELERMINPAGPTEGHVIRPSDGKEPHRIVFIHCVGSRCPGKEE
KGEAYCSRICCMFILKNAQLIKQHEPDAEVYCCYMDVRAFGKGYEEYYERAQKQFGVRFIRGRPAEIVEDPETKNLIVRV
EDTLTGEPMEIEADLVVLGCGLVAPEETYSKLADILGIDRSPDGFFKELHPKLEPVSTKVRGVQIAGVAQGPKDIPDTVA
QAKGAASEASIPMSQGKVEIELITATVDEDVCGGCGACAQVCPFDAIEMVEKDGKRVAEVQDVACQGCGQCAAACPSGAM
QLRYYRDEQLMPQIEALLAEALEEEEEE

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 73575; Mature: 73444

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDKDDVRIGVFVCHCGVNIKASVDVEEVVEYAKKLPGVVYATDYPFFCADPGQEIIQEA
CCCCCCEEEEEEEEECCCCEEECCCHHHHHHHHHHCCCEEEECCCCEEECCCHHHHHHHH
IKEHDLDRVVVAACTPKIHENTFRNCVKEAGLSPYYMEMVNIREHCSFVHMQEPEKATEK
HHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEECCCCHHHHHH
AKDLIRAAVERAKRLEDVPTKEVEVENSVLIIGGGIAGIQAALDLADQGFKVYLVEKEPT
HHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCHHHHHHHHHHCCCCEEEEEEECCCC
IGGNMARLAKTFPTDDCAMILAPKMVQVGNHPNIEMITYAEVKDVDGYIGNFEVTIEKKP
CCCCHHHHHHHCCCCCCHHHHCCHHHCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCC
RYVDEDACTGCGVCAEVCPIEVPNEFDLGIGTRKAIYVPFPQAMPLVYTIDMEHCIQCGL
CCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECHHHHHHCCC
CEEACPQDPPAIDFDQEPEEIRLKVGTIIVATGYEEFDASKLEEYGYGKYDNVITTLELE
CHHHCCCCCCCCCCCCCHHHEEEEEEEEEEEECCCHHCHHHHHHCCCCCCCCEEEEEEHH
RMINPAGPTEGHVIRPSDGKEPHRIVFIHCVGSRCPGKEEKGEAYCSRICCMFILKNAQL
HHCCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHH
IKQHEPDAEVYCCYMDVRAFGKGYEEYYERAQKQFGVRFIRGRPAEIVEDPETKNLIVRV
HHCCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHCEEEECCCCHHHCCCCCCCEEEEEE
EDTLTGEPMEIEADLVVLGCGLVAPEETYSKLADILGIDRSPDGFFKELHPKLEPVSTKV
ECCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCHHC
RGVQIAGVAQGPKDIPDTVAQAKGAASEASIPMSQGKVEIELITATVDEDVCGGCGACAQ
CCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCHHCCCCCHHHH
VCPFDAIEMVEKDGKRVAEVQDVACQGCGQCAAACPSGAMQLRYYRDEQLMPQIEALLAE
HCCCHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHH
ALEEEEEE
HHHHHCCC
>Mature Secondary Structure 
GDKDDVRIGVFVCHCGVNIKASVDVEEVVEYAKKLPGVVYATDYPFFCADPGQEIIQEA
CCCCCEEEEEEEEECCCCEEECCCHHHHHHHHHHCCCEEEECCCCEEECCCHHHHHHHH
IKEHDLDRVVVAACTPKIHENTFRNCVKEAGLSPYYMEMVNIREHCSFVHMQEPEKATEK
HHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEECCCCHHHHHH
AKDLIRAAVERAKRLEDVPTKEVEVENSVLIIGGGIAGIQAALDLADQGFKVYLVEKEPT
HHHHHHHHHHHHHHHHCCCCCCEEECCCEEEEECCHHHHHHHHHHCCCCEEEEEEECCCC
IGGNMARLAKTFPTDDCAMILAPKMVQVGNHPNIEMITYAEVKDVDGYIGNFEVTIEKKP
CCCCHHHHHHHCCCCCCHHHHCCHHHCCCCCCCEEEEEEEEEECCCCCCCCEEEEEECCC
RYVDEDACTGCGVCAEVCPIEVPNEFDLGIGTRKAIYVPFPQAMPLVYTIDMEHCIQCGL
CCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECHHHHHHCCC
CEEACPQDPPAIDFDQEPEEIRLKVGTIIVATGYEEFDASKLEEYGYGKYDNVITTLELE
CHHHCCCCCCCCCCCCCHHHEEEEEEEEEEEECCCHHCHHHHHHCCCCCCCCEEEEEEHH
RMINPAGPTEGHVIRPSDGKEPHRIVFIHCVGSRCPGKEEKGEAYCSRICCMFILKNAQL
HHCCCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCHH
IKQHEPDAEVYCCYMDVRAFGKGYEEYYERAQKQFGVRFIRGRPAEIVEDPETKNLIVRV
HHCCCCCCCEEEEEEEHHHHCCCHHHHHHHHHHHHCEEEECCCCHHHCCCCCCCEEEEEE
EDTLTGEPMEIEADLVVLGCGLVAPEETYSKLADILGIDRSPDGFFKELHPKLEPVSTKV
ECCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCHHC
RGVQIAGVAQGPKDIPDTVAQAKGAASEASIPMSQGKVEIELITATVDEDVCGGCGACAQ
CCEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEECCCHHCCCCCHHHH
VCPFDAIEMVEKDGKRVAEVQDVACQGCGQCAAACPSGAMQLRYYRDEQLMPQIEALLAE
HCCCHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHH
ALEEEEEE
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]