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The map label for this gene is thiL [H]

Identifier: 18978249

GI number: 18978249

Start: 1730235

End: 1731149

Strand: Direct

Name: thiL [H]

Synonym: PF1877

Alternate gene names: 18978249

Gene position: 1730235-1731149 (Clockwise)

Preceding gene: 18978247

Following gene: 18978250

Centisome position: 90.67

GC content: 40.66

Gene sequence:

>915_bases
ATGAAAGAGACCGAAATCATCAAGTTGTTTCAAGAAGAATTGAAGTCAAAAGTGCTTGGAGACGATGCAGGATTTATAAA
ACTTGGGGACAGATGGCTATTACTAACAAATGACATGTTAGTGTGGAGAACAGATGTTCCCGACTTCATGACCCCCGAAG
AAGCTGGAGCAAAAGTTGTTACAATGAACGTAAGTGACATAGCAGCCATGGGAGGAAAGCCGATAGGATTCTTCTTTTCT
CTGGGACTTCCAAGAGATATTAACGAAAAAACACTAAGAGAAATTGCCAAAGGAATTAAAAGAGGGACTAAAAGGTACAA
TGTGGAGGTTCTAAGTGGAGACACAAACGAGAGCAATGAGCTTGTTATAGACGGAGGAGCCATTGGAGAAGCAGAAAGAA
TTCTCTTGAGAAGTGGTGCAAAACCTGGAGAGGTGGTTTGTGTTACTGGAGATCTTGGTAGGCCTCTAACTGCCCTTCTA
CTATGGTTGAAAGGAGAAAAAATTCCCAGGGAGATAGCTGAAAAAATGAAAAATCCTATTGCAAGGGTAAGGGAAGGGTT
AGAATTAGCAAACTACGCAAGCTCAGCAATTGACATAAGCGATGGACTATCGAAGGAACTCTGGGAGATATCAAAAGCGA
GTAAAGTAAAAATAGTTATAGACCCAAATTCGCTTCCAGTACATGAAAAGGTTAAAGAGATCGTTAAAAACCCAGTAGAA
GTTGCTCTTGCCAGTGGAGAGGAGTTTGAACTTGTGTTCACGATATCCCAGGAGTATTTGGACATCCTAAGCTTTGAATT
TTCTATAATTGGAAGAGTCGAAAAAGGAGAAGGAGTGTATACAACAACAGGAGAAAAAGTGCCAATGCGTGGATGGGAAC
ATTTTGCTGGTGGTAATAATGATATTGGAAGTTAG

Upstream 100 bases:

>100_bases
ATGTAGCATAAGCCTCTAACGTTGCCTCATTCATTGGCATCACCATTAAATTAAAACTTGACGATAAATATAAACCTTTA
ACTTGTTATGGTGAGGAAAG

Downstream 100 bases:

>100_bases
GAAATTCCAAGTAAAAAATAAAGCAGTTTACATAGGGACATTAAGTGAGGACAAGATTTTTGGAATTATATTTTCTATAG
ATGAGCCGGAAGTTATAAGG

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MKETEIIKLFQEELKSKVLGDDAGFIKLGDRWLLLTNDMLVWRTDVPDFMTPEEAGAKVVTMNVSDIAAMGGKPIGFFFS
LGLPRDINEKTLREIAKGIKRGTKRYNVEVLSGDTNESNELVIDGGAIGEAERILLRSGAKPGEVVCVTGDLGRPLTALL
LWLKGEKIPREIAEKMKNPIARVREGLELANYASSAIDISDGLSKELWEISKASKVKIVIDPNSLPVHEKVKEIVKNPVE
VALASGEEFELVFTISQEYLDILSFEFSIIGRVEKGEGVYTTTGEKVPMRGWEHFAGGNNDIGS

Sequences:

>Translated_304_residues
MKETEIIKLFQEELKSKVLGDDAGFIKLGDRWLLLTNDMLVWRTDVPDFMTPEEAGAKVVTMNVSDIAAMGGKPIGFFFS
LGLPRDINEKTLREIAKGIKRGTKRYNVEVLSGDTNESNELVIDGGAIGEAERILLRSGAKPGEVVCVTGDLGRPLTALL
LWLKGEKIPREIAEKMKNPIARVREGLELANYASSAIDISDGLSKELWEISKASKVKIVIDPNSLPVHEKVKEIVKNPVE
VALASGEEFELVFTISQEYLDILSFEFSIIGRVEKGEGVYTTTGEKVPMRGWEHFAGGNNDIGS
>Mature_304_residues
MKETEIIKLFQEELKSKVLGDDAGFIKLGDRWLLLTNDMLVWRTDVPDFMTPEEAGAKVVTMNVSDIAAMGGKPIGFFFS
LGLPRDINEKTLREIAKGIKRGTKRYNVEVLSGDTNESNELVIDGGAIGEAERILLRSGAKPGEVVCVTGDLGRPLTALL
LWLKGEKIPREIAEKMKNPIARVREGLELANYASSAIDISDGLSKELWEISKASKVKIVIDPNSLPVHEKVKEIVKNPVE
VALASGEEFELVFTISQEYLDILSFEFSIIGRVEKGEGVYTTTGEKVPMRGWEHFAGGNNDIGS

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=322, Percent_Identity=30.1242236024845, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 33449; Mature: 33449

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETEIIKLFQEELKSKVLGDDAGFIKLGDRWLLLTNDMLVWRTDVPDFMTPEEAGAKVV
CCHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEECCEEEEECCCCCCCCCHHHCCEEE
TMNVSDIAAMGGKPIGFFFSLGLPRDINEKTLREIAKGIKRGTKRYNVEVLSGDTNESNE
EEEHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCE
LVIDGGAIGEAERILLRSGAKPGEVVCVTGDLGRPLTALLLWLKGEKIPREIAEKMKNPI
EEEECCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
ARVREGLELANYASSAIDISDGLSKELWEISKASKVKIVIDPNSLPVHEKVKEIVKNPVE
HHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCE
VALASGEEFELVFTISQEYLDILSFEFSIIGRVEKGEGVYTTTGEKVPMRGWEHFAGGNN
EEEECCCCEEEEEEECHHHHHHHHHHEEEEEEEECCCEEEEECCCCCCCCCHHHHCCCCC
DIGS
CCCC
>Mature Secondary Structure
MKETEIIKLFQEELKSKVLGDDAGFIKLGDRWLLLTNDMLVWRTDVPDFMTPEEAGAKVV
CCHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEECCEEEEECCCCCCCCCHHHCCEEE
TMNVSDIAAMGGKPIGFFFSLGLPRDINEKTLREIAKGIKRGTKRYNVEVLSGDTNESNE
EEEHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCE
LVIDGGAIGEAERILLRSGAKPGEVVCVTGDLGRPLTALLLWLKGEKIPREIAEKMKNPI
EEEECCCCCHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCHHHHHHHHHHHH
ARVREGLELANYASSAIDISDGLSKELWEISKASKVKIVIDPNSLPVHEKVKEIVKNPVE
HHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCE
VALASGEEFELVFTISQEYLDILSFEFSIIGRVEKGEGVYTTTGEKVPMRGWEHFAGGNN
EEEECCCCEEEEEEECHHHHHHHHHHEEEEEEEECCCEEEEECCCCCCCCCHHHHCCCCC
DIGS
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]