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The map label for this gene is purO

Identifier: 20093527

GI number: 20093527

Start: 79695

End: 80291

Strand: Direct

Name: purO

Synonym: MK0087

Alternate gene names: 20093527

Gene position: 79695-80291 (Clockwise)

Preceding gene: 20093526

Following gene: 20093530

Centisome position: 4.7

GC content: 61.47

Gene sequence:

>597_bases
GTGTACGTCGGCCGGTTTTTACTCGCCGGGAAGCTGGAGGACGGGACACCGATCGCCGTATACGGCGTCTGCAGTCGCAG
CTTCTCGGATCGACGTATCGAGGTCCGTGAGGGTGCGGCGTTCGTGGTTCCTGAAGATCCGAGCTACATCACCGAGAACC
CGTACGTGACCTACACCTGCGCCCGGATCGTCGACGAGTTCCTGGTGCTCACCAACGGCGCCCAGACAGATCCTATCGCG
GACAAGCTGGAGTCGGGAGTACCACCCAGGGAGGCGCTCGTATCCGTCACCTTCGCGATGGATTACGAACACGACGAGTA
CAATACACCGAGGATCTCCCTGATCACGGACGGCGAAACGTTCTGGCTAGGACGGGTCGCACCGGAGGAAGTGTACTTCA
GGGTCATGAAGCCGAAGGACGGTGAGGGGTACTTACTGTCCGTGTACGGGGAGTACGCCGAGGTCCCGTCGAAACCCAAC
ATGACCCTCGATCGGGAGGACCCGCTGGAGTGCGATCCGGTACCGTCCTTCGAGCACTACGTTTGCTCGGTGATCGCACG
GCACGATGGCGGCCGTTGGTCCCTCGAGGCCAGGTGA

Upstream 100 bases:

>100_bases
CGGAGTCCCCGAAGCGATATGGGTCCTGGAGGTGGAGGAGTTCGGCCCGCTAATAGTCACCGTGGACGCGCACGGTAACG
AGCTGGCGGGTGAGTGAACC

Downstream 100 bases:

>100_bases
GTCAGCCTACCTCCAACAGCCTCGCGTTTCCGGGCGGCATAGCCCTCATCACGTCGTCTACAGTCAGATAACGGCGTAGG
TTCTCCACCTCCTTCTTGAA

Product: IMP cyclohydrolase

Products: NA

Alternate protein names: IMP synthase; Inosinicase

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MYVGRFLLAGKLEDGTPIAVYGVCSRSFSDRRIEVREGAAFVVPEDPSYITENPYVTYTCARIVDEFLVLTNGAQTDPIA
DKLESGVPPREALVSVTFAMDYEHDEYNTPRISLITDGETFWLGRVAPEEVYFRVMKPKDGEGYLLSVYGEYAEVPSKPN
MTLDREDPLECDPVPSFEHYVCSVIARHDGGRWSLEAR

Sequences:

>Translated_198_residues
MYVGRFLLAGKLEDGTPIAVYGVCSRSFSDRRIEVREGAAFVVPEDPSYITENPYVTYTCARIVDEFLVLTNGAQTDPIA
DKLESGVPPREALVSVTFAMDYEHDEYNTPRISLITDGETFWLGRVAPEEVYFRVMKPKDGEGYLLSVYGEYAEVPSKPN
MTLDREDPLECDPVPSFEHYVCSVIARHDGGRWSLEAR
>Mature_198_residues
MYVGRFLLAGKLEDGTPIAVYGVCSRSFSDRRIEVREGAAFVVPEDPSYITENPYVTYTCARIVDEFLVLTNGAQTDPIA
DKLESGVPPREALVSVTFAMDYEHDEYNTPRISLITDGETFWLGRVAPEEVYFRVMKPKDGEGYLLSVYGEYAEVPSKPN
MTLDREDPLECDPVPSFEHYVCSVIARHDGGRWSLEAR

Specific function: Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP

COG id: COG3363

COG function: function code F; Archaeal IMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal IMP cyclohydrolase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURO_METKA (Q8TZ52)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613374.1
- ProteinModelPortal:   Q8TZ52
- GeneID:   1477390
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0087
- NMPDR:   fig|190192.1.peg.87
- HOGENOM:   HBG539724
- OMA:   REDPLEC
- ProtClustDB:   PRK04151
- BioCyc:   MKAN190192:MK0087-MONOMER
- BRENDA:   3.5.4.10
- HAMAP:   MF_00705
- InterPro:   IPR010191
- InterPro:   IPR020600
- Gene3D:   G3DSA:3.60.20.20
- PIRSF:   PIRSF004866
- TIGRFAMs:   TIGR01922

Pfam domain/function: PF07826 IMP_cyclohyd; SSF75569 PurO_cyclohydro

EC number: =3.5.4.10

Molecular weight: Translated: 22289; Mature: 22289

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVGRFLLAGKLEDGTPIAVYGVCSRSFSDRRIEVREGAAFVVPEDPSYITENPYVTYTC
CCCCCEEEEEECCCCCCEEEEEEECCCCCCCEEEEECCEEEEEECCCCEECCCCEEEEEH
ARIVDEFLVLTNGAQTDPIADKLESGVPPREALVSVTFAMDYEHDEYNTPRISLITDGET
HHHHHHHHEECCCCCCCHHHHHHHCCCCCHHHEEEEEEEEECCCCCCCCCEEEEEECCCE
FWLGRVAPEEVYFRVMKPKDGEGYLLSVYGEYAEVPSKPNMTLDREDPLECDPVPSFEHY
EEEECCCHHHEEEEEECCCCCCCEEEEEECCHHHCCCCCCCEECCCCCCCCCCCCCHHHH
VCSVIARHDGGRWSLEAR
HHHHHEECCCCEEEEECC
>Mature Secondary Structure
MYVGRFLLAGKLEDGTPIAVYGVCSRSFSDRRIEVREGAAFVVPEDPSYITENPYVTYTC
CCCCCEEEEEECCCCCCEEEEEEECCCCCCCEEEEECCEEEEEECCCCEECCCCEEEEEH
ARIVDEFLVLTNGAQTDPIADKLESGVPPREALVSVTFAMDYEHDEYNTPRISLITDGET
HHHHHHHHEECCCCCCCHHHHHHHCCCCCHHHEEEEEEEEECCCCCCCCCEEEEEECCCE
FWLGRVAPEEVYFRVMKPKDGEGYLLSVYGEYAEVPSKPNMTLDREDPLECDPVPSFEHY
EEEECCCHHHEEEEEECCCCCCCEEEEEECCHHHCCCCCCCEECCCCCCCCCCCCCHHHH
VCSVIARHDGGRWSLEAR
HHHHHEECCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014