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The map label for this gene is tktB [C]

Identifier: 18978060

GI number: 18978060

Start: 1568979

End: 1569632

Strand: Direct

Name: tktB [C]

Synonym: PF1688

Alternate gene names: 18978060

Gene position: 1568979-1569632 (Clockwise)

Preceding gene: 18978059

Following gene: 18978061

Centisome position: 82.22

GC content: 41.13

Gene sequence:

>654_bases
GTGAGTGAAGTTCTTACAGTAAAGTTAAAAGAGATGCTAAAGCCTGTTAATGGCTTCCACATGAACTCCTCCTTAACTTG
CCTTAGAATACTCCAAGCAGTTTTAGAACTAAAGAAGGAAGAAGATACGATAATAATAAGCAAGGGACATTCAGCCCCAG
CATTCTACGTTTTGCTCTGGAAAATGGGACTAATAAGTGACGAAGAACTTATGAGCTTCGCAGAAATTGACGGACTTCCA
AGCCACGTAACTAGAGGACTCCCCTTTATTGAAGTCTCTTCAGGATCACTAGGTCAAGGCCTCTCTGTTGCAAACGGTAT
AGCACTAGCTAAAAAGATGGACAACAAGAAAGGCAGAATATTCGTTATTTTAGGAGATGGAGAGCTAGATGAGGGTCAAA
TATGGGAAGCTGCCATGACAGCAGCTCACCACAACCTTGACAATGTTGTAGCAATTATTGACAGAAATTACCACCAGCTT
ACAGGACATACTGAAGATATACTCGCAAAAGAACCGTTAGCAGAGAAGTGGAAGGCCTTTGGATGGGAGGTTAGGGAAGT
TGAAAATAATGTGGAAAAGCTAAAGGAAACCATAATCGAGCTAGAAAAGATCAATGATAGACCAAAAGTCATAATAGCGA
GGTGGAATTGGTGA

Upstream 100 bases:

>100_bases
GAGCTAGGATTGATAGAATACGGAACAAAGGATGATCCAAAACCCGTTAGATTGACTGAAGAAGGAAAACTTGTTCTGAC
AATTTTAAGAGGTGATGGAA

Downstream 100 bases:

>100_bases
TAGAAAGCTTCAGAGAAGCTTTCGGAAGAGCACTTGTCGAAATTGGGAAGAAAAGAGAAGAGGTTGTAGTAATTGATGCG
GATGTAAAAGGCTCAACAAA

Product: transketolase N-terminal section

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 217; Mature: 216

Protein sequence:

>217_residues
MSEVLTVKLKEMLKPVNGFHMNSSLTCLRILQAVLELKKEEDTIIISKGHSAPAFYVLLWKMGLISDEELMSFAEIDGLP
SHVTRGLPFIEVSSGSLGQGLSVANGIALAKKMDNKKGRIFVILGDGELDEGQIWEAAMTAAHHNLDNVVAIIDRNYHQL
TGHTEDILAKEPLAEKWKAFGWEVREVENNVEKLKETIIELEKINDRPKVIIARWNW

Sequences:

>Translated_217_residues
MSEVLTVKLKEMLKPVNGFHMNSSLTCLRILQAVLELKKEEDTIIISKGHSAPAFYVLLWKMGLISDEELMSFAEIDGLP
SHVTRGLPFIEVSSGSLGQGLSVANGIALAKKMDNKKGRIFVILGDGELDEGQIWEAAMTAAHHNLDNVVAIIDRNYHQL
TGHTEDILAKEPLAEKWKAFGWEVREVENNVEKLKETIIELEKINDRPKVIIARWNW
>Mature_216_residues
SEVLTVKLKEMLKPVNGFHMNSSLTCLRILQAVLELKKEEDTIIISKGHSAPAFYVLLWKMGLISDEELMSFAEIDGLPS
HVTRGLPFIEVSSGSLGQGLSVANGIALAKKMDNKKGRIFVILGDGELDEGQIWEAAMTAAHHNLDNVVAIIDRNYHQLT
GHTEDILAKEPLAEKWKAFGWEVREVENNVEKLKETIIELEKINDRPKVIIARWNW

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI133778974, Length=183, Percent_Identity=36.6120218579235, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI205277463, Length=180, Percent_Identity=35, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI4507521, Length=180, Percent_Identity=35, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI225637463, Length=165, Percent_Identity=32.7272727272727, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI225637461, Length=165, Percent_Identity=32.7272727272727, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI225637459, Length=165, Percent_Identity=32.7272727272727, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1788808, Length=190, Percent_Identity=31.0526315789474, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI48994911, Length=190, Percent_Identity=27.3684210526316, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539652, Length=220, Percent_Identity=35.4545454545455, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6325331, Length=186, Percent_Identity=36.0215053763441, Blast_Score=93, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319593, Length=190, Percent_Identity=32.1052631578947, Blast_Score=82, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24666278, Length=208, Percent_Identity=34.6153846153846, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45551847, Length=200, Percent_Identity=35, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI45550715, Length=200, Percent_Identity=35, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24645119, Length=200, Percent_Identity=35, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 24382; Mature: 24250

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVLTVKLKEMLKPVNGFHMNSSLTCLRILQAVLELKKEEDTIIISKGHSAPAFYVLLW
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
KMGLISDEELMSFAEIDGLPSHVTRGLPFIEVSSGSLGQGLSVANGIALAKKMDNKKGRI
HHCCCCHHHHHHHHHHCCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEE
FVILGDGELDEGQIWEAAMTAAHHNLDNVVAIIDRNYHQLTGHTEDILAKEPLAEKWKAF
EEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHCCCCHHHHHCCCHHHHHHHH
GWEVREVENNVEKLKETIIELEKINDRPKVIIARWNW
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
>Mature Secondary Structure 
SEVLTVKLKEMLKPVNGFHMNSSLTCLRILQAVLELKKEEDTIIISKGHSAPAFYVLLW
CCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
KMGLISDEELMSFAEIDGLPSHVTRGLPFIEVSSGSLGQGLSVANGIALAKKMDNKKGRI
HHCCCCHHHHHHHHHHCCCHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCEE
FVILGDGELDEGQIWEAAMTAAHHNLDNVVAIIDRNYHQLTGHTEDILAKEPLAEKWKAF
EEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHCCCCHHHHHCCCHHHHHHHH
GWEVREVENNVEKLKETIIELEKINDRPKVIIARWNW
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]