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The map label for this gene is pgcA [H]

Identifier: 19746456

GI number: 19746456

Start: 1252045

End: 1253739

Strand: Reverse

Name: pgcA [H]

Synonym: spyM18_1521

Alternate gene names: 19746456

Gene position: 1253739-1252045 (Counterclockwise)

Preceding gene: 19746457

Following gene: 19746455

Centisome position: 66.16

GC content: 37.99

Gene sequence:

>1695_bases
ATGACTTACAACGAGGTATATCAAGAATGGTTGCACAATAATGATCTTAGTGATGATATTAAAGCAGATTTAGCAGCCAT
AAAAGACAATGAGGCTGAGATTCAAGATCGTTTTTACAAAACACTTGAATTTGGAACAGCAGGGCTAAGAGGAAAACTTG
GAGCAGGCACCAATCGCATGAATACCTATATGGTTGGTAAGGCAGCACAAGCTTTAGCTAATACTATTATTGATCATGGA
CCTGAAGCGGTTAAAAAGGGCATTGCGGTTAGTTATGATGTTCGCTATCAATCTAGAACATTTGCAGAATTAACATGCTC
TATTATGGCAGCTAACGGTATTAAGGCGTACCTTTATAAAGGGATTCGGCCAACACCAATGTGTTCGTACGCTATTCGTG
CTTTGGGATGTATCTCTGGTGTTATGATTACGGCTAGTCACAATCCCCAAGCTTACAATGGTTACAAAGCTTATTGGCAA
GAAGGTTCTCAAATTTTGGATGACATTGCGGATCAAATTGCACAACACATGGCTGCACTAACTCAGTATCAGGAAATCAA
ACAAATGCCTTTTGAAAAGGCTCTGGACAGTGGACTTGTTACTTATATTGATGAGAGTATTGAAGAAGCATATAAAAAAG
AAGTGCTTGGTTTAACGATTAATGATACTGACATTGATAAGTCAGTCCGAGTAGTCTATACCCCTTTAAATGGTGTTGGG
AATCTACCAGTGCGTGAGGTTTTAAGACGCCGCGGTTTTGAAAATGTTTATGTGGTACCTGAGCAGGAAATGCCCGATCC
TGATTTTACAACAGTTGGCTATCCTAATCCCGAAGTCCCTAAAACTTTTGCATATTCAGAAAAATTAGGTAAGGCAGTTG
ATGCTGATATTTTGATTGCAACTGATCCAGATTGTGACCGTGTGGCTTTAGAAGTTAAAAACGCAGTCGGTGACTATGTT
TTTCTCAATGGCAATAAAATCGGAGCGCTTTTATCTTACTATATCTTTTCACAACGATTTGACTTAGGCAATTTACCGGC
TAATCCTGTTTTAGTGAAATCCATTGTAACAGGAGACTTGTCACGGGCTATTGCTAGCCATTATGGTATTGAAACCGTTG
AAACATTGACTGGTTTTAAGAATATTTGTGGCAAGGCAAACGAATATGATGTGACGAAACAGAAAAACTATCTGTTTGGT
TATGAAGAAAGTATTGGTTTTTGCTATGGCACTTTTGTTCGTGACAAAGACGCTGTTAGCGCCTCTATGATGATTGTAGA
AATGGCAGCTTACTACAAGAAAAAGGGGCAGAATTTACTAGATGTTTTGCAGACTATTTATGCGACATTTGGGTATTATA
ATGAACGTCAAATTGCCTTGGAGCTTGAGGGGATAGAAGGACAAAAACGCATTGCGAGGATAATGGAAGATTTCAGACAG
ACACCAATAGCTAGTGTTGCAGAGATGGCGTTAGACAAGACAATTGATTTTATTGATGGCTATCAAGATTTTCCAAAACA
AAACTGTCTCAAATTTTATTTGGATGATGGTTCTTGGTATGCACTTAGACCATCAGGAACAGAGCCTAAAATAAAATTTT
ATTTATATACTATTGGCCAAACACAAGAAAATAGTGCAACAAAATTAGATGCTATTGAAACAGCGTGTCGCACAAAAATA
AATCAGGTTAATTAA

Upstream 100 bases:

>100_bases
TTTAGATTATTTGATACTATTCAGTTGTCTCCCTTAGAGAAAGCGATTTCTTGTTTTGGAGCTGATTTTTACCATTTGGT
CTTAGAATAGGATGAGTAAT

Downstream 100 bases:

>100_bases
ACATCAAAAATGGATAACACTTTTACACTATTTTTCCATATAAACAACTACAAAAGGAGGTGAGACTTTTAGGCACCTTC
TTTTTCTTGTAGGTGCCACT

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MTYNEVYQEWLHNNDLSDDIKADLAAIKDNEAEIQDRFYKTLEFGTAGLRGKLGAGTNRMNTYMVGKAAQALANTIIDHG
PEAVKKGIAVSYDVRYQSRTFAELTCSIMAANGIKAYLYKGIRPTPMCSYAIRALGCISGVMITASHNPQAYNGYKAYWQ
EGSQILDDIADQIAQHMAALTQYQEIKQMPFEKALDSGLVTYIDESIEEAYKKEVLGLTINDTDIDKSVRVVYTPLNGVG
NLPVREVLRRRGFENVYVVPEQEMPDPDFTTVGYPNPEVPKTFAYSEKLGKAVDADILIATDPDCDRVALEVKNAVGDYV
FLNGNKIGALLSYYIFSQRFDLGNLPANPVLVKSIVTGDLSRAIASHYGIETVETLTGFKNICGKANEYDVTKQKNYLFG
YEESIGFCYGTFVRDKDAVSASMMIVEMAAYYKKKGQNLLDVLQTIYATFGYYNERQIALELEGIEGQKRIARIMEDFRQ
TPIASVAEMALDKTIDFIDGYQDFPKQNCLKFYLDDGSWYALRPSGTEPKIKFYLYTIGQTQENSATKLDAIETACRTKI
NQVN

Sequences:

>Translated_564_residues
MTYNEVYQEWLHNNDLSDDIKADLAAIKDNEAEIQDRFYKTLEFGTAGLRGKLGAGTNRMNTYMVGKAAQALANTIIDHG
PEAVKKGIAVSYDVRYQSRTFAELTCSIMAANGIKAYLYKGIRPTPMCSYAIRALGCISGVMITASHNPQAYNGYKAYWQ
EGSQILDDIADQIAQHMAALTQYQEIKQMPFEKALDSGLVTYIDESIEEAYKKEVLGLTINDTDIDKSVRVVYTPLNGVG
NLPVREVLRRRGFENVYVVPEQEMPDPDFTTVGYPNPEVPKTFAYSEKLGKAVDADILIATDPDCDRVALEVKNAVGDYV
FLNGNKIGALLSYYIFSQRFDLGNLPANPVLVKSIVTGDLSRAIASHYGIETVETLTGFKNICGKANEYDVTKQKNYLFG
YEESIGFCYGTFVRDKDAVSASMMIVEMAAYYKKKGQNLLDVLQTIYATFGYYNERQIALELEGIEGQKRIARIMEDFRQ
TPIASVAEMALDKTIDFIDGYQDFPKQNCLKFYLDDGSWYALRPSGTEPKIKFYLYTIGQTQENSATKLDAIETACRTKI
NQVN
>Mature_563_residues
TYNEVYQEWLHNNDLSDDIKADLAAIKDNEAEIQDRFYKTLEFGTAGLRGKLGAGTNRMNTYMVGKAAQALANTIIDHGP
EAVKKGIAVSYDVRYQSRTFAELTCSIMAANGIKAYLYKGIRPTPMCSYAIRALGCISGVMITASHNPQAYNGYKAYWQE
GSQILDDIADQIAQHMAALTQYQEIKQMPFEKALDSGLVTYIDESIEEAYKKEVLGLTINDTDIDKSVRVVYTPLNGVGN
LPVREVLRRRGFENVYVVPEQEMPDPDFTTVGYPNPEVPKTFAYSEKLGKAVDADILIATDPDCDRVALEVKNAVGDYVF
LNGNKIGALLSYYIFSQRFDLGNLPANPVLVKSIVTGDLSRAIASHYGIETVETLTGFKNICGKANEYDVTKQKNYLFGY
EESIGFCYGTFVRDKDAVSASMMIVEMAAYYKKKGQNLLDVLQTIYATFGYYNERQIALELEGIEGQKRIARIMEDFRQT
PIASVAEMALDKTIDFIDGYQDFPKQNCLKFYLDDGSWYALRPSGTEPKIKFYLYTIGQTQENSATKLDAIETACRTKIN
QVN

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=565, Percent_Identity=31.858407079646, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI31377548, Length=537, Percent_Identity=30.3538175046555, Blast_Score=226, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI71993870, Length=550, Percent_Identity=30.5454545454545, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI71993878, Length=291, Percent_Identity=31.6151202749141, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6323934, Length=452, Percent_Identity=33.8495575221239, Blast_Score=214, Evalue=4e-56,
Organism=Drosophila melanogaster, GI20129809, Length=577, Percent_Identity=31.5424610051993, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24651977, Length=464, Percent_Identity=33.8362068965517, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24653722, Length=448, Percent_Identity=29.4642857142857, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17864244, Length=442, Percent_Identity=23.7556561085973, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 63142; Mature: 63011

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYNEVYQEWLHNNDLSDDIKADLAAIKDNEAEIQDRFYKTLEFGTAGLRGKLGAGTNRM
CCHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NTYMVGKAAQALANTIIDHGPEAVKKGIAVSYDVRYQSRTFAELTCSIMAANGIKAYLYK
CEEEHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHC
GIRPTPMCSYAIRALGCISGVMITASHNPQAYNGYKAYWQEGSQILDDIADQIAQHMAAL
CCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TQYQEIKQMPFEKALDSGLVTYIDESIEEAYKKEVLGLTINDTDIDKSVRVVYTPLNGVG
HHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCC
NLPVREVLRRRGFENVYVVPEQEMPDPDFTTVGYPNPEVPKTFAYSEKLGKAVDADILIA
CCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEE
TDPDCDRVALEVKNAVGDYVFLNGNKIGALLSYYIFSQRFDLGNLPANPVLVKSIVTGDL
CCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
SRAIASHYGIETVETLTGFKNICGKANEYDVTKQKNYLFGYEESIGFCYGTFVRDKDAVS
HHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCEEEEEHCCCCHHHH
ASMMIVEMAAYYKKKGQNLLDVLQTIYATFGYYNERQIALELEGIEGQKRIARIMEDFRQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
TPIASVAEMALDKTIDFIDGYQDFPKQNCLKFYLDDGSWYALRPSGTEPKIKFYLYTIGQ
CHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCCEEEECCCCCCCEEEEEEEEECC
TQENSATKLDAIETACRTKINQVN
CCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TYNEVYQEWLHNNDLSDDIKADLAAIKDNEAEIQDRFYKTLEFGTAGLRGKLGAGTNRM
CHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NTYMVGKAAQALANTIIDHGPEAVKKGIAVSYDVRYQSRTFAELTCSIMAANGIKAYLYK
CEEEHHHHHHHHHHHHHHCCHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHC
GIRPTPMCSYAIRALGCISGVMITASHNPQAYNGYKAYWQEGSQILDDIADQIAQHMAAL
CCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TQYQEIKQMPFEKALDSGLVTYIDESIEEAYKKEVLGLTINDTDIDKSVRVVYTPLNGVG
HHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCEEEEEECCCCCC
NLPVREVLRRRGFENVYVVPEQEMPDPDFTTVGYPNPEVPKTFAYSEKLGKAVDADILIA
CCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEE
TDPDCDRVALEVKNAVGDYVFLNGNKIGALLSYYIFSQRFDLGNLPANPVLVKSIVTGDL
CCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
SRAIASHYGIETVETLTGFKNICGKANEYDVTKQKNYLFGYEESIGFCYGTFVRDKDAVS
HHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCCCEEEEEHCCCCHHHH
ASMMIVEMAAYYKKKGQNLLDVLQTIYATFGYYNERQIALELEGIEGQKRIARIMEDFRQ
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
TPIASVAEMALDKTIDFIDGYQDFPKQNCLKFYLDDGSWYALRPSGTEPKIKFYLYTIGQ
CHHHHHHHHHHHHHHHHHCCHHHCCCCCCEEEEEECCCEEEECCCCCCCEEEEEEEEECC
TQENSATKLDAIETACRTKINQVN
CCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]