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The map label for this gene is dxs [C]

Identifier: 18978061

GI number: 18978061

Start: 1569629

End: 1570552

Strand: Direct

Name: dxs [C]

Synonym: PF1689

Alternate gene names: 18978061

Gene position: 1569629-1570552 (Clockwise)

Preceding gene: 18978060

Following gene: 18978062

Centisome position: 82.25

GC content: 41.88

Gene sequence:

>924_bases
GTGATAGAAAGCTTCAGAGAAGCTTTCGGAAGAGCACTTGTCGAAATTGGGAAGAAAAGAGAAGAGGTTGTAGTAATTGA
TGCGGATGTAAAAGGCTCAACAAAGACAATATATTTCGAAAAAGCATTCCCAAAAAGATTTATCCAAGTCGGAATAAGCG
AACAAGATATGATAGGAACTGCGGCAGGGCTTGCAATTGCGGGTAAGATACCAGTAGCCTCTGCATTTGCAGTATTCCTA
ATGAGGGCCTGGGAACAGATAAGAAATACCGTAGCAAGAGACAACCTAAACGTGAAGATAGTAGGAACCCATTCGGGATT
TTCAGATTACATGGATGGATCATCCCATCAGTGTCTGGAAGATATCGCCCTTATGAGGGTTTTACCAAACATGAAGGTGG
TTGTCCCAGCAGACGCATACGCAACAAAAGTGCTGCTCGAGCAGATTATAGACACTTATGGACCAGTATATATGAGGTTG
GGAAGAGACTATGCTCCAAGGGTTTACGAGGATGGGACAAAGATAAAGCTAGGAAAGGCCAATGTGTTAAGAAAAGGAAA
GGAAATACTTCTAGTGGCAGCTGGAACTTTAGTCCATACAGCGTTAAATGTAGCTAAAATGCTTGAGAAACTGAATGTAG
ATGCGAGTGTTATTGACATGCATACAATAAAGCCACTTGACGAAAAAACTCTCTTGAACTATGCAAAAAGAGCTGAATTA
GTTATTACCCTTGAAGAACACAGCATTTATGGAGGGCTAGGAGGAGCAGTTGCGGAGGTTTTGAGCGAAAAACTTCCCAG
GAGAGTAGTTCGGATAGGAACAGTAGAGTTTGGACAATCTGGTAGGGATTATCTTGCACTTCTAGACAGGTATGGATTAA
CACCCGACAAAATCTACCAAAAAATTGTCCAGGTGGTGATGTAA

Upstream 100 bases:

>100_bases
TTAGGGAAGTTGAAAATAATGTGGAAAAGCTAAAGGAAACCATAATCGAGCTAGAAAAGATCAATGATAGACCAAAAGTC
ATAATAGCGAGGTGGAATTG

Downstream 100 bases:

>100_bases
TTTGAGCGTTATGAAGTACTCAAAAGAATACAAAGAGAAGACCGTAGTTAAAATCAATGACGTTAAGTTTGGTGAGGGGT
TCACAATAATCGCAGGGCCA

Product: transketolase C-terminal section

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MIESFREAFGRALVEIGKKREEVVVIDADVKGSTKTIYFEKAFPKRFIQVGISEQDMIGTAAGLAIAGKIPVASAFAVFL
MRAWEQIRNTVARDNLNVKIVGTHSGFSDYMDGSSHQCLEDIALMRVLPNMKVVVPADAYATKVLLEQIIDTYGPVYMRL
GRDYAPRVYEDGTKIKLGKANVLRKGKEILLVAAGTLVHTALNVAKMLEKLNVDASVIDMHTIKPLDEKTLLNYAKRAEL
VITLEEHSIYGGLGGAVAEVLSEKLPRRVVRIGTVEFGQSGRDYLALLDRYGLTPDKIYQKIVQVVM

Sequences:

>Translated_307_residues
MIESFREAFGRALVEIGKKREEVVVIDADVKGSTKTIYFEKAFPKRFIQVGISEQDMIGTAAGLAIAGKIPVASAFAVFL
MRAWEQIRNTVARDNLNVKIVGTHSGFSDYMDGSSHQCLEDIALMRVLPNMKVVVPADAYATKVLLEQIIDTYGPVYMRL
GRDYAPRVYEDGTKIKLGKANVLRKGKEILLVAAGTLVHTALNVAKMLEKLNVDASVIDMHTIKPLDEKTLLNYAKRAEL
VITLEEHSIYGGLGGAVAEVLSEKLPRRVVRIGTVEFGQSGRDYLALLDRYGLTPDKIYQKIVQVVM
>Mature_307_residues
MIESFREAFGRALVEIGKKREEVVVIDADVKGSTKTIYFEKAFPKRFIQVGISEQDMIGTAAGLAIAGKIPVASAFAVFL
MRAWEQIRNTVARDNLNVKIVGTHSGFSDYMDGSSHQCLEDIALMRVLPNMKVVVPADAYATKVLLEQIIDTYGPVYMRL
GRDYAPRVYEDGTKIKLGKANVLRKGKEILLVAAGTLVHTALNVAKMLEKLNVDASVIDMHTIKPLDEKTLLNYAKRAEL
VITLEEHSIYGGLGGAVAEVLSEKLPRRVVRIGTVEFGQSGRDYLALLDRYGLTPDKIYQKIVQVVM

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=301, Percent_Identity=33.2225913621262, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI4507521, Length=301, Percent_Identity=33.2225913621262, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI225637461, Length=298, Percent_Identity=36.5771812080537, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI225637463, Length=298, Percent_Identity=36.5771812080537, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI225637459, Length=298, Percent_Identity=36.5771812080537, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI133778974, Length=307, Percent_Identity=33.5504885993485, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4557353, Length=232, Percent_Identity=28.0172413793103, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI34101272, Length=232, Percent_Identity=28.0172413793103, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI291084858, Length=273, Percent_Identity=26.007326007326, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI156564403, Length=280, Percent_Identity=26.4285714285714, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI1786622, Length=279, Percent_Identity=32.9749103942652, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI48994911, Length=320, Percent_Identity=24.6875, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539652, Length=297, Percent_Identity=37.037037037037, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17506935, Length=204, Percent_Identity=27.4509803921569, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538422, Length=277, Percent_Identity=25.9927797833935, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24645119, Length=305, Percent_Identity=32.4590163934426, Blast_Score=157, Evalue=8e-39,
Organism=Drosophila melanogaster, GI45551847, Length=305, Percent_Identity=32.4590163934426, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI45550715, Length=305, Percent_Identity=32.4590163934426, Blast_Score=157, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24666278, Length=300, Percent_Identity=33, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI21358145, Length=262, Percent_Identity=30.5343511450382, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24650940, Length=262, Percent_Identity=30.5343511450382, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI160714828, Length=238, Percent_Identity=28.1512605042017, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI160714832, Length=238, Percent_Identity=28.1512605042017, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 33959; Mature: 33959

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIESFREAFGRALVEIGKKREEVVVIDADVKGSTKTIYFEKAFPKRFIQVGISEQDMIGT
CCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHHH
AAGLAIAGKIPVASAFAVFLMRAWEQIRNTVARDNLNVKIVGTHSGFSDYMDGSSHQCLE
HHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCCCCHHHHH
DIALMRVLPNMKVVVPADAYATKVLLEQIIDTYGPVYMRLGRDYAPRVYEDGTKIKLGKA
HHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCEEEECCH
NVLRKGKEILLVAAGTLVHTALNVAKMLEKLNVDASVIDMHTIKPLDEKTLLNYAKRAEL
HHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCHHHHHHHHHHCEE
VITLEEHSIYGGLGGAVAEVLSEKLPRRVVRIGTVEFGQSGRDYLALLDRYGLTPDKIYQ
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHCCCCHHHHHH
KIVQVVM
HHHHHHC
>Mature Secondary Structure
MIESFREAFGRALVEIGKKREEVVVIDADVKGSTKTIYFEKAFPKRFIQVGISEQDMIGT
CCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHHH
AAGLAIAGKIPVASAFAVFLMRAWEQIRNTVARDNLNVKIVGTHSGFSDYMDGSSHQCLE
HHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHCCCCCHHHHH
DIALMRVLPNMKVVVPADAYATKVLLEQIIDTYGPVYMRLGRDYAPRVYEDGTKIKLGKA
HHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCCCEEEECCH
NVLRKGKEILLVAAGTLVHTALNVAKMLEKLNVDASVIDMHTIKPLDEKTLLNYAKRAEL
HHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCCCCCHHHHHHHHHHCEE
VITLEEHSIYGGLGGAVAEVLSEKLPRRVVRIGTVEFGQSGRDYLALLDRYGLTPDKIYQ
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHHHHCCCCHHHHHH
KIVQVVM
HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]