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The map label for this gene is prsA [H]

Identifier: 19746356

GI number: 19746356

Start: 1170758

End: 1171813

Strand: Reverse

Name: prsA [H]

Synonym: spyM18_1400

Alternate gene names: 19746356

Gene position: 1171813-1170758 (Counterclockwise)

Preceding gene: 19746357

Following gene: 19746355

Centisome position: 61.84

GC content: 36.17

Gene sequence:

>1056_bases
ATGAAAAACTCAAATAAACTCATTGCTAGTGTTGTGACATTGGCCTCAGTGATGGCTTTAGCAGCTTGTCAATCAACTAA
TGACAATACTAAGGTTATTTCGATGAAAGGTGATACAATTAGCGTTAGTGATTTTTACAATGAAACAAAAAACACAGAAG
TATCGCAAAAAGCGATGCTAAATCTGGTAATTAGTCGTGTTTTTGAAGCTCAATATGGTGATAAGGTTTCAAAAAAAGAA
GTTGAAAAGGCGTATCATAAAACAGCTGAACAGTATGGCGCTTCATTCTCTGCTGCTTTGGCACAATCAAGCTTGACACC
TGAGACTTTTAAGCGTCAGATCCGCTCTTCAAAATTAGTAGAATATGCGGTTAAAGAAGCAGCTAAAAAAGAATTGACAA
CACAAGAATATAAGAAAGCATATGAATCTTATACTCCAACAATGGCAGTCGAAATGATTACTTTAGATAATGATGAGACA
GCTAAATCAGTCTTAGAGGAACTAAAAGCCGAAGGCGCAGACTTTACAGCTATTGCTAAAGAAAAAACAACAACACCTGA
GAAAAAAGTGACCTATAAATTTGATTCAGGCGCGATAAATGTACCGACTGATGTCGTAAAAGCGGCTTCAAGTTTGAATG
AGGGGGGCATATCAGACGTTATCTCGGTTTTAGATCCAACTTCTTATCAAAAGAAGTTTTACATTGTTAAGGTGACTAAA
AAAGCAGAAAAAAAATCAGATTGGCAAGAATATAAGAAACGTTTGAAAGCTATCATTATAGCTGAAAAATCAAAAGATAT
GAATTTCCAGAACAAGGTTATTGCAAATGCATTGGATAAAGCTAATGTAAAAATTAAAGACAAAGCTTTTGCTAATATTT
TGGCGCAATATGCAAATCTTGGTCAAAAAACTAAAGCTGCAAGTGAAAGTTCAACAACCAGCGAATCATCAAAAGCTGCA
GAAGAGAACCCATCAGAATCAGAGCAAACACAGACATCATCAGCTGAAGAACCAACTGAGACTGAGGCTCAGACGCAAGA
GCCAGCTGCACAATAA

Upstream 100 bases:

>100_bases
TTCGTAAAAATCAAGCAGATATTGTATTACCAGATTAAGTAACATTGATAAATTTATGTTATAATAAATTAGTTAAAGAT
AAAAAGGAGCTCAGAAGTAA

Downstream 100 bases:

>100_bases
GTAGGATTTTATTGACTAATCAGTTAAAAAAACTTATAATAATTTAGTTAAGAATTGTTTATCAAGGATTAGATACAGAA
AAGTGACGGTTGCTGCGAGT

Product: foldase protein PrsA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSDFYNETKNTEVSQKAMLNLVISRVFEAQYGDKVSKKE
VEKAYHKTAEQYGASFSAALAQSSLTPETFKRQIRSSKLVEYAVKEAAKKELTTQEYKKAYESYTPTMAVEMITLDNDET
AKSVLEELKAEGADFTAIAKEKTTTPEKKVTYKFDSGAINVPTDVVKAASSLNEGGISDVISVLDPTSYQKKFYIVKVTK
KAEKKSDWQEYKKRLKAIIIAEKSKDMNFQNKVIANALDKANVKIKDKAFANILAQYANLGQKTKAASESSTTSESSKAA
EENPSESEQTQTSSAEEPTETEAQTQEPAAQ

Sequences:

>Translated_351_residues
MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSDFYNETKNTEVSQKAMLNLVISRVFEAQYGDKVSKKE
VEKAYHKTAEQYGASFSAALAQSSLTPETFKRQIRSSKLVEYAVKEAAKKELTTQEYKKAYESYTPTMAVEMITLDNDET
AKSVLEELKAEGADFTAIAKEKTTTPEKKVTYKFDSGAINVPTDVVKAASSLNEGGISDVISVLDPTSYQKKFYIVKVTK
KAEKKSDWQEYKKRLKAIIIAEKSKDMNFQNKVIANALDKANVKIKDKAFANILAQYANLGQKTKAASESSTTSESSKAA
EENPSESEQTQTSSAEEPTETEAQTQEPAAQ
>Mature_351_residues
MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSDFYNETKNTEVSQKAMLNLVISRVFEAQYGDKVSKKE
VEKAYHKTAEQYGASFSAALAQSSLTPETFKRQIRSSKLVEYAVKEAAKKELTTQEYKKAYESYTPTMAVEMITLDNDET
AKSVLEELKAEGADFTAIAKEKTTTPEKKVTYKFDSGAINVPTDVVKAASSLNEGGISDVISVLDPTSYQKKFYIVKVTK
KAEKKSDWQEYKKRLKAIIIAEKSKDMNFQNKVIANALDKANVKIKDKAFANILAQYANLGQKTKAASESSTTSESSKAA
EENPSESEQTQTSSAEEPTETEAQTQEPAAQ

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR008880 [H]

Pfam domain/function: NA

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 38534; Mature: 38534

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSDFYNETKNTEVSQKAML
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHCCCHHHHHHHH
NLVISRVFEAQYGDKVSKKEVEKAYHKTAEQYGASFSAALAQSSLTPETFKRQIRSSKLV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
EYAVKEAAKKELTTQEYKKAYESYTPTMAVEMITLDNDETAKSVLEELKAEGADFTAIAK
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEECC
EKTTTPEKKVTYKFDSGAINVPTDVVKAASSLNEGGISDVISVLDPTSYQKKFYIVKVTK
CCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECC
KAEKKSDWQEYKKRLKAIIIAEKSKDMNFQNKVIANALDKANVKIKDKAFANILAQYANL
HHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCC
GQKTKAASESSTTSESSKAAEENPSESEQTQTSSAEEPTETEAQTQEPAAQ
CHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MKNSNKLIASVVTLASVMALAACQSTNDNTKVISMKGDTISVSDFYNETKNTEVSQKAML
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEHHHHHHHHCCCHHHHHHHH
NLVISRVFEAQYGDKVSKKEVEKAYHKTAEQYGASFSAALAQSSLTPETFKRQIRSSKLV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
EYAVKEAAKKELTTQEYKKAYESYTPTMAVEMITLDNDETAKSVLEELKAEGADFTAIAK
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCEEEECC
EKTTTPEKKVTYKFDSGAINVPTDVVKAASSLNEGGISDVISVLDPTSYQKKFYIVKVTK
CCCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECC
KAEKKSDWQEYKKRLKAIIIAEKSKDMNFQNKVIANALDKANVKIKDKAFANILAQYANL
HHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHCC
GQKTKAASESSTTSESSKAAEENPSESEQTQTSSAEEPTETEAQTQEPAAQ
CHHHHHCCCCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]