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The map label for this gene is ycdF [H]

Identifier: 18978225

GI number: 18978225

Start: 1710535

End: 1711314

Strand: Direct

Name: ycdF [H]

Synonym: PF1853

Alternate gene names: 18978225

Gene position: 1710535-1711314 (Clockwise)

Preceding gene: 18978222

Following gene: 18978227

Centisome position: 89.64

GC content: 38.21

Gene sequence:

>780_bases
ATGAACATTTTAATAACAGCTTCTTCAAGAGGAATAGGCTTCAATGTGGCCAAGGAACTCCTCAAAAAAGGACACAGAGT
AGTAATATCGTCTAGCAATGAAAAAAATTTAGAAAAAGCCCTAGAAGAGCTAAAAGAATATGAAAAAGTCTATCCGATTA
AAGCAGATCTCTCAAAAAAAGAAGAAATTAAAAACATGGTAGAAAAGGCCTGGGAAATTTTAGGAAAAATAGATGTCCTT
GTTTGGAATGCCCCTAATGTAAAGTGTGAACCCTGCATGATTCACGAATTAGATTATGAAGATTGGGTAGAAGGAGCCTT
GCTTCACATAATTGCCCCAGGCTACCTAACAACTCTTCTCCTTAATAAATGGTTGAAAAATAACACAAGAGGGATAATAA
TCTACTTAAGTTCTGCTTCAGTTTTAGAGCCAATGCCTCCCCTCCTTCTCGCAGACAGTACTAGGGCAGGATTAATTCAG
CTTGCTAAAGGAATATCTAGGGCCTATGGAAAGAGAGGAATAAGGGCATACACAGTACTACTTGGGAGCTTTGATACCCC
AGGAGCTAGAGAAAACCTAAGAAGACTAGCAGAAAAAAGGGGTGTTGATCCAGAAGAGCTATGGAAAAAGGAAGTTATTG
AAAGAACTCCTCTTCAAAGAACTGGAAAATGGGAAGAACTAGGAGAATTAATAGAATTCTTACTTAGCGATAACGCCGAA
TATATGCTAGGCTCTACAATTCTCTTTGATGGAGCAATGACTAGGAGCGTTCTTCTTTAA

Upstream 100 bases:

>100_bases
AAAATAAATTTCAGTCAAAAGTTGACAAATTCTCACGTTTGTGTAATAAAAATGACCACATAGGAACGTTTTAATAGGGG
AGTACACTAATGTCAATCGT

Downstream 100 bases:

>100_bases
TTTTCTCTACAACCCTTATCTCCTCTATTTTAGTATAGGGATATTGGCCTTTCTCATCTTTTTCTACAGCCTTTACCATG
TCCCAAATCGTTAAGAGAGC

Product: glucose-1-dehydrogenase

Products: NA

Alternate protein names: GLCDH-II; GDH-II; General stress protein 74; GSP74 [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNILITASSRGIGFNVAKELLKKGHRVVISSSNEKNLEKALEELKEYEKVYPIKADLSKKEEIKNMVEKAWEILGKIDVL
VWNAPNVKCEPCMIHELDYEDWVEGALLHIIAPGYLTTLLLNKWLKNNTRGIIIYLSSASVLEPMPPLLLADSTRAGLIQ
LAKGISRAYGKRGIRAYTVLLGSFDTPGARENLRRLAEKRGVDPEELWKKEVIERTPLQRTGKWEELGELIEFLLSDNAE
YMLGSTILFDGAMTRSVLL

Sequences:

>Translated_259_residues
MNILITASSRGIGFNVAKELLKKGHRVVISSSNEKNLEKALEELKEYEKVYPIKADLSKKEEIKNMVEKAWEILGKIDVL
VWNAPNVKCEPCMIHELDYEDWVEGALLHIIAPGYLTTLLLNKWLKNNTRGIIIYLSSASVLEPMPPLLLADSTRAGLIQ
LAKGISRAYGKRGIRAYTVLLGSFDTPGARENLRRLAEKRGVDPEELWKKEVIERTPLQRTGKWEELGELIEFLLSDNAE
YMLGSTILFDGAMTRSVLL
>Mature_259_residues
MNILITASSRGIGFNVAKELLKKGHRVVISSSNEKNLEKALEELKEYEKVYPIKADLSKKEEIKNMVEKAWEILGKIDVL
VWNAPNVKCEPCMIHELDYEDWVEGALLHIIAPGYLTTLLLNKWLKNNTRGIIIYLSSASVLEPMPPLLLADSTRAGLIQ
LAKGISRAYGKRGIRAYTVLLGSFDTPGARENLRRLAEKRGVDPEELWKKEVIERTPLQRTGKWEELGELIEFLLSDNAE
YMLGSTILFDGAMTRSVLL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI5031737, Length=255, Percent_Identity=28.6274509803922, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI32483357, Length=257, Percent_Identity=26.8482490272374, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=24.5136186770428, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI66933014, Length=234, Percent_Identity=26.0683760683761, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503301, Length=238, Percent_Identity=26.890756302521, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI33667109, Length=186, Percent_Identity=28.494623655914, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=253, Percent_Identity=25.296442687747, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=25.9842519685039, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=25.968992248062, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=25.4826254826255, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=22.8, Blast_Score=64, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=253, Percent_Identity=26.8774703557312, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17560676, Length=251, Percent_Identity=26.2948207171315, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=256, Percent_Identity=25.390625, Blast_Score=80, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324126, Length=236, Percent_Identity=26.6949152542373, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21355319, Length=253, Percent_Identity=27.6679841897233, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=28.4046692607004, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=28.3464566929134, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=27.9527559055118, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.47 [H]

Molecular weight: Translated: 29235; Mature: 29235

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILITASSRGIGFNVAKELLKKGHRVVISSSNEKNLEKALEELKEYEKVYPIKADLSKK
CEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCCHH
EEIKNMVEKAWEILGKIDVLVWNAPNVKCEPCMIHELDYEDWVEGALLHIIAPGYLTTLL
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LNKWLKNNTRGIIIYLSSASVLEPMPPLLLADSTRAGLIQLAKGISRAYGKRGIRAYTVL
HHHHHHCCCCEEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEE
LGSFDTPGARENLRRLAEKRGVDPEELWKKEVIERTPLQRTGKWEELGELIEFLLSDNAE
EECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
YMLGSTILFDGAMTRSVLL
HHCCCHHEECCHHHHHHCC
>Mature Secondary Structure
MNILITASSRGIGFNVAKELLKKGHRVVISSSNEKNLEKALEELKEYEKVYPIKADLSKK
CEEEEEECCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCHHCCCHH
EEIKNMVEKAWEILGKIDVLVWNAPNVKCEPCMIHELDYEDWVEGALLHIIAPGYLTTLL
HHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
LNKWLKNNTRGIIIYLSSASVLEPMPPLLLADSTRAGLIQLAKGISRAYGKRGIRAYTVL
HHHHHHCCCCEEEEEECCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEE
LGSFDTPGARENLRRLAEKRGVDPEELWKKEVIERTPLQRTGKWEELGELIEFLLSDNAE
EECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCC
YMLGSTILFDGAMTRSVLL
HHCCCHHEECCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9298659 [H]