Click here to switch to the map view.

The map label for this gene is TRM1_2 [H]

Identifier: 20093629

GI number: 20093629

Start: 181481

End: 182362

Strand: Direct

Name: TRM1_2 [H]

Synonym: MK0189

Alternate gene names: 20093629

Gene position: 181481-182362 (Clockwise)

Preceding gene: 20093628

Following gene: 20093630

Centisome position: 10.71

GC content: 59.98

Gene sequence:

>882_bases
GTGAGGACCGACGGAGGGGTGAAGAGGGTCGCAGGCGCTGAGTTCGTCCTTTATAAGGAAGGGGGATCGGAGTTTTACGT
GCCGGACCCGGAACGTTACTCTCAGGATGGCCTTCCCACCCGTGATGCACCGGTAGCGTTCGCACCGAACGCCGCCGTGA
ACAGGTCCGTACTCGTCCTGTTCCACCGAGTACGTCCTGTGAGGAGGTTCGGAGACGTGTTCTGTGGTGTCGGCGCCAGG
GCCATCCGCCTTCATATTGAAGCCGAGGTGGAGTGGTCCGTACTATCCGATGTGAACCCCATTGCGTGTCAAATCGCAAT
GATCAACGTCCGGAGACTCGGACTACCATCGGAGGTTAGGTGTATGGATGCCGTCGCCGCACTTTCTACCTTCGACTTCG
ATGCCGTCGACTTGGACGTGTTCGGGACCCCGATACCGTTCGCCCAAGCCGCGTTTCGGTGCGTACGCGACGGTTACGTG
CACGTCACCGCCACAGACCTCGAATCGCTGTATACCCCGGCGGCCCGCCGCAAATATCTCCTCGAGGGACCGCTCCCTCG
GCGGGACACGGATCTAGAGGTCCGGGCTGTGGTAGGAGCCTTAGCGCGCTTAGCGGCTTCAGTTGACATCGGGATCGAGC
CGATGTACTGCCTCGTCGAGCCCGGGGTTAGGATTCGGGTGGGATTGGAGTGCCGTAGGGGCCGGTCCAGAGCGAACGAA
ACTTTGGATATGCTAGACTACGTCGACGGGGTAGGACCGGTCTGGGGAGGTGATCTTCACGACGAAGACGTCGTCGAGGA
GATGTTGGAAGAGCTCGACTGTACGGGTTGGAGCGAAAAACACGCCCGGGACGTCCGGAAGTCCCTAGAGGTAACATTTT
GA

Upstream 100 bases:

>100_bases
GAGCTGGCGTTCGCCGACGAGTGGTTAGGAGTGGTACCCGGAGAACTGTCATGGTCGTACCCTTGCCACTGCCTCGTGGA
GCCTAGCGGGGATGATGAGG

Downstream 100 bases:

>100_bases
GTATTCGAGGCGGATAGTCGGCGGGTGTCTCGAGTTGAACGAGGTGATCAGGGAGGTGGAGAAAGTCCGAGAAGCTCGAA
TTGCACGGACGCTGGCCACC

Product: N2,N2-dimethylguanosine tRNA methyltransferase

Products: NA

Alternate protein names: tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MRTDGGVKRVAGAEFVLYKEGGSEFYVPDPERYSQDGLPTRDAPVAFAPNAAVNRSVLVLFHRVRPVRRFGDVFCGVGAR
AIRLHIEAEVEWSVLSDVNPIACQIAMINVRRLGLPSEVRCMDAVAALSTFDFDAVDLDVFGTPIPFAQAAFRCVRDGYV
HVTATDLESLYTPAARRKYLLEGPLPRRDTDLEVRAVVGALARLAASVDIGIEPMYCLVEPGVRIRVGLECRRGRSRANE
TLDMLDYVDGVGPVWGGDLHDEDVVEEMLEELDCTGWSEKHARDVRKSLEVTF

Sequences:

>Translated_293_residues
MRTDGGVKRVAGAEFVLYKEGGSEFYVPDPERYSQDGLPTRDAPVAFAPNAAVNRSVLVLFHRVRPVRRFGDVFCGVGAR
AIRLHIEAEVEWSVLSDVNPIACQIAMINVRRLGLPSEVRCMDAVAALSTFDFDAVDLDVFGTPIPFAQAAFRCVRDGYV
HVTATDLESLYTPAARRKYLLEGPLPRRDTDLEVRAVVGALARLAASVDIGIEPMYCLVEPGVRIRVGLECRRGRSRANE
TLDMLDYVDGVGPVWGGDLHDEDVVEEMLEELDCTGWSEKHARDVRKSLEVTF
>Mature_293_residues
MRTDGGVKRVAGAEFVLYKEGGSEFYVPDPERYSQDGLPTRDAPVAFAPNAAVNRSVLVLFHRVRPVRRFGDVFCGVGAR
AIRLHIEAEVEWSVLSDVNPIACQIAMINVRRLGLPSEVRCMDAVAALSTFDFDAVDLDVFGTPIPFAQAAFRCVRDGYV
HVTATDLESLYTPAARRKYLLEGPLPRRDTDLEVRAVVGALARLAASVDIGIEPMYCLVEPGVRIRVGLECRRGRSRANE
TLDMLDYVDGVGPVWGGDLHDEDVVEEMLEELDCTGWSEKHARDVRKSLEVTF

Specific function: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups [H]

COG id: COG1867

COG function: function code J; N2,N2-dimethylguanosine tRNA methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TRM1 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022923
- InterPro:   IPR002905 [H]

Pfam domain/function: PF02005 TRM [H]

EC number: =2.1.1.32 [H]

Molecular weight: Translated: 32440; Mature: 32440

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTDGGVKRVAGAEFVLYKEGGSEFYVPDPERYSQDGLPTRDAPVAFAPNAAVNRSVLVL
CCCCCCCHHHCCCEEEEEECCCCEEECCCCHHHCCCCCCCCCCCEEECCCCCCCHHHHHH
FHRVRPVRRFGDVFCGVGARAIRLHIEAEVEWSVLSDVNPIACQIAMINVRRLGLPSEVR
HHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEHHHCCCCCCEEEEEEEEHHHCCCCHHHH
CMDAVAALSTFDFDAVDLDVFGTPIPFAQAAFRCVRDGYVHVTATDLESLYTPAARRKYL
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEEECCHHHHHCCHHHHHEE
LEGPLPRRDTDLEVRAVVGALARLAASVDIGIEPMYCLVEPGVRIRVGLECRRGRSRANE
ECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCHHCCHHHHHH
TLDMLDYVDGVGPVWGGDLHDEDVVEEMLEELDCTGWSEKHARDVRKSLEVTF
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRTDGGVKRVAGAEFVLYKEGGSEFYVPDPERYSQDGLPTRDAPVAFAPNAAVNRSVLVL
CCCCCCCHHHCCCEEEEEECCCCEEECCCCHHHCCCCCCCCCCCEEECCCCCCCHHHHHH
FHRVRPVRRFGDVFCGVGARAIRLHIEAEVEWSVLSDVNPIACQIAMINVRRLGLPSEVR
HHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEHHHCCCCCCEEEEEEEEHHHCCCCHHHH
CMDAVAALSTFDFDAVDLDVFGTPIPFAQAAFRCVRDGYVHVTATDLESLYTPAARRKYL
HHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEEECCHHHHHCCHHHHHEE
LEGPLPRRDTDLEVRAVVGALARLAASVDIGIEPMYCLVEPGVRIRVGLECRRGRSRANE
ECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCHHCCHHHHHH
TLDMLDYVDGVGPVWGGDLHDEDVVEEMLEELDCTGWSEKHARDVRKSLEVTF
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA