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The map label for this gene is speH

Identifier: 18978302

GI number: 18978302

Start: 1780133

End: 1780552

Strand: Direct

Name: speH

Synonym: PF1930

Alternate gene names: 18978302

Gene position: 1780133-1780552 (Clockwise)

Preceding gene: 18978300

Following gene: 18978303

Centisome position: 93.29

GC content: 42.14

Gene sequence:

>420_bases
ATGGATACAATAGGATATCACTATGTTGTTGAAGCTGCTGGTTGCGATCCTGAAGTCATCGCTGACCCAAACAAGATTAG
AGAGATCTTTCTCGAAGCAGCAAAAGTAGGAAACATGGAAGTTAAGGCTAGCTACTTCTTTAAGTTCTCACCTATGGGGG
TAAGTGGAGTTGTCATAGTTGCCGAAAGTCACATTTCCGTCCACACTTGGCCCGAGAAAGGATATGCTGCTTTAGATGTC
TATACATGCGGTGAAAAAGCAGATCCAGAAAAGGCCGTTGATTACATCTTAGAGAAGTTTAAAGCAAAGTACGCTCACGT
ATCAGAATTAAAGAGGGGGATTGAGGAGGAAGATAGCACATTTACTCATACCATCCTAACCTGGGAAGAAAAACTTGACA
GAAGAAACGGCAACAAGTAA

Upstream 100 bases:

>100_bases
ACTAAAATATCCCGATAATTTCTTTTCACTATACCAAAAAACTTTAAAAGTATCCCCATTCCAGTATCAAAATGTAAATA
GAAGGTGGGGAGGTGAGAGA

Downstream 100 bases:

>100_bases
TTCTTCTCTTCCTTGGCTTTTTCTTGATGCTTTTCTATTTCTACCTAATATGGGTTTTAGGGCTCAATGTTTTTTTTTTT
TGTGATGAATATTCCAAGGT

Product: S-adenosylmethionine decarboxylase proenzyme

Products: NA

Alternate protein names: AdoMetDC; SAMDC

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MDTIGYHYVVEAAGCDPEVIADPNKIREIFLEAAKVGNMEVKASYFFKFSPMGVSGVVIVAESHISVHTWPEKGYAALDV
YTCGEKADPEKAVDYILEKFKAKYAHVSELKRGIEEEDSTFTHTILTWEEKLDRRNGNK

Sequences:

>Translated_139_residues
MDTIGYHYVVEAAGCDPEVIADPNKIREIFLEAAKVGNMEVKASYFFKFSPMGVSGVVIVAESHISVHTWPEKGYAALDV
YTCGEKADPEKAVDYILEKFKAKYAHVSELKRGIEEEDSTFTHTILTWEEKLDRRNGNK
>Mature_139_residues
MDTIGYHYVVEAAGCDPEVIADPNKIREIFLEAAKVGNMEVKASYFFKFSPMGVSGVVIVAESHISVHTWPEKGYAALDV
YTCGEKADPEKAVDYILEKFKAKYAHVSELKRGIEEEDSTFTHTILTWEEKLDRRNGNK

Specific function: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine

COG id: COG1586

COG function: function code E; S-adenosylmethionine decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPEH_PYRFU (Q8TZQ6)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579659.1
- ProteinModelPortal:   Q8TZQ6
- SMR:   Q8TZQ6
- EnsemblBacteria:   EBPYRT00000005483
- GeneID:   1469810
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1930
- NMPDR:   fig|186497.1.peg.1980
- GeneTree:   EBGT00050000022184
- HOGENOM:   HBG485559
- OMA:   VEAAGCD
- ProtClustDB:   PRK04025
- BRENDA:   4.1.1.50
- HAMAP:   MF_00464
- InterPro:   IPR003826
- InterPro:   IPR016067
- InterPro:   IPR017716
- Gene3D:   G3DSA:3.60.90.10
- TIGRFAMs:   TIGR03330

Pfam domain/function: PF02675 AdoMet_dc; SSF56276 S-AdenosylMet_decarbase_core

EC number: =4.1.1.50

Molecular weight: Translated: 15662; Mature: 15662

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: ACT_SITE 63-63 ACT_SITE 68-68 ACT_SITE 83-83

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTIGYHYVVEAAGCDPEVIADPNKIREIFLEAAKVGNMEVKASYFFKFSPMGVSGVVIV
CCCCCEEEEEEECCCCCCEECCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCEEEEE
AESHISVHTWPEKGYAALDVYTCGEKADPEKAVDYILEKFKAKYAHVSELKRGIEEEDST
EECCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FTHTILTWEEKLDRRNGNK
EEEEEEEHHHHHHHCCCCC
>Mature Secondary Structure
MDTIGYHYVVEAAGCDPEVIADPNKIREIFLEAAKVGNMEVKASYFFKFSPMGVSGVVIV
CCCCCEEEEEEECCCCCCEECCHHHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCEEEEE
AESHISVHTWPEKGYAALDVYTCGEKADPEKAVDYILEKFKAKYAHVSELKRGIEEEDST
EECCEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FTHTILTWEEKLDRRNGNK
EEEEEEEHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA