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The map label for this gene is TtdA [C]

Identifier: 20093525

GI number: 20093525

Start: 78242

End: 79153

Strand: Direct

Name: TtdA [C]

Synonym: MK0085

Alternate gene names: 20093525

Gene position: 78242-79153 (Clockwise)

Preceding gene: 20093524

Following gene: 20093526

Centisome position: 4.62

GC content: 62.72

Gene sequence:

>912_bases
ATGCCCGACGACTCGGATCGAGAGCTGCTCGAAAGCATAGCCGAAGCCACAGTCGAAGCGTTGCGCGTGGCCGAAACTAA
GCTTCCGGATGACGTGCTGGAGAGGGTCGAACGGGCCCTGGAGGAGGAAGAAGACGACCATGCCCGGATGATGCTGGAGG
CGATCCTTGAGAACGTCCGCATCGCCGAGGAGAAAGGACTACCGATGTGCCAAGACACCGGACTGATCACGGTCTTTGCG
GAGATCGGCCGCGAGTTCCCGCTGAGGCTGGCCGGGACCATCCGGGACGGGATCGAGGAGGGTATCCGGCGGGCCACGGA
GGAGATACCACTTCGACCTAACGTGGTCCATCCGATCAGTAGGGAGAACACAGGTGATAACACCGGAGATCGTGTACCCA
TCGTGCGGTTCCTTCCGACCAAAGGGGAGGAGTTGAGGCTCCACTTCCTGCCCAAAGGTTTCGGGTCCGAGAACTCCAGC
GCCGTGACTCGGTTATTACCCACGGAAGGGTTGGAAGGCGTCCGCGAGTTCGTGATCAAGACCGTGCGCGAGGCCGGCGG
GATGCCGTGCCCACCGATCGTGCTGGGCGTGGGAGTCGGAGGTACGATCGATGAGGCCGCGCACTTGGCCAAGCTGGCCC
TGTTCCGACCACTGAACGTCAGGAATCCGGACCCGGAGATCGCGAAGCTGGAGGAAGAGCTACTGGAGGAGATCAACCGG
CTGGGCGTAGGTCCAATGGGTCTCGGGGGTCGAACTACGGCACTGGCGGTCAACGTCGAGCTAGCTTACACCCACACGGC
CGGGCTGCCGGTGGCAGTGAATGTACAGTGCTGGGCGGCCCGGAGGGCGACCGCGATCGTGTACCCGGACGGCTTCTTCG
AGGTCACTCAACGCGAGTATCCGCGGGGGTAA

Upstream 100 bases:

>100_bases
CCAGTGGCCGGCGCGGACGTGGCTCCCGTGAACGAGCGAGTTTTATGGAGACGATCCCGAGCTGCCCGCACACTCCGAAA
CTTGCCGGGGAGTGGGGGTC

Downstream 100 bases:

>100_bases
TCGATTGACCGAACACCACCTGGAAGTCCCTCTCGAGAAGGAGGAACGGCTCACCGAGCTGGAGGTAGGCGATGTAGTGT
ACCTGAGCGGAACCATAATC

Product: fumarate hydratase class I

Products: NA

Alternate protein names: Fumarase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MPDDSDRELLESIAEATVEALRVAETKLPDDVLERVERALEEEEDDHARMMLEAILENVRIAEEKGLPMCQDTGLITVFA
EIGREFPLRLAGTIRDGIEEGIRRATEEIPLRPNVVHPISRENTGDNTGDRVPIVRFLPTKGEELRLHFLPKGFGSENSS
AVTRLLPTEGLEGVREFVIKTVREAGGMPCPPIVLGVGVGGTIDEAAHLAKLALFRPLNVRNPDPEIAKLEEELLEEINR
LGVGPMGLGGRTTALAVNVELAYTHTAGLPVAVNVQCWAARRATAIVYPDGFFEVTQREYPRG

Sequences:

>Translated_303_residues
MPDDSDRELLESIAEATVEALRVAETKLPDDVLERVERALEEEEDDHARMMLEAILENVRIAEEKGLPMCQDTGLITVFA
EIGREFPLRLAGTIRDGIEEGIRRATEEIPLRPNVVHPISRENTGDNTGDRVPIVRFLPTKGEELRLHFLPKGFGSENSS
AVTRLLPTEGLEGVREFVIKTVREAGGMPCPPIVLGVGVGGTIDEAAHLAKLALFRPLNVRNPDPEIAKLEEELLEEINR
LGVGPMGLGGRTTALAVNVELAYTHTAGLPVAVNVQCWAARRATAIVYPDGFFEVTQREYPRG
>Mature_302_residues
PDDSDRELLESIAEATVEALRVAETKLPDDVLERVERALEEEEDDHARMMLEAILENVRIAEEKGLPMCQDTGLITVFAE
IGREFPLRLAGTIRDGIEEGIRRATEEIPLRPNVVHPISRENTGDNTGDRVPIVRFLPTKGEELRLHFLPKGFGSENSSA
VTRLLPTEGLEGVREFVIKTVREAGGMPCPPIVLGVGVGGTIDEAAHLAKLALFRPLNVRNPDPEIAKLEEELLEEINRL
GVGPMGLGGRTTALAVNVELAYTHTAGLPVAVNVQCWAARRATAIVYPDGFFEVTQREYPRG

Specific function: Unknown

COG id: COG1951

COG function: function code C; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I fumarase family [H]

Homologues:

Organism=Escherichia coli, GI1789442, Length=297, Percent_Identity=33.3333333333333, Blast_Score=178, Evalue=3e-46,
Organism=Escherichia coli, GI1790564, Length=267, Percent_Identity=28.0898876404494, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1787897, Length=285, Percent_Identity=27.3684210526316, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004646 [H]

Pfam domain/function: PF05681 Fumerase [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 33265; Mature: 33134

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDDSDRELLESIAEATVEALRVAETKLPDDVLERVERALEEEEDDHARMMLEAILENVR
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IAEEKGLPMCQDTGLITVFAEIGREFPLRLAGTIRDGIEEGIRRATEEIPLRPNVVHPIS
HHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
RENTGDNTGDRVPIVRFLPTKGEELRLHFLPKGFGSENSSAVTRLLPTEGLEGVREFVIK
CCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHH
TVREAGGMPCPPIVLGVGVGGTIDEAAHLAKLALFRPLNVRNPDPEIAKLEEELLEEINR
HHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
LGVGPMGLGGRTTALAVNVELAYTHTAGLPVAVNVQCWAARRATAIVYPDGFFEVTQREY
CCCCCCCCCCCCEEEEEEEEEEEEECCCCCEEEEEEEEECCCEEEEECCCCHHHHHHHCC
PRG
CCC
>Mature Secondary Structure 
PDDSDRELLESIAEATVEALRVAETKLPDDVLERVERALEEEEDDHARMMLEAILENVR
CCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IAEEKGLPMCQDTGLITVFAEIGREFPLRLAGTIRDGIEEGIRRATEEIPLRPNVVHPIS
HHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
RENTGDNTGDRVPIVRFLPTKGEELRLHFLPKGFGSENSSAVTRLLPTEGLEGVREFVIK
CCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHH
TVREAGGMPCPPIVLGVGVGGTIDEAAHLAKLALFRPLNVRNPDPEIAKLEEELLEEINR
HHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
LGVGPMGLGGRTTALAVNVELAYTHTAGLPVAVNVQCWAARRATAIVYPDGFFEVTQREY
CCCCCCCCCCCCEEEEEEEEEEEEECCCCCEEEEEEEEECCCEEEEECCCCHHHHHHHCC
PRG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]