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The map label for this gene is lysK

Identifier: 18978058

GI number: 18978058

Start: 1567538

End: 1568518

Strand: Direct

Name: lysK

Synonym: PF1686

Alternate gene names: 18978058

Gene position: 1567538-1568518 (Clockwise)

Preceding gene: 18978057

Following gene: 18978059

Centisome position: 82.15

GC content: 41.28

Gene sequence:

>981_bases
ATGATATCTACGGAAGAAAAAATTGAGTTTCTTAAACGCCTTGTTGAAATCTATAGTCCGACGGGAAAAGAAAATGGGGT
TGCTAAGTTCCTCATTAAATCCTTTGAAAATTATGGGATAGAGGCATATCTCGATGATGTAGGGAACGTAATCGCTGTAA
AAAAGGGAAAGGGACCACTAATCCTATTAGCTGGCCATATGGATACAGTTCCGGGCTATATTCCCGTCAGGATTGAGAAC
GGAGAGCTATGGGGCAGAGGGGCTGTCGATGCAAAAGGGCCATTAGCTACTTTCTTTTTTGCTACAATAGAAAGTGACGC
AAACATAATTTTTGCTGGGTTAGTGGATGAAGAAGGATTTTCCAAGGGGGCAAAGAACTTAGAAGTTCCAAAACCTGATT
ACATAATTGTGGGAGAACCAAGTGGAACCAATGGAGTAACGATTGGATACAAAGGTAGTTTAACAGTTAAGTTTACAGAA
ACAGTAGAAAAAGTGCACGGCAGCATTGGAGTCGGAGCAGCTGAAAAACTAATAGAGAAATGGCTCACTATAGCCAAGTA
CTTCGGTGAGGGCTTTAACAGTCTGAGCGGAAGAATTGTCAAATTTGTTGCATATGAAAGGGAGTTTGACTTTTTTGGAG
AGATGATAGTTAATTTAAGAACTCCTCCCGGATATATGCCTCCAAAAGAATGGGACATCATTGACTTTGTTCCAGCATAT
GAAGTAAGTAGAACTTCTCCCCTTGTAAGAGCGTTCGTTAGAGCAATAAGGAAAGCAGGTTACAAGCCGAAGCTAAAGAA
AAAAACTGGCACAGCCGATACAAATATTCTCGGACCAAAGTATGGAGTGGATGCAATAGCATATGGGCCTGGAGATTCCA
AGCTTGACCACACTCCCTACGAAAGGATAAAGCTCAGGGAATACCTAGAAGCTATTGAAATCCTTAAAAACGCAATTCTC
GAGCTCAGCTCAAACGATTGA

Upstream 100 bases:

>100_bases
GTTCACACAGCGGGGCAGCGGGTTATAAGACTTCTCCCACCTCTTATAATTAGCAAAGATGAGATAAATCAAGCAAAATC
GGCCATTGAAGGTGTTATTA

Downstream 100 bases:

>100_bases
CAAACCGCTACTTTTCTAATTCATATCTTGACAAATTTTGTCATTTGGATAGGAACAGTTGCCCAAGAATTTAAATACTC
TTTTTATTTTCTTTGTGGAT

Product: acetyl-lysine deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MISTEEKIEFLKRLVEIYSPTGKENGVAKFLIKSFENYGIEAYLDDVGNVIAVKKGKGPLILLAGHMDTVPGYIPVRIEN
GELWGRGAVDAKGPLATFFFATIESDANIIFAGLVDEEGFSKGAKNLEVPKPDYIIVGEPSGTNGVTIGYKGSLTVKFTE
TVEKVHGSIGVGAAEKLIEKWLTIAKYFGEGFNSLSGRIVKFVAYEREFDFFGEMIVNLRTPPGYMPPKEWDIIDFVPAY
EVSRTSPLVRAFVRAIRKAGYKPKLKKKTGTADTNILGPKYGVDAIAYGPGDSKLDHTPYERIKLREYLEAIEILKNAIL
ELSSND

Sequences:

>Translated_326_residues
MISTEEKIEFLKRLVEIYSPTGKENGVAKFLIKSFENYGIEAYLDDVGNVIAVKKGKGPLILLAGHMDTVPGYIPVRIEN
GELWGRGAVDAKGPLATFFFATIESDANIIFAGLVDEEGFSKGAKNLEVPKPDYIIVGEPSGTNGVTIGYKGSLTVKFTE
TVEKVHGSIGVGAAEKLIEKWLTIAKYFGEGFNSLSGRIVKFVAYEREFDFFGEMIVNLRTPPGYMPPKEWDIIDFVPAY
EVSRTSPLVRAFVRAIRKAGYKPKLKKKTGTADTNILGPKYGVDAIAYGPGDSKLDHTPYERIKLREYLEAIEILKNAIL
ELSSND
>Mature_326_residues
MISTEEKIEFLKRLVEIYSPTGKENGVAKFLIKSFENYGIEAYLDDVGNVIAVKKGKGPLILLAGHMDTVPGYIPVRIEN
GELWGRGAVDAKGPLATFFFATIESDANIIFAGLVDEEGFSKGAKNLEVPKPDYIIVGEPSGTNGVTIGYKGSLTVKFTE
TVEKVHGSIGVGAAEKLIEKWLTIAKYFGEGFNSLSGRIVKFVAYEREFDFFGEMIVNLRTPPGYMPPKEWDIIDFVPAY
EVSRTSPLVRAFVRAIRKAGYKPKLKKKTGTADTNILGPKYGVDAIAYGPGDSKLDHTPYERIKLREYLEAIEILKNAIL
ELSSND

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; fifth step. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family. LysK subfamily

Homologues:

Organism=Caenorhabditis elegans, GI17551016, Length=249, Percent_Identity=30.5220883534137, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LYSK_PYRFU (Q8U0B3)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579415.1
- ProteinModelPortal:   Q8U0B3
- EnsemblBacteria:   EBPYRT00000005544
- GeneID:   1469563
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1686
- NMPDR:   fig|186497.1.peg.1734
- GeneTree:   EBGT00050000022564
- HOGENOM:   HBG728841
- OMA:   SVDAKGP
- ProtClustDB:   PRK04443
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_01120
- InterPro:   IPR001261
- InterPro:   IPR010175
- InterPro:   IPR002933
- TIGRFAMs:   TIGR01902

Pfam domain/function: PF01546 Peptidase_M20

EC number: 3.5.1.-

Molecular weight: Translated: 35931; Mature: 35931

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: ACT_SITE 68-68 ACT_SITE 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISTEEKIEFLKRLVEIYSPTGKENGVAKFLIKSFENYGIEAYLDDVGNVIAVKKGKGPL
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCCE
ILLAGHMDTVPGYIPVRIENGELWGRGAVDAKGPLATFFFATIESDANIIFAGLVDEEGF
EEEECCCCCCCCEEEEEEECCCEECCCCCCCCCCHHEEEEEEECCCCCEEEEEEECCCCH
SKGAKNLEVPKPDYIIVGEPSGTNGVTIGYKGSLTVKFTETVEKVHGSIGVGAAEKLIEK
HCCCCCCCCCCCCEEEEECCCCCCCEEEEECCEEEEEEHHHHHHHHCCCCCCHHHHHHHH
WLTIAKYFGEGFNSLSGRIVKFVAYEREFDFFGEMIVNLRTPPGYMPPKEWDIIDFVPAY
HHHHHHHHHCCHHHHHHHEEEEEHHHCCHHHHHHHHEEECCCCCCCCCCCCCEEECCCCC
EVSRTSPLVRAFVRAIRKAGYKPKLKKKTGTADTNILGPKYGVDAIAYGPGDSKLDHTPY
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHH
ERIKLREYLEAIEILKNAILELSSND
HHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MISTEEKIEFLKRLVEIYSPTGKENGVAKFLIKSFENYGIEAYLDDVGNVIAVKKGKGPL
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEECCCCCE
ILLAGHMDTVPGYIPVRIENGELWGRGAVDAKGPLATFFFATIESDANIIFAGLVDEEGF
EEEECCCCCCCCEEEEEEECCCEECCCCCCCCCCHHEEEEEEECCCCCEEEEEEECCCCH
SKGAKNLEVPKPDYIIVGEPSGTNGVTIGYKGSLTVKFTETVEKVHGSIGVGAAEKLIEK
HCCCCCCCCCCCCEEEEECCCCCCCEEEEECCEEEEEEHHHHHHHHCCCCCCHHHHHHHH
WLTIAKYFGEGFNSLSGRIVKFVAYEREFDFFGEMIVNLRTPPGYMPPKEWDIIDFVPAY
HHHHHHHHHCCHHHHHHHEEEEEHHHCCHHHHHHHHEEECCCCCCCCCCCCCEEECCCCC
EVSRTSPLVRAFVRAIRKAGYKPKLKKKTGTADTNILGPKYGVDAIAYGPGDSKLDHTPY
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHH
ERIKLREYLEAIEILKNAILELSSND
HHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA