| Definition | Pyrococcus furiosus DSM 3638, complete genome. |
|---|---|
| Accession | NC_003413 |
| Length | 1,908,256 |
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The map label for this gene is dapE [H]
Identifier: 18978420
GI number: 18978420
Start: 1889624
End: 1890964
Strand: Direct
Name: dapE [H]
Synonym: PF2048
Alternate gene names: 18978420
Gene position: 1889624-1890964 (Clockwise)
Preceding gene: 18978419
Following gene: 18978423
Centisome position: 99.02
GC content: 40.87
Gene sequence:
>1341_bases ATGAGGTCCGCATCACCTGAGGGGATGGATATGGACGTGCTTGAACTTCTTTCTCAATTGGTTGAGTTCGAAACCGTTAA TGATCCAGCAAAGGGAATAAAACCCACCAAAGAATGTCCCAAGTTCATCAAAGATACGCTGGAAGAGTGGGAAGTTGAAG CTGACGTTTTTGAAGAGAACGGCTATTATGGAGTATTAGGGGAAATTGGAAAAGGTTATCCAAAGCTCCTCTTCATGGCT CACTTCGACGTAGTCCCAGTAAATCCAGAAGAGTGGAACACAGATCCATTCAAATTAACCATAATAGGAAACAAAGCGTA TGGAAGGGGAAGCGTTGATGATAAAGGGAATGTTGCTGCGGTGATGGTAGCACTAAAAGAGCTTGCAAAAGAAGATATCA AAGGAAAAATAATCTTTGCCTTTACTGGAGATGAAGAAATTGGAGGATTCCTCGCTAGCAAGATTGCTGAGAGATTAAAA GAAGAGAACAAGCTACCAAAGTACATGATCAATGCAGACGGAATAGGAATGAAACCAATAATTAGGAGAAGAAAGGGGTT TGGAGCGGTTATTAGAGTTCCGATTAAGAAGATCAAGGTTAAAGGGAAAATAAAATCCAAAACATTCAAGGTAAACACCC CAATTTTAGAAACAAGACATGCTGCATATTTTCTCCCAGGAGTAGACACTCATCCACTAATAGCAGCTTCACACTTCGTA AGAACAAAAGAAGTCCCTGTAGTTTCCCTTGAGGGGAAATTCTTGAAAGGTAACGTTGTTCCCAGTGAAGTTACTTTAAC TTACCTTGAAAGAGGAGATGGAGAAGAAGTTGAAGTGGACCTTGGATTGACAGAGCTGATGAGGTCAATAGTTCCAGTTG TGAGGGCTCCAATAAAGGCGGAAAAATACAGCGACTATGGAGTGTCAATAACGCCAAACATGTATTCCATCGAAAACGAA AAACACGTTTTAAGGCTCGATATAAGGGCGATGAGTAATTCAAAAGAAGATATCGAAAAGACATTAAAAGAAGTTATCTC GTTCACTTTGCCAGAGGGAGAACTCGAAGTCAAAACTAACGAAAAAGCAGGTTATCTCTTCACAAGTCCTGAAGAAAAGA TCGTGAAAGTTGCATTGGAAGTTCTCAGAGAGCTTGGCGAAGATGTTAAACCAGTTGAGGGTCCTGGAGCCTCAGATTCA AGGTACTTCACCCCATATGGCGTAAAGGCAATAGATATCGGGCCTAAAGGAGGAAATATCCACGGACCTAATGAATTCGT TGAAATAGACTCCCTAAAAAAGATGCCAAAAGTGTATAAGGAAATTGCACTAAGGCTTTGA
Upstream 100 bases:
>100_bases CGGCAGCTACCCTGTTCCCATCATCGGGCAATTAGATTTATTACTCAAAGGTTTTTAACATCTATCACCCAATGATGATG GATCAACCGGCTGAAGTATG
Downstream 100 bases:
>100_bases TTCCAAAAAGTCAAGGAGTATTCTAATATCTGTTTTAAATGGCTCACTCGCCTTCTTTTCTTCCTCTCTTAACACCACTA TTGCCTCTTCAAGATCATTT
Product: peptidase
Products: NA
Alternate protein names: SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase [H]
Number of amino acids: Translated: 446; Mature: 446
Protein sequence:
>446_residues MRSASPEGMDMDVLELLSQLVEFETVNDPAKGIKPTKECPKFIKDTLEEWEVEADVFEENGYYGVLGEIGKGYPKLLFMA HFDVVPVNPEEWNTDPFKLTIIGNKAYGRGSVDDKGNVAAVMVALKELAKEDIKGKIIFAFTGDEEIGGFLASKIAERLK EENKLPKYMINADGIGMKPIIRRRKGFGAVIRVPIKKIKVKGKIKSKTFKVNTPILETRHAAYFLPGVDTHPLIAASHFV RTKEVPVVSLEGKFLKGNVVPSEVTLTYLERGDGEEVEVDLGLTELMRSIVPVVRAPIKAEKYSDYGVSITPNMYSIENE KHVLRLDIRAMSNSKEDIEKTLKEVISFTLPEGELEVKTNEKAGYLFTSPEEKIVKVALEVLRELGEDVKPVEGPGASDS RYFTPYGVKAIDIGPKGGNIHGPNEFVEIDSLKKMPKVYKEIALRL
Sequences:
>Translated_446_residues MRSASPEGMDMDVLELLSQLVEFETVNDPAKGIKPTKECPKFIKDTLEEWEVEADVFEENGYYGVLGEIGKGYPKLLFMA HFDVVPVNPEEWNTDPFKLTIIGNKAYGRGSVDDKGNVAAVMVALKELAKEDIKGKIIFAFTGDEEIGGFLASKIAERLK EENKLPKYMINADGIGMKPIIRRRKGFGAVIRVPIKKIKVKGKIKSKTFKVNTPILETRHAAYFLPGVDTHPLIAASHFV RTKEVPVVSLEGKFLKGNVVPSEVTLTYLERGDGEEVEVDLGLTELMRSIVPVVRAPIKAEKYSDYGVSITPNMYSIENE KHVLRLDIRAMSNSKEDIEKTLKEVISFTLPEGELEVKTNEKAGYLFTSPEEKIVKVALEVLRELGEDVKPVEGPGASDS RYFTPYGVKAIDIGPKGGNIHGPNEFVEIDSLKKMPKVYKEIALRL >Mature_446_residues MRSASPEGMDMDVLELLSQLVEFETVNDPAKGIKPTKECPKFIKDTLEEWEVEADVFEENGYYGVLGEIGKGYPKLLFMA HFDVVPVNPEEWNTDPFKLTIIGNKAYGRGSVDDKGNVAAVMVALKELAKEDIKGKIIFAFTGDEEIGGFLASKIAERLK EENKLPKYMINADGIGMKPIIRRRKGFGAVIRVPIKKIKVKGKIKSKTFKVNTPILETRHAAYFLPGVDTHPLIAASHFV RTKEVPVVSLEGKFLKGNVVPSEVTLTYLERGDGEEVEVDLGLTELMRSIVPVVRAPIKAEKYSDYGVSITPNMYSIENE KHVLRLDIRAMSNSKEDIEKTLKEVISFTLPEGELEVKTNEKAGYLFTSPEEKIVKVALEVLRELGEDVKPVEGPGASDS RYFTPYGVKAIDIGPKGGNIHGPNEFVEIDSLKKMPKVYKEIALRL
Specific function: Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bact
COG id: COG0624
COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the peptidase M20A family. DapE subfamily [H]
Homologues:
None
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005941 - InterPro: IPR002933 - InterPro: IPR011650 [H]
Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]
EC number: =3.5.1.18 [H]
Molecular weight: Translated: 49630; Mature: 49630
Theoretical pI: Translated: 5.85; Mature: 5.85
Prosite motif: PS00758 ARGE_DAPE_CPG2_1 ; PS00759 ARGE_DAPE_CPG2_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRSASPEGMDMDVLELLSQLVEFETVNDPAKGIKPTKECPKFIKDTLEEWEVEADVFEEN CCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHCCCCEEEECC GYYGVLGEIGKGYPKLLFMAHFDVVPVNPEEWNTDPFKLTIIGNKAYGRGSVDDKGNVAA CCEEECCCCCCCCHHEEEEEECCEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHH VMVALKELAKEDIKGKIIFAFTGDEEIGGFLASKIAERLKEENKLPKYMINADGIGMKPI HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHH IRRRKGFGAVIRVPIKKIKVKGKIKSKTFKVNTPILETRHAAYFLPGVDTHPLIAASHFV HHHHCCCCEEEEEEEEEEEEEEEEECCEEEECCCCEECCCCEEEECCCCCCCHHHHHHHE RTKEVPVVSLEGKFLKGNVVPSEVTLTYLERGDGEEVEVDLGLTELMRSIVPVVRAPIKA EECCCCEEEECCCEEECCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCC EKYSDYGVSITPNMYSIENEKHVLRLDIRAMSNSKEDIEKTLKEVISFTLPEGELEVKTN CCCCCCCEEECCCEEEECCCCEEEEEEEEHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEC EKAGYLFTSPEEKIVKVALEVLRELGEDVKPVEGPGASDSRYFTPYGVKAIDIGPKGGNI CCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCEEEEEECCCCCCC HGPNEFVEIDSLKKMPKVYKEIALRL CCCCHHEEHHHHHHHHHHHHHHHHCC >Mature Secondary Structure MRSASPEGMDMDVLELLSQLVEFETVNDPAKGIKPTKECPKFIKDTLEEWEVEADVFEEN CCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHHHHHHHHCCCCEEEECC GYYGVLGEIGKGYPKLLFMAHFDVVPVNPEEWNTDPFKLTIIGNKAYGRGSVDDKGNVAA CCEEECCCCCCCCHHEEEEEECCEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCHHH VMVALKELAKEDIKGKIIFAFTGDEEIGGFLASKIAERLKEENKLPKYMINADGIGMKPI HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHH IRRRKGFGAVIRVPIKKIKVKGKIKSKTFKVNTPILETRHAAYFLPGVDTHPLIAASHFV HHHHCCCCEEEEEEEEEEEEEEEEECCEEEECCCCEECCCCEEEECCCCCCCHHHHHHHE RTKEVPVVSLEGKFLKGNVVPSEVTLTYLERGDGEEVEVDLGLTELMRSIVPVVRAPIKA EECCCCEEEECCCEEECCCCCCCEEEEEEECCCCCEEEEECCHHHHHHHHHHHHHCCCCC EKYSDYGVSITPNMYSIENEKHVLRLDIRAMSNSKEDIEKTLKEVISFTLPEGELEVKTN CCCCCCCEEECCCEEEECCCCEEEEEEEEHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEC EKAGYLFTSPEEKIVKVALEVLRELGEDVKPVEGPGASDSRYFTPYGVKAIDIGPKGGNI CCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCEEEEEECCCCCCC HGPNEFVEIDSLKKMPKVYKEIALRL CCCCHHEEHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA