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The map label for this gene is sbm [H]

Identifier: 18978318

GI number: 18978318

Start: 1799153

End: 1799587

Strand: Direct

Name: sbm [H]

Synonym: PF1946

Alternate gene names: 18978318

Gene position: 1799153-1799587 (Clockwise)

Preceding gene: 18978316

Following gene: 18978319

Centisome position: 94.28

GC content: 41.84

Gene sequence:

>435_bases
ATGGTAGAGAGATCTAAAGTTAGAGTCCTAATCGCCAAGCCCGGGCTTGATGGACATGACAGAGGAGCAAAAGTTGTGGC
AAGAGCCCTTAGAGATGCTGGTTATGAAGTTATATATACGGGAATTAGACAGACTCCAGAACAGATAGTTGAGGCTGTCA
TTGAAGAAGATGTTGACGTTCTTGGGATAAGCATTTTGTCAGGAGCTCATATGGTTCTAATACCTAAGATACTAAAACTG
TTGGAGGAGAAAGGAATAAAGCCTGGAGAAGATATTCTAGTTGTTGCTGGGGGAATAATTCCACCAGATGACGCCGAAGA
ACTAAAGAAGATGGGAGTTGCAGAAGTTTTTGGCCCCGGAACTCCTCTAAAAACCATAATTGAGTTCATCGACAAAAACG
TTGAAAAGCTCAAGAAGTTCAGATCCTCTACTTAA

Upstream 100 bases:

>100_bases
TAAATAAAAATCTTGCCTTGTTTAGGATAAAATGTCCAAATTCTTTACATTTAGCAACCTTTAAATATTATTTCACGTTA
GTAAAACTTGGGGGAAGATA

Downstream 100 bases:

>100_bases
TCCTTTTATATTGTTCTTGGATAATTTCTCCAGTGATGATGTATGATAGACGACCTTGTAGAGAGAATGAGAAAAGGGGA
CAGAAGAGCCGTTGCTAGGC

Product: methylmalonyl-CoAmutase, subunit alpha

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 144; Mature: 144

Protein sequence:

>144_residues
MVERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVEAVIEEDVDVLGISILSGAHMVLIPKILKL
LEEKGIKPGEDILVVAGGIIPPDDAEELKKMGVAEVFGPGTPLKTIIEFIDKNVEKLKKFRSST

Sequences:

>Translated_144_residues
MVERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVEAVIEEDVDVLGISILSGAHMVLIPKILKL
LEEKGIKPGEDILVVAGGIIPPDDAEELKKMGVAEVFGPGTPLKTIIEFIDKNVEKLKKFRSST
>Mature_144_residues
MVERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVEAVIEEDVDVLGISILSGAHMVLIPKILKL
LEEKGIKPGEDILVVAGGIIPPDDAEELKKMGVAEVFGPGTPLKTIIEFIDKNVEKLKKFRSST

Specific function: Unknown

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=142, Percent_Identity=42.2535211267606, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1789284, Length=116, Percent_Identity=50, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI25144500, Length=131, Percent_Identity=45.8015267175573, Blast_Score=109, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 15651; Mature: 15651

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVEAVIEEDVDV
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCHHH
LGISILSGAHMVLIPKILKLLEEKGIKPGEDILVVAGGIIPPDDAEELKKMGVAEVFGPG
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHCCHHHHCCCC
TPLKTIIEFIDKNVEKLKKFRSST
CCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVERSKVRVLIAKPGLDGHDRGAKVVARALRDAGYEVIYTGIRQTPEQIVEAVIEEDVDV
CCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHCCHHH
LGISILSGAHMVLIPKILKLLEEKGIKPGEDILVVAGGIIPPDDAEELKKMGVAEVFGPG
HHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHCCHHHHCCCC
TPLKTIIEFIDKNVEKLKKFRSST
CCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]