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The map label for this gene is FumA [H]

Identifier: 20093526

GI number: 20093526

Start: 79158

End: 79691

Strand: Direct

Name: FumA [H]

Synonym: MK0086

Alternate gene names: 20093526

Gene position: 79158-79691 (Clockwise)

Preceding gene: 20093525

Following gene: 20093527

Centisome position: 4.67

GC content: 63.3

Gene sequence:

>534_bases
TTGACCGAACACCACCTGGAAGTCCCTCTCGAGAAGGAGGAACGGCTCACCGAGCTGGAGGTAGGCGATGTAGTGTACCT
GAGCGGAACCATAATCACGGCTCGCGACAAAGCCCACCAGCGGATTTTCGAGGAAGGTGAGGAACCCCCCGTAGATCTCG
AAGGAGCCGCCGTGTTCCACGCGGGTCCCGTGGTCAGGCGCGTCGACGACGGCTACGAGCTGGTGGTGATAGGCCCCACG
ACGAGCACGCGGATGGCGAAGTACCTCGAGGATATCGTGGATGCGGGCGTGAAGTTGATCGTCGGGAAGGGAGGCATGGG
TCCAGACGCCCCCGAGGTGATGAAGGATCGCGCCGTATACCTCACGGCGCCGGGAGGGTGCGCCGCGCTCCTTGCCGAGC
GGGTGAAAAGCATCCGAGAGGTGCACTGGTTGGACCTCGGAGTCCCCGAAGCGATATGGGTCCTGGAGGTGGAGGAGTTC
GGCCCGCTAATAGTCACCGTGGACGCGCACGGTAACGAGCTGGCGGGTGAGTGA

Upstream 100 bases:

>100_bases
GTGAATGTACAGTGCTGGGCGGCCCGGAGGGCGACCGCGATCGTGTACCCGGACGGCTTCTTCGAGGTCACTCAACGCGA
GTATCCGCGGGGGTAATCGA

Downstream 100 bases:

>100_bases
ACCGTGTACGTCGGCCGGTTTTTACTCGCCGGGAAGCTGGAGGACGGGACACCGATCGCCGTATACGGCGTCTGCAGTCG
CAGCTTCTCGGATCGACGTA

Product: fumarate hydratase class I

Products: NA

Alternate protein names: L-TTD beta [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTEHHLEVPLEKEERLTELEVGDVVYLSGTIITARDKAHQRIFEEGEEPPVDLEGAAVFHAGPVVRRVDDGYELVVIGPT
TSTRMAKYLEDIVDAGVKLIVGKGGMGPDAPEVMKDRAVYLTAPGGCAALLAERVKSIREVHWLDLGVPEAIWVLEVEEF
GPLIVTVDAHGNELAGE

Sequences:

>Translated_177_residues
MTEHHLEVPLEKEERLTELEVGDVVYLSGTIITARDKAHQRIFEEGEEPPVDLEGAAVFHAGPVVRRVDDGYELVVIGPT
TSTRMAKYLEDIVDAGVKLIVGKGGMGPDAPEVMKDRAVYLTAPGGCAALLAERVKSIREVHWLDLGVPEAIWVLEVEEF
GPLIVTVDAHGNELAGE
>Mature_176_residues
TEHHLEVPLEKEERLTELEVGDVVYLSGTIITARDKAHQRIFEEGEEPPVDLEGAAVFHAGPVVRRVDDGYELVVIGPTT
STRMAKYLEDIVDAGVKLIVGKGGMGPDAPEVMKDRAVYLTAPGGCAALLAERVKSIREVHWLDLGVPEAIWVLEVEEFG
PLIVTVDAHGNELAGE

Specific function: Unknown

COG id: COG1838

COG function: function code C; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789443, Length=168, Percent_Identity=51.1904761904762, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1787897, Length=166, Percent_Identity=34.3373493975904, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790564, Length=166, Percent_Identity=34.3373493975904, Blast_Score=77, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004647 [H]

Pfam domain/function: PF05683 Fumerase_C [H]

EC number: =4.2.1.32 [H]

Molecular weight: Translated: 19245; Mature: 19114

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHHLEVPLEKEERLTELEVGDVVYLSGTIITARDKAHQRIFEEGEEPPVDLEGAAVFH
CCCCCCCCCCCHHHHHHEECCCCEEEEECEEEEECCHHHHHHHHCCCCCCCCCCCCEEEE
AGPVVRRVDDGYELVVIGPTTSTRMAKYLEDIVDAGVKLIVGKGGMGPDAPEVMKDRAVY
CCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHCCEEE
LTAPGGCAALLAERVKSIREVHWLDLGVPEAIWVLEVEEFGPLIVTVDAHGNELAGE
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
TEHHLEVPLEKEERLTELEVGDVVYLSGTIITARDKAHQRIFEEGEEPPVDLEGAAVFH
CCCCCCCCCCHHHHHHEECCCCEEEEECEEEEECCHHHHHHHHCCCCCCCCCCCCEEEE
AGPVVRRVDDGYELVVIGPTTSTRMAKYLEDIVDAGVKLIVGKGGMGPDAPEVMKDRAVY
CCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHCCEEE
LTAPGGCAALLAERVKSIREVHWLDLGVPEAIWVLEVEEFGPLIVTVDAHGNELAGE
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]