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The map label for this gene is norM [H]

Identifier: 18978222

GI number: 18978222

Start: 1706913

End: 1708280

Strand: Direct

Name: norM [H]

Synonym: PF1850

Alternate gene names: 18978222

Gene position: 1706913-1708280 (Clockwise)

Preceding gene: 18978218

Following gene: 18978225

Centisome position: 89.45

GC content: 41.3

Gene sequence:

>1368_bases
ATGAGTGAGCTAAGAAGGAAAATATGGAGCCTAGCATGGCCAGCAATAGCTGGGAACATAAGTCAAACATTGCTCAACCT
AGTCGATATGATGATTTTAGGTCATGTCAGCGCTATTGCCTTGGGAGCTGTTGGACTAGGAGGACAGATTAGTTGGTTCA
TGTTTCCAATAATGATCGCTGTTTCCACTGGAACTTTAGCTATAGTAGCTAGAAGGGTTGGGGAAGGAAAACTTGAAGAG
GCTTCAAGGGTAGCAGAGCAAAGTATGTACTTAGCTTTTCTTCTTGGTATTCCAGTAATGCTTTTCGGAATTTTCTTTGG
AGATGAAATTCTAAGAATCATGGGTGCCAAAGGAGAAGTTCTCGAGATTGGATACGAATATCTAAAAGTGTTATTCCTAT
TCTATCCAATTAGATTTGTGGGGTTTGTATTTTTCTCAGCTCTTAGGGGAGCGGGAGATACAAAGACCCCAATGAAACTC
AATATTCTAATGAACGTCTTAAACGGCGTGTTTGATTATCTTTTAGTTTTTGGAAAACTTGGATTTCCCAGGCTTGGCCC
AGTAGGCGCCGCCTGGGCTTCAGGAATAGGAATTACAGTCTCGTTTTTAATTGGAATGTTGTTGTTTTTGAATGGCAAAC
TCGTCATTAAGCCTGTGATAGAGTGGAGGTTGCATCTTGATATAGTTGAAAAGATATTGAGAATCGGCACTCCCGCTTTA
CTTGAGAGAGGGCTATTTAGCTTCTACAACTTCCTTTACATGGCTATAGTCACAAGGTTCGGAGAAATAGCATTATCGGC
TCATCAAATTGGGCTGAGAGTGGAGAGCATAGCATACATGCCAGCATTTGGATTTAGTATCGCAACTTCTGCCCTAGTAG
GACAGAGCTTAGGAGCTAAAAAGCCTGATGAAGCTGAAAAGATAGTTAAAGAGTCTCTAAAGATGACAACGATCTTTATG
AGCGTAATGGCTTTTGTGTTGATGGCATTCCCAAGTATCCTAGTTAGGCCATTTCTATCCCCGACAGACCCTTACTATGA
GGAGGTTAAGAGACTAGCAGTTATATACCTCATAATAGTTGGGATAAGCGAAATACCTTTGGGAGTAATCTTCGTGTTGA
GTGGAGCCCTTAGGGGAGCTGGAGACACAAAGAGTCCCCTATATGTAACAGCAATTAGCAAACTTCTCTTTAGAATTATG
CCCTCCTATATTCTGGGATTTGGAGTTTCACTTCCAAGTCTAGGCTTGGAATTCAAAGGGTTGGGAGTAATTGCCGCCTG
GATAGGAATGAGCCTTGAAACATTTATTTCAGCCGGGCTGTTCTGGATAGTATTTAGAAAAGGAAGATGGAAAAAGATAA
AGATTTAG

Upstream 100 bases:

>100_bases
GATTTTTGTCTAAAAAACAAGGGGAAGCTTTTCCACAAAAATCTTATAAATTACAACTTTCCTTTTATCGTTTAGATACA
AATTGTAATTGGGATGATGC

Downstream 100 bases:

>100_bases
GTGCTACTCCTTAGCTCTTTAATAATCTCCATTAGCTCATCCACGTCCCTAACTTTATTGAGAATGTCTTTAGGAATTAT
TGGAACTTTCCCAACAACTT

Product: damage-inducible protein DinF

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSELRRKIWSLAWPAIAGNISQTLLNLVDMMILGHVSAIALGAVGLGGQISWFMFPIMIAVSTGTLAIVARRVGEGKLEE
ASRVAEQSMYLAFLLGIPVMLFGIFFGDEILRIMGAKGEVLEIGYEYLKVLFLFYPIRFVGFVFFSALRGAGDTKTPMKL
NILMNVLNGVFDYLLVFGKLGFPRLGPVGAAWASGIGITVSFLIGMLLFLNGKLVIKPVIEWRLHLDIVEKILRIGTPAL
LERGLFSFYNFLYMAIVTRFGEIALSAHQIGLRVESIAYMPAFGFSIATSALVGQSLGAKKPDEAEKIVKESLKMTTIFM
SVMAFVLMAFPSILVRPFLSPTDPYYEEVKRLAVIYLIIVGISEIPLGVIFVLSGALRGAGDTKSPLYVTAISKLLFRIM
PSYILGFGVSLPSLGLEFKGLGVIAAWIGMSLETFISAGLFWIVFRKGRWKKIKI

Sequences:

>Translated_455_residues
MSELRRKIWSLAWPAIAGNISQTLLNLVDMMILGHVSAIALGAVGLGGQISWFMFPIMIAVSTGTLAIVARRVGEGKLEE
ASRVAEQSMYLAFLLGIPVMLFGIFFGDEILRIMGAKGEVLEIGYEYLKVLFLFYPIRFVGFVFFSALRGAGDTKTPMKL
NILMNVLNGVFDYLLVFGKLGFPRLGPVGAAWASGIGITVSFLIGMLLFLNGKLVIKPVIEWRLHLDIVEKILRIGTPAL
LERGLFSFYNFLYMAIVTRFGEIALSAHQIGLRVESIAYMPAFGFSIATSALVGQSLGAKKPDEAEKIVKESLKMTTIFM
SVMAFVLMAFPSILVRPFLSPTDPYYEEVKRLAVIYLIIVGISEIPLGVIFVLSGALRGAGDTKSPLYVTAISKLLFRIM
PSYILGFGVSLPSLGLEFKGLGVIAAWIGMSLETFISAGLFWIVFRKGRWKKIKI
>Mature_454_residues
SELRRKIWSLAWPAIAGNISQTLLNLVDMMILGHVSAIALGAVGLGGQISWFMFPIMIAVSTGTLAIVARRVGEGKLEEA
SRVAEQSMYLAFLLGIPVMLFGIFFGDEILRIMGAKGEVLEIGYEYLKVLFLFYPIRFVGFVFFSALRGAGDTKTPMKLN
ILMNVLNGVFDYLLVFGKLGFPRLGPVGAAWASGIGITVSFLIGMLLFLNGKLVIKPVIEWRLHLDIVEKILRIGTPALL
ERGLFSFYNFLYMAIVTRFGEIALSAHQIGLRVESIAYMPAFGFSIATSALVGQSLGAKKPDEAEKIVKESLKMTTIFMS
VMAFVLMAFPSILVRPFLSPTDPYYEEVKRLAVIYLIIVGISEIPLGVIFVLSGALRGAGDTKSPLYVTAISKLLFRIMP
SYILGFGVSLPSLGLEFKGLGVIAAWIGMSLETFISAGLFWIVFRKGRWKKIKI

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=460, Percent_Identity=25.4347826086956, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI48994890, Length=425, Percent_Identity=24.9411764705882, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49999; Mature: 49868

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHEEEECCCCEECCC
>Mature Secondary Structure 
SELRRKIWSLAWPAIAGNISQTLLNLVDMMILGHVSAIALGAVGLGGQISWFMFPIMIA
CHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHEEEECCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]