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The map label for this gene is secY [H]

Identifier: 18978173

GI number: 18978173

Start: 1671649

End: 1673055

Strand: Reverse

Name: secY [H]

Synonym: PF1801

Alternate gene names: 18978173

Gene position: 1673055-1671649 (Counterclockwise)

Preceding gene: 161484705

Following gene: 18978172

Centisome position: 87.67

GC content: 43.14

Gene sequence:

>1407_bases
ATGGGAGCTAGGGACATAATTTATGCTCTAGAAAGATGGTTTCCCGAGGTTGAAAGGCCAAAGAGACGTGTTCCATTAAG
AGAAAGATTTATGTGGACTGGAGTTGCACTAATTCTCTACTATGTTCTCGCTGAAATTCCCGTCTATGGAATCCCTGAAA
GAATTCAGGACTACTTCCAGTTTTTAAGAGTGGTATTGGCTGGAAGAAATGGATCAATATTAACTTTAGGAATTGGGCCC
ATTGTTACCGCGGGAATTATTCTCCAGCTTCTTGTAGGTTCTGAGATAATAAAGCTTGACCTGGCAAATCCCGAAGATAG
AAGATTTTACCAAGCACTGCAGAGAGTCTTCTCAGTGTTTATGTGTTTCTTTGAGGCTGCAGTGTGGATACTAGGCGGGG
CATTTGGTAGGGTTGGAGTTGATGTTACGTATGCTATAGCAGTGTTGATGATACTTCAACTTGCAATGGGTGGTATAGTC
CTAATAATCCTTGACGAGCTCGTTAGTAAGTGGGGAATAGGAAGCGGTATAAGTCTCTTCATAGCTGCTGGAGTGTCTCA
AACTATACTCACAAGAAGCCTTAATCCATTAACTGATCCCAACATAATTGACCCCTTAACAGGACAACCTGCAATAGTAG
GTGCAATCCCATACTTCATCCAGCACATCCTTAAAGGAGATCTATGGGGGGCTATATATAGAGGAGGGTCAGCTCCAGAT
ATGTTAAGCGTCGTTGCAACAATAGTGGTGTTCTTTATAGTGGTTTACTTTGAGAGCATGCGTGTTGAAATTCCATTGGG
ATATAGAGGGGTAACAGTGAGGGGAAGTTATCCAATAAGATTCCTTTATGTAAGTAACATTCCGATAATCCTAACGTTTG
CCCTTTACGCTAACATTCAGCTTTGGGCCAGAGTGCTTGATAGGCTTGGCCATCCATGGCTTGGAAGATTTGATCCCACT
ACAGGTTCTCCAATCTCGGGCTTTGTACTCTACGTAATACCTCCAAGAAACATATTCAGCGTTATAGATAACCCCGTTAG
GGCGATAGTATATCTCATCCTGACGGTAATTTTCAGTTTGCTATTTGGATACCTGTGGGTAGAACTGACGGGACTCGATG
CAAGGTCAATAGCAAGGCAGCTCCAGAGGGCTGGACTTCAAATTCCAGGATTTAGAAGGGATCCAAGAACTTTGGAGAAG
GTCTTGCAAAGATATATTCCATATGTGACCTTCTGGGGTTCACTGACAGTAGCTTTAATAGCTGTGTTGGCAGACTTCCT
TGGAGCTCTTGGAACGGGAACTGGTATATTACTTACGGTCGGTATCCTCTACAGGTTCTACGAGGAAATTGCAAGAGAAC
AGATAACAGAGATGTTCCCAGCTTTGAGGAAATTGTTTGGCGCTTAG

Upstream 100 bases:

>100_bases
GGCAGAAGAGAAAATTAAGGCTGCTGGAGGAGAAGCTGTTCTCGTTTAATCTCCCTTATTTTTTTGCTTCATGAGAATAA
ACGAGCAAAGGTGTTGAAAC

Downstream 100 bases:

>100_bases
TCTTTTTGCCTTTTCTTAACTTTCTCCATAATAGTTTTAAATACTTTCAGAATTGTAAAATTTTGGGGTGAGAAATGCCT
TTTGTGGTCATCATTACGGG

Product: preprotein translocase subunit SecY

Products: NA

Alternate protein names: Protein transport protein SEC61 subunit alpha homolog [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MGARDIIYALERWFPEVERPKRRVPLRERFMWTGVALILYYVLAEIPVYGIPERIQDYFQFLRVVLAGRNGSILTLGIGP
IVTAGIILQLLVGSEIIKLDLANPEDRRFYQALQRVFSVFMCFFEAAVWILGGAFGRVGVDVTYAIAVLMILQLAMGGIV
LIILDELVSKWGIGSGISLFIAAGVSQTILTRSLNPLTDPNIIDPLTGQPAIVGAIPYFIQHILKGDLWGAIYRGGSAPD
MLSVVATIVVFFIVVYFESMRVEIPLGYRGVTVRGSYPIRFLYVSNIPIILTFALYANIQLWARVLDRLGHPWLGRFDPT
TGSPISGFVLYVIPPRNIFSVIDNPVRAIVYLILTVIFSLLFGYLWVELTGLDARSIARQLQRAGLQIPGFRRDPRTLEK
VLQRYIPYVTFWGSLTVALIAVLADFLGALGTGTGILLTVGILYRFYEEIAREQITEMFPALRKLFGA

Sequences:

>Translated_468_residues
MGARDIIYALERWFPEVERPKRRVPLRERFMWTGVALILYYVLAEIPVYGIPERIQDYFQFLRVVLAGRNGSILTLGIGP
IVTAGIILQLLVGSEIIKLDLANPEDRRFYQALQRVFSVFMCFFEAAVWILGGAFGRVGVDVTYAIAVLMILQLAMGGIV
LIILDELVSKWGIGSGISLFIAAGVSQTILTRSLNPLTDPNIIDPLTGQPAIVGAIPYFIQHILKGDLWGAIYRGGSAPD
MLSVVATIVVFFIVVYFESMRVEIPLGYRGVTVRGSYPIRFLYVSNIPIILTFALYANIQLWARVLDRLGHPWLGRFDPT
TGSPISGFVLYVIPPRNIFSVIDNPVRAIVYLILTVIFSLLFGYLWVELTGLDARSIARQLQRAGLQIPGFRRDPRTLEK
VLQRYIPYVTFWGSLTVALIAVLADFLGALGTGTGILLTVGILYRFYEEIAREQITEMFPALRKLFGA
>Mature_467_residues
GARDIIYALERWFPEVERPKRRVPLRERFMWTGVALILYYVLAEIPVYGIPERIQDYFQFLRVVLAGRNGSILTLGIGPI
VTAGIILQLLVGSEIIKLDLANPEDRRFYQALQRVFSVFMCFFEAAVWILGGAFGRVGVDVTYAIAVLMILQLAMGGIVL
IILDELVSKWGIGSGISLFIAAGVSQTILTRSLNPLTDPNIIDPLTGQPAIVGAIPYFIQHILKGDLWGAIYRGGSAPDM
LSVVATIVVFFIVVYFESMRVEIPLGYRGVTVRGSYPIRFLYVSNIPIILTFALYANIQLWARVLDRLGHPWLGRFDPTT
GSPISGFVLYVIPPRNIFSVIDNPVRAIVYLILTVIFSLLFGYLWVELTGLDARSIARQLQRAGLQIPGFRRDPRTLEKV
LQRYIPYVTFWGSLTVALIAVLADFLGALGTGTGILLTVGILYRFYEEIAREQITEMFPALRKLFGA

Specific function: Involved in protein export. Interacts with secE to allow the translocation of proteins across the plasma membrane, by forming part of a channel [H]

COG id: COG0201

COG function: function code U; Preprotein translocase subunit SecY

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the secY/SEC61-alpha family [H]

Homologues:

Organism=Homo sapiens, GI7019415, Length=457, Percent_Identity=35.4485776805252, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI14589847, Length=460, Percent_Identity=35.2173913043478, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI217330618, Length=460, Percent_Identity=33.9130434782609, Blast_Score=236, Evalue=5e-62,
Organism=Homo sapiens, GI217330616, Length=405, Percent_Identity=33.0864197530864, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17543770, Length=457, Percent_Identity=34.3544857768052, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6323411, Length=472, Percent_Identity=32.8389830508475, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6319760, Length=490, Percent_Identity=26.1224489795918, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI19920826, Length=474, Percent_Identity=33.7552742616034, Blast_Score=263, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002208
- InterPro:   IPR023201
- InterPro:   IPR019561 [H]

Pfam domain/function: PF10559 Plug_translocon; PF00344 SecY [H]

EC number: NA

Molecular weight: Translated: 52300; Mature: 52169

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS00755 SECY_1 ; PS00756 SECY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGARDIIYALERWFPEVERPKRRVPLRERFMWTGVALILYYVLAEIPVYGIPERIQDYFQ
CCHHHHHHHHHHHCCHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FLRVVLAGRNGSILTLGIGPIVTAGIILQLLVGSEIIKLDLANPEDRRFYQALQRVFSVF
HHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHH
MCFFEAAVWILGGAFGRVGVDVTYAIAVLMILQLAMGGIVLIILDELVSKWGIGSGISLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHH
IAAGVSQTILTRSLNPLTDPNIIDPLTGQPAIVGAIPYFIQHILKGDLWGAIYRGGSAPD
HHHCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
MLSVVATIVVFFIVVYFESMRVEIPLGYRGVTVRGSYPIRFLYVSNIPIILTFALYANIQ
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHH
LWARVLDRLGHPWLGRFDPTTGSPISGFVLYVIPPRNIFSVIDNPVRAIVYLILTVIFSL
HHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHH
LFGYLWVELTGLDARSIARQLQRAGLQIPGFRRDPRTLEKVLQRYIPYVTFWGSLTVALI
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
AVLADFLGALGTGTGILLTVGILYRFYEEIAREQITEMFPALRKLFGA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GARDIIYALERWFPEVERPKRRVPLRERFMWTGVALILYYVLAEIPVYGIPERIQDYFQ
CHHHHHHHHHHHCCHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FLRVVLAGRNGSILTLGIGPIVTAGIILQLLVGSEIIKLDLANPEDRRFYQALQRVFSVF
HHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHH
MCFFEAAVWILGGAFGRVGVDVTYAIAVLMILQLAMGGIVLIILDELVSKWGIGSGISLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHH
IAAGVSQTILTRSLNPLTDPNIIDPLTGQPAIVGAIPYFIQHILKGDLWGAIYRGGSAPD
HHHCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
MLSVVATIVVFFIVVYFESMRVEIPLGYRGVTVRGSYPIRFLYVSNIPIILTFALYANIQ
HHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHH
LWARVLDRLGHPWLGRFDPTTGSPISGFVLYVIPPRNIFSVIDNPVRAIVYLILTVIFSL
HHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHHH
LFGYLWVELTGLDARSIARQLQRAGLQIPGFRRDPRTLEKVLQRYIPYVTFWGSLTVALI
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHH
AVLADFLGALGTGTGILLTVGILYRFYEEIAREQITEMFPALRKLFGA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]