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The map label for this gene is trpC

Identifier: 18978083

GI number: 18978083

Start: 1589057

End: 1589743

Strand: Reverse

Name: trpC

Synonym: PF1711

Alternate gene names: 18978083

Gene position: 1589743-1589057 (Counterclockwise)

Preceding gene: 18978087

Following gene: 18978082

Centisome position: 83.31

GC content: 39.3

Gene sequence:

>687_bases
GTGGTGATTTTTGGACTGAGCAGGGCTATTAGAAAGGCTAAGAAAAATCCTATTATAGCAGAAATCAAAGTCTATTCTCC
AAAATATGGAGATCTTTTACGGGGCAGGGATCCTCTAAGGATTTTGAGGGCATATGAAGAAGCTGGAGCTGTGGGGATTT
CTTACATAACAGATCAAAAGTATTTCAAAGGGAGCTTTGACTTTCTAAAAGTTTTATGTAAGGAAACTACCCTCCCAGTG
CTGAGGAAGGACTTTATAACAAGCAAAGAGGAAATTGAAAAAACTGCCGAAGTTGGTGCCTCTGCTGTTCTATTAATAAC
TAGAATATTGAAAGATAAGCTGCCAGAGTTTGTGGATTATGCAAAAGAGCATGGGCTTGACACTCTAGTGGAAGTTCATA
CCGAAGATGAGCTAAAGCTCGCAATTAAAACAAATTCTACAATGATAGGAATAAACAATAGGGACATTGGAAAGCTAGAG
ATGGACGATGGAGATGTTTCTCTAACTGAAATTTTAGCTCCAAAAATCCCAGGAAAATTCGTGAAAGTTAGTGAAAGCGG
AATAGCAACATTGGAAGATTTGAAGAGGGCCTTAAGGGTTGCTGATGCTGCACTCATTGGGACGGCTTTAATGAAAGCTG
AAAATCCCGCAGAACTTCTCAAAAAATTCGTGGAGGCTGAGATATAA

Upstream 100 bases:

>100_bases
AAATTCTCATCAAACATGTGTATTCAATTCTAGCTTGATAGAGCTGTCCAAATGTTTAAATTTATCATGTTATTTTTGTC
GTAGTGGTGGAGTATAATGG

Downstream 100 bases:

>100_bases
TGCTGGAGAAGATAGTAGAAAATAGGCATTTATCCTTCGAGGAGGCTTACGACTTATTTAACATCCTCAAGGAAGAAAGC
GAAGTTAGGATTGCAGCATA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MVIFGLSRAIRKAKKNPIIAEIKVYSPKYGDLLRGRDPLRILRAYEEAGAVGISYITDQKYFKGSFDFLKVLCKETTLPV
LRKDFITSKEEIEKTAEVGASAVLLITRILKDKLPEFVDYAKEHGLDTLVEVHTEDELKLAIKTNSTMIGINNRDIGKLE
MDDGDVSLTEILAPKIPGKFVKVSESGIATLEDLKRALRVADAALIGTALMKAENPAELLKKFVEAEI

Sequences:

>Translated_228_residues
MVIFGLSRAIRKAKKNPIIAEIKVYSPKYGDLLRGRDPLRILRAYEEAGAVGISYITDQKYFKGSFDFLKVLCKETTLPV
LRKDFITSKEEIEKTAEVGASAVLLITRILKDKLPEFVDYAKEHGLDTLVEVHTEDELKLAIKTNSTMIGINNRDIGKLE
MDDGDVSLTEILAPKIPGKFVKVSESGIATLEDLKRALRVADAALIGTALMKAENPAELLKKFVEAEI
>Mature_228_residues
MVIFGLSRAIRKAKKNPIIAEIKVYSPKYGDLLRGRDPLRILRAYEEAGAVGISYITDQKYFKGSFDFLKVLCKETTLPV
LRKDFITSKEEIEKTAEVGASAVLLITRILKDKLPEFVDYAKEHGLDTLVEVHTEDELKLAIKTNSTMIGINNRDIGKLE
MDDGDVSLTEILAPKIPGKFVKVSESGIATLEDLKRALRVADAALIGTALMKAENPAELLKKFVEAEI

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=205, Percent_Identity=34.6341463414634, Blast_Score=107, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6322638, Length=224, Percent_Identity=32.5892857142857, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_PYRFU (Q8U088)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579440.1
- ProteinModelPortal:   Q8U088
- SMR:   Q8U088
- EnsemblBacteria:   EBPYRT00000006048
- GeneID:   1469588
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1711
- NMPDR:   fig|186497.1.peg.1759
- GeneTree:   EBGT00050000022896
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_A
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 25308; Mature: 25308

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIFGLSRAIRKAKKNPIIAEIKVYSPKYGDLLRGRDPLRILRAYEEAGAVGISYITDQK
CEEECHHHHHHHHHCCCCEEEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCH
YFKGSFDFLKVLCKETTLPVLRKDFITSKEEIEKTAEVGASAVLLITRILKDKLPEFVDY
HHCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
AKEHGLDTLVEVHTEDELKLAIKTNSTMIGINNRDIGKLEMDDGDVSLTEILAPKIPGKF
HHHCCCHHEEEECCCCCEEEEEEECCEEEEECCCCCCEEEECCCCCHHHHHHCCCCCCCE
VKVSESGIATLEDLKRALRVADAALIGTALMKAENPAELLKKFVEAEI
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MVIFGLSRAIRKAKKNPIIAEIKVYSPKYGDLLRGRDPLRILRAYEEAGAVGISYITDQK
CEEECHHHHHHHHHCCCCEEEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCH
YFKGSFDFLKVLCKETTLPVLRKDFITSKEEIEKTAEVGASAVLLITRILKDKLPEFVDY
HHCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
AKEHGLDTLVEVHTEDELKLAIKTNSTMIGINNRDIGKLEMDDGDVSLTEILAPKIPGKF
HHHCCCHHEEEECCCCCEEEEEEECCEEEEECCCCCCEEEECCCCCHHHHHHCCCCCCCE
VKVSESGIATLEDLKRALRVADAALIGTALMKAENPAELLKKFVEAEI
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA