Click here to switch to the map view.

The map label for this gene is argD

Identifier: 18978057

GI number: 18978057

Start: 1566463

End: 1567563

Strand: Direct

Name: argD

Synonym: PF1685

Alternate gene names: 18978057

Gene position: 1566463-1567563 (Clockwise)

Preceding gene: 18978056

Following gene: 18978058

Centisome position: 82.09

GC content: 39.51

Gene sequence:

>1101_bases
ATGAGCTTGTACAGGAAGAGACTAAGGCTCGTAAAAGGAGAAGGAATTTACGTATGGGATTCCCAGGGAAAGAAGTACAT
AGACTTAATAGCAGGTATTGGAGTAAACGTTCTAGGACACAATCATCCCGAGTGGGTAAGTGAATTGCAGGAACAGCTAG
AAAAGCTTGTAGTTGCAGGCCCAATGTTTGATCATGAGGAAAAGTACGAGATGCTTGAAGAACTTGAAAAATTTGTCACA
TACGAATACGTATACATAGGAAATTCAGGAACAGAAGCAGTTGAAGCTGCATTAAAGTTTGCTAGGCTTTATACCGGGAG
AAAAGAGATAATAGCTATGACAAACGCTTTCCATGGAAGGACAATGGGGGCTTTAAGTGCTACTTGGAAACCAAAGTATA
GAGAAGACTTCAAACCTTTAGTTCCTGGGTTTAAGCACATACCTTTCAACGATGTTGAAGCAGCAAAAGAAGCAATAACT
ACGGAAACTGCAGCTGTAATATTTGAGCCAATTCAAGGAGAAGGAGGAGTTGTTCCAGCAAATGAAGAGTTCGTCAAAAC
ACTTAGAGATCTTACTGAAGACAAAGGAGCCTTGCTAATTGCAGATGAAGTTCAGAGTGGTCTTAGGACAGGAAAATTTC
TAGCTATTGAGCATTACAAAGTGGAACCAGACATTGTAACTATGGGTAAGGGCATTGGAAATGGAGTGCCAGTAAGCTTA
ACATTAACAAACTTTGACGTGGAAAGAGGGAAACACGGATCAACATTTGGAGGAAATCCTCTAGCCTGTAAAGCTGTGGC
CGTAACTCTAAGAATTTTGAGAAGAGAAAAACTAATCGAAAAAGCTGCTGAAAAGTTCATTGAAATAAAAGGAGAAAATG
TTGTCTTAACGAGAGGAAAAGGGCTAATGATAGGAATAGTCATGAAAAAACCCGTAGCTAAAGTGGTAGAAGAACTTCAA
AATAGAGGTTATCTCGTTCACACAGCGGGGCAGCGGGTTATAAGACTTCTCCCACCTCTTATAATTAGCAAAGATGAGAT
AAATCAAGCAAAATCGGCCATTGAAGGTGTTATTAATGATATCTACGGAAGAAAAAATTGA

Upstream 100 bases:

>100_bases
TGAAAAAGAAGCTTCTTATGGCCAAAGAAGCGATAAACAGTGGTATTAAGAACGTTGTAATTGAAGGATTAAACGGAAGG
ACGGTGATATATTGAGGGAA

Downstream 100 bases:

>100_bases
GTTTCTTAAACGCCTTGTTGAAATCTATAGTCCGACGGGAAAAGAAAATGGGGTTGCTAAGTTCCTCATTAAATCCTTTG
AAAATTATGGGATAGAGGCA

Product: acetylornithine/acetyl-lysine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSLYRKRLRLVKGEGIYVWDSQGKKYIDLIAGIGVNVLGHNHPEWVSELQEQLEKLVVAGPMFDHEEKYEMLEELEKFVT
YEYVYIGNSGTEAVEAALKFARLYTGRKEIIAMTNAFHGRTMGALSATWKPKYREDFKPLVPGFKHIPFNDVEAAKEAIT
TETAAVIFEPIQGEGGVVPANEEFVKTLRDLTEDKGALLIADEVQSGLRTGKFLAIEHYKVEPDIVTMGKGIGNGVPVSL
TLTNFDVERGKHGSTFGGNPLACKAVAVTLRILRREKLIEKAAEKFIEIKGENVVLTRGKGLMIGIVMKKPVAKVVEELQ
NRGYLVHTAGQRVIRLLPPLIISKDEINQAKSAIEGVINDIYGRKN

Sequences:

>Translated_366_residues
MSLYRKRLRLVKGEGIYVWDSQGKKYIDLIAGIGVNVLGHNHPEWVSELQEQLEKLVVAGPMFDHEEKYEMLEELEKFVT
YEYVYIGNSGTEAVEAALKFARLYTGRKEIIAMTNAFHGRTMGALSATWKPKYREDFKPLVPGFKHIPFNDVEAAKEAIT
TETAAVIFEPIQGEGGVVPANEEFVKTLRDLTEDKGALLIADEVQSGLRTGKFLAIEHYKVEPDIVTMGKGIGNGVPVSL
TLTNFDVERGKHGSTFGGNPLACKAVAVTLRILRREKLIEKAAEKFIEIKGENVVLTRGKGLMIGIVMKKPVAKVVEELQ
NRGYLVHTAGQRVIRLLPPLIISKDEINQAKSAIEGVINDIYGRKN
>Mature_365_residues
SLYRKRLRLVKGEGIYVWDSQGKKYIDLIAGIGVNVLGHNHPEWVSELQEQLEKLVVAGPMFDHEEKYEMLEELEKFVTY
EYVYIGNSGTEAVEAALKFARLYTGRKEIIAMTNAFHGRTMGALSATWKPKYREDFKPLVPGFKHIPFNDVEAAKEAITT
ETAAVIFEPIQGEGGVVPANEEFVKTLRDLTEDKGALLIADEVQSGLRTGKFLAIEHYKVEPDIVTMGKGIGNGVPVSLT
LTNFDVERGKHGSTFGGNPLACKAVAVTLRILRREKLIEKAAEKFIEIKGENVVLTRGKGLMIGIVMKKPVAKVVEELQN
RGYLVHTAGQRVIRLLPPLIISKDEINQAKSAIEGVINDIYGRKN

Specific function: Involved in both the arginine and lysine biosynthetic pathways

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=375, Percent_Identity=35.7333333333333, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI284507298, Length=297, Percent_Identity=36.3636363636364, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI13994255, Length=433, Percent_Identity=28.6374133949192, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI24119277, Length=409, Percent_Identity=26.161369193154, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI37574042, Length=395, Percent_Identity=26.3291139240506, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI226442705, Length=395, Percent_Identity=25.5696202531646, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI226442709, Length=365, Percent_Identity=26.5753424657534, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI188536080, Length=412, Percent_Identity=23.7864077669903, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI38679950, Length=412, Percent_Identity=23.7864077669903, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI38679946, Length=412, Percent_Identity=23.7864077669903, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1788044, Length=361, Percent_Identity=39.612188365651, Blast_Score=247, Evalue=7e-67,
Organism=Escherichia coli, GI1789759, Length=377, Percent_Identity=37.4005305039788, Blast_Score=240, Evalue=9e-65,
Organism=Escherichia coli, GI145693181, Length=365, Percent_Identity=37.2602739726027, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=32.5, Blast_Score=181, Evalue=7e-47,
Organism=Escherichia coli, GI1789016, Length=400, Percent_Identity=32.25, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1786349, Length=275, Percent_Identity=34.9090909090909, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1786991, Length=402, Percent_Identity=29.8507462686567, Blast_Score=128, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI25144271, Length=381, Percent_Identity=38.8451443569554, Blast_Score=244, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI25144274, Length=273, Percent_Identity=39.9267399267399, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI32564660, Length=417, Percent_Identity=32.6139088729017, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71992977, Length=409, Percent_Identity=27.3838630806846, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71981843, Length=155, Percent_Identity=36.1290322580645, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17541228, Length=415, Percent_Identity=25.3012048192771, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=390, Percent_Identity=36.9230769230769, Blast_Score=229, Evalue=7e-61,
Organism=Saccharomyces cerevisiae, GI6323470, Length=391, Percent_Identity=33.2480818414322, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6321456, Length=277, Percent_Identity=27.7978339350181, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357415, Length=373, Percent_Identity=35.9249329758713, Blast_Score=221, Evalue=8e-58,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=28.0373831775701, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI28574759, Length=428, Percent_Identity=28.5046728971963, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI21356575, Length=407, Percent_Identity=27.027027027027, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI281366494, Length=414, Percent_Identity=26.5700483091787, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24667139, Length=414, Percent_Identity=26.5700483091787, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24667143, Length=414, Percent_Identity=26.5700483091787, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_PYRFU (Q8U0B4)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579414.1
- ProteinModelPortal:   Q8U0B4
- SMR:   Q8U0B4
- EnsemblBacteria:   EBPYRT00000005525
- GeneID:   1469562
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1685
- NMPDR:   fig|186497.1.peg.1733
- GeneTree:   EBGT00050000022264
- HOGENOM:   HBG725944
- OMA:   SLSITWN
- ProtClustDB:   PRK04013
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 40705; Mature: 40574

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 117-117 BINDING 120-120 BINDING 254-254 BINDING 255-255

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLYRKRLRLVKGEGIYVWDSQGKKYIDLIAGIGVNVLGHNHPEWVSELQEQLEKLVVAG
CCHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCC
PMFDHEEKYEMLEELEKFVTYEYVYIGNSGTEAVEAALKFARLYTGRKEIIAMTNAFHGR
CCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCHHEEEEHHCCCCC
TMGALSATWKPKYREDFKPLVPGFKHIPFNDVEAAKEAITTETAAVIFEPIQGEGGVVPA
CCCCCCCCCCCCHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCCCC
NEEFVKTLRDLTEDKGALLIADEVQSGLRTGKFLAIEHYKVEPDIVTMGKGIGNGVPVSL
CHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCEEEEEEEECCCCEEEECCCCCCCCEEEE
TLTNFDVERGKHGSTFGGNPLACKAVAVTLRILRREKLIEKAAEKFIEIKGENVVLTRGK
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCC
GLMIGIVMKKPVAKVVEELQNRGYLVHTAGQRVIRLLPPLIISKDEINQAKSAIEGVIND
CEEEEEEHHCHHHHHHHHHHHCCEEEEECHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHH
IYGRKN
HCCCCC
>Mature Secondary Structure 
SLYRKRLRLVKGEGIYVWDSQGKKYIDLIAGIGVNVLGHNHPEWVSELQEQLEKLVVAG
CHHHHHHHHCCCCCEEEECCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHCC
PMFDHEEKYEMLEELEKFVTYEYVYIGNSGTEAVEAALKFARLYTGRKEIIAMTNAFHGR
CCCCCHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCHHEEEEHHCCCCC
TMGALSATWKPKYREDFKPLVPGFKHIPFNDVEAAKEAITTETAAVIFEPIQGEGGVVPA
CCCCCCCCCCCCHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHEEEEEEECCCCCCCCC
NEEFVKTLRDLTEDKGALLIADEVQSGLRTGKFLAIEHYKVEPDIVTMGKGIGNGVPVSL
CHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCEEEEEEEECCCCEEEECCCCCCCCEEEE
TLTNFDVERGKHGSTFGGNPLACKAVAVTLRILRREKLIEKAAEKFIEIKGENVVLTRGK
EEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEEEECCC
GLMIGIVMKKPVAKVVEELQNRGYLVHTAGQRVIRLLPPLIISKDEINQAKSAIEGVIND
CEEEEEEHHCHHHHHHHHHHHCCEEEEECHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHH
IYGRKN
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA