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The map label for this gene is nadC [H]

Identifier: 18978350

GI number: 18978350

Start: 1829236

End: 1830066

Strand: Direct

Name: nadC [H]

Synonym: PF1978

Alternate gene names: 18978350

Gene position: 1829236-1830066 (Clockwise)

Preceding gene: 18978349

Following gene: 18978354

Centisome position: 95.86

GC content: 42.84

Gene sequence:

>831_bases
ATGGAGATTCCAATTTCATACCTCTTAAAATTTGTTGAGGAAGATGCTCCTTACGGAGATATAACTAGTGAGGCAGTTAT
TCCCAGGGAGATGAGTGCTAAAGGGGTAATAATAGCGAAGCAAGAGGGGATCATAGCGGGAGTTGATGAAGCCAGAAAGC
TCTTCGAGTACTTTGGAGTTGAAGTCAATGTAAAAAAGCAAGACGGCGAATTCGTCAAGAAGGGAGATGTAATAATGGAA
GTTAAAGGAAACGCCAGGGCTATTCTGCTAGTAGAGAGAACCGCCCTCAACATAATAGGAAGAATGAGCGGAATTGCCAC
AGAAACTAGGAGACTAGTTGACATTGTTAGAGAAGTAAATCCAAAAGTAAAGATAGCGGGAACTAGGAAAAGTTTGTTGA
GGCTTCTAGATAAGAAGGCCATCATGATTGGAGGAGGGGAACCTCACAGATTTTCCCTGAGCGATGCAATACTTATCAAG
GATAATCACCTTGCCCTAGTTCCCCTAGAAGAAGCAATAAGAAGGGCCAAGGAATTCAGCGTATACAAAGTGGTGGAGGT
TGAAGTTGAAAGTCTGGAGGATGCAATAAAAGCGGCAAAAGCGGGGGCCGACGTAATAATGCTTGATAACATGACGCCCG
AAGAAATAGAGAGAGTTATAGAGGAGCTCAAGAAGTTGGGATTAAGGGAAAAAGTTAAGATTGAAATATCGGGAGGGATA
ACTCCAGAAAATATAAGAGAGTACGCAAGACTCGATGTGGATGTTATAAGCCTCGGCTACCTAACTCATTCCGTGAAGAA
CTTCGATGTCAGTCTTGAGATTGTGGGATGA

Upstream 100 bases:

>100_bases
CCTAAGGGATATGAAATATGAAGTCACCGTTCCAGAGGAGATAGCCGAAAAGGCAAGAAAAGCCATTGAAAGAATGCTTG
AGATGAGTTGAGGTGTTTCT

Downstream 100 bases:

>100_bases
GAGGCTTTCTCTTAACTGGCCCCCTGGGATACTCCTCCTCAAATATCTCAGCCGTAAACTTGTACACTTTTGTATCTTCA
TCAAGCCAGCAGTCTGGTGG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MEIPISYLLKFVEEDAPYGDITSEAVIPREMSAKGVIIAKQEGIIAGVDEARKLFEYFGVEVNVKKQDGEFVKKGDVIME
VKGNARAILLVERTALNIIGRMSGIATETRRLVDIVREVNPKVKIAGTRKSLLRLLDKKAIMIGGGEPHRFSLSDAILIK
DNHLALVPLEEAIRRAKEFSVYKVVEVEVESLEDAIKAAKAGADVIMLDNMTPEEIERVIEELKKLGLREKVKIEISGGI
TPENIREYARLDVDVISLGYLTHSVKNFDVSLEIVG

Sequences:

>Translated_276_residues
MEIPISYLLKFVEEDAPYGDITSEAVIPREMSAKGVIIAKQEGIIAGVDEARKLFEYFGVEVNVKKQDGEFVKKGDVIME
VKGNARAILLVERTALNIIGRMSGIATETRRLVDIVREVNPKVKIAGTRKSLLRLLDKKAIMIGGGEPHRFSLSDAILIK
DNHLALVPLEEAIRRAKEFSVYKVVEVEVESLEDAIKAAKAGADVIMLDNMTPEEIERVIEELKKLGLREKVKIEISGGI
TPENIREYARLDVDVISLGYLTHSVKNFDVSLEIVG
>Mature_276_residues
MEIPISYLLKFVEEDAPYGDITSEAVIPREMSAKGVIIAKQEGIIAGVDEARKLFEYFGVEVNVKKQDGEFVKKGDVIME
VKGNARAILLVERTALNIIGRMSGIATETRRLVDIVREVNPKVKIAGTRKSLLRLLDKKAIMIGGGEPHRFSLSDAILIK
DNHLALVPLEEAIRRAKEFSVYKVVEVEVESLEDAIKAAKAGADVIMLDNMTPEEIERVIEELKKLGLREKVKIEISGGI
TPENIREYARLDVDVISLGYLTHSVKNFDVSLEIVG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=269, Percent_Identity=33.8289962825279, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI1786299, Length=261, Percent_Identity=34.8659003831418, Blast_Score=129, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6321162, Length=277, Percent_Identity=34.2960288808664, Blast_Score=153, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30637; Mature: 30637

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIPISYLLKFVEEDAPYGDITSEAVIPREMSAKGVIIAKQEGIIAGVDEARKLFEYFGV
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEECHHHHHHHHHHHCC
EVNVKKQDGEFVKKGDVIMEVKGNARAILLVERTALNIIGRMSGIATETRRLVDIVREVN
EEEEECCCCCEEECCCEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKVKIAGTRKSLLRLLDKKAIMIGGGEPHRFSLSDAILIKDNHLALVPLEEAIRRAKEFS
CCEEEECCHHHHHHHHCCCEEEEECCCCCEEECCCEEEEECCCEEEEEHHHHHHHHHHCC
VYKVVEVEVESLEDAIKAAKAGADVIMLDNMTPEEIERVIEELKKLGLREKVKIEISGGI
EEEEEEHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCC
TPENIREYARLDVDVISLGYLTHSVKNFDVSLEIVG
CHHHHHHHHHCCHHHEEHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure
MEIPISYLLKFVEEDAPYGDITSEAVIPREMSAKGVIIAKQEGIIAGVDEARKLFEYFGV
CCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEECHHHHHHHHHHHCC
EVNVKKQDGEFVKKGDVIMEVKGNARAILLVERTALNIIGRMSGIATETRRLVDIVREVN
EEEEECCCCCEEECCCEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKVKIAGTRKSLLRLLDKKAIMIGGGEPHRFSLSDAILIKDNHLALVPLEEAIRRAKEFS
CCEEEECCHHHHHHHHCCCEEEEECCCCCEEECCCEEEEECCCEEEEEHHHHHHHHHHCC
VYKVVEVEVESLEDAIKAAKAGADVIMLDNMTPEEIERVIEELKKLGLREKVKIEISGGI
EEEEEEHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEEEEEEECCC
TPENIREYARLDVDVISLGYLTHSVKNFDVSLEIVG
CHHHHHHHHHCCHHHEEHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]