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The map label for this gene is hisI [H]

Identifier: 18978036

GI number: 18978036

Start: 1548216

End: 1548881

Strand: Direct

Name: hisI [H]

Synonym: PF1664

Alternate gene names: 18978036

Gene position: 1548216-1548881 (Clockwise)

Preceding gene: 18978035

Following gene: 18978037

Centisome position: 81.13

GC content: 38.29

Gene sequence:

>666_bases
ATGGAATTCCAGTTAGACTTGATTAGAGGTGAGCATATGGAAATTGAAAAGTTATTGGAGCAAGTAAACTGGGAAAAGAA
CAATGGGATTGTCCCCGTCATAGTTCAGGATGAAAAAGGAGAAGTTCTTACACTTGCATATATGAACAAAGAAGCCCTTA
GAAAAACTCTTGAAACGGGAATTGCCCACTACTACTCACGTTCCAAGGGTAGAATTAGAATGAAAGGAGAAGTTAGTGGG
AATATACAGACAGTTAAAGAGATAAAAATTGATTGTGACAATGACGCCCTCTTGCTAATAGTTTCTCCAAAAGGACCTGC
CTGTCACACTGGAAACTATTCATGCTTTTATAGAAAGCTTGGAGAACCAGAGAGAGTGCTCCCAATAGATTATTCTCTTT
CAATTCTAAAGGAGCTCGAAGAGATAATAAAAAGAAGGAAAGAAACCCCCGTTGAAGGTTCATATACGTCCAAACTTTTT
AAGGAAGGGAGAGAAAAGATCTACAAAAAATTTGGAGAAGAAGCTATAGAAGTCCTCGTTGCTGAGAAAAGGGAAAGGAT
AATCTACGAAGTTGCAGACTTATTATATCACCTTCTAGTGCTCCTTACATATAATGACATTTCTCTAGGAGAGGTTATGA
ACGAGTTAAGGAGGCGGAGAAAGTGA

Upstream 100 bases:

>100_bases
TTAGAAGTATTTAGGATAGGTTCTGATGCTGCATTAGCGGCATCAATTTTCCACTATGGTGAATATACGGTAAGGGAACT
GAAGATGTTTCTTGCCAAAA

Downstream 100 bases:

>100_bases
TCTGGGAAGAAATTCTAAACTTCGAGCCCTATAGAGCCGTAGAAGGAAACTACAGAATATGGCTTGATAAAAATGAAAGT
CCCTATGACCTCCCTCCCCA

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MEFQLDLIRGEHMEIEKLLEQVNWEKNNGIVPVIVQDEKGEVLTLAYMNKEALRKTLETGIAHYYSRSKGRIRMKGEVSG
NIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDYSLSILKELEEIIKRRKETPVEGSYTSKLF
KEGREKIYKKFGEEAIEVLVAEKRERIIYEVADLLYHLLVLLTYNDISLGEVMNELRRRRK

Sequences:

>Translated_221_residues
MEFQLDLIRGEHMEIEKLLEQVNWEKNNGIVPVIVQDEKGEVLTLAYMNKEALRKTLETGIAHYYSRSKGRIRMKGEVSG
NIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDYSLSILKELEEIIKRRKETPVEGSYTSKLF
KEGREKIYKKFGEEAIEVLVAEKRERIIYEVADLLYHLLVLLTYNDISLGEVMNELRRRRK
>Mature_221_residues
MEFQLDLIRGEHMEIEKLLEQVNWEKNNGIVPVIVQDEKGEVLTLAYMNKEALRKTLETGIAHYYSRSKGRIRMKGEVSG
NIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKLGEPERVLPIDYSLSILKELEEIIKRRKETPVEGSYTSKLF
KEGREKIYKKFGEEAIEVLVAEKRERIIYEVADLLYHLLVLLTYNDISLGEVMNELRRRRK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=213, Percent_Identity=42.7230046948357, Blast_Score=169, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319819, Length=209, Percent_Identity=34.4497607655502, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 25706; Mature: 25706

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFQLDLIRGEHMEIEKLLEQVNWEKNNGIVPVIVQDEKGEVLTLAYMNKEALRKTLETG
CCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHH
IAHYYSRSKGRIRMKGEVSGNIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKL
HHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHC
GEPERVLPIDYSLSILKELEEIIKRRKETPVEGSYTSKLFKEGREKIYKKFGEEAIEVLV
CCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEKRERIIYEVADLLYHLLVLLTYNDISLGEVMNELRRRRK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEFQLDLIRGEHMEIEKLLEQVNWEKNNGIVPVIVQDEKGEVLTLAYMNKEALRKTLETG
CCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHH
IAHYYSRSKGRIRMKGEVSGNIQTVKEIKIDCDNDALLLIVSPKGPACHTGNYSCFYRKL
HHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHC
GEPERVLPIDYSLSILKELEEIIKRRKETPVEGSYTSKLFKEGREKIYKKFGEEAIEVLV
CCCCCEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEKRERIIYEVADLLYHLLVLLTYNDISLGEVMNELRRRRK
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA