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The map label for this gene is aroC [H]

Identifier: 18978072

GI number: 18978072

Start: 1580641

End: 1581651

Strand: Direct

Name: aroC [H]

Synonym: PF1700

Alternate gene names: 18978072

Gene position: 1580641-1581651 (Clockwise)

Preceding gene: 18978071

Following gene: 18978073

Centisome position: 82.83

GC content: 40.75

Gene sequence:

>1011_bases
GTGCCTCCTGGGATAAGAGTTAACCTGGAGGAGTTAAAAGCCGAACTTGAAAGAAGAAAGGGGATTTCCAAATTTTCAAC
TGCCAGAAAAGAGAGCGACGAACCTATAATAATTTCCGGAGTTTTTAGAGGATACACTACTGGAGCTCCAATAACAGTAA
TTGTGGAAAATAAAGACGTAGATTCTTCATATTATGAGGAGATCAAAGATACTCCTCGACCTGGGCATGCAGATTATCCA
GCAAAGATCAAGTATTTTGGCTTCAATGACTATCGAGGAGGAGGAAGGTTTTCTGGAAGGCTAACTATAGGCTTTGTAAT
CGCCGGATATTTCGCCAAGAAGATTCTCGAACCAGTGGGAGTAAAAATTAAAGCCTATATAAAGAGAGTTGGAAAAGTGG
AAGCTAGAAACATGAGCATCGAGGAAATATTCAATTCTCCGAACCCTTACTGCCCAGATGAAGATGCATTTAAAGAGATG
CTTAAGGAGATGGAAAGTGCAAAAAAGTCTGGAGACAGCGTTGGTGGAGTGGTAGAGGTTGTTGCAATAAACGTTCCCCC
AGGATTAGGTGGACCTTATGAGGATGATATAGAAGCTGATCTTGCCTCAACATTTTTCAGAATTCCAGCTGTAAAGGGTG
TTGAGTTTGGACTTGGATTTAAGGTTAGTGAAAAGAGAGGTAGTGAAGTAAACGACCCTTATGTCATAAAGAACGGAGAA
ATACAGACGGTAACAAACAATCATGGAGGCATTATAGGAGGAATAACAACAGGAATGCCAATAGTAGCTAGAATAGCGTT
CAAACCAACTCCCTCAATATACCTTCCCCAAAAAACCGTAAATTTAAGAGAAATGAAGGAAACAACTATAAAGCTAAAGG
GGAGATTTGACTCCTGCATAGTTCCTAAAGCTCTTCCCGTGGTTGAAGGTGCAATGGCCTTTGTGCTTGCAGATCACTTT
CTTAGGAGGTTAGCCTGGGAAAGATATGTCCACCTATCCAAAGAATTTTAA

Upstream 100 bases:

>100_bases
GAGGATTTAATGAGGGTGATAAAATGAATGGGAAAATGTTGTCATTTCACTTATTTGGAGAGAGTCATGGGAAAGCCGTA
GGAGAGTTCTAATAGAAGGA

Downstream 100 bases:

>100_bases
ATAAAAGGACAACCAAAAAGTGGGGATGGTGATGCCACGCCAATATCAACGAATTTAGATGAACAAATGACAACATTAAA
ACTCCTTAGAAAGGAGATAG

Product: chorismate synthase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate phospholyase [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MPPGIRVNLEELKAELERRKGISKFSTARKESDEPIIISGVFRGYTTGAPITVIVENKDVDSSYYEEIKDTPRPGHADYP
AKIKYFGFNDYRGGGRFSGRLTIGFVIAGYFAKKILEPVGVKIKAYIKRVGKVEARNMSIEEIFNSPNPYCPDEDAFKEM
LKEMESAKKSGDSVGGVVEVVAINVPPGLGGPYEDDIEADLASTFFRIPAVKGVEFGLGFKVSEKRGSEVNDPYVIKNGE
IQTVTNNHGGIIGGITTGMPIVARIAFKPTPSIYLPQKTVNLREMKETTIKLKGRFDSCIVPKALPVVEGAMAFVLADHF
LRRLAWERYVHLSKEF

Sequences:

>Translated_336_residues
MPPGIRVNLEELKAELERRKGISKFSTARKESDEPIIISGVFRGYTTGAPITVIVENKDVDSSYYEEIKDTPRPGHADYP
AKIKYFGFNDYRGGGRFSGRLTIGFVIAGYFAKKILEPVGVKIKAYIKRVGKVEARNMSIEEIFNSPNPYCPDEDAFKEM
LKEMESAKKSGDSVGGVVEVVAINVPPGLGGPYEDDIEADLASTFFRIPAVKGVEFGLGFKVSEKRGSEVNDPYVIKNGE
IQTVTNNHGGIIGGITTGMPIVARIAFKPTPSIYLPQKTVNLREMKETTIKLKGRFDSCIVPKALPVVEGAMAFVLADHF
LRRLAWERYVHLSKEF
>Mature_335_residues
PPGIRVNLEELKAELERRKGISKFSTARKESDEPIIISGVFRGYTTGAPITVIVENKDVDSSYYEEIKDTPRPGHADYPA
KIKYFGFNDYRGGGRFSGRLTIGFVIAGYFAKKILEPVGVKIKAYIKRVGKVEARNMSIEEIFNSPNPYCPDEDAFKEML
KEMESAKKSGDSVGGVVEVVAINVPPGLGGPYEDDIEADLASTFFRIPAVKGVEFGLGFKVSEKRGSEVNDPYVIKNGEI
QTVTNNHGGIIGGITTGMPIVARIAFKPTPSIYLPQKTVNLREMKETTIKLKGRFDSCIVPKALPVVEGAMAFVLADHFL
RRLAWERYVHLSKEF

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; seventh step. [C]

COG id: COG0082

COG function: function code E; Chorismate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chorismate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1788669, Length=327, Percent_Identity=43.7308868501529, Blast_Score=226, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6321290, Length=344, Percent_Identity=37.5, Blast_Score=199, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000453
- InterPro:   IPR020541 [H]

Pfam domain/function: PF01264 Chorismate_synt [H]

EC number: =4.2.3.5 [H]

Molecular weight: Translated: 37176; Mature: 37045

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS00788 CHORISMATE_SYNTHASE_2 ; PS00789 CHORISMATE_SYNTHASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPGIRVNLEELKAELERRKGISKFSTARKESDEPIIISGVFRGYTTGAPITVIVENKDV
CCCCCEEEHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEECCCC
DSSYYEEIKDTPRPGHADYPAKIKYFGFNDYRGGGRFSGRLTIGFVIAGYFAKKILEPVG
CHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCEECCEEEEHHHHHHHHHHHHHHHHC
VKIKAYIKRVGKVEARNMSIEEIFNSPNPYCPDEDAFKEMLKEMESAKKSGDSVGGVVEV
CHHHHHHHHHCCHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEE
VAINVPPGLGGPYEDDIEADLASTFFRIPAVKGVEFGLGFKVSEKRGSEVNDPYVIKNGE
EEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCEEECCCCCCCCCCCEEEECCE
IQTVTNNHGGIIGGITTGMPIVARIAFKPTPSIYLPQKTVNLREMKETTIKLKGRFDSCI
EEEEECCCCCEEECHHCCCCEEEEEEECCCCCEECCCCCCCHHHHHHHEEEEECCCCCCC
VPKALPVVEGAMAFVLADHFLRRLAWERYVHLSKEF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PPGIRVNLEELKAELERRKGISKFSTARKESDEPIIISGVFRGYTTGAPITVIVENKDV
CCCCEEEHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEECCCC
DSSYYEEIKDTPRPGHADYPAKIKYFGFNDYRGGGRFSGRLTIGFVIAGYFAKKILEPVG
CHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCCEECCEEEEHHHHHHHHHHHHHHHHC
VKIKAYIKRVGKVEARNMSIEEIFNSPNPYCPDEDAFKEMLKEMESAKKSGDSVGGVVEV
CHHHHHHHHHCCHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEE
VAINVPPGLGGPYEDDIEADLASTFFRIPAVKGVEFGLGFKVSEKRGSEVNDPYVIKNGE
EEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCEEECCCCCCCCCCCEEEECCE
IQTVTNNHGGIIGGITTGMPIVARIAFKPTPSIYLPQKTVNLREMKETTIKLKGRFDSCI
EEEEECCCCCEEECHHCCCCEEEEEEECCCCCEECCCCCCCHHHHHHHEEEEECCCCCCC
VPKALPVVEGAMAFVLADHFLRRLAWERYVHLSKEF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]