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The map label for this gene is GRS1

Identifier: 20093592

GI number: 20093592

Start: 150700

End: 152415

Strand: Reverse

Name: GRS1

Synonym: MK0152

Alternate gene names: 20093592

Gene position: 152415-150700 (Counterclockwise)

Preceding gene: 20093593

Following gene: 20093590

Centisome position: 8.99

GC content: 60.78

Gene sequence:

>1716_bases
TTGACCGAGGATGTCTACGAACGTATCATGGAGATCGCACGCCGACGCGGGTTCATACTGCCTGCGTTCCGCATCTACGG
GGGAGCCCGGGGCTTCTACGACTACGGTCCCCTGGGAGCACTCCTGAAGCGGAAGATCGAGGAGAAGTGGCGCGAGTACT
ACGTCCATAAGGAAGGTTTCATGGAAATCGAAGCTCCCAACCTGCTCATAGGCGAGGTGTTCGAGGCTTCCGGTCACGTC
GAGCACTTCATAGACCCCATGACTCACTGCAGCGAGTGTGGCGAGTTCTTCCGTGCCGATCACTTGGCCGAGGAGGAGCT
GGGAGTCGACGCCGAAGGAATGTCGCCCGAGGAGTTGGAGGACTTGATCCGTGAGCACGACCTCCGATGTCCCGAGTGCG
GTGGGGAGCTCGCTGAGGTTACTGAGTTCAACCTAATGTTCGACACGAACATCGGTCCCAAGGAGGGTCGAACGGGGTAT
TTGCGTCCGGAGACCGCCCAGGCTATCTTCATCCAGTTCAAGGACCTTTACCGATGGGCGCGCCAGAAGCTTCCCTTCGG
CGTCGTGCAGATAGGTCGCGCGTACCGAAACGAGATCAGCCCGCGACAGGGTGTGATCCGTCTCCGCGAGTTCACTCAGG
CCGAGGCTGAAGTCTTCTTCGACCCCGAGGAGAAGGAGTACCCAGGGTTCGAGCGCTACGCGGACGAAGTCCTCAAGTTC
TACCCCATAGAGGAACAGCGGAAGGAGAACGGCGAGATGCTGGAGATGTCCGTTCGTGAGGCAGTCGAGGAGGGCATGGT
CAGTCAACCCATCGGCTACTTCCTCGGTCTCACCAAGCGTATGCTCAACGAGATGGGGGTCCCGAACGAAGCCATCCGAT
CGCGTCAGCACCTTCCCGAAGAGCGGGCACACTACGCCAGCGACTGTTGGGACGTGGAGGTGAAGCTGGAGCGGTTCGGG
TGGGTTGAAGTCGTCGGGATCGCGGACAGGACGGATTACGACCTTAAGAAGCACTCGGAACACAGCGGAGAGGACCTACG
GGCCTTCCGCGAGCTGGAGGAGCCCAAGATAGTCTACCGCCCGGAACCCGTGATGAAGGAGCTCGGACCGAGGTTCAAGT
CGGACGCCCCGAAGATCGCGGAGGCGCTACGTCGGATCACCGCGGAGAGCGAGGACGAGCTGAAGGGAGGTCTCACCGTC
GAAGTCGACGGCAAGGAGGTAGAGGTGCCACCGGAGTGCTACGAAATCGTCAAGGAGAAGGTCACGGGCGAGCGGTTCTA
CCCGCACGTGATCGAACCTTCCTACGGTATCGATCGTATCCTGTATTGCGTCCTCGAGCACAACTTCGACCCGGAGGAGG
GCGTGTTCAGGTTCCCGGCCTGGCTGGCGCCGATCGAGGTGGGAGTGTTCCCACTGCTGAAGCGCAGCGACATGGTCGAG
TACGCCCGACGCGTGGCCCGCATGCTACGTGAGGAAGGATTTACGGTCGAGTACGACGACTCCGGTTCGATAGGCAGACG
ATACGCTCGCGCCGACGAGATCGGTGTTCCGTACTGCGTCACCGTAGACCACGAAACTCTCGAGGACGACACGGTGACGA
TCAGGGACAGGGACACGACCGAGCAGGTCCGCGTGGAGGTCGACGAGCTAGCGGACGTACTACGTGGGCTCATCGACGGT
GACCTCGAGTTCGAGGAGGCCGGTGACCCCGTTTGA

Upstream 100 bases:

>100_bases
AAGGAGAGCGTGAAGACGATCCTCGTGGCCGAGGAGCACGTACTCAAGCTGTACGGGGTAGCGGAAGCAGTCTACGAGAT
ATGAGGTAGGGGGCACGGAA

Downstream 100 bases:

>100_bases
CCATCTCGACCCACTCCGGTACCGACACCTCCCCATCGGGTTCGTCGTAACCGGGTAGGTACGGCTTCATATCGACCACC
GGCGATCCGGCTCGGGCGTC

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS

Number of amino acids: Translated: 571; Mature: 570

Protein sequence:

>571_residues
MTEDVYERIMEIARRRGFILPAFRIYGGARGFYDYGPLGALLKRKIEEKWREYYVHKEGFMEIEAPNLLIGEVFEASGHV
EHFIDPMTHCSECGEFFRADHLAEEELGVDAEGMSPEELEDLIREHDLRCPECGGELAEVTEFNLMFDTNIGPKEGRTGY
LRPETAQAIFIQFKDLYRWARQKLPFGVVQIGRAYRNEISPRQGVIRLREFTQAEAEVFFDPEEKEYPGFERYADEVLKF
YPIEEQRKENGEMLEMSVREAVEEGMVSQPIGYFLGLTKRMLNEMGVPNEAIRSRQHLPEERAHYASDCWDVEVKLERFG
WVEVVGIADRTDYDLKKHSEHSGEDLRAFRELEEPKIVYRPEPVMKELGPRFKSDAPKIAEALRRITAESEDELKGGLTV
EVDGKEVEVPPECYEIVKEKVTGERFYPHVIEPSYGIDRILYCVLEHNFDPEEGVFRFPAWLAPIEVGVFPLLKRSDMVE
YARRVARMLREEGFTVEYDDSGSIGRRYARADEIGVPYCVTVDHETLEDDTVTIRDRDTTEQVRVEVDELADVLRGLIDG
DLEFEEAGDPV

Sequences:

>Translated_571_residues
MTEDVYERIMEIARRRGFILPAFRIYGGARGFYDYGPLGALLKRKIEEKWREYYVHKEGFMEIEAPNLLIGEVFEASGHV
EHFIDPMTHCSECGEFFRADHLAEEELGVDAEGMSPEELEDLIREHDLRCPECGGELAEVTEFNLMFDTNIGPKEGRTGY
LRPETAQAIFIQFKDLYRWARQKLPFGVVQIGRAYRNEISPRQGVIRLREFTQAEAEVFFDPEEKEYPGFERYADEVLKF
YPIEEQRKENGEMLEMSVREAVEEGMVSQPIGYFLGLTKRMLNEMGVPNEAIRSRQHLPEERAHYASDCWDVEVKLERFG
WVEVVGIADRTDYDLKKHSEHSGEDLRAFRELEEPKIVYRPEPVMKELGPRFKSDAPKIAEALRRITAESEDELKGGLTV
EVDGKEVEVPPECYEIVKEKVTGERFYPHVIEPSYGIDRILYCVLEHNFDPEEGVFRFPAWLAPIEVGVFPLLKRSDMVE
YARRVARMLREEGFTVEYDDSGSIGRRYARADEIGVPYCVTVDHETLEDDTVTIRDRDTTEQVRVEVDELADVLRGLIDG
DLEFEEAGDPV
>Mature_570_residues
TEDVYERIMEIARRRGFILPAFRIYGGARGFYDYGPLGALLKRKIEEKWREYYVHKEGFMEIEAPNLLIGEVFEASGHVE
HFIDPMTHCSECGEFFRADHLAEEELGVDAEGMSPEELEDLIREHDLRCPECGGELAEVTEFNLMFDTNIGPKEGRTGYL
RPETAQAIFIQFKDLYRWARQKLPFGVVQIGRAYRNEISPRQGVIRLREFTQAEAEVFFDPEEKEYPGFERYADEVLKFY
PIEEQRKENGEMLEMSVREAVEEGMVSQPIGYFLGLTKRMLNEMGVPNEAIRSRQHLPEERAHYASDCWDVEVKLERFGW
VEVVGIADRTDYDLKKHSEHSGEDLRAFRELEEPKIVYRPEPVMKELGPRFKSDAPKIAEALRRITAESEDELKGGLTVE
VDGKEVEVPPECYEIVKEKVTGERFYPHVIEPSYGIDRILYCVLEHNFDPEEGVFRFPAWLAPIEVGVFPLLKRSDMVEY
ARRVARMLREEGFTVEYDDSGSIGRRYARADEIGVPYCVTVDHETLEDDTVTIRDRDTTEQVRVEVDELADVLRGLIDGD
LEFEEAGDPV

Specific function: Catalyzes the attachment of glycine to tRNA(Gly)

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI116805340, Length=606, Percent_Identity=38.6138613861386, Blast_Score=410, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17554996, Length=599, Percent_Identity=38.5642737896494, Blast_Score=400, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI32564541, Length=599, Percent_Identity=38.5642737896494, Blast_Score=400, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6319597, Length=633, Percent_Identity=37.7567140600316, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6325338, Length=605, Percent_Identity=36.0330578512397, Blast_Score=379, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24664462, Length=577, Percent_Identity=39.6880415944541, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI21357965, Length=577, Percent_Identity=39.6880415944541, Blast_Score=405, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYG_METKA (Q8TYY9)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613439.1
- ProteinModelPortal:   Q8TYY9
- SMR:   Q8TYY9
- GeneID:   1477455
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0152
- NMPDR:   fig|190192.1.peg.152
- HOGENOM:   HBG319978
- OMA:   AYRNEIS
- ProtClustDB:   PRK04173
- BioCyc:   MKAN190192:MK0152-MONOMER
- BRENDA:   6.1.1.14
- GO:   GO:0005737
- HAMAP:   MF_00253_A
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022960
- InterPro:   IPR002315
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR10745
- PRINTS:   PR01043
- TIGRFAMs:   TIGR00389

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.14

Molecular weight: Translated: 66080; Mature: 65949

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 98-98 BINDING 164-164

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDVYERIMEIARRRGFILPAFRIYGGARGFYDYGPLGALLKRKIEEKWREYYVHKEGF
CCHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
MEIEAPNLLIGEVFEASGHVEHFIDPMTHCSECGEFFRADHLAEEELGVDAEGMSPEELE
EEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHH
DLIREHDLRCPECGGELAEVTEFNLMFDTNIGPKEGRTGYLRPETAQAIFIQFKDLYRWA
HHHHHCCCCCCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RQKLPFGVVQIGRAYRNEISPRQGVIRLREFTQAEAEVFFDPEEKEYPGFERYADEVLKF
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHH
YPIEEQRKENGEMLEMSVREAVEEGMVSQPIGYFLGLTKRMLNEMGVPNEAIRSRQHLPE
CCCHHHHHCCCHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCH
ERAHYASDCWDVEVKLERFGWVEVVGIADRTDYDLKKHSEHSGEDLRAFRELEEPKIVYR
HHHHHHCCCEEEEEEHHHCCCEEEEEECCCCCCCHHHCCCCCCHHHHHHHHCCCCCEEEC
PEPVMKELGPRFKSDAPKIAEALRRITAESEDELKGGLTVEVDGKEVEVPPECYEIVKEK
CCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCEEEEECCCEECCCHHHHHHHHHH
VTGERFYPHVIEPSYGIDRILYCVLEHNFDPEEGVFRFPAWLAPIEVGVFPLLKRSDMVE
HCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHH
YARRVARMLREEGFTVEYDDSGSIGRRYARADEIGVPYCVTVDHETLEDDTVTIRDRDTT
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCH
EQVRVEVDELADVLRGLIDGDLEFEEAGDPV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TEDVYERIMEIARRRGFILPAFRIYGGARGFYDYGPLGALLKRKIEEKWREYYVHKEGF
CHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
MEIEAPNLLIGEVFEASGHVEHFIDPMTHCSECGEFFRADHLAEEELGVDAEGMSPEELE
EEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCHHHHH
DLIREHDLRCPECGGELAEVTEFNLMFDTNIGPKEGRTGYLRPETAQAIFIQFKDLYRWA
HHHHHCCCCCCCCCCCHHHHHEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
RQKLPFGVVQIGRAYRNEISPRQGVIRLREFTQAEAEVFFDPEEKEYPGFERYADEVLKF
HHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHH
YPIEEQRKENGEMLEMSVREAVEEGMVSQPIGYFLGLTKRMLNEMGVPNEAIRSRQHLPE
CCCHHHHHCCCHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCH
ERAHYASDCWDVEVKLERFGWVEVVGIADRTDYDLKKHSEHSGEDLRAFRELEEPKIVYR
HHHHHHCCCEEEEEEHHHCCCEEEEEECCCCCCCHHHCCCCCCHHHHHHHHCCCCCEEEC
PEPVMKELGPRFKSDAPKIAEALRRITAESEDELKGGLTVEVDGKEVEVPPECYEIVKEK
CCHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHCCCEEEEECCCEECCCHHHHHHHHHH
VTGERFYPHVIEPSYGIDRILYCVLEHNFDPEEGVFRFPAWLAPIEVGVFPLLKRSDMVE
HCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHH
YARRVARMLREEGFTVEYDDSGSIGRRYARADEIGVPYCVTVDHETLEDDTVTIRDRDTT
HHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCCH
EQVRVEVDELADVLRGLIDGDLEFEEAGDPV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014