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The map label for this gene is hisB

Identifier: 18978032

GI number: 18978032

Start: 1545679

End: 1546209

Strand: Direct

Name: hisB

Synonym: PF1660

Alternate gene names: 18978032

Gene position: 1545679-1546209 (Clockwise)

Preceding gene: 18978031

Following gene: 18978033

Centisome position: 81.0

GC content: 41.43

Gene sequence:

>531_bases
GTGAGGAGAACTACAAAAGAAACGGATATAATTGTAGAAATCGGGAAAAAAGGAGAAATAAAGACAAATGACTTAATCCT
AGATCACATGCTTACTGCCTTTGCATTTTATCTAGGAAAGGACATGAGGATCACGGCAACGTATGACTTGAGGCACCACT
TATGGGAAGATATTGGAATAACCCTTGGAGAAGCGCTTAGAGAGAATCTTCCAGAAAAGTTCACAAGGTTTGGGAATGCA
ATAATGCCAATGGACGATGCTCTTGTCTTAGTTTCAGTGGACATTTCAAATAGACCCTATGCAAATGTGGATGTAAACAT
AAAAGATGCAGAAGAAGGATTCGCAGTTTCTCTCCTAAAAGAATTTGTTTGGGGGCTCGCTCGCGGACTTAGAGCTACGA
TCCACATAAAACAACTAAGCGGTGAAAATGCCCACCATATAGTAGAGGCCGCATTTAAGGGGCTTGGAATGGCTCTGAGA
GTAGCAACTAAAGAGAGTGAGAGAGTTGAAAGCACAAAGGGGGTATTGTAA

Upstream 100 bases:

>100_bases
ACTCCACAAAAAGAGCTTGGAGGTTAGAAAATGAGAAAGAAGGCTAATCATTGTGAAATCAACTGTGTAATTAAAGATAC
CTTTTATTGGGGTGAAGAAA

Downstream 100 bases:

>100_bases
TGGATAGAATTGCAATAGTCGACCTAGGAATTGGTAATCTAGCAAACGTAAAGAAGGCCCTAAAAGGATATATAACTAGC
GATCCTTACGAGATAGAGAA

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MRRTTKETDIIVEIGKKGEIKTNDLILDHMLTAFAFYLGKDMRITATYDLRHHLWEDIGITLGEALRENLPEKFTRFGNA
IMPMDDALVLVSVDISNRPYANVDVNIKDAEEGFAVSLLKEFVWGLARGLRATIHIKQLSGENAHHIVEAAFKGLGMALR
VATKESERVESTKGVL

Sequences:

>Translated_176_residues
MRRTTKETDIIVEIGKKGEIKTNDLILDHMLTAFAFYLGKDMRITATYDLRHHLWEDIGITLGEALRENLPEKFTRFGNA
IMPMDDALVLVSVDISNRPYANVDVNIKDAEEGFAVSLLKEFVWGLARGLRATIHIKQLSGENAHHIVEAAFKGLGMALR
VATKESERVESTKGVL
>Mature_176_residues
MRRTTKETDIIVEIGKKGEIKTNDLILDHMLTAFAFYLGKDMRITATYDLRHHLWEDIGITLGEALRENLPEKFTRFGNA
IMPMDDALVLVSVDISNRPYANVDVNIKDAEEGFAVSLLKEFVWGLARGLRATIHIKQLSGENAHHIVEAAFKGLGMALR
VATKESERVESTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=185, Percent_Identity=36.7567567567568, Blast_Score=93, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6324776, Length=182, Percent_Identity=36.8131868131868, Blast_Score=107, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_PYRFU (P58880)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_579389.1
- ProteinModelPortal:   P58880
- SMR:   P58880
- EnsemblBacteria:   EBPYRT00000005831
- GeneID:   1469537
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1660
- NMPDR:   fig|186497.1.peg.1708
- GeneTree:   EBGT00050000023529
- HOGENOM:   HBG289010
- OMA:   FGWAIIP
- ProtClustDB:   PRK00951
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 19736; Mature: 19736

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRTTKETDIIVEIGKKGEIKTNDLILDHMLTAFAFYLGKDMRITATYDLRHHLWEDIGI
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHH
TLGEALRENLPEKFTRFGNAIMPMDDALVLVSVDISNRPYANVDVNIKDAEEGFAVSLLK
HHHHHHHHCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHH
EFVWGLARGLRATIHIKQLSGENAHHIVEAAFKGLGMALRVATKESERVESTKGVL
HHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCC
>Mature Secondary Structure
MRRTTKETDIIVEIGKKGEIKTNDLILDHMLTAFAFYLGKDMRITATYDLRHHLWEDIGI
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHH
TLGEALRENLPEKFTRFGNAIMPMDDALVLVSVDISNRPYANVDVNIKDAEEGFAVSLLK
HHHHHHHHCCHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHH
EFVWGLARGLRATIHIKQLSGENAHHIVEAAFKGLGMALRVATKESERVESTKGVL
HHHHHHHHCCEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA