| Definition | Streptococcus pyogenes MGAS8232, complete genome. |
|---|---|
| Accession | NC_003485 |
| Length | 1,895,017 |
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The map label for this gene is secA [H]
Identifier: 19746746
GI number: 19746746
Start: 1551353
End: 1553872
Strand: Reverse
Name: secA [H]
Synonym: spyM18_1873
Alternate gene names: 19746746
Gene position: 1553872-1551353 (Counterclockwise)
Preceding gene: 19746748
Following gene: 19746745
Centisome position: 82.0
GC content: 41.35
Gene sequence:
>2520_bases ATGGCCAATATTCTACGCAAAGTTATCGAAAATGACAAAGGCGAACTAAGAAAATTAGAAAAAATTGCAAAAAAAGTAGA ATCCTACGCAGACCAAATGGCGTCATTGTCGGATAGAGATCTACAGGGAAAAACACTTGAATTTAAAGAACGCTATCAAA AAGGTGAGACCCTCGAACAACTATTACCTGAGGCTTTCGCAGTTGTTCGTGAAGCAGCAAAACGTGTGTTGGGCTTGTTC CCTTATCGTGTTCAAATTATGGGAGGAATTGTTCTTCATAACGGGGATGTCCCTGAAATGCGTACTGGTGAAGGAAAAAC TCTTACAGCCACCATGCCAGTTTATCTCAATGCTATTGCTGGTGAGGGTGTTCACGTTATTACTGTTAATGAGTATCTTT CAACGCGTGACGCTACCGAAATGGGTGAAGTGTATAGCTGGTTAGGTCTTTCAGTTGGGATCAACCTAGCTGCTAAGTCT CCTGCTGAAAAACGTGAAGCTTATAATTGTGATATTACTTATTCAACCAACTCTGAAGTCGGTTTTGATTACCTTCGTGA CAACATGGTTGTTCGCCAGGAAGACATGGTACAACGCCCACTCAATTTTGCCTTGGTTGATGAAGTGGACTCAGTCTTAA TTGACGAGGCAAGGACACCTTTAATTGTCTCTGGTGCTGTTAGCTCTGAAACCAATCAATTGTATATTCGTGCTGACATG TTTGTAAAAACTCTGACGTCAGTGGATTATGTTATTGATGTGCCCACTAAAACGATTGGATTAAGCGATTCAGGTATTGA TAAAGCTGAGAGTTATTTTAACTTGAGCAATCTTTACGATATTGAAAATGTAGCCTTGACTCACTTTATAGACAACGCCC TTCGTGCAAACTATATTATGTTGTTAGATATCGATTATGTGGTCAGCGAGGATGGTGAGATTCTTATTGTTGACCAATTT ACAGGTCGTACGATGGAAGGGCGTCGCTTCTCAGACGGCTTGCACCAAGCTATTGAGGCAAAAGAAGGCGTTCGTATTCA GGAAGAATCAAAAACCAGCGCCTCAATCACCTACCAAAATATGTTTCGTATGTACAAAAAATTGGCAGGTATGACTGGTA CTGCGAAGACCGAGGAAGAAGAATTTCGCGAAGTTTATAACATGCGTATTATTCCAATTCCAACCAATCGTCCAATTGCC CGTATTGATCACACTGATTTGCTTTACCCGACCTTAGAATCAAAGTTTAGAGCAGTTGTGGAAGACGTTAAAACGCGTCA TGCAAAAGGACAACCTATCCTTGTAGGTACGGTTGCTGTTGAAACTAGTGATTTGATTTCACGCAAGCTGGTTGAAGCAG GGATTCCTCATGAGGTTTTGAATGCTAAAAATCACTTTAAAGAAGCTCAAATCATTATGAATGCTGGGCAACGTGGTGCT GTTACAATCGCAACTAACATGGCTGGTCGTGGTACTGATATCAAGCTTGGTGAAGGTGTTCGTGAACTTGGTGGGTTATG TGTCATTGGTACAGAGCGTCATGAAAGCCGTCGTATCGATAACCAGCTTCGTGGGCGTTCAGGTCGTCAAGGAGATCCAG GTGAATCCCAATTCTATCTTTCATTAGAAGATGATTTGATGAGACGTTTCGGCTCTGATCGTATAAAAGCCTTTTTGGAC CGGATGAAATTAGATGAAGAAGACACCGTTATTAAATCAGGTATGTTAGGTCGTCAAGTGGAATCTGCTCAAAAACGGGT TGAAGGAAATAACTACGATACCCGTAAACAGGTCTTACAATATGATGATGTGATGCGTGAACAGCGTGAAATTATCTATG CTAACCGTCGTGATGTCATAACTGCTAATCGAGATCTTGGCCCAGAAATTAAAGCTATGATCAAGCGTACTATCGACCGT GCTGTAGATGCTCATGCACGTAGCAATCGTAAAGATGCTATAGATGCTATTGTAACTTTTGCTAGGACCTCGCTGGTACC AGAAGAGTCTATTAGTGCTAAAGAGTTACGTGGTTTAAAAGATGATCAAATCAAAGAGAAGCTTTATCAAAGAGCGCTTG CTATCTATGACCAGCAACTATCAAAACTTCGTGATCAAGAAGCCATTATTGAATTCCAAAAAGTACTCATTTTGATGATT GTGGATAACAAATGGACTGAACACATTGATGCCTTAGATCAACTTCGTAATGCTGTTGGACTTCGGGGGTATGCTCAAAA TAACCCTGTGGTGGAATACCAAGCAGAAGGTTTCAAGATGTTCCAAGATATGATTGGTGCTATCGAGTTTGATGTAACAC GTACCATGATGAAAGCACAAATTCACGAACAAGAACGTGAACGTGCAAGTCAACGTGCCACAACAGCAGCACCTCAAAAC ATCCAATCGCAGCAGTCAGCTAACACCGATGATTTACCCAAAGTGGAGCGTAACGAAGCTTGTCCATGTGGTTCAGGCAA AAAATTCAAAAATTGTCACGGTCGTAAATCCTTCTCATAA
Upstream 100 bases:
>100_bases ATTATGACTCTCTGTTTCTCTGATAACTTTACCAACCTTTCTTGAACTGCCTACATATTTATGTTAAAATGAAATGATTA GATGATCGAAAGGAAAGAGA
Downstream 100 bases:
>100_bases GAACGAGACACAACAGGACAAAGTTAGGTATATAGAAAGAAGCTGAGAATAATTCTCAGCTTCTCACTGTTTAAATCTTC TAACATTAAGATGAAATAAG
Product: preprotein translocase subunit SecA
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 839; Mature: 838
Protein sequence:
>839_residues MANILRKVIENDKGELRKLEKIAKKVESYADQMASLSDRDLQGKTLEFKERYQKGETLEQLLPEAFAVVREAAKRVLGLF PYRVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNAIAGEGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKS PAEKREAYNCDITYSTNSEVGFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRADM FVKTLTSVDYVIDVPTKTIGLSDSGIDKAESYFNLSNLYDIENVALTHFIDNALRANYIMLLDIDYVVSEDGEILIVDQF TGRTMEGRRFSDGLHQAIEAKEGVRIQEESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIA RIDHTDLLYPTLESKFRAVVEDVKTRHAKGQPILVGTVAVETSDLISRKLVEAGIPHEVLNAKNHFKEAQIIMNAGQRGA VTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMRRFGSDRIKAFLD RMKLDEEDTVIKSGMLGRQVESAQKRVEGNNYDTRKQVLQYDDVMREQREIIYANRRDVITANRDLGPEIKAMIKRTIDR AVDAHARSNRKDAIDAIVTFARTSLVPEESISAKELRGLKDDQIKEKLYQRALAIYDQQLSKLRDQEAIIEFQKVLILMI VDNKWTEHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFKMFQDMIGAIEFDVTRTMMKAQIHEQERERASQRATTAAPQN IQSQQSANTDDLPKVERNEACPCGSGKKFKNCHGRKSFS
Sequences:
>Translated_839_residues MANILRKVIENDKGELRKLEKIAKKVESYADQMASLSDRDLQGKTLEFKERYQKGETLEQLLPEAFAVVREAAKRVLGLF PYRVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNAIAGEGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKS PAEKREAYNCDITYSTNSEVGFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRADM FVKTLTSVDYVIDVPTKTIGLSDSGIDKAESYFNLSNLYDIENVALTHFIDNALRANYIMLLDIDYVVSEDGEILIVDQF TGRTMEGRRFSDGLHQAIEAKEGVRIQEESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIA RIDHTDLLYPTLESKFRAVVEDVKTRHAKGQPILVGTVAVETSDLISRKLVEAGIPHEVLNAKNHFKEAQIIMNAGQRGA VTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMRRFGSDRIKAFLD RMKLDEEDTVIKSGMLGRQVESAQKRVEGNNYDTRKQVLQYDDVMREQREIIYANRRDVITANRDLGPEIKAMIKRTIDR AVDAHARSNRKDAIDAIVTFARTSLVPEESISAKELRGLKDDQIKEKLYQRALAIYDQQLSKLRDQEAIIEFQKVLILMI VDNKWTEHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFKMFQDMIGAIEFDVTRTMMKAQIHEQERERASQRATTAAPQN IQSQQSANTDDLPKVERNEACPCGSGKKFKNCHGRKSFS >Mature_838_residues ANILRKVIENDKGELRKLEKIAKKVESYADQMASLSDRDLQGKTLEFKERYQKGETLEQLLPEAFAVVREAAKRVLGLFP YRVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNAIAGEGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKSP AEKREAYNCDITYSTNSEVGFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRADMF VKTLTSVDYVIDVPTKTIGLSDSGIDKAESYFNLSNLYDIENVALTHFIDNALRANYIMLLDIDYVVSEDGEILIVDQFT GRTMEGRRFSDGLHQAIEAKEGVRIQEESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIAR IDHTDLLYPTLESKFRAVVEDVKTRHAKGQPILVGTVAVETSDLISRKLVEAGIPHEVLNAKNHFKEAQIIMNAGQRGAV TIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMRRFGSDRIKAFLDR MKLDEEDTVIKSGMLGRQVESAQKRVEGNNYDTRKQVLQYDDVMREQREIIYANRRDVITANRDLGPEIKAMIKRTIDRA VDAHARSNRKDAIDAIVTFARTSLVPEESISAKELRGLKDDQIKEKLYQRALAIYDQQLSKLRDQEAIIEFQKVLILMIV DNKWTEHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFKMFQDMIGAIEFDVTRTMMKAQIHEQERERASQRATTAAPQNI QSQQSANTDDLPKVERNEACPCGSGKKFKNCHGRKSFS
Specific function: Part of the Sec protein translocase complex. Interacts with the secYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular mo
COG id: COG0653
COG function: function code U; Preprotein translocase subunit SecA (ATPase, RNA helicase)
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm (By similarity). Note=Distribution is 50-50 (By similarity) [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the secA family [H]
Homologues:
Organism=Escherichia coli, GI1786287, Length=906, Percent_Identity=44.3708609271523, Blast_Score=735, Evalue=0.0,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004027 - InterPro: IPR000185 - InterPro: IPR020937 - InterPro: IPR011115 - InterPro: IPR014018 - InterPro: IPR011130 - InterPro: IPR011116 [H]
Pfam domain/function: PF02810 SEC-C; PF07517 SecA_DEAD; PF01043 SecA_PP_bind; PF07516 SecA_SW [H]
EC number: NA
Molecular weight: Translated: 94706; Mature: 94575
Theoretical pI: Translated: 5.69; Mature: 5.69
Prosite motif: PS01312 SECA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.6 %Cys (Translated Protein) 3.2 %Met (Translated Protein) 3.8 %Cys+Met (Translated Protein) 0.6 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 3.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MANILRKVIENDKGELRKLEKIAKKVESYADQMASLSDRDLQGKTLEFKERYQKGETLEQ CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHH LLPEAFAVVREAAKRVLGLFPYRVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNAIA HHHHHHHHHHHHHHHHHHCCCHHEEEECCEEEECCCCCCCCCCCCCEEEEEHHHHHHHCC GEGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKSPAEKREAYNCDITYSTNSEV CCCEEEEEEHHHHHHCCHHHHHHHHHHHHHHHCCEEECCCCHHHHHCCCCEEEECCCCCC GFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRADM CHHHHHCCCEECHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEHHH FVKTLTSVDYVIDVPTKTIGLSDSGIDKAESYFNLSNLYDIENVALTHFIDNALRANYIM HHHHHHCCCEEEECCCCEECCCCCCCHHHHHHHCHHHHCCHHHHHHHHHHHHHHHCCEEE LLDIDYVVSEDGEILIVDQFTGRTMEGRRFSDGLHQAIEAKEGVRIQEESKTSASITYQN EEEEEHEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHH MFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIARIDHTDLLYPTLESKFRAVV HHHHHHHHHCCCCCCCCCHHHHHHHHCCEEEEECCCCCCEEECCCHHHHHHHHHHHHHHH EDVKTRHAKGQPILVGTVAVETSDLISRKLVEAGIPHEVLNAKNHFKEAQIIMNAGQRGA HHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCE VTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYL EEEEECCCCCCCCEECCCCHHHHCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEE SLEDDLMRRFGSDRIKAFLDRMKLDEEDTVIKSGMLGRQVESAQKRVEGNNYDTRKQVLQ EEHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHH YDDVMREQREIIYANRRDVITANRDLGPEIKAMIKRTIDRAVDAHARSNRKDAIDAIVTF HHHHHHHHHHHEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH ARTSLVPEESISAKELRGLKDDQIKEKLYQRALAIYDQQLSKLRDQEAIIEFQKVLILMI HHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE VDNKWTEHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFKMFQDMIGAIEFDVTRTMMKAQ ECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH IHEQERERASQRATTAAPQNIQSQQSANTDDLPKVERNEACPCGSGKKFKNCHGRKSFS HHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCC >Mature Secondary Structure ANILRKVIENDKGELRKLEKIAKKVESYADQMASLSDRDLQGKTLEFKERYQKGETLEQ HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHH LLPEAFAVVREAAKRVLGLFPYRVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNAIA HHHHHHHHHHHHHHHHHHCCCHHEEEECCEEEECCCCCCCCCCCCCEEEEEHHHHHHHCC GEGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKSPAEKREAYNCDITYSTNSEV CCCEEEEEEHHHHHHCCHHHHHHHHHHHHHHHCCEEECCCCHHHHHCCCCEEEECCCCCC GFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRADM CHHHHHCCCEECHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEHHH FVKTLTSVDYVIDVPTKTIGLSDSGIDKAESYFNLSNLYDIENVALTHFIDNALRANYIM HHHHHHCCCEEEECCCCEECCCCCCCHHHHHHHCHHHHCCHHHHHHHHHHHHHHHCCEEE LLDIDYVVSEDGEILIVDQFTGRTMEGRRFSDGLHQAIEAKEGVRIQEESKTSASITYQN EEEEEHEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHH MFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIARIDHTDLLYPTLESKFRAVV HHHHHHHHHCCCCCCCCCHHHHHHHHCCEEEEECCCCCCEEECCCHHHHHHHHHHHHHHH EDVKTRHAKGQPILVGTVAVETSDLISRKLVEAGIPHEVLNAKNHFKEAQIIMNAGQRGA HHHHHHCCCCCCEEEEEEEECHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCE VTIATNMAGRGTDIKLGEGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYL EEEEECCCCCCCCEECCCCHHHHCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCEEEE SLEDDLMRRFGSDRIKAFLDRMKLDEEDTVIKSGMLGRQVESAQKRVEGNNYDTRKQVLQ EEHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHH YDDVMREQREIIYANRRDVITANRDLGPEIKAMIKRTIDRAVDAHARSNRKDAIDAIVTF HHHHHHHHHHHEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH ARTSLVPEESISAKELRGLKDDQIKEKLYQRALAIYDQQLSKLRDQEAIIEFQKVLILMI HHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEE VDNKWTEHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFKMFQDMIGAIEFDVTRTMMKAQ ECCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH IHEQERERASQRATTAAPQNIQSQQSANTDDLPKVERNEACPCGSGKKFKNCHGRKSFS HHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA