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The map label for this gene is trpD

Identifier: 18978082

GI number: 18978082

Start: 1588083

End: 1589057

Strand: Reverse

Name: trpD

Synonym: PF1710

Alternate gene names: 18978082

Gene position: 1589057-1588083 (Counterclockwise)

Preceding gene: 18978083

Following gene: 18978081

Centisome position: 83.27

GC content: 39.49

Gene sequence:

>975_bases
ATGCTGGAGAAGATAGTAGAAAATAGGCATTTATCCTTCGAGGAGGCTTACGACTTATTTAACATCCTCAAGGAAGAAAG
CGAAGTTAGGATTGCAGCATATCTCGCGGCTCTCCAAACTAAAGGGTATACTTCAGAGGAAATAGCGGGATTTGCAAAGG
CAATGAGAGACAATGCAATTAAGTTGGATCTTGGGGAGGTTCTAGACACTGCTGGTACTGGAGGAGATAAATCATTCACG
ATAAATGTAAGCACTGCATCAGCCCTTATTCTTTCAGAATATACAAAGGTAGCTAAGCATGGCAATGTCTCCGTAACTTC
AAGAAGTGGTTCTGCAAATCTTCTAGAGGCCCTGGGAATAAACATCAAGATTTCTCCAGAGAAGGCTAAAGAGATGATTG
AAAAAGTTAACTTCACATTTATATTTGCTCCAATGTATCATCCAGCCCTAAAGAGAATAATGCCCGTAAGGAAAGAATTG
GGAATAAAGACCATTTTCAACATTTTGGGACCGCTAGCAAATCCAGCAAATCCAGCTTATCAAGTTGTAGGAGTTAATTC
TAGAGACCTAGTAGAGAAGATGGCAAGAGCTCTAAATTACCTCGGTGTTAAAAGAGCTACAGTTGTTCATGGTAGCGGAT
TGGATGAGATTAGTCCAGAGAAAGAAACTATAGTTGCCGAAGTCAATAGAGGTGACATAGATTTTTACACTGTTACTCCT
GAAGACTTCGGATTGGCTAGAACTAAAGTTATCCCCTGCTATTCTCCAGAAGAAAGTGCAGAGAGAATTAGAGCTGTTTT
GCGTGGAAATGGAAAAAATGAAGACAGGAATTTTGTCTTAATAAATTCGGCTATGGCACTTTATACAATAGGGATCGCCT
CTGATTTGAAAGAAGGAGTAGAACTGGCTGAGAATGTTCTAGGAGAAAAAATAATAAAGAAATTGGAGGAGATTGCATGC
TTATCAAAGAGTTAG

Upstream 100 bases:

>100_bases
GGGCCTTAAGGGTTGCTGATGCTGCACTCATTGGGACGGCTTTAATGAAAGCTGAAAATCCCGCAGAACTTCTCAAAAAA
TTCGTGGAGGCTGAGATATA

Downstream 100 bases:

>100_bases
ATCGAGTGTCTCCTCTTCGCTTATACCTTATTCTCAGACAACTTGAGTATCCTTTTATCCTAATGTCAGCAGAAAAGCAT
AGCAAAAAGGCCAGATTCAC

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MLEKIVENRHLSFEEAYDLFNILKEESEVRIAAYLAALQTKGYTSEEIAGFAKAMRDNAIKLDLGEVLDTAGTGGDKSFT
INVSTASALILSEYTKVAKHGNVSVTSRSGSANLLEALGINIKISPEKAKEMIEKVNFTFIFAPMYHPALKRIMPVRKEL
GIKTIFNILGPLANPANPAYQVVGVNSRDLVEKMARALNYLGVKRATVVHGSGLDEISPEKETIVAEVNRGDIDFYTVTP
EDFGLARTKVIPCYSPEESAERIRAVLRGNGKNEDRNFVLINSAMALYTIGIASDLKEGVELAENVLGEKIIKKLEEIAC
LSKS

Sequences:

>Translated_324_residues
MLEKIVENRHLSFEEAYDLFNILKEESEVRIAAYLAALQTKGYTSEEIAGFAKAMRDNAIKLDLGEVLDTAGTGGDKSFT
INVSTASALILSEYTKVAKHGNVSVTSRSGSANLLEALGINIKISPEKAKEMIEKVNFTFIFAPMYHPALKRIMPVRKEL
GIKTIFNILGPLANPANPAYQVVGVNSRDLVEKMARALNYLGVKRATVVHGSGLDEISPEKETIVAEVNRGDIDFYTVTP
EDFGLARTKVIPCYSPEESAERIRAVLRGNGKNEDRNFVLINSAMALYTIGIASDLKEGVELAENVLGEKIIKKLEEIAC
LSKS
>Mature_324_residues
MLEKIVENRHLSFEEAYDLFNILKEESEVRIAAYLAALQTKGYTSEEIAGFAKAMRDNAIKLDLGEVLDTAGTGGDKSFT
INVSTASALILSEYTKVAKHGNVSVTSRSGSANLLEALGINIKISPEKAKEMIEKVNFTFIFAPMYHPALKRIMPVRKEL
GIKTIFNILGPLANPANPAYQVVGVNSRDLVEKMARALNYLGVKRATVVHGSGLDEISPEKETIVAEVNRGDIDFYTVTP
EDFGLARTKVIPCYSPEESAERIRAVLRGNGKNEDRNFVLINSAMALYTIGIASDLKEGVELAENVLGEKIIKKLEEIAC
LSKS

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=278, Percent_Identity=41.726618705036, Blast_Score=199, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320561, Length=308, Percent_Identity=32.1428571428571, Blast_Score=129, Evalue=9e-31,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_PYRFU (Q8U089)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579439.1
- ProteinModelPortal:   Q8U089
- SMR:   Q8U089
- EnsemblBacteria:   EBPYRT00000005745
- GeneID:   1469587
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1710
- NMPDR:   fig|186497.1.peg.1758
- GeneTree:   EBGT00050000023294
- HOGENOM:   HBG559996
- OMA:   LGVYSPE
- ProtClustDB:   PRK00188
- BRENDA:   2.4.2.18
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 35484; Mature: 35484

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKIVENRHLSFEEAYDLFNILKEESEVRIAAYLAALQTKGYTSEEIAGFAKAMRDNAI
CCHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCE
KLDLGEVLDTAGTGGDKSFTINVSTASALILSEYTKVAKHGNVSVTSRSGSANLLEALGI
EEEHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCC
NIKISPEKAKEMIEKVNFTFIFAPMYHPALKRIMPVRKELGIKTIFNILGPLANPANPAY
CEEECHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
QVVGVNSRDLVEKMARALNYLGVKRATVVHGSGLDEISPEKETIVAEVNRGDIDFYTVTP
EEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEECC
EDFGLARTKVIPCYSPEESAERIRAVLRGNGKNEDRNFVLINSAMALYTIGIASDLKEGV
CCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
ELAENVLGEKIIKKLEEIACLSKS
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLEKIVENRHLSFEEAYDLFNILKEESEVRIAAYLAALQTKGYTSEEIAGFAKAMRDNAI
CCHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCE
KLDLGEVLDTAGTGGDKSFTINVSTASALILSEYTKVAKHGNVSVTSRSGSANLLEALGI
EEEHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCC
NIKISPEKAKEMIEKVNFTFIFAPMYHPALKRIMPVRKELGIKTIFNILGPLANPANPAY
CEEECHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCE
QVVGVNSRDLVEKMARALNYLGVKRATVVHGSGLDEISPEKETIVAEVNRGDIDFYTVTP
EEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEECCCCEEEEEECC
EDFGLARTKVIPCYSPEESAERIRAVLRGNGKNEDRNFVLINSAMALYTIGIASDLKEGV
CCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHH
ELAENVLGEKIIKKLEEIACLSKS
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA