Click here to switch to the map view.

The map label for this gene is hisC

Identifier: 18978037

GI number: 18978037

Start: 1548878

End: 1549894

Strand: Direct

Name: hisC

Synonym: PF1665

Alternate gene names: 18978037

Gene position: 1548878-1549894 (Clockwise)

Preceding gene: 18978036

Following gene: 33359570

Centisome position: 81.17

GC content: 38.05

Gene sequence:

>1017_bases
GTGATCTGGGAAGAAATTCTAAACTTCGAGCCCTATAGAGCCGTAGAAGGAAACTACAGAATATGGCTTGATAAAAATGA
AAGTCCCTATGACCTCCCTCCCCAACTTAAAGAGGAGATATTAGAAGAACTCAAGAGAATAGAGTTTAATAGATATCCTC
ACATAACCTCAGACCCTCTAAGAGAGGCCCTCGCAGAATTCTACGGACTAAAAAAAGAAAACATAGCCGTTGGGAATGGT
AGTGACGAACTAATAAATTATCTTGTGAAGATGTTCAAGGGAAAGTACATAGTCGTTACCTCCCCCACTTTTGGCATGTA
TTCATTTTTTGCGAAGCTTCATGGAATTCCAGTGAAAGACATTCCCCTAAAGGAGGACTTCACAATTGATGGAGAGAGAA
TTGCAGAAGAAGGAAAAGCAGCATCAGCAATTTTCATAGCCTCACCAAACAACCCTACGGGAAACTCTCAACCAGAAAAT
GAAGTCCTCAAAGTTCTAGACTCTGGGAGAGTAGTTATACTTGATGAAGCCTATTCTGAGTTTTCGGGAAAAAGCTTCAT
ACCAAAAATCAGTGAGTATGAAAATTTAGTAATTCTAAGGACGTTTTCAAAGGCGTTTGGACTTGCTGGAATTAGATGTG
GATATATGATAGCAAATGAAAAGATTATAGATGCTTTATACAGAATACTCCCTCCATACAATCTTAATTCCTTGACAATG
ACAGTGGCTATAAAGATGTTAGAACACTATGATATTGTCAAGAGAAGAATTAAACTTATTGTAAAGGAACGAGAAAGAAT
TAGAAGAGAATTTATAGAATACTCCTATCCGAGTGAAGCTAACTTTCTTCTTATGAAGCTCGATGCATACGATTATCTTC
TAAAGAAGGGGATTGTCGTGAGAAAGTTATCTGGAAGGCTAGAGGGTCACATTAGGGTAACAATAGGAAAAAAATGGGAA
AATGATGAGCTGATTAAAGCCCTAAAAGAATTCCTGGAGGAGTGCAGATGTGGATAG

Upstream 100 bases:

>100_bases
TCTACGAAGTTGCAGACTTATTATATCACCTTCTAGTGCTCCTTACATATAATGACATTTCTCTAGGAGAGGTTATGAAC
GAGTTAAGGAGGCGGAGAAA

Downstream 100 bases:

>100_bases
TCTTTGATGTAGATGGTGTACTCATAGACACTAGCGAGAGTTATGATATGGCAACAAAGCTCACAGTAGAGTACTTTCTT
TCCCACCTGGGAATTAAGAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MIWEEILNFEPYRAVEGNYRIWLDKNESPYDLPPQLKEEILEELKRIEFNRYPHITSDPLREALAEFYGLKKENIAVGNG
SDELINYLVKMFKGKYIVVTSPTFGMYSFFAKLHGIPVKDIPLKEDFTIDGERIAEEGKAASAIFIASPNNPTGNSQPEN
EVLKVLDSGRVVILDEAYSEFSGKSFIPKISEYENLVILRTFSKAFGLAGIRCGYMIANEKIIDALYRILPPYNLNSLTM
TVAIKMLEHYDIVKRRIKLIVKERERIRREFIEYSYPSEANFLLMKLDAYDYLLKKGIVVRKLSGRLEGHIRVTIGKKWE
NDELIKALKEFLEECRCG

Sequences:

>Translated_338_residues
MIWEEILNFEPYRAVEGNYRIWLDKNESPYDLPPQLKEEILEELKRIEFNRYPHITSDPLREALAEFYGLKKENIAVGNG
SDELINYLVKMFKGKYIVVTSPTFGMYSFFAKLHGIPVKDIPLKEDFTIDGERIAEEGKAASAIFIASPNNPTGNSQPEN
EVLKVLDSGRVVILDEAYSEFSGKSFIPKISEYENLVILRTFSKAFGLAGIRCGYMIANEKIIDALYRILPPYNLNSLTM
TVAIKMLEHYDIVKRRIKLIVKERERIRREFIEYSYPSEANFLLMKLDAYDYLLKKGIVVRKLSGRLEGHIRVTIGKKWE
NDELIKALKEFLEECRCG
>Mature_338_residues
MIWEEILNFEPYRAVEGNYRIWLDKNESPYDLPPQLKEEILEELKRIEFNRYPHITSDPLREALAEFYGLKKENIAVGNG
SDELINYLVKMFKGKYIVVTSPTFGMYSFFAKLHGIPVKDIPLKEDFTIDGERIAEEGKAASAIFIASPNNPTGNSQPEN
EVLKVLDSGRVVILDEAYSEFSGKSFIPKISEYENLVILRTFSKAFGLAGIRCGYMIANEKIIDALYRILPPYNLNSLTM
TVAIKMLEHYDIVKRRIKLIVKERERIRREFIEYSYPSEANFLLMKLDAYDYLLKKGIVVRKLSGRLEGHIRVTIGKKWE
NDELIKALKEFLEECRCG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=349, Percent_Identity=32.9512893982808, Blast_Score=190, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6322075, Length=380, Percent_Identity=32.8947368421053, Blast_Score=159, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_PYRFU (Q8TH25)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579394.1
- ProteinModelPortal:   Q8TH25
- SMR:   Q8TH25
- EnsemblBacteria:   EBPYRT00000005620
- GeneID:   1469542
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1665
- NMPDR:   fig|186497.1.peg.1713
- GeneTree:   EBGT00050000022474
- HOGENOM:   HBG646350
- OMA:   HFNENLF
- ProtClustDB:   PRK03967
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39087; Mature: 39087

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIWEEILNFEPYRAVEGNYRIWLDKNESPYDLPPQLKEEILEELKRIEFNRYPHITSDPL
CCHHHHHCCCCCEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHH
REALAEFYGLKKENIAVGNGSDELINYLVKMFKGKYIVVTSPTFGMYSFFAKLHGIPVKD
HHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCC
IPLKEDFTIDGERIAEEGKAASAIFIASPNNPTGNSQPENEVLKVLDSGRVVILDEAYSE
CCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEECCHHH
FSGKSFIPKISEYENLVILRTFSKAFGLAGIRCGYMIANEKIIDALYRILPPYNLNSLTM
CCCCCCCCCHHCCCCEEEEEEHHHHHCCCCCEECEEECCHHHHHHHHHHCCCCCCCHHHH
TVAIKMLEHYDIVKRRIKLIVKERERIRREFIEYSYPSEANFLLMKLDAYDYLLKKGIVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHCCHHE
RKLSGRLEGHIRVTIGKKWENDELIKALKEFLEECRCG
EECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIWEEILNFEPYRAVEGNYRIWLDKNESPYDLPPQLKEEILEELKRIEFNRYPHITSDPL
CCHHHHHCCCCCEEECCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHH
REALAEFYGLKKENIAVGNGSDELINYLVKMFKGKYIVVTSPTFGMYSFFAKLHGIPVKD
HHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCCC
IPLKEDFTIDGERIAEEGKAASAIFIASPNNPTGNSQPENEVLKVLDSGRVVILDEAYSE
CCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEECCHHH
FSGKSFIPKISEYENLVILRTFSKAFGLAGIRCGYMIANEKIIDALYRILPPYNLNSLTM
CCCCCCCCCHHCCCCEEEEEEHHHHHCCCCCEECEEECCHHHHHHHHHHCCCCCCCHHHH
TVAIKMLEHYDIVKRRIKLIVKERERIRREFIEYSYPSEANFLLMKLDAYDYLLKKGIVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHCCHHE
RKLSGRLEGHIRVTIGKKWENDELIKALKEFLEECRCG
EECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA