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The map label for this gene is hemK [C]

Identifier: 18978045

GI number: 18978045

Start: 1557144

End: 1557749

Strand: Reverse

Name: hemK [C]

Synonym: PF1673

Alternate gene names: 18978045

Gene position: 1557749-1557144 (Counterclockwise)

Preceding gene: 18978046

Following gene: 18978043

Centisome position: 81.63

GC content: 38.61

Gene sequence:

>606_bases
ATGAGAATGGAGTATATGGGTTTGAAAATTGAAATATCAGAGGAGGTTTATGAGCCAGCGGAAGATTCTTTCCTTTTGGC
TGAGGTTCTTCTAAAGGAAGTTAGGGATGAGGACATTGTACTGGATATGGGGACGGGAAGTGGTATCTTAGCACTTTTAG
CGGCAAAAAAAGCGAAATTTGTTGTCGGCGTTGACATAAATGAAAGAGCCGTTGATATTGCTTGGAAAAATGCAGTCAAT
AATGACGTAAAAAATGTGATCTTTGTAAAGAGCGATTTATTTGAGAACATTAGGGGCAGATTCTCTCTAATAGTTTTCAA
CCCTCCATATCTCCCAGGAGAAGATGAAGAAATTAGAGACCCTATAGATTTAGCCCTAATTGGGGGTAAAACTGGTGGAG
AAGTAATTGAACGCTTTGCAAAACACGTGAAAGATTTTCTTCTTCCTGGGGGAAGAGTTCTCCTTTTATATAGCTCACTC
ACTAAAATTAACGTAAGAAAGTTATTTGATGAACTTGGGTTCAAAACTGCGATTGTGGCTAAGGAAAAATTGTTTTTTGA
GGAGTTATACGTCATGAAGGCTGAGCTCTCTTTACACTTCCGATGA

Upstream 100 bases:

>100_bases
CGGGTGGTGTAGCCCGGCCTATCATGCGGGACTGTCACTCCCGCGACCCGGGTTCAAATCCCGGCCCGGGCGCCAAAATT
CTTCTTTCTATTTTGTTCCT

Downstream 100 bases:

>100_bases
ACCTTACAACCGGCTTTTCATGGTGTTCTTCTTGAGACCATTCTTCTTCAATGTAATCTTTTAACTTTGCTTCATATAGT
AGGAGTTTGGGCTTTACATT

Product: protoporphyrinogen oxidase

Products: NA

Alternate protein names: M.MjaHemkP [H]

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MRMEYMGLKIEISEEVYEPAEDSFLLAEVLLKEVRDEDIVLDMGTGSGILALLAAKKAKFVVGVDINERAVDIAWKNAVN
NDVKNVIFVKSDLFENIRGRFSLIVFNPPYLPGEDEEIRDPIDLALIGGKTGGEVIERFAKHVKDFLLPGGRVLLLYSSL
TKINVRKLFDELGFKTAIVAKEKLFFEELYVMKAELSLHFR

Sequences:

>Translated_201_residues
MRMEYMGLKIEISEEVYEPAEDSFLLAEVLLKEVRDEDIVLDMGTGSGILALLAAKKAKFVVGVDINERAVDIAWKNAVN
NDVKNVIFVKSDLFENIRGRFSLIVFNPPYLPGEDEEIRDPIDLALIGGKTGGEVIERFAKHVKDFLLPGGRVLLLYSSL
TKINVRKLFDELGFKTAIVAKEKLFFEELYVMKAELSLHFR
>Mature_201_residues
MRMEYMGLKIEISEEVYEPAEDSFLLAEVLLKEVRDEDIVLDMGTGSGILALLAAKKAKFVVGVDINERAVDIAWKNAVN
NDVKNVIFVKSDLFENIRGRFSLIVFNPPYLPGEDEEIRDPIDLALIGGKTGGEVIERFAKHVKDFLLPGGRVLLLYSSL
TKINVRKLFDELGFKTAIVAKEKLFFEELYVMKAELSLHFR

Specific function: Putative protein methyltransferase. May methylate a Gln residue in target proteins [H]

COG id: COG2890

COG function: function code J; Methylase of polypeptide chain release factors

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hemK family [H]

Homologues:

Organism=Homo sapiens, GI87159829, Length=196, Percent_Identity=32.6530612244898, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787463, Length=182, Percent_Identity=29.1208791208791, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193204212, Length=194, Percent_Identity=32.4742268041237, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320344, Length=205, Percent_Identity=28.780487804878, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI78706836, Length=203, Percent_Identity=30.0492610837438, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR004557
- InterPro:   IPR007848 [H]

Pfam domain/function: PF05175 MTS [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 22726; Mature: 22726

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMEYMGLKIEISEEVYEPAEDSFLLAEVLLKEVRDEDIVLDMGTGSGILALLAAKKAKF
CCCEEEEEEEEECHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCEE
VVGVDINERAVDIAWKNAVNNDVKNVIFVKSDLFENIRGRFSLIVFNPPYLPGEDEEIRD
EEEECCCCCEEEEEEHHHCCCCHHHEEEEHHHHHHHCCCEEEEEEECCCCCCCCCHHHCC
PIDLALIGGKTGGEVIERFAKHVKDFLLPGGRVLLLYSSLTKINVRKLFDELGFKTAIVA
CEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEHH
KEKLFFEELYVMKAELSLHFR
HHHHHHHHHHHHEEEEEEECC
>Mature Secondary Structure
MRMEYMGLKIEISEEVYEPAEDSFLLAEVLLKEVRDEDIVLDMGTGSGILALLAAKKAKF
CCCEEEEEEEEECHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCEE
VVGVDINERAVDIAWKNAVNNDVKNVIFVKSDLFENIRGRFSLIVFNPPYLPGEDEEIRD
EEEECCCCCEEEEEEHHHCCCCHHHEEEEHHHHHHHCCCEEEEEEECCCCCCCCCHHHCC
PIDLALIGGKTGGEVIERFAKHVKDFLLPGGRVLLLYSSLTKINVRKLFDELGFKTAIVA
CEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCCEEEHH
KEKLFFEELYVMKAELSLHFR
HHHHHHHHHHHHEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]