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The map label for this gene is proC [H]

Identifier: 18978087

GI number: 18978087

Start: 1594946

End: 1595731

Strand: Reverse

Name: proC [H]

Synonym: PF1715

Alternate gene names: 18978087

Gene position: 1595731-1594946 (Counterclockwise)

Preceding gene: 18978088

Following gene: 18978083

Centisome position: 83.62

GC content: 39.31

Gene sequence:

>786_bases
ATGAAGGTTGCTGTAATTGGAGCGGGAACAATTGGGAGTGCTGTTGCAAAGGCCTTGGCTGAAAGTAATTACGAAGTCAT
TGCTACAAGGAGAAGCATTGAAAAGGTTAAATGGTTGGAGAAATATGGGGTAAAACTTGAAAAAGACAACAAAAAAGCCA
GTAGGGAAGCGGATATCGTGATTATCGCAGTAAAGCCAAATAAAGTAGGAAAGGTTCTTGAAGAAATAAAGGAAGAAGTT
GAAAGTAAAATTGTGATATCTTTAGCGGCGGGAATTCCAATAAAGCTTCTTAAGAGGTTTGCAAATGCAAAATTTGTGAG
GGCTATGCCAAATATAGCTGTTCTCGTAAAAGAGTCCTTTACAGCCTATGCAACGGAAGATTTAAGCGAAGAGGAAATTA
GAACTGTTGAAAAAATCTTTGAGTCCTTTGGGAAGTATATAAGAATCGACGAAGAATATATGGATGCCATAACTGGATTA
AGTGGCTCTGGACCAGCTTATGTCTCTGTGTTTTTAGAAGCCATGATATATGGCGGTTTACGGGTTGGACTCCCAAGAGA
TATTGCAAAACTTGCGGCCGCTCAAACCCTCTTAGGCACTGCGAAGCTCTTACTAAATTTTGAGGGACACCCTGCTGAAA
TTAGAGATATGGTAATTACCCCCGGAGGAACAACGATAGATGGGATATTTGAGTTGGAGGAAGGAAAAATTAGAACAACA
ATAATGAAAGCCATTGATGCAGCAACTAAAAAATCAAAGATCTTATCCACAAGGTTATCTCCTTAA

Upstream 100 bases:

>100_bases
GAAAAAGCTAGAACTTGAGGGTATGTTGGGATAAATGACGAAGTATTCTCAAGAAGAGTTATAAACATTCTACATTATTT
CCAAAGTTTAGGTGAAATAA

Downstream 100 bases:

>100_bases
AACTACTGAAGCTGCATATTCTTCAACATTTTCTTCGATTTTTCTGATCCAGTATTCTCTCAGTTCTTTGATTTCAAACT
CTTCTTGAGTTTTTGTTTTC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MKVAVIGAGTIGSAVAKALAESNYEVIATRRSIEKVKWLEKYGVKLEKDNKKASREADIVIIAVKPNKVGKVLEEIKEEV
ESKIVISLAAGIPIKLLKRFANAKFVRAMPNIAVLVKESFTAYATEDLSEEEIRTVEKIFESFGKYIRIDEEYMDAITGL
SGSGPAYVSVFLEAMIYGGLRVGLPRDIAKLAAAQTLLGTAKLLLNFEGHPAEIRDMVITPGGTTIDGIFELEEGKIRTT
IMKAIDAATKKSKILSTRLSP

Sequences:

>Translated_261_residues
MKVAVIGAGTIGSAVAKALAESNYEVIATRRSIEKVKWLEKYGVKLEKDNKKASREADIVIIAVKPNKVGKVLEEIKEEV
ESKIVISLAAGIPIKLLKRFANAKFVRAMPNIAVLVKESFTAYATEDLSEEEIRTVEKIFESFGKYIRIDEEYMDAITGL
SGSGPAYVSVFLEAMIYGGLRVGLPRDIAKLAAAQTLLGTAKLLLNFEGHPAEIRDMVITPGGTTIDGIFELEEGKIRTT
IMKAIDAATKKSKILSTRLSP
>Mature_261_residues
MKVAVIGAGTIGSAVAKALAESNYEVIATRRSIEKVKWLEKYGVKLEKDNKKASREADIVIIAVKPNKVGKVLEEIKEEV
ESKIVISLAAGIPIKLLKRFANAKFVRAMPNIAVLVKESFTAYATEDLSEEEIRTVEKIFESFGKYIRIDEEYMDAITGL
SGSGPAYVSVFLEAMIYGGLRVGLPRDIAKLAAAQTLLGTAKLLLNFEGHPAEIRDMVITPGGTTIDGIFELEEGKIRTT
IMKAIDAATKKSKILSTRLSP

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797095, Length=270, Percent_Identity=37.7777777777778, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI24797097, Length=270, Percent_Identity=37.7777777777778, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=37.037037037037, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI198041662, Length=263, Percent_Identity=34.6007604562738, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1786585, Length=264, Percent_Identity=35.2272727272727, Blast_Score=145, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17569021, Length=271, Percent_Identity=34.6863468634686, Blast_Score=162, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17540664, Length=279, Percent_Identity=27.2401433691756, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320861, Length=288, Percent_Identity=29.1666666666667, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24648116, Length=268, Percent_Identity=32.4626865671642, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI21358587, Length=267, Percent_Identity=29.9625468164794, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24647700, Length=156, Percent_Identity=32.0512820512821, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28446; Mature: 28446

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAVIGAGTIGSAVAKALAESNYEVIATRRSIEKVKWLEKYGVKLEKDNKKASREADIV
CEEEEEECCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCEEECCCCCCCCCCCEE
IIAVKPNKVGKVLEEIKEEVESKIVISLAAGIPIKLLKRFANAKFVRAMPNIAVLVKESF
EEEECCCHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCHHHHHCCCEEEEEECCH
TAYATEDLSEEEIRTVEKIFESFGKYIRIDEEYMDAITGLSGSGPAYVSVFLEAMIYGGL
HHHHHCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCCCHHHHHHHHHHHHHCCE
RVGLPRDIAKLAAAQTLLGTAKLLLNFEGHPAEIRDMVITPGGTTIDGIFELEEGKIRTT
EECCCHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHH
IMKAIDAATKKSKILSTRLSP
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVAVIGAGTIGSAVAKALAESNYEVIATRRSIEKVKWLEKYGVKLEKDNKKASREADIV
CEEEEEECCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCEEECCCCCCCCCCCEE
IIAVKPNKVGKVLEEIKEEVESKIVISLAAGIPIKLLKRFANAKFVRAMPNIAVLVKESF
EEEECCCHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCHHHHHCCCEEEEEECCH
TAYATEDLSEEEIRTVEKIFESFGKYIRIDEEYMDAITGLSGSGPAYVSVFLEAMIYGGL
HHHHHCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCCCHHHHHHHHHHHHHCCE
RVGLPRDIAKLAAAQTLLGTAKLLLNFEGHPAEIRDMVITPGGTTIDGIFELEEGKIRTT
EECCCHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEECCCCCEEEEEEEECCCHHHHH
IMKAIDAATKKSKILSTRLSP
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]