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The map label for this gene is hisD

Identifier: 18978031

GI number: 18978031

Start: 1544485

End: 1545612

Strand: Direct

Name: hisD

Synonym: PF1659

Alternate gene names: 18978031

Gene position: 1544485-1545612 (Clockwise)

Preceding gene: 18978030

Following gene: 18978032

Centisome position: 80.94

GC content: 40.51

Gene sequence:

>1128_bases
ATGGACATTGAAGAATACGTCAGGGAGATTTTGAAAGATATCCGGGAAAGAGGATTAGAGGCAATAAGAGAGTACTCAAA
AAAATTCGACGGATATGAAGGCCCATTTGAAGTCTCAAAGGAGGAGTTTAAGGAAGCTGAAGAAAGAATTCCAGAAAGGG
ATAAAGAAATTATAAAGAGAACTCTCAAGAGAATTGAGAAATACCATAGAAAACAACTAAAGCAGGACATTTTATACATC
GAGAATGGCTCTCTCTATGGGCTAATATACAAGCCACTCAAGAGAATAGGGATATATGTCCCAGGTGGGAAACCGCTGCC
TTCAACTCTAATGATGGTAGGAGTCCCCGCAAGGGTCGCTGGAGTTAAGGAAATCGTTGTAACAAACCCACCCAAAGATG
GGAAAGTAAATCCATACATCCTGTACATAGCAAAACTCCTCAAGATTGAAGAAGTATACAAGCTCGGAGGAATTCAGGCA
ATAGCTGCCATGGCTTATGGTATTGGAATGAAAAAGGTCCAAAAGATCTTTGGGCCTGGGAATAAGTTTGTCAATGAAGC
AAAGAGACAAGTTTTTGGAATTGTCGGGATAGACAGTTTGGCTGGCCCTTCTGAAATAGCAGTAATTGCAGATGAAAGTG
CGGATAAAGATTTCGTTCTTTACGATTTGTTAAGCCAATTAGAACACGGAAAAGATAGCAAGGCATGGTTATTGACGACG
TCAAAAGAACTAGCAGATTACTGTAATAGAGAGGGAATAACAGTTATCGTGTGTAGCTCTCTTGAGGAATGCTGTAAGAA
AGCTAATGAAATAGCTCCAGAACACCTTGAGATAATAACTAGAGAACCCCTAAAATTGGTAGACTTAATTGAAAATGCAG
GTGCGATATACCTAGGGCTATACACACCAGTTCCTGCAGCTGACTACTTCTTAGGAGTTAATCACGTTCTCCCAACGGGA
GGTGCGGCAAAATTCATGGGTGTTCTCACAGTTTGGGACTTCATGAAGCCAATAAGCATTGCAATGGTTAGTAGAGAGGA
GTTTATCTCTGAAAGAGAGCTGGGAATAAGATTAGCTGAAATAGAAGGAATAGAACTCCACAAAAAGAGCTTGGAGGTTA
GAAAATGA

Upstream 100 bases:

>100_bases
ATAATGGATGTTTCAGCGCTCCTCTTAGTAAATCGCATTTCTCAAAAGATGTTCTTTGAAGAAATTAATTCTTTCATAAC
AAAAATTAGGAGGTCTGTTT

Downstream 100 bases:

>100_bases
GAAAGAAGGCTAATCATTGTGAAATCAACTGTGTAATTAAAGATACCTTTTATTGGGGTGAAGAAAGTGAGGAGAACTAC
AAAAGAAACGGATATAATTG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MDIEEYVREILKDIRERGLEAIREYSKKFDGYEGPFEVSKEEFKEAEERIPERDKEIIKRTLKRIEKYHRKQLKQDILYI
ENGSLYGLIYKPLKRIGIYVPGGKPLPSTLMMVGVPARVAGVKEIVVTNPPKDGKVNPYILYIAKLLKIEEVYKLGGIQA
IAAMAYGIGMKKVQKIFGPGNKFVNEAKRQVFGIVGIDSLAGPSEIAVIADESADKDFVLYDLLSQLEHGKDSKAWLLTT
SKELADYCNREGITVIVCSSLEECCKKANEIAPEHLEIITREPLKLVDLIENAGAIYLGLYTPVPAADYFLGVNHVLPTG
GAAKFMGVLTVWDFMKPISIAMVSREEFISERELGIRLAEIEGIELHKKSLEVRK

Sequences:

>Translated_375_residues
MDIEEYVREILKDIRERGLEAIREYSKKFDGYEGPFEVSKEEFKEAEERIPERDKEIIKRTLKRIEKYHRKQLKQDILYI
ENGSLYGLIYKPLKRIGIYVPGGKPLPSTLMMVGVPARVAGVKEIVVTNPPKDGKVNPYILYIAKLLKIEEVYKLGGIQA
IAAMAYGIGMKKVQKIFGPGNKFVNEAKRQVFGIVGIDSLAGPSEIAVIADESADKDFVLYDLLSQLEHGKDSKAWLLTT
SKELADYCNREGITVIVCSSLEECCKKANEIAPEHLEIITREPLKLVDLIENAGAIYLGLYTPVPAADYFLGVNHVLPTG
GAAKFMGVLTVWDFMKPISIAMVSREEFISERELGIRLAEIEGIELHKKSLEVRK
>Mature_375_residues
MDIEEYVREILKDIRERGLEAIREYSKKFDGYEGPFEVSKEEFKEAEERIPERDKEIIKRTLKRIEKYHRKQLKQDILYI
ENGSLYGLIYKPLKRIGIYVPGGKPLPSTLMMVGVPARVAGVKEIVVTNPPKDGKVNPYILYIAKLLKIEEVYKLGGIQA
IAAMAYGIGMKKVQKIFGPGNKFVNEAKRQVFGIVGIDSLAGPSEIAVIADESADKDFVLYDLLSQLEHGKDSKAWLLTT
SKELADYCNREGITVIVCSSLEECCKKANEIAPEHLEIITREPLKLVDLIENAGAIYLGLYTPVPAADYFLGVNHVLPTG
GAAKFMGVLTVWDFMKPISIAMVSREEFISERELGIRLAEIEGIELHKKSLEVRK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=398, Percent_Identity=39.1959798994975, Blast_Score=263, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6319819, Length=405, Percent_Identity=36.5432098765432, Blast_Score=244, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_PYRFU (O59626)

Other databases:

- EMBL:   AB013080
- EMBL:   AE009950
- RefSeq:   NP_579388.1
- ProteinModelPortal:   O59626
- SMR:   O59626
- EnsemblBacteria:   EBPYRT00000004782
- GeneID:   1469536
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1659
- NMPDR:   fig|186497.1.peg.1707
- GeneTree:   EBGT00050000023439
- HOGENOM:   HBG329596
- OMA:   TEWEVEK
- ProtClustDB:   PRK00877
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 42179; Mature: 42179

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 274-274 ACT_SITE 275-275 BINDING 99-99 BINDING 159-159 BINDING 181-181 BINDING 204-204 BINDING 226-226 BINDING 229-229 BINDING 275-275 BINDING 308-308 BINDING 362-362 BINDING 367-367

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIEEYVREILKDIRERGLEAIREYSKKFDGYEGPFEVSKEEFKEAEERIPERDKEIIKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHH
TLKRIEKYHRKQLKQDILYIENGSLYGLIYKPLKRIGIYVPGGKPLPSTLMMVGVPARVA
HHHHHHHHHHHHHHHHEEEEECCCEEEHHHHHHHHCEEECCCCCCCCHHHHHHCCCHHHH
GVKEIVVTNPPKDGKVNPYILYIAKLLKIEEVYKLGGIQAIAAMAYGIGMKKVQKIFGPG
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHCCC
NKFVNEAKRQVFGIVGIDSLAGPSEIAVIADESADKDFVLYDLLSQLEHGKDSKAWLLTT
HHHHHHHHHHHHHEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
SKELADYCNREGITVIVCSSLEECCKKANEIAPEHLEIITREPLKLVDLIENAGAIYLGL
CHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCEEEEEE
YTPVPAADYFLGVNHVLPTGGAAKFMGVLTVWDFMKPISIAMVSREEFISERELGIRLAE
CCCCCHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEE
IEGIELHKKSLEVRK
ECCHHHHHHHHCCCC
>Mature Secondary Structure
MDIEEYVREILKDIRERGLEAIREYSKKFDGYEGPFEVSKEEFKEAEERIPERDKEIIKR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHH
TLKRIEKYHRKQLKQDILYIENGSLYGLIYKPLKRIGIYVPGGKPLPSTLMMVGVPARVA
HHHHHHHHHHHHHHHHEEEEECCCEEEHHHHHHHHCEEECCCCCCCCHHHHHHCCCHHHH
GVKEIVVTNPPKDGKVNPYILYIAKLLKIEEVYKLGGIQAIAAMAYGIGMKKVQKIFGPG
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHCCC
NKFVNEAKRQVFGIVGIDSLAGPSEIAVIADESADKDFVLYDLLSQLEHGKDSKAWLLTT
HHHHHHHHHHHHHEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEEEEC
SKELADYCNREGITVIVCSSLEECCKKANEIAPEHLEIITREPLKLVDLIENAGAIYLGL
CHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHCCCEEEEEE
YTPVPAADYFLGVNHVLPTGGAAKFMGVLTVWDFMKPISIAMVSREEFISERELGIRLAE
CCCCCHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEE
IEGIELHKKSLEVRK
ECCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA