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The map label for this gene is manA [H]

Identifier: 19746748

GI number: 19746748

Start: 1555093

End: 1556046

Strand: Reverse

Name: manA [H]

Synonym: spyM18_1876

Alternate gene names: 19746748

Gene position: 1556046-1555093 (Counterclockwise)

Preceding gene: 19746749

Following gene: 19746746

Centisome position: 82.11

GC content: 40.99

Gene sequence:

>954_bases
ATGTCAGAACCATTATTTCTAAAATCAACCATGCACGACAGGATTTGGGGTGGCACCAAGTTGAGAGATGTCTTTGCTTA
CAACATCCCAAGTGACACCACAGGTGAGTATTGGGCTATTTCTGCTCATCCTAATGGTGTTTCGACAGTTACTAATGGAC
GTTATCAAGGACAGCCTTTAAATACATTATATGCGCAAGAGCCGGCCTTGTTTGGGAATCCAAAGGAAGAAGTTTTTCCA
CTGTTAACTAAGATTTTAGATGCTAATGACTGGCTAAGTGTCCAAGTTCATCCTGATGATGCTTATGGACGTGAACATGA
AGGAGAATTAGGCAAGACAGAATGCTGGTATATTATTTCTGCCGAAGAAGGTTCTGAAATTGTATACGGCCATCAGGCCA
AGTCCAAAGAAGACCTTCGTGCCATGATTGAAGCAGGCGCTTGGGATGATTTGCTGACTCGTGTCCCAGTCAAAGCAGGC
GATTTTTTCTATGTTCCAAGTGGCACCATGCATGCGATCGGCAAGGGAATTCTTATTTTAGAAACCCAGCAGTCATCTGA
TACCACTTATCGGGTTTATGATTTTGACCGTAAGGACGTTAATGGTAATCTTCGTGACCTTCATATTGAAAAGTCTATTG
ATGTCTTAACGATTGGTAAGCCAGAAAATAGCGTGCCAGCCACTATAGTTTTGGATAATATGGTAGAAACAACTTTAGTC
TCAACGCCATTTTTCACTGTTTACAAATGGGTAACTAGTCAAATGGTTGACATGAAACAAGCTGCGCCTTATCTTTTAGT
GAGTGTTTTAAAAGGTCAAGGAAAACTCTATGTGGACCAGAAGGCTTATGAGCTAGAAAAAGGCATGCACTTTATCTTGC
CTAACGATGTTAAATCGTGGTCATTTGATGGTCAATTAGAAATGATTGTGAGTCACCCCAATCAACTCGTTTAA

Upstream 100 bases:

>100_bases
AAATAGGGTCTGTTTTTGCCTGCTTGTCTAGTAAAAGAAAGCGCAGTCAGCTAGAACATGCTATAATAAACAGAGATTAA
CATCAGAAGCGAGGAATATT

Downstream 100 bases:

>100_bases
TACCATGGTATCAATGTGAGAAAAAAGGATAAAATTATGACTCGCCAAATTTCAAGTTGAAGTTAGCCAGTTTTAACATT
TCTACTGGCGACTTGTAGTT

Product: mannose-6-phosphate isomerase

Products: NA

Alternate protein names: Phosphohexomutase; Phosphomannose isomerase; PMI [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSEPLFLKSTMHDRIWGGTKLRDVFAYNIPSDTTGEYWAISAHPNGVSTVTNGRYQGQPLNTLYAQEPALFGNPKEEVFP
LLTKILDANDWLSVQVHPDDAYGREHEGELGKTECWYIISAEEGSEIVYGHQAKSKEDLRAMIEAGAWDDLLTRVPVKAG
DFFYVPSGTMHAIGKGILILETQQSSDTTYRVYDFDRKDVNGNLRDLHIEKSIDVLTIGKPENSVPATIVLDNMVETTLV
STPFFTVYKWVTSQMVDMKQAAPYLLVSVLKGQGKLYVDQKAYELEKGMHFILPNDVKSWSFDGQLEMIVSHPNQLV

Sequences:

>Translated_317_residues
MSEPLFLKSTMHDRIWGGTKLRDVFAYNIPSDTTGEYWAISAHPNGVSTVTNGRYQGQPLNTLYAQEPALFGNPKEEVFP
LLTKILDANDWLSVQVHPDDAYGREHEGELGKTECWYIISAEEGSEIVYGHQAKSKEDLRAMIEAGAWDDLLTRVPVKAG
DFFYVPSGTMHAIGKGILILETQQSSDTTYRVYDFDRKDVNGNLRDLHIEKSIDVLTIGKPENSVPATIVLDNMVETTLV
STPFFTVYKWVTSQMVDMKQAAPYLLVSVLKGQGKLYVDQKAYELEKGMHFILPNDVKSWSFDGQLEMIVSHPNQLV
>Mature_316_residues
SEPLFLKSTMHDRIWGGTKLRDVFAYNIPSDTTGEYWAISAHPNGVSTVTNGRYQGQPLNTLYAQEPALFGNPKEEVFPL
LTKILDANDWLSVQVHPDDAYGREHEGELGKTECWYIISAEEGSEIVYGHQAKSKEDLRAMIEAGAWDDLLTRVPVKAGD
FFYVPSGTMHAIGKGILILETQQSSDTTYRVYDFDRKDVNGNLRDLHIEKSIDVLTIGKPENSVPATIVLDNMVETTLVS
TPFFTVYKWVTSQMVDMKQAAPYLLVSVLKGQGKLYVDQKAYELEKGMHFILPNDVKSWSFDGQLEMIVSHPNQLV

Specific function: Unknown

COG id: COG1482

COG function: function code G; Phosphomannose isomerase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 1 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR001250
- InterPro:   IPR014628
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01238 PMI_typeI [H]

EC number: =5.3.1.8 [H]

Molecular weight: Translated: 35656; Mature: 35525

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPLFLKSTMHDRIWGGTKLRDVFAYNIPSDTTGEYWAISAHPNGVSTVTNGRYQGQPL
CCCCEEEHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCEEECCEECCCCC
NTLYAQEPALFGNPKEEVFPLLTKILDANDWLSVQVHPDDAYGREHEGELGKTECWYIIS
CHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEE
AEEGSEIVYGHQAKSKEDLRAMIEAGAWDDLLTRVPVKAGDFFYVPSGTMHAIGKGILIL
CCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCEEEECCCCHHHCCCCEEEE
ETQQSSDTTYRVYDFDRKDVNGNLRDLHIEKSIDVLTIGKPENSVPATIVLDNMVETTLV
EECCCCCCEEEEEECCCCCCCCCEEEEEEECCCCEEEECCCCCCCCEEEEECCHHHHHHH
STPFFTVYKWVTSQMVDMKQAAPYLLVSVLKGQGKLYVDQKAYELEKGMHFILPNDVKSW
CCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEECCHHHHHHCCCEEEECCCCCCC
SFDGQLEMIVSHPNQLV
CCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SEPLFLKSTMHDRIWGGTKLRDVFAYNIPSDTTGEYWAISAHPNGVSTVTNGRYQGQPL
CCCEEEHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEECCCCCCEEECCEECCCCC
NTLYAQEPALFGNPKEEVFPLLTKILDANDWLSVQVHPDDAYGREHEGELGKTECWYIIS
CHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEE
AEEGSEIVYGHQAKSKEDLRAMIEAGAWDDLLTRVPVKAGDFFYVPSGTMHAIGKGILIL
CCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCEEEECCCCHHHCCCCEEEE
ETQQSSDTTYRVYDFDRKDVNGNLRDLHIEKSIDVLTIGKPENSVPATIVLDNMVETTLV
EECCCCCCEEEEEECCCCCCCCCEEEEEEECCCCEEEECCCCCCCCEEEEECCHHHHHHH
STPFFTVYKWVTSQMVDMKQAAPYLLVSVLKGQGKLYVDQKAYELEKGMHFILPNDVKSW
CCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEECCHHHHHHCCCEEEECCCCCCC
SFDGQLEMIVSHPNQLV
CCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8293960; 12397186 [H]