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The map label for this gene is pncB [H]

Identifier: 19746573

GI number: 19746573

Start: 1385211

End: 1386671

Strand: Reverse

Name: pncB [H]

Synonym: spyM18_1664

Alternate gene names: 19746573

Gene position: 1386671-1385211 (Counterclockwise)

Preceding gene: 19746574

Following gene: 19746572

Centisome position: 73.17

GC content: 40.31

Gene sequence:

>1461_bases
ATGTATAAAGATGATAGTTTAACTCTCCATACTGATTTGTATCAGATTAATATGATGCAAGTTTATTTTGAGCAGGGCAT
TCATAATCGTCATGCGGTGTTTGAAGTCTATTTCCGCAAGGAACCTTTTAACAATGGTTATGCTGTTTTTGCCGGTTTAC
AGCGCATGGTGGAGTACCTAGAGCAATTTCAATTTTCAGAAACAGATTTGGCTTACCTTGAAGAACTGGGTTATCCAGAA
AACTTTTTGACCTACCTTAAAGAGTTACGATTAGAATTGACCATCCGTTCAGCTAAAGAAGGAGATTTGGTTTTTGCTAA
TGAGCCGATTGTGCAAGTAGAAGGCCCTCTAGGTCAGTGTCAGTTGGTCGAAACAGCTCTTTTAAACATTGTTAACTTCC
AGACCTTGATTGCTACAAAGGCTGCTCGTATTCGTTCTGTGATTGAGGATGAACCCCTTTTGGAATTTGGCACCCGTCGT
GCACAGGAACTAGATGCTGCGATTTGGGGAACCCGCGCAGCGATGATTGGTGGAGCAGATGCAACAAGTAATGTGAGAGC
AGGTAAACGCTTTGGTATCCCTGTTTCAGGTACGCATGCTCATGCTTTAGTGCAAGCCTATGGTAATGATTATGATGCTT
TCATGGCTTATGCTAAGACCCATAAAGATTGTGTGTTTCTTGTTGACACCTATGACACACTTAAAGTAGGTGTGCCAACA
GCTATCCGAGTAGCCAAAGAAATGGGTGACAAGATTAATTTTCTAGGTGTTCGATTGGACTCTGGTGACTTGGCTTACCT
CTCAAAAACAGTCCGTCAGCAGTTAGACGACGCTGGTTTTACCGAGGCTAAGATCTATGCTTCTAATGACCTCGATGAAA
ATACCATCCTCAACTTAAAAATGCAAAAGGCCAAAATTGATGTTTGGGGTGTTGGAACCAAACTGATCACAGCCTATGAT
CAGCCTGCCTTAGGTGCTGTTTATAAGATTGTCTCTATTGAGCAAGAAGATGGTAGCATGCGTGATACGATCAAATTATC
AAATAATGCAGAAAAAGTATCCACACCAGGTAAAAAACAAGTTTGGCGCATCACCAGTCGTGAAAAAGGCAAATCAGAAG
GCGACTATATCACGTTTACTGATATTAATGTTAATGAATTAACTGAGATTGAGATGTTCCATCCGACCTATACCTATATT
AAGAAAACCGTCAGAAATTTTGATGCAATTCCTCTCTTAGTTGATATTTTTGTCAAGGGAGAATTAGTTTACCAGCTACC
GACCTTAGCTGAAATCAAGGCTTATGCTAAAAAAGAATTTGACAAGCTTTGGGATGAATACAAGCGTGTCTTAAATCCTC
AAGACTACCCAGTAGACTTAGCCCGTGATGTGTGGCAAAACAAGATGGCCTTAATTGATAACATTCGCAAAGATGCTTAT
GGAAAGAGTGATTTAAAATGA

Upstream 100 bases:

>100_bases
TTTTACTTTAGCGATAACTCAAGTTATTTCTAAATCCTAGCCAAAGAGTCCTTTTTAAAATATGTTATAATAGTAACAAT
AATTCAAAGGAGTCCCCTTT

Downstream 100 bases:

>100_bases
CATTACAAGAAGAGATTATCCGACAATTAGGCGTCAAGGCTAGCATTGATCCGAAAGAAGAAATTCGGAAAACCGTTGAT
TTTTTAAAAACTTATCTGCG

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFNNGYAVFAGLQRMVEYLEQFQFSETDLAYLEELGYPE
NFLTYLKELRLELTIRSAKEGDLVFANEPIVQVEGPLGQCQLVETALLNIVNFQTLIATKAARIRSVIEDEPLLEFGTRR
AQELDAAIWGTRAAMIGGADATSNVRAGKRFGIPVSGTHAHALVQAYGNDYDAFMAYAKTHKDCVFLVDTYDTLKVGVPT
AIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLDDAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYD
QPALGAVYKIVSIEQEDGSMRDTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITFTDINVNELTEIEMFHPTYTYI
KKTVRNFDAIPLLVDIFVKGELVYQLPTLAEIKAYAKKEFDKLWDEYKRVLNPQDYPVDLARDVWQNKMALIDNIRKDAY
GKSDLK

Sequences:

>Translated_486_residues
MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFNNGYAVFAGLQRMVEYLEQFQFSETDLAYLEELGYPE
NFLTYLKELRLELTIRSAKEGDLVFANEPIVQVEGPLGQCQLVETALLNIVNFQTLIATKAARIRSVIEDEPLLEFGTRR
AQELDAAIWGTRAAMIGGADATSNVRAGKRFGIPVSGTHAHALVQAYGNDYDAFMAYAKTHKDCVFLVDTYDTLKVGVPT
AIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLDDAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYD
QPALGAVYKIVSIEQEDGSMRDTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITFTDINVNELTEIEMFHPTYTYI
KKTVRNFDAIPLLVDIFVKGELVYQLPTLAEIKAYAKKEFDKLWDEYKRVLNPQDYPVDLARDVWQNKMALIDNIRKDAY
GKSDLK
>Mature_486_residues
MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFNNGYAVFAGLQRMVEYLEQFQFSETDLAYLEELGYPE
NFLTYLKELRLELTIRSAKEGDLVFANEPIVQVEGPLGQCQLVETALLNIVNFQTLIATKAARIRSVIEDEPLLEFGTRR
AQELDAAIWGTRAAMIGGADATSNVRAGKRFGIPVSGTHAHALVQAYGNDYDAFMAYAKTHKDCVFLVDTYDTLKVGVPT
AIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLDDAGFTEAKIYASNDLDENTILNLKMQKAKIDVWGVGTKLITAYD
QPALGAVYKIVSIEQEDGSMRDTIKLSNNAEKVSTPGKKQVWRITSREKGKSEGDYITFTDINVNELTEIEMFHPTYTYI
KKTVRNFDAIPLLVDIFVKGELVYQLPTLAEIKAYAKKEFDKLWDEYKRVLNPQDYPVDLARDVWQNKMALIDNIRKDAY
GKSDLK

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=527, Percent_Identity=31.3092979127135, Blast_Score=243, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71997952, Length=534, Percent_Identity=35.9550561797753, Blast_Score=301, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI71997947, Length=534, Percent_Identity=35.9550561797753, Blast_Score=301, Evalue=5e-82,
Organism=Caenorhabditis elegans, GI71997955, Length=217, Percent_Identity=45.1612903225806, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24581587, Length=526, Percent_Identity=34.6007604562738, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI161076680, Length=206, Percent_Identity=42.2330097087379, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24581595, Length=206, Percent_Identity=42.2330097087379, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI28574709, Length=206, Percent_Identity=42.2330097087379, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24581593, Length=206, Percent_Identity=42.2330097087379, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24581591, Length=206, Percent_Identity=42.2330097087379, Blast_Score=153, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 55224; Mature: 55224

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFNNGYAVFAGLQRMVEYL
CCCCCCEEEEECCEEHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHH
EQFQFSETDLAYLEELGYPENFLTYLKELRLELTIRSAKEGDLVFANEPIVQVEGPLGQC
HHHCCCCCHHHHHHHCCCCHHHHHHHHHHHEEEEEECCCCCCEEEECCCEEEECCCCCCH
QLVETALLNIVNFQTLIATKAARIRSVIEDEPLLEFGTRRAQELDAAIWGTRAAMIGGAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHEECCCC
ATSNVRAGKRFGIPVSGTHAHALVQAYGNDYDAFMAYAKTHKDCVFLVDTYDTLKVGVPT
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCEEECCCH
AIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLDDAGFTEAKIYASNDLDENTILNLK
HHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEE
MQKAKIDVWGVGTKLITAYDQPALGAVYKIVSIEQEDGSMRDTIKLSNNAEKVSTPGKKQ
EEEEEEEEEECCCEEEEECCCCHHHHHEEEEEEECCCCCCEEEEEECCCCHHCCCCCHHH
VWRITSREKGKSEGDYITFTDINVNELTEIEMFHPTYTYIKKTVRNFDAIPLLVDIFVKG
EEEECCCCCCCCCCCEEEEEECCHHHCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHCCC
ELVYQLPTLAEIKAYAKKEFDKLWDEYKRVLNPQDYPVDLARDVWQNKMALIDNIRKDAY
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
GKSDLK
CCCCCC
>Mature Secondary Structure
MYKDDSLTLHTDLYQINMMQVYFEQGIHNRHAVFEVYFRKEPFNNGYAVFAGLQRMVEYL
CCCCCCEEEEECCEEHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHH
EQFQFSETDLAYLEELGYPENFLTYLKELRLELTIRSAKEGDLVFANEPIVQVEGPLGQC
HHHCCCCCHHHHHHHCCCCHHHHHHHHHHHEEEEEECCCCCCEEEECCCEEEECCCCCCH
QLVETALLNIVNFQTLIATKAARIRSVIEDEPLLEFGTRRAQELDAAIWGTRAAMIGGAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHEECCCC
ATSNVRAGKRFGIPVSGTHAHALVQAYGNDYDAFMAYAKTHKDCVFLVDTYDTLKVGVPT
CCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCEEECCCH
AIRVAKEMGDKINFLGVRLDSGDLAYLSKTVRQQLDDAGFTEAKIYASNDLDENTILNLK
HHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEE
MQKAKIDVWGVGTKLITAYDQPALGAVYKIVSIEQEDGSMRDTIKLSNNAEKVSTPGKKQ
EEEEEEEEEECCCEEEEECCCCHHHHHEEEEEEECCCCCCEEEEEECCCCHHCCCCCHHH
VWRITSREKGKSEGDYITFTDINVNELTEIEMFHPTYTYIKKTVRNFDAIPLLVDIFVKG
EEEECCCCCCCCCCCEEEEEECCHHHCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHCCC
ELVYQLPTLAEIKAYAKKEFDKLWDEYKRVLNPQDYPVDLARDVWQNKMALIDNIRKDAY
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
GKSDLK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]